Dithiocarbamate

Organotin(IV) compounds have received tremendous attention for their synthesis, characterization and biological activities and their ability to bind with sulfur ligand such as dithiocarbamate ligand. Organotin(IV) dithiocarbamate complexes can be synthesized by the reaction of carbon disulphide with secondary amine. Four new organotin(IV) dithiocarbamate complexes were successfully synthesized by the reactions between di-2-ethylhexyldithiocarbamate, C16H34NCS2 and N-methylbutyldithiocarbamate, C5H12NCS2 with dibutyltin(IV) dichloride and triphenyltin(IV) chloride, RxSnClx (R = Bu, Ph) and (x = 1, 2 or 3). These series of complexes were synthesized using " in situ " insertion method and characterized by determination of melting point, CHNS elemental analysis, infrared spectroscopy (FT-IR) and UV-vis spectroscopy. The melting points of the synthesized compounds were in the range 88.3-128.4 °C. The experimental CHNS data of the compounds, mostly exhibit the calculated CHNS values. Using infrared spectra (FT-IR), the formation of organotin(IV) dithiocarbamate complexes were confirmed by the presence of v(C=N +) at 1464-1497 cm-1 , v(C-S) at 963-1025 cm-1 and v(Sn-S) at 412-445 cm-1 in all complexes. Besides that, the UV-vis analysis showed the peaks chromophore of N=C within range 259-260 nm, nonbonding electron on sulphur and charges transferred between the tin metal and ligand (M-L). Using TGA analysis, complex 1 and 3 show two degradation curve but complex 2 and 4 shows only one degradation curves. The antibacterial activity of all synthesized organotin(IV) dithiocarbamate complexes were then determined towards four types of bacterial strains which were Escherichia coli, Staphylococcus aureus, Salmonella thypi and Bacillus cereus. Penicillin was used as positive control and streptomycin as negative control in order to compare diameter of inhibition zone between both controls and complexes. From antibacterial test, almost all synthesized complexes were found to give positive results. Thus, it can be concluded that the complexes formed do have applications in biological and medical aspects.

This paper studies the structure and properties of
platinum complexes of dithiocarbamate derivatives.
Dithiocarbamate complexes are found to be very stable and are
highly water soluble due to the presences of hydrophilic moiety
in their structure. Such complexes have been used as metal
complexing species for several decades. They form chelates with
almost all metals ions in the Periodic table and have found
numerous applications on biological, agricultural, electronics
and act as stabilizing agents in electroless copper plating. In this
work, ethylenediamine and diethanolamine dithiocarbamates are
prepared and complexed with Pt(II) salts to form stable
complexes. The complexes are characterized by Rapid Elemental
Analysis. The structure of the stable complexes are confirmed
with Electronic and I.R Spectral Analysis.

Electrogenerated cyanomethyl anion promotes the reaction between primary or secondary amines, carbon disulfide, and alkyl or benzyl halide. Secondary amines are converted to alkyl or benzyl dithiocarbamates, whereas primary amines give N-substituted alkyl or benzyl 3-amino-2-cyanodithiocrotonates. The mechanisms are discussed.

sulfonamide (sulfadiazine) with some N-alkyl-N-phenyl dithiocarbamate have been synthesized and characterized by elemental analysis, conductivity measurements, UV-Vis and FTIR spectroscopy. The complexes are formulated as four coordinate MN2S2 species in which the metal ions are coordinated to one molecule of sulfadiazine through the pyrimidinyl and sulfulnamido nitrogen atoms and one molecule of dithiocarbamate through two sulfur atoms with both molecules acting as bidentate chelating ligands. The in vitro antibacterial activities of the complexes and sulfadiazine were evaluated against eight bacteria strains using the agar well diffusion method. The metal complexes showed varied antibacterial properties and their minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) were determined.

The title molecule, C15H18N2S2, adopts the Z configuration. The dihedral angle between the planes of the phenyl ring and the CH-NH-C=C(CN)-C(=S)-S fragment is 76.10 (5) Å. The molecular structure is stabilized by a weak intramolecular N-HS hydrogen bond [HS = 2.29 (3) Å, NS = 2.981 (2) Å and N-HS = 145 (2)°].