- Strasbourg, Alsace, France
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An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers of peroxynitrite. Also disclosed are... more
An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers of peroxynitrite. Also disclosed are methods of using such a composition, which include treating the skin for signs of chronological or pre-mature aging.
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Research Interests: Traditional Medicine, Biology, Evaluation, Pharmacognosy, Medicinal Plants, and 13 moreMedicine, In Vitro, Animals, Pharmazie, Plant extracts, Plasmodium falciparum, Antimalarials, Biological activity, Extract, Plante Medicinale, Paludisme, Spectroscopie, and Pharmacology and pharmaceutical sciences
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Several species of the genus Vochysia (Vochysiaceae) are used by traditional communities in South America to relieve ailments linked to inflammation, such as skin sores, asthma and pulmonary congestion. As the cAMP phosphodiesterase 4... more
Several species of the genus Vochysia (Vochysiaceae) are used by traditional communities in South America to relieve ailments linked to inflammation, such as skin sores, asthma and pulmonary congestion. As the cAMP phosphodiesterase 4 isozyme (PDE4) is currently considered as an intracellular target for new antiinflammatory drugs, several constituents of Vochysia pacifica Cuatrec., an endemic tree from the Western coast of Colombia, were tested for their ability to inhibit PDE4. Purification of the methanol extract of the stem bark of this species led to the isolation of seven known triterpene derivatives: betulinic acid, sericic acid, 24-hydroxytormentic acid, trachelosperogenin B, 24-hydroxytormentic acid glucosyl ester, quadranoside I and niga-ichigoside F1. One triterpene glycoside, quadranoside I, and two triterpenes, betulinic and sericic acids, exhibited mild inhibitory activity on the isolated PDE4 isozyme.
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The antiplasmodial, leishmanicidal and antitrypanosomal activities of eight natural biflavonoids were estimated in vitro on a chloroquine-resistant strain of Plasmodium falciparum, axenically grown Leishmania donovani amastigotes and... more
The antiplasmodial, leishmanicidal and antitrypanosomal activities of eight natural biflavonoids were estimated in vitro on a chloroquine-resistant strain of Plasmodium falciparum, axenically grown Leishmania donovani amastigotes and Trypanosoma cruzi trypomastigotes and Trypanosoma brucei rhodesiense bloodstream forms. Lanaroflavone showed the highest antiplasmodial activity (IC(50) = 0.48 microM), isoginkgetin was the most active leishmanicidal compound (IC(50) = 1.9 microM), whereas ginkgetin (IC(50) = 11 microM) and isoginkgetin (IC(50) = 13 microM) showed the best antitrypanosomal activity in our assays. The cytotoxicity and the selectivity indices for the most active compounds were also estimated. Lanaroflavone exhibited a high selectivity index value (SI = 159), indicating selective antiplasmodial activity.
Research Interests: Complementary and Alternative Medicine, Plant Biology, Biology, Medicine, Phytomedicine, and 11 moreAnimals, Selection Index, Rats, Trypanosoma Cruzi, Trypanosoma brucei, Plasmodium falciparum, Toxicity Tests, Reference standards, Muscle cells, Pharmacology and pharmaceutical sciences, and Leishmania donovani
Research Interests: Chemistry, Phytochemistry, Mass Spectrometry, Biology, Magnetic Resonance Spectroscopy, and 15 moreSaponins, Medicine, Biological Sciences, ROOT, Natural Product, Stereochemistry, Plant Roots, CHEMICAL SCIENCES, Isolation, Optical Rotation, Chemical Structure, Molecular Structure, Carbohydrate Sequence, Molecular Sequence Data, and Medical and Health Sciences
Research Interests: Microbiology, Phytochemistry, Biology, Medicine, Biological Sciences, and 15 moreAntimicrobial activity, STEM, Antimicrobial, Pseudomonas aeruginosa, CHEMICAL SCIENCES, Bark, Antibacterial activity, Bignoniaceae, Isolation, Anthraquinones, Microbial Sensitivity Tests, Pseudomonas Aeruginosa, Molecular Structure, Triterpenes, and Medical and Health Sciences
... The phytochemical analysis of the aerial parts of Thalia geniculata. ... Sitoindoside I was isolated previously from Musa paradisiaca.(Ghosal et al., 1984), Dracaena draco.(Hernandez et al., 2004) and Cremanthodium ellisii.(Wang et... more
... The phytochemical analysis of the aerial parts of Thalia geniculata. ... Sitoindoside I was isolated previously from Musa paradisiaca.(Ghosal et al., 1984), Dracaena draco.(Hernandez et al., 2004) and Cremanthodium ellisii.(Wang et al., 2004). ...
