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Journal of Pharmaceutical and Biomedical Analysis
Bioactive alkaloid extracts from Narcissus broussonetii: Mass spectral studies2012 •
Natural product communications
Chemical composition of bioactive alkaloid extracts from some Narcissus species and varieties and their biological activity2014 •
Alkaloid extracts of eight Narcissus (Amaryllidaceae) species and varieties were studied with respect to their acetylcholinesterase (HuAChE) and butyrylcholinesterase (HuBuChE) inhibitory activity and alkaloid patterns. Thirty alkaloids were determined by GC/MS, and twenty-five of them identified from their mass spectra, retention times and retention indexes. Promising HuAChE inhibition activity was demonstrated by six Narcissus taxa and HuBuChE inhibition by N. jonquila cv. Double Campernelle and N. nanus cv. Elka with IC50 values of 24.1 +/- 1.9 microg/mL and 25.1 +/- 1.8 microg/mL, respectively. Two alkaloids were isolated in pure form using preparative TLC and identified as the galanthamine type alkaloid narwedine and the lycorine type alkaloid incartine. Both compounds were tested for their biological activity. They were considered inactive in HuAChE/HuBuChE assays, but showed promising prolyl oligopeptidase inhibition activities with IC50 values of 0.95 +/- 0.12 mM and 0.91 ğ ...
Natural Product Communications
Chemical Composition of Bioactive Alkaloid Extracts from Some <i>Narcissus</i> Species and Varieties and their Biological Activity2014 •
Archives of pharmacal research
Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity2018 •
Fifteen Amaryllidaceae alkaloids (1-15) of various structural types were isolated by standard chromatographic methods from fresh bulbs of Narcissus poeticus cv. Pink Parasol. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic analyses, and by comparison with literature data. Narcipavline (5) and narcikachnine (6) are reported here for the first time. In their structure are combined two basic structural types of Amaryllidaceae alkaloids (galanthamine- and galanthindole-structural types), which represent a new structural type of these compounds. Alkaloids isolated in sufficient amounts were evaluated for their human erythrocytic acetylcholinesterase, and human serum butyrylcholinesterase (HuBuChE) inhibition activity using Ellman's method. Z-Gly-Pro-p-nitroanilide was used as substrate in the prolyl oligopeptidase (POP) assay. Untested alkaloids were also screened for their cytotoxic activity against a small panel of human cancer cells, which spanned ce...
1999 •
2002 •
Chemistry & Biodiversity
HPTLC and GC/MS Study of Amaryllidaceae Alkaloids of Two Narcissus Species2015 •
Journal of Natural Products
Narcissus Alkaloids, XIV. (+)-8-O-Acetylhomolycorine and Vasconine, Two Novel Alkaloids from Narcissus vasconicus1992 •
Bulletin of the Chemical Society of Ethiopia
<b>Nauclefolinine: A new alkaloid from the roots of <i>Nauclea latifolia</i></b>2004 •
Social Scientist
The Return of the Colonial in Indian Economic History: The Last Phase of Colonialism in India2008 •
2023 •
MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Visuelle Kompetenz: Bilddidaktische Zugänge zum Umgang mit Fotografie2013 •
1999 •
Situación de los disfemismos en la lengua española
Situación de los disfemismos en la lengua española2024 •
Journal of Polymers and the Environment
Nano Graphene-Reinforced Bio-nanocomposites Based on NR/PLA: The Morphological, Thermal and Rheological Perspective2019 •
Applied and Environmental Microbiology
Pathological and Molecular Characterization of <i>Xanthomonas campestris</i> Strains Causing Diseases of Cassava ( <i>Manihot esculenta</i> )1994 •
Jurnal Ilmiah Matematika dan Pendidikan Matematika
Variasi Variabel Pengaruh Fix Dan Random Terhadap Produksi Gula Dan Tetes2012 •
Journal of Biomolecular Structure & Dynamics
In vitro, in vivo and in silico rationale for the muscle loss due to therapeutic drugs used in the treatment of Mycobacterium tuberculosis infection2020 •
Canadian Journal of Mathematics
On Best Proximity Points in Metric and Banach Spaces2011 •
Brain and Cognition
What aspects of face processing are impaired in developmental prosopagnosia?2006 •