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Protein-damaging stresses, such as exposure to elevated temperature, alcohol, and heavy metals and microbial infections, increase the amount of misfolded proteins in cells, which may lead to formation of toxic protein aggregates. In order... more
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      Heat Shock Transcription FactorTranscriptionPhD ThesisPosttranslational Modifications
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      InflammationTranscription FactorsHeat Shock Transcription FactorSignal Transduction
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      FluorescenceMultidisciplinaryHeat Shock Transcription FactorWestern blotting
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      GeneticsPlant BiologyTranscription FactorsPlant Molecular Biology
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      Free RadicalsToxicologyApoptosisHeat Shock Transcription Factor
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      Cognitive ScienceBiologyEnzyme InhibitorsApoptosis
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      Transcription FactorsMolecular endocrinologyHeat Shock Transcription FactorSignal Transduction
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      BiologyMotor neuronApoptosisMedicine
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      Drosophila melanogasterOxidative StressTranscription FactorsHeat Shock Transcription Factor
The most daunting issue of global climate change is the deleterious impact of extreme temperatures on tea productivity and quality, which has resulted in a quest among researchers and growers. The current study aims to unravel molecular... more
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      TranscriptomicsPlant Stress PhysiologyHeat Shock Transcription FactorPlant Physiology
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      Medical MicrobiologyHeat Shock Transcription FactorBiological SciencesHumans
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      Heat Shock Transcription FactorBiological SciencesBiosciencesTranscription Factor
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      BiologyTranscription FactorsMedicineHeat Shock Transcription Factor
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      GeneticsAfghanistanPakistanBiology
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      Gene expressionHeat Shock Transcription Factor
The induction of heat shock genes (HSPs) is thought to be primarily regulated by heat shock transcription factors (HSFs), which bind target sequences on HSP promoters, called heat shock elements (HSEs). In this study, we investigated the... more
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      Gene expressionHeat Shock Transcription FactorMolecular MechanicsBiological Sciences
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      Heat Shock Transcription FactorQuality ControlMolecular chaperonesHumans
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      KineticsCell CycleTranscription FactorsHeat Shock Transcription Factor
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      BioinformaticsGeneticsWaterMolecular Biology
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      Cognitive ScienceHeat TreatmentTranscription FactorsHeat Shock Transcription Factor
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      MultidisciplinaryHeat Shock Transcription FactorSignal TransductionSignal Transduction Pathway Models
Differentiation of multipotential hematopoietic cells into lineage-committed precursors involves the selection and maintenance of appropriate programs of gene expression, regulated by specific transcription factors. Using human K562... more
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      PhysiologyTranscription FactorsGene expressionHeat Shock Transcription Factor
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      BacteriologyCell CycleOxidative StressRNA polymerase
Heat shock transcription factor (HSF) mediates the transcriptional response of eukaryotic cells to heat, infection and inflammation, pharmacological agents, and other stresses. Although genes encoding heat shock proteins (HSPs) are the... more
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      PharmacologyMolecular BiologyBiologyStress Responses (Cellular Biology)
Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that... more
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      PharmacologyMolecular BiologyBiologyStress Responses (Cellular Biology)
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      Gene expressionHeat Shock Transcription FactorAmericanTranscription Factor
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      BiochemistryOncologyCellular BiologyMolecular Biology
Based on phylogeny of DNA-binding domains and the organization of hydrophobic repeats, two families of heat shock transcription factors (HSFs) exist in plants. Class A HSFs are involved in the activation of the heat shock response, but... more
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      GeneticsPlant BiologyTobaccoTranscription Factors
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      GeneticsHeat Shock Transcription FactorT cell receptorCell Division
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      Heat Shock Transcription FactorCell DeathProgrammed cell deathNeuronal Differentiation
In mammalian and Drosophila cells, heat stress strongly reduces general protein translation while activating cap-independent translation mechanisms to promote the expression of stress-response proteins. In contrast, in Saccharomyces... more
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      PharmacologyMolecular BiologyRNABiology
Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the mounting evidence... more
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      PharmacologyMolecular BiologyBiologyStress Responses (Cellular Biology)
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      Plant BiologyBiologyMedicineHeat Shock Transcription Factor
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      BioinformaticsGeneticsWaterMolecular Biology
Background Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2β) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes. SWI/SNF... more
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      BioinformaticsGeneticsGene regulationLife Sciences
Based on phylogeny of DNA-binding domains and the organization of hydrophobic repeats, two families of heat shock transcription factors (HSFs) exist in plants. Class A HSFs are involved in the activation of the heat shock response, but... more
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      GeneticsPlant BiologyPlant Molecular BiologyHeat Shock Transcription Factor
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      Mass SpectrometryHeat TreatmentHeat Shock Transcription FactorCellular
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      Developmental BiologyKineticsHeat Shock Transcription FactorBiological Sciences
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      NeurosciencePsychiatryDiabetesHeat Shock Transcription Factor
Organisms are constantly exposed to acute and chronic stress conditions, which challenge the maintenance of protein homeostasis. Heat Shock Proteins (HSPs) function as molecular chaperones to stabilize protein structures, facilitate... more
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      CancerAgingHeat Shock Transcription FactorNeurodegenerative Diseases
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      Transcription FactorsGene expressionHeat Shock Transcription FactorBiological Sciences
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      Heat Shock Transcription FactorEscherichia coliProtein expression and purificationBiochemistry and cell biology
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      Transcription FactorsHeat Shock Transcription FactorBiological SciencesHumans
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      PharmacologyBiochemistryBioinformaticsEvolutionary Biology
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      Transcription FactorsHeat Shock Transcription FactorWestern blottingHumans
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      BioinformaticsGeneticsWaterMolecular Biology
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      Oxidative StressTranscription FactorsHeat Shock Transcription FactorBiological Sciences
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      GeneticsPlant BiologyHeat TreatmentTranscription Factors
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      SymbiosisGene expressionEnvironmental ChangeHeat Shock Transcription Factor