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Research Interests: Chemistry, Organic Chemistry, Leishmania, Medicine, Anticholinesterase, and 15 moreAnimals, Ic, Acetylcholinesterase, Cholinesterase inhibitors, Molecules, Phenolic Compounds, Phenols, Xanthone, Phenolic compound, Veterinary Sciences, Trypanocidal Agents, Antiprotozoal, Leishmanicidal, Clusiaceae, and Aché
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Haitian empirical medicine sprang from both European (16th to 19th century) and African (especially voodoo) traditional therapies. The use of medicinal herbs is highly developed. Our purpose was to list the plants held to be antifertility... more
Haitian empirical medicine sprang from both European (16th to 19th century) and African (especially voodoo) traditional therapies. The use of medicinal herbs is highly developed. Our purpose was to list the plants held to be antifertility agents in the island. We identified about twenty species more or less currently used by the women as abortifacients or emmenagogues. The chemistry and active components of a few species are well-known. However, for most of them, some were partially studied, and no relation could be established between their chemical composition and their potential activities, and the rest are chemically unknown. We chemically screened extracts of Casearia ilicifolia, Eleutherine bulbosa, Rhoeo spathacea and Stemodia durantifolia, and identified flavonoids, triterpenes and sterols in the leaves of C. ilicifolia, and naphthoquinones, and a new anthraquinone, anthracene-9,10-dione-1,5-diol-4-methoxy-3-methyl-2-carboxylic acid methyl ester, in the bulbs of E, bulbosa. R. spathacea showed a stimulative activity on mouse uterus. Antifertility screening tests of C. ilicifolia and E. bulbosa showed activity in rats, but also probably toxicity.
Research Interests: Chemistry, Complementary and Alternative Medicine, Magic, Plant Biology, Haiti, and 15 moreCulture, Biology, Ethnopharmacology, Medicinal Plants, Medicine, Humans, Mice, Female, Animals, Hormones, Anthraquinone, embryo implantation, Chemical Phenomena, Pharmacology and pharmaceutical sciences, and Contraceptive Agents
Research Interests: Complementary and Alternative Medicine, Plant Biology, Biology, Cameroon, Ethnopharmacology, and 15 moreMedicinal Plants, Cytotoxicity, Medicine, Cell line, Animals, Chagas disease, Bignoniaceae, Plant extracts, Apocynaceae, Antiprotozoal, Medicinal Plant, Cell Survival, Clusiaceae, Pharmacology and pharmaceutical sciences, and Leishmania donovani
Research Interests: Colombia, Complementary and Alternative Medicine, Traditional Medicine, Plant Biology, Biology, and 15 moreEthnopharmacology, Leishmania, Medicine, Animals, Selection Index, Plant extracts, Plasmodium falciparum, Antimalarials, Trypanocidal Agents, Antiprotozoal, Plante Medicinale, Leishmaniose, Paludisme, Ethnopharmacologie, and Pharmacology and pharmaceutical sciences
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Research Interests: Complementary and Alternative Medicine, Traditional Medicine, Plant Biology, Biology, Pharmacognosy, and 15 moreFlavonoids, Medicine, Phytotherapy, Humans, Animals, Anacardiaceae, Chagas disease, Plant extracts, Trypanosoma Cruzi, Antimalarials, Fitoterapia, Trypanocidal Agents, Antiprotozoal, Polyphenol, and Plant Leaves
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Haitian empirical medicine sprang from both European (16th to 19th century) and African (especially voodoo) traditional therapies. The use of medicinal herbs is highly developed. Our purpose was to list the plants held to be antifertility... more
Haitian empirical medicine sprang from both European (16th to 19th century) and African (especially voodoo) traditional therapies. The use of medicinal herbs is highly developed. Our purpose was to list the plants held to be antifertility agents in the island. We identified about twenty species more or less currently used by the women as abortifacients or emmenagogues. The chemistry and active components of a few species are well-known. However, for most of them, some were partially studied, and no relation could be established between their chemical composition and their potential activities, and the rest are chemically unknown. We chemically screened extracts of Casearia ilicifolia, Eleutherine bulbosa, Rhoeo spathacea and Stemodia durantifolia, and identified flavonoids, triterpenes and sterols in the leaves of C. ilicifolia, and naphthoquinones, and a new anthraquinone, anthracene-9,10-dione-1,5-diol-4-methoxy-3-methyl-2-carboxylic acid methyl ester, in the bulbs of E, bulbosa. ...
Research Interests: Chemistry, Complementary and Alternative Medicine, Magic, Plant Biology, Haiti, and 15 moreCulture, Biology, Ethnopharmacology, Medicinal Plants, Medicine, Pregnancy, Humans, Mice, Female, Animals, Hormones, embryo implantation, Chemical Phenomena, Pharmacology and pharmaceutical sciences, and Contraceptive Agents
Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new... more
Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new compounds 1 and 5 have been established by nmr studies and comparison with previously described products.
