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Preprint ARTICLE | doi:10.20944/preprints202309.1624.v1

On Positive Recurrence of M_n/GI/1/∞ Model

Alexander Veretennikov

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: M/GI/1/∞; positive recurrence; general service distribution function

Online: 25 September 2023 (05:37:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0160.v1

Targeted Therapeutic Options and Future Perspectives for HER2-Positive Breast Cancer

Angelica Ferrando-Díez, Eudald Felip, Anna Pous, Milana Bergamino Sirven, Mireia Margelí

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; HER2-positive; estrogen receptor positive; triple-positive; HER2-targeted therapy; immunotherapy

Online: 10 June 2022 (11:03:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2199.v1

Hope Mediates Stress to Reduce Burden in Family Caregivers of Persons with Dementia

Jocelyn Shealy McGee, Edward C. Polson, Dennis Myers, Angela McClellan, Rebecca Meraz, Weiming Ke, Holly Carlson Zhao

Subject: Public Health And Healthcare, Other Keywords: Alzheimer's disease; dementia; cargiving; burden; hope; positive psychology; positive aspects of caregiving; stress; coping

Online: 28 December 2023 (14:36:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2180.v1

A Fibration of Fermat Surface in Characteristic

Xiaokun Zhong

Subject: Computer Science And Mathematics, Mathematics Keywords: positive characteristic; fibrations; automorphisms of surfaces

Online: 27 July 2024 (07:02:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0943.v1

Revealing a Binary Pattern Validates 3n+1 Problem for All Positive Integers

Budee U Zaman

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Binary pattern,Positive integers ,Collatz conjecture

Online: 15 April 2024 (10:55:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints201911.0214.v1

Unbiasing in the Genome Analysis of Iconic Shark Species

Kazuaki Yamaguchi, Shigehiro Kuraku

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shark; genome; longevity; gigantism; positive selection

Online: 18 November 2019 (07:46:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1069.v1

The Creative Awareness Theory: A Grounded Theory Study of Inherent Self-Regulation in Attention Deficit-Hyperactivity Disorder

Rebecca E. Champ, Marios Adamou, Warren Gillibrand, Sally Arrey, Barry Tolchard

Subject: Social Sciences, Psychiatry And Mental Health Keywords: adult ADHD; neurodevelopmental disorders; self-regulation; grounded theory; self-determination theory; positive aspects; positive attributes; creative adjustment

Online: 13 September 2024 (09:00:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1782.v1

Longitudinal Associations between Emotional Resilience and Mental Health among Chinese Adolescents in the School Context: The Mediating Role of Positive Emotions

Zhongmin Zhu, Biao Sang, Junsheng Liu, Yuyang Zhao, Ying Liu, Ning Liu

Subject: Public Health And Healthcare, Other Keywords: adolescents; emotional resilience; positive emotions; mental health

Online: 25 June 2024 (16:25:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1289.v1

The Role of the Hippocampus Concerning Personal Narrative Construction and Mental Health Signifying Positive Health Outcomes Through a Narrative Development Process

Carol Nash

Subject: Social Sciences, Psychology Keywords: hippocampus; narrative; mental health; positive health outcomes

Online: 20 September 2023 (02:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0332.v2

Witnessing Evolution of SARS-CoV-2 through Comparative Phylogenomics: The Proximate Origin is Guangdong, not Wuhan

Özgül Doğan, Ertan Mahir Korkmaz, Mahir Budak, Battal Çıplak, Hasan Hüseyin Başıbüyük

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: coronavirus; substitution rate; positive selection; demographic dynamics

Online: 21 June 2020 (16:10:26 CEST)

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A new form of coronavirus called severe acute respiratory disease coronavirus type 2 (SARS-CoV-2) is currently causing a pandemic. A six-month evolutionary history of SARS-CoV-2 is witnessed by characterising the total genome of 821 samples using comparative phylogenomic approaches. Our analyses produced striking inclusive results that may guide scientists/professionals for the past/future of pandemic. Phylogenetic and time estimation analyses suggest the proximate origin of pandemic strain as Guangdong and the origin time as first half of September 2019, not Wuhan and December 2019, respectively. The viral genome experienced a substitution rate similar to other RNA viruses, but it is particularly high in some of the peptides encoding sequences such as leader protein, E gene, orf8, orf10, nsp10, N gene, S gene and M gene and nsp4, while low in nsp11, orf7a, 3C-like proteinase, nsp9, nsp8 and endoRNase. Most strikingly, the divergence rate of amino acid sequences is high proportional to nucleotide divergence. Additionally, specific non-synonymous mutations in nsp3 and nsp6 evolved under positive selection. The exponential growth rate (r), doubling time (Td) and R₀ were estimated to be 47.43 per year, 5.39 days and 2.72, respectively. Comparison of synapomorphies distinguishing the SARS-CoV-2 and the candidate ancestor bat coronavirus indicates that mutation pattern in nsp3 and S gene enabled the new strain to invade human and become a pandemic strain. We arrive at the following main conclusions: (i) six months evolution of viral genome is nearly neutral, (ii) origin of pandemic is not Wuhan and predates formal reports, (iii) although viral population is ongoing an exponential growth, the doubling time is evolving towards shortening, and (iv) divergence rate of total genome is similar to other RNA viruses, but it is prominently high in some genes while low in some others and evolution in these genes should be closely monitored as their protein products intervening to pathogenicity, virulence and immune response.

Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0632.v1

A Longitudinal Multi-Method Inquiry of Educational Workers Use of Interventions for Positive Mental Health and Wellbeing

Astrid Helene Kendrick, Mawuli Kofi Tay, Lisa Everitt, Rachel Pagaling, Shelly Russell-Mayhew

Subject: Social Sciences, Education Keywords: compassion fatigue; burnout; interventions; positive mental health; wellbeing

Online: 9 October 2024 (12:20:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1429.v1

Impaired Regulation of Emotion in Bipolar Disorder: Behavioral and Neurophysiological Signatures

Mathilde Carminati, Frédéric Isel, Josselin Houenou, Michèle Wessa, Chantal Henry

Subject: Public Health And Healthcare, Other Keywords: bipolar disorder; emotion regulation; EEG; late positive potential

Online: 18 January 2024 (14:48:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0029.v1

Disentangling the Effects of Mindfulness, Savoring, and Depressive Symptoms among Emerging Adults

Rebecca Y. M. Cheung, Melody C. Y. Ng

Subject: Social Sciences, Psychology Keywords: savoring; mindfulness; depressive symptoms; emerging adults; positive experiences

Online: 2 March 2023 (04:11:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0784.v1

Artificial Compassion—From An AI Scholar

Cindy Mason

Subject: Social Sciences, Anthropology Keywords: Artificial Intelligence, Robots, Compassion, Human Sciences, Positive Plasticity

Online: 30 April 2021 (10:36:45 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0021.v2

Bottleneck, Isolate, Amplify, Select (BIAS) as a Mechanistic Framework for Intracellular Population Dynamics of Positive Sense RNA Viruses

Feng Qu, Limin Zheng, Shaoyan Zhang, Rong Sun, Jason Slot, Miyashita Shuhei

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: virus; population bottleneck; positive sense RNA virus; evolution

Online: 1 October 2020 (08:28:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1493.v1

Factors Associated with Opportunistic Infections Among HIV-Positive Patients: A Retrospective Study

Kamva Siduna, Dominic Abaver

Subject: Public Health And Healthcare, Other Keywords: Opportunistic Infection, HIV-Positive Patients, Retrospective Study, Risk Factors

Online: 18 October 2024 (12:01:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0804.v1

Positive Carbon Building Methodology in Co-Design with Residents

Dorin Beu, Alessio Pacchiana, Elena Rastei, Horaţiu Albu, Theodor Contolencu

Subject: Engineering, Architecture, Building And Construction Keywords: E.U. Climate Goals; Positive C. Building; nZEB; Life Cycle

Online: 11 October 2024 (03:09:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0527.v1

Native Infective Endocarditis: A State of the Art Review

Francesco Nappi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Infective Endocarditis; Native Valve Endocarditis; Vegetation; gram-positive bacteria

Online: 10 June 2024 (08:35:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1717.v1

Retrospective Review of Positive Newborn Screening Results for Isovaleric Acidemia and Development of a Strategy to Improve the Efficacy of Newborn Screening in the UK.

