Artocarpus Altilis

Breadfruit is a traditional staple crop and an important component of Pacific Island agrosystems. This article reviews documentation related to breadfruit in Vanuatu with a focus on ethnobotanical data recorded from the first contacts with European voyagers and missionaries to the most recent survey conducted on several islands in 2009. Tree management practices, food and non-food uses, conservation techniques, as well as ritual magic intended to increase yields and protect the crop, are described. A database of 539 cultivar names has been compiled. Some lines for future research within the social and biological sciences are proposed.

Present study reveals the comparative bioefficacy assessment of leaf and fruit extracts of breadfruit (Artocarpus altilis) using different solvents (petroleum ether, methanol and ethyl acetate) against various pathogenic organisms like Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus mutans and Enterococcus faecalis by disc diffusion assay through determination of MIC (minimal inhibitory concentrations). Steroids, phenols, phytosterols, gums & resins and terpenoids were found in the ethyl acetate and methanolic leaf extracts. Flavonoids were present in the petroleum ether and ethyl acetate leaf extracts whereas tannins were detected only in the methanolic leaf extract of Artocarpus altilis. Methanolic and ethyl acetate fruit extracts exhibits the presence of steroids, phenols and flavonoids. Zone of inhibition for Streptococcus mutans, Enterococcus faecalis, Staphylococcus aureus and Pseudomonas aeruginosa were noted maximum with 50 µl of leaf extracts in ethyl acetate and methanol, 20 µl of petroleum ether leaf extract, 25 µl of petroleum ether leaf extract and 50µl of methanolic leaf extract respectively. The above observation for fruit extracts varies. The MIC values ranges from 0.3 mg/ml to 0.6 mg/ml which correspond to variations in different solvent media used for leaf extracts against four different pathogenic microbes. Maximum growth inhibition of Streptococcus mutans and Enterococcus faecalis was noticed with 25 µl of methanolic fruit extracts with a MIC value of 0.45 and 0.3 mg/ml respectively. Staphylococcus aureus and Pseudomonas aeruginosa showed maximum zone of inhibition by 25 µl of ethyl acetate fruit extract with a MIC value of 0.45 mg/ml for both.

Aim: Selection of a suitable solvent is important and utilized in the extraction of desirable chemical components in medicinal plants. Study Design: Chemical analysis of various extracts of Artocarpus altilis fruit pulp using standard analytical procedures. Methodology: Fruit pulp of Artocarpus altilis (Parkinson) Fosberg or breadfruit (seedless) were extracted with six solvents categorized into polar (Acetone, Methanol and Aqueous) and non-polar (Ethyl acetate, Hexane and Chloroform) types using cold maceration method, the qualitative and quantitative phytochemical assay was done on the respective extracts using the standard methods. Results: Phytochemical screening of the non-polar solvent extract revealed the presence of Steroid, Terpenoids, Flavonoids, carbohydrates, oil and fat for all the solvents, except petroleum ether crude extract. The quantitative analysis has revealed that ethanolic extract of A.altilis fruit pulp is very rich in phenols (11.16 ±0.13); alkaloids (9.42±0.21); flavonoids (2.50 ±0.09) and Steroid (1.21±0.05) which is in the order of phenols >alkaloids> flavonoids >Steroid which gives a very strong reason to select this plant for future evaluation of cytotoxic intern anticancer and other pharmacological properties. Conclusion: The phytochemical constituents detected in varying quantities depend on the polarity of the substances, Artocarpus altilis could be exploited and extracted very well using a polar solvent like ethanol, acetone and aqueous. Further investigations regarding more biological activities of the ethanolic extract need to be conducted.

Jackfruit seeds are an underutilized waste in many tropical countries. This work demonstrates the potential of roasted jackfruit seeds to develop chocolate aroma. Twenty-seven different roasted jackfruit seed flours were produced from local jackfruit by acidifying or fermenting the seeds prior to drying and then roasting under different time/temperature combinations. The chocolate aroma of groups of four flours were ranked by a sensory panel (n = 162), and response surface methodology was used to identify optimum conditions. The results indicated a significant and positive influence of fermentation and acidification on the production of chocolate aroma. SPME/GC-MS of the flours showed that important aroma compounds such as 2,3-diethyl-5-methylpyrazine and 2-phenylethyl acetate were substantially higher in the fermented product and that the more severe roasting conditions produced 2-3 times more 2,3-diethyl-5-methylpyrazine, but less 3-methylbutanal. Moisture, aw, pH, luminosity, and...

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

An investigation of the chemical constituents inArtocarpus obtususspecies led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC50values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC50values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC50values of more than 30 μg/mL.