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"As Georges Méliès discovered to his astonished glee in the late nineteenth century, moving pictures do more than just record reality—they create one. Through stop-trick substitutions, multiple exposures, and splices, celluloid becomes a... more
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Abstract: Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as well as modulation of cell signaling. They can also decrease DNA... more
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Three linen textiles discovered in the Ramon I rock shelter, in the Makhtesh Ramon, date from c. 3000 BCE, the Early Bronze Age II, based on direct dating of the textiles and their excavation contexts. In addition to adding important and... more
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Graphical Abstract Highlights d The first atomic structure of a human spliceosome d The conformation of the spliceosome just prior to exon ligation d Mechanistic insights on Prp17, Slu7, PRKRIP1, and the EJC d Intron interlocked with... more
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The spliceosome, one of the most complex machineries of eukaryotic cells, removes intronic sequences from primary transcripts to generate functional messenger and long noncoding RNAs (lncRNA). Genetic, biochemical, and structural data... more
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Agrobacterium tumefaciens is a commonly used tool for transforming dicotyledonous plants. The underlying mechanism of transformation however is not very well understood. One problem complicating the analysis of this mechanism is the fact... more
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Polymerase chain reaction analysis was used to identify aberrant splicing of the simian virus 40 small-t intron present in pRSVcat. We examined factors governing the selection and relative use of aberrant 5' splice sites derived from... more
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It is clear now that proteins lacking ordered structure, generally known as intrinsically disordered proteins (IDPs), possess numerous biological functions that complement functional repertoires of ordered proteins. IDPs are common in... more
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The introduction of FTTH leads to high costs, especially in fiber deployment. In operations we face a high complexity and corresponding high cost of fiber splicing compared to copper welding. However, fiber based access networks are less... more
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Neurofibromatosis type 1 is one of the most common neurocutaneous autosomal dominant disorders. It is caused by mutations in the neurofibromatosis type 1 (NF1) gene and approximately 30–40% of them affect the correct splicing of NF1... more
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We have shown that the splicing isoform of Dp71 (Dp71d) localizes to the nucleus of PC12 cells, an established cell line derived from a rat pheochromocytoma; however, the mechanisms governing its nuclear localization are unknown. As... more
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