Rachel S Carling, Katy Hedgethorne, Anupam Chakrapani, Patricia L Hall, Nick Flynn, Toby Greenfield, Stuart J. Moat, Joshua Ssali, Lynette Shakespeare, Nazia Taj, Mark Anderson, Teresa H.Y. Wu, Arunabha Ghosh, Hugh Lemonde, Germaine Pierre, Mark Sharrard, Sreevidya Sreekantam, James R Bonham

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: isovaleric acidemia; false positive; newborn screening; inherited metabolic disease.

Online: 24 January 2024 (09:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0683.v1

Pathogenic Potential of Coagulase-Positive Staphylococcus Strains Isolated from Aviary Capercaillies and Free-Living Birds in South-Eastern Poland

Magdalena Sulikowska, Agnieszka Marek, Łukasz Sebastian Jarosz, Ewelina Pyzik, Dagmara Stępień-Pyśniak, Tomasz Hauschild

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: free-living birds; capercaillies; coagulase-positive Staphylococcus; virulence genes

Online: 9 January 2024 (05:25:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0726.v1

An Impact-Centered Sustainable Positive Experience Design Model

Chunmao Wu, Xuan Wang

Subject: Social Sciences, Psychology Keywords: Impact-centered design; sustainable design; positive experience; design model

Online: 13 October 2023 (07:11:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0237.v1

Positive Parenting and Sociodemographic Factors Related to the Development of Chilean Children Born to Adolescent Mothers

Laura Léniz-Maturana, Rosa Vilaseca, David Leiva, Rodrigo Gallardo-Rodríguez

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: adolescent mothers; positive parenting; child development; family sociodemographic factors

Online: 5 October 2023 (06:48:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0116.v1

The Influence of Perceived Security in Childhood on Adult Self-Concept: the Mediating Role of Resilience and Self-Esteem

Juan Carlos Martín Quintana, Pedro Francisco Alemán Ramos, Paula Morales Almeida

Subject: Public Health And Healthcare, Other Keywords: Security; Attachment; Positive parenting; Resilience; Self-esteem; Self-concept

Online: 2 August 2023 (08:04:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0821.v1

On a System of Hadamard Fractional Differential Equations With Nonlocal Boundary Conditions on an Unbounded Domain

Rodica Luca, Alexandru Tudorache

Subject: Computer Science And Mathematics, Analysis Keywords: Hadamard fractional differential equations; nonlocal boundary conditions; positive solutions

Online: 11 May 2023 (08:29:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0041.v1

Employee Well-being in the Perspective of Positive Psychology and of the Job Demands-Resources Theory. The Role of Trust Within the Organization

Agnieszka Czerw, Damian Grabowski, Agata Chudzicka-Czupała, Katarzyna Stapor, Marta Żywiołek-Szeja

Subject: Social Sciences, Psychology Keywords: Well-being; Positive psychology; Organizational psychology; Job demands-resources

Online: 2 March 2023 (10:20:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0349.v1

Isoflurane Rescue Schizophrenia-related Deficits through Parvalbumin-positive Neurons in the Dentate Gyrus

Hualing Peng, Jie Jia, Yi-Sheng Lu, Hua Zheng

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: isoflurane; schizophrenia; adult neurogenesis; synaptic plasticity; parvalbumin-positive interneuron

Online: 23 September 2022 (02:05:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0431.v1

Management of Bladder Cancer Patients with Clinical Evidence of Lymph Node Invasion (cN+)