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A new 4,5-di-O-caffeoylquinic acid butyl ester (1) was isolated from an ethyl acetate soluble fraction of Isertia pittieri stems, along with three known compounds, 1,5-di-O-caffeoylquinic acid (2), 3,4-di-O-caffeoylquinic acid (3) and... more
A new 4,5-di-O-caffeoylquinic acid butyl ester (1) was isolated from an ethyl acetate soluble fraction of Isertia pittieri stems, along with three known compounds, 1,5-di-O-caffeoylquinic acid (2), 3,4-di-O-caffeoylquinic acid (3) and 4,5-di-O-caffeoylquinic acid (4).
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Two new 27-nor-triterpenoid saponins, pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-[beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl] ester (1) and pyrocincholic acid 3... more
Two new 27-nor-triterpenoid saponins, pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-[beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl] ester (1) and pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl(1-->6)-beta-D-glucopyranosyl-28-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl] ester (2) were isolated from the stem bark of Isertia pittieri, together with two known bidesmosidic quinovic acid glycosides. The structures of 1 and 2 were determined on the basis of spectroscopic studies.
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Research Interests: Complementary and Alternative Medicine, Plant Biology, Cameroon, Ethnopharmacology, Medicinal Plants, and 15 moreCell line, Animals, Visceral Leishmaniasis, Selection Index, Chagas disease, Bignoniaceae, Plant extracts, Rats, Trypanosoma Cruzi, Trypanosoma brucei, Trypanosoma brucei brucei, Plasmodium falciparum, Apocynaceae, Medicinal Plant, and Cell Survival
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A new, fast and reliable procedure for the quantification of the major compounds of Hypericum perforatum L. has been developed. Four naphthodianthrones (protopseudohypericin, pseudohypericin, protohypericin, hypericin) and two... more
A new, fast and reliable procedure for the quantification of the major compounds of Hypericum perforatum L. has been developed. Four naphthodianthrones (protopseudohypericin, pseudohypericin, protohypericin, hypericin) and two phloroglucinols (hyperforin, adhyperforin) were assayed by HPLC using a short (17 min) linear gradient, with hypericin and hyperforin as external standards. Extraction of dried plant material with methanol in the dark at room temperature for 2 h led to a complete recovery of phloroglucinols but only a partial recovery of the naphthodianthrone derivatives. Treatment of plant material with water:ethanol (40:60, v/v) in a water bath shaker at 80°C led to the total extraction of hypericins, but a 10% loss of total hyperforins was also observed. The two extraction methods, applied successively to the same sample, allowed the complete extraction of all compounds of interest. A 5 min exposure of the crude extract of H. perforatum to sunlight (1 E/m2) induced a 96% loss of hyperforins, whereas the dry plant material lost only 20% of hyperforins after 2 h exposure to sunlight (24 E/m2). Copyright © 2001 John Wiley & Sons, Ltd.
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Research Interests: Phytochemistry, Biological Sciences, Antimicrobial activity, STEM, Antimicrobial, and 12 morePseudomonas aeruginosa, CHEMICAL SCIENCES, Bark, Antibacterial activity, Bignoniaceae, Isolation, Anthraquinones, Gram-negative bacteria, Microbial Sensitivity Tests, Pseudomonas Aeruginosa, Molecular Structure, and Triterpenes
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The following saponosides: mimonosides A (Ma), B (Mb) and C (Me), isolated from the bark of Mimosa tenuiflora (Willd.) Poiret (Mimosaceae) were tested for their influence on cell growth. These effects were evaluated in vitro on a panel of... more
The following saponosides: mimonosides A (Ma), B (Mb) and C (Me), isolated from the bark of Mimosa tenuiflora (Willd.) Poiret (Mimosaceae) were tested for their influence on cell growth. These effects were evaluated in vitro on a panel of lymphoma cells from human and murine origins and on murine lymphocytes (thymocytes and splenocytes). The three saponins did not exhibit any growth influence on two tumour cell lines (Molt 4 and RDM 4). However, they exhibit an important increase of incorporation of tritiated thymidine into DNA of cultured lymphocytes in vitro. Synergic effects of the saponins with concanavaline A (Con A) and lipopolysaccharide (LPS) on the lymphocytes were observed.
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Two new coumarins, 7-methoxy-5-prenylcoumarin (isocedrelopsin) (1) and 3',4'-dihydrobraylin... more
Two new coumarins, 7-methoxy-5-prenylcoumarin (isocedrelopsin) (1) and 3',4'-dihydrobraylin (2), were isolated from the trunk bark of Cedrelopsis grevei, along with five known coumarins, microfolicoumarin (6,7-dimethoxy-5-prenylcoumarin, (3), obliquin (4), 8-methoxyobliquin (5), aesculetin (6), cedrelopsin (7) and scoparone (8).