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    • Brain Slice Electrophysiology
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      ElectrophysiologyEpilepsySeizureAnticonvulsant
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      ElectrophysiologyEpilepsySeizureAnticonvulsant
Key points r The laserspritzer we developed activates axo-axonic synapses (AASs) with spatial resolutions of less than 40 μm. r AASs innervate the entire length of the axon initial segment (AIS), as opposed to forming a highly... more
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      ImmunohistochemistryGABAergic NeurotransmissionOptogeneticsBrain Slice Electrophysiology
The purpose of this study was to investigate the anticonvulsant activity of the volatile oil of nutmeg, the dried seed kernel of Myristica fragrans Houtt, using well-established animal seizure models and to evaluate its potential for... more
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    •   23  
      ElectrophysiologyEpilepsyBiological SciencesSeizure
Distributed microelectrode array (MEA) recordings from consistent, viable, ≥500 µm thick tissue preparations over time periods from days to weeks may aid in studying a wide range of problems in neurobiology that require in vivo-like... more
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      Multi-electrode Arrays (MEAs)Brain Slice ElectrophysiologyNeural cell culture
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      ElectrophysiologyEpilepsySeizureAnticonvulsant
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      Brain Slice ElectrophysiologyBNST
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    •   3  
      NeuroscienceStrokeBrain Slice Electrophysiology
The purpose of this study was to investigate the anticonvulsant activity of the volatile oil of nutmeg, the dried seed kernel of Myristica fragrans Houtt, using well-established animal seizure models and to evaluate its potential for... more
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    •   23  
      ElectrophysiologyEpilepsyBiological SciencesSeizure
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      Neural NetworksNeurophysiologyDown SyndromeCerebral Cortex
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      ElectrophysiologyEpilepsySeizureAnticonvulsant
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      Brain Slice ElectrophysiologyBNST
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      ElectrophysiologyEpilepsyAnticonvulsantBrain Slice Electrophysiology
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      NeurosciencePsychologyAnimal BehaviorFear
Inhibitory synaptic transmission in the amygdala has a pivotal role in fear learning and its extinction. However, the local circuits formed by GABAergic inhibitory interneurons within the amygdala and their detailed function in shaping... more
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      NeuroscienceAnimal BehaviorMulti-photon (2-photon) microscopySynaptic Plasticity
Determining the electrical properties of the extracellular space around neurons is important for understanding the genesis of extracellular potentials, as well as for localizing neuronal activity from extracellular recordings. However,... more
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      BiophysicsBiophysical ChemistryBiological SciencesPhysical sciences
... Phenytoin was synthesized in 1908, and was recognized as a first non sedating antiepileptic drug after the pioneering studies of Merritt and Putnam using an electroshock-induced seizure model in cats [74-76]. Since then... more
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      ElectrophysiologyEpilepsySeizurePharmaceuticals
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      ElectrophysiologyEpilepsySeizureHippocampus
Sensory information is processed and transmitted through the synaptic structure of local cortical circuits, but it is unclear how modulation of this architecture influences the cortical representation of sensory stimuli. Acetylcholine... more
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      Two-photon MicroscopyNeural CircuitryBrain Slice ElectrophysiologyNeocortex
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      NeuroscienceBrain Slice Electrophysiology