Bartosz Małkiewicz, Adam Gurwin, Jakub Karwacki, Krystian Nagi, Klaudia Knecht-Gurwin, Krzysztof Hober, Magdalena Łyko, Kamil Kowalczyk, Wojciech Krajewski, Anna Kołodziej, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: bladder cancer; clinically positive lymph nodes; diagnosis; treatment; lymphadenectomy

Online: 25 August 2022 (10:05:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0012.v3

Quantifying Nature Positive

Anna-Mieke Mathilde Vlieg, Shadia Moazzem, Direshni Naiker, Delwyn Gloria Jones

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nature-Positive; Quantified Benefit Assessment; Security; Wellness; Viability; Gain

Online: 21 April 2022 (17:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1031.v1

The Impact of Positive Reinforcement on AI Decision-Making Processes

Tapomoy Adhikari

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Positive reinforcement; reinforcement learning; decision-making; artificial intelligence; reward shaping

Online: 15 October 2024 (03:55:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0885.v1

The Temporality of Rewards: Analysis of the Impacts of Positive and Negative Habits

Marcus Vinicius Gomes Pereira

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: positive habits; negative habits; reward system; habit formation

Online: 13 August 2024 (08:45:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0628.v1

The Skill of Positive Solitude Moderates the Relationship between 24 Character-Strengths and Flourishing in the Second Half of Life

Noa Bachman, Yuval Palgi, Ehud Bodner

Subject: Social Sciences, Psychology Keywords: Flourishing; loneliness; positive solitude; 24 character-strengths (VIA); well-being

Online: 11 June 2024 (08:43:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0968.v1

Multiple Positive Solutions for a Coupled System of Fractional Order BVP with p-Laplacian Operators and Parameters

Abdullah Ali H. Ahmadini, Mahammad Khuddush, Sabbavarapu Nageswara Rao

Subject: Arts And Humanities, Humanities Keywords: Fractional derivative; Positive solutions; Boundary value problems; p-Laplacian; parameters

Online: 14 September 2023 (09:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0506.v2

Effect of Continuous Positive Airway Pressure Given as Treatment for Obstructive Sleep Apnea on Central Corneal Thickness: Results at 12 Months

Pedro Naranjo-Bonilla, Estefania Mira-Padilla, María Carmen Muñoz-Villanueva, Bernabé Jurado Gámez, Rafael Giménez-Gómez

Subject: Medicine And Pharmacology, Ophthalmology Keywords: central corneal thickness; obstructive sleep apnea; continuous positive airway pressure

Online: 13 July 2023 (05:23:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0114.v1

Frequency-Shift of Quartz Crystal Microbalance Depends on the Length of Actin Filaments

Naoki Matsumoto, Honoka Kobayashi, Taiki Nishimura, Hideki Ashizawa, Takashi Kuwahara, Hajime Honda, Ikuko Fujiwara

Subject: Engineering, Bioengineering Keywords: quartz crystal microbalance; actin; positive frequency shift; physical property; biomolecule

Online: 3 May 2023 (08:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0277.v2

A Quantitative Poisitive Energy District Definition with Contextual Targets

Simon Schneider, Thomas Zelger, David Sengl, José Baptista

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Positive energy districts; PED definition; Context Factors; energy balance assessment

Online: 27 April 2023 (02:54:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0998.v1

Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV Positive and HIV Negative Individuals

Ariane Gomes Paixão, Marcos Abreu Almeida, Roberta Espírito Santo Correia, Beatriz Brittes Kamiensky, Rosely Maria Zancopé-Oliveira, Marcia dos Santos Lazera, Bodo Wanke, Cristiane da Cruz Lamas

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Histoplasmosis; Brazil; Epidemiology; HIV positive; AIDS; Immunosuppression; Culture; Serology; Mortality

Online: 26 April 2023 (14:58:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0816.v1

Characterization of Positive Invariance of Quadratic Convex Sets for Discrete Systems Using Optimization Approaches

Yuyao Lei, Hongli Yang, Ivan Ganchev Ivanov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: discrete-time dynamic systems; positive invariance; ellipsoid; Lorenz cone; optimization

