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Ikaros/IKZF1 is an essential transcription factor expressed throughout hematopoiesis. IKZF1 is implicated in lymphocyte and myeloid differentiation and negative regulation of cell proliferation. In humans, somatic mutations in IKZF1 have... more
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      ImmunologyIkarosImmune DeficiencyClinical Investigation
Genome-wide sequencing studies in pediatric cancer cohorts indicate that about 10% of patients have germline mutations within cancer predisposition genes. Within this group, primary immune deficiencies take the priority regarding the... more
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      LymphomaEBVImmune Deficiency
EBV infection is ubiquitous in humans, but the majority of infections have an asymptomatic or self-limiting clinical course. Rarely, individuals may develop a pathological EBV infection with a variety of life threatening complications... more
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      Herpes and HerpesvirusesInfectious DiseasesEpstein-Barr virusImmune Deficiency
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      EthicsPalliative CareNarrationHumans
Ikaros/IKZF1 is an essential transcription factor expressed throughout hematopoiesis. IKZF1 is implicated in lymphocyte and myeloid differentiation and negative regulation of cell proliferation. In humans, somatic mutations in IKZF1 have... more
    • by 
    •   5  
      ImmunologyIkarosImmune DeficiencyClinical Investigation
Human cytomegalovirus (HCMV) is a significant pathogen in immunocompromised individuals, with the potential to cause fatal pneumonitis and colitis, as well as increasing the risk of organ rejection in transplant patients. With the advent... more
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      Herpes and HerpesvirusesNext generation sequencingPaediatricsCytomegalovirus
Ikaros/IKZF1 is an essential transcription factor expressed throughout hematopoiesis. IKZF1 is implicated in lymphocyte and myeloid differentiation and negative regulation of cell proliferation. In humans, somatic mutations in IKZF1 have... more
    • by 
    •   5  
      ImmunologyIkarosImmune DeficiencyClinical Investigation