Online: 24 April 2023 (04:10:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0437.v1

Differences in Psychological Vulnerability, Mental Health Liter-Acy, Positive Mental Health, and Health Behaviours in Portu-Guese Higher Education Students: A Cross-Sectional Study

Maria José Nogueira, José Carlos Carvalho, Patrício Soares Costa, Carlos Alberto Sequeira

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: nursing health promotion; literacy; positive mental health; psychological vulnerability; students

Online: 27 March 2023 (03:34:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0357.v1

From Deficit to Strength-Based Aboriginal Health Research – Learning from those Who Flourish

Jonathan Bullen, Trish Hill-Wall, Kate Anderson, Alex Brown, Clint Bracknell, Elizabeth A. Newnham, Gail Garvey, Lea Waters

Subject: Social Sciences, Psychology Keywords: Aboriginal; First Nations; wellbeing; salutogenesis; flourishing; positive psychology; complex systems

Online: 21 February 2023 (09:09:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0196.v1

SARS-CoV-2 PCR Persistence and Duration of COVID-19 Symptoms in Health Professionals

Tatiana Schäffer Gregianini, Ludmila Fiorenzano Baethgen, Richard Steiner Salvato, Ivone Andreatta Menegolla, CEVS COVID-19 Team, Ana Beatriz Gorini da Veiga

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS-CoV-2; PCR persistent positive; respiratory infection; COVID-19

Online: 12 December 2022 (09:04:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0515.v1

Positive Adult Education Learned Helplessness and the Pygmalion Effect

David Cobos-Sanchiz, Manuel-Jesús Perea-Rodriguez, Juan-Agustín Morón-Marchena, María-Carmen Muñoz-Díaz

Subject: Social Sciences, Education Keywords: Positive education; Pygmalion effect; learned helplessness; lifelong education; adult education

Online: 29 November 2021 (07:52:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0439.v1

One Possible Reinfection with SARS-CoV-2 Validated by 205-days Interval of Re-detection in Sapporo City, Japan

Toshiaki Asakura, Akiko Tamakoshi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; reinfection; re-detected positive; Japan

Online: 16 April 2021 (11:09:45 CEST)

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Working Paper BRIEF REPORT

Positive Rate Is Useful to Evaluate the Sufficiency of RT-PCR Test Availability for COVID-19

Sadao Suzuki

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; RT-PCR test; pre-test probability; positive rate

Online: 5 May 2020 (06:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0126.v1

Viral strategies of manipulating autophagy to benefit infection

Ho Him Wong, Sumana Sanyal

Subject: Biology And Life Sciences, Virology Keywords: Autophagy; positive stranded RNA virus; proviral autophagy; viral subversion strategies

Online: 10 May 2019 (14:00:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0305.v1

Influence of Congruency between Ideal Self and Brand Image on Sustainable Happiness

Jeongsoo Han, Mina Jun, Miyea Kim, Sookyoung Key

Subject: Business, Economics And Management, Marketing Keywords: sustainable happiness; ideal self; ideal social self; brand identification; positive

Online: 17 July 2018 (10:39:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0582.v1

It Is Not Always Bad, Positive Experiences of Guardians Utilizing Vhembe Primary Health Care Facilities for Under-Five Child Health Services: An Interpretative Phenomenology Study

Livhuwani Tshivhase, Idah Moyo, Sophy Mogatlogedi Moloko

Subject: Public Health And Healthcare, Primary Health Care Keywords: Child health services; guardians; positive experiences; primary healthcare; under-five child

Online: 11 June 2024 (15:03:33 CEST)

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Introduction: Guardians play a pivotal role in the management of childhood illness. Their responsibilities include home managing childhood illnesses and supporting continuity of care following healthcare facility treatment. Evidence has shown that guardians' negative experience in health care facilities when accessing under-five childcare services impacts their utilization of such facilities. Exploration of guardians' experiences is important in providing the evidence base necessary for quality childcare and reducing under-five morbidity and mortality. The study aimed to explore the experiences of guardians of children under five regarding the care received in Vhembe healthcare facilities. Methods: A qualitative approach using an interpretative phenomenology analysis (IPA) was used for this study. The study was conducted in eight primary healthcare facilities in the Vhembe district, with the highest headcount for children under five. Sixteen guardians were purposefully sampled for the study. Data analysis was done following the IPA steps of data analysis. Trustworthiness criteria were followed: credibility, confirmability, dependability, authenticity, and transferability. Ethical approval was obtained from the university and the province, followed by permission from the district and the operational managers before data collection. Results: The three emerging themes are associated with participants' positive experiences as they interfaced within the healthcare system: quality care, healthcare environment, support, and empowerment. The ten sub-themes were: timely service provision, availability of medicines, perceived nursing competence and professionalism, person-centred care, welcoming environment, effective communication, positive attitude of healthcare providers, guardians’ satisfaction with care received, guardians' involvement in childcare and community support. Conclusion: It is indeed not always bad. The participants in this study had positive care experiences, which is crucial in the optimal utilization of health care services, resulting in improved health outcomes.

Preprint ARTICLE | doi:10.20944/preprints202405.1193.v1

The Impact of Culture Negativity on the Outcomes of Revision Total Knee Arthroplasty for Chronic PJI

Emily M Ronan, Garrett Ruff, Itay Ashkenazi, Hayley Raymond, Casey Cardillo, Jordan C Villa, Ran Schwarzkopf, Vinay K Aggarwal

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: revision total knee arthroplasty; culture-positive; culture-negative; periprosthetic joint infection

Online: 17 May 2024 (15:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0832.v1

What Am I Doing for (Their) a Living? Positive Impact and Innovative Behavior at Work: The Mediating Role of Needs Satisfaction

Konstantinos Papachristopoulos, Marc Antoine Gradito Dupord, Florence Jauvin, Jacques Forest, Patrick Coulombe

Subject: Social Sciences, Psychology Keywords: positive impact; needs satisfaction; prosocial motivation; benevolence; innovative work behavior; creativity

Online: 13 September 2023 (09:03:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0917.v1

On \Sigma-classes in E^8. IV. The neighbourhood of F_{22}

Peter Engel

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: lattice of translations, parallelohedra, cone of positive quadratic forms, \Sigma-subcones

Online: 13 July 2023 (10:00:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0024.v1

Indexing Inefficacy of Efforts to Stop Escalation of COVID Mortality

Ram Shanmugam, Lawrence Fulton, Jose Betancourt, Gerardo J Pacheco

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Positive Poisson distribution, Under dispersion, Bayesian analysis, prediction, index of infectivity.

Online: 1 December 2022 (10:25:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0415.v1

Development of a Positive Psychology Well-Being Intervention in a Community Pharmacy Setting

Jennifer Louise Ward, Alison Sparkes, Ricketts Marie, Paul Hewlett, Amie-Louise Prior, Britt Hallingberg, Delyth Higman James

Subject: Social Sciences, Psychology Keywords: community pharmacy; well-being; positive psychology; public health; intervention; PERMA, diary.

Online: 22 November 2022 (09:44:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0053.v2

Protective Factors and Burnout Risk of Teachers During the COVID-19 Pandemic – A Two-Step Cluster Analysis

Camelia-Mădălina Răducu, Elena Stănculescu

Subject: Social Sciences, Psychology Keywords: COVID-19, positive emotionality, professional experience, selfcontrol, teacher burnout, well-being

Online: 26 October 2022 (09:37:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0164.v1

Neoadjuvant Pertuzumab plus Trastuzumab in Combination with Docetaxel and Carboplatin in Patients with HER2 Positive Breast Cancer: Real-World Data from a National Institute of Oncology in Poland.

Agnieszka Irena Jagiełło-Gruszfeld, Magdalena Rosinska, Malgorzata Meluch, Katarzyna Pogoda, Anna Niwińska, Renata Sienkiewicz, Aleksander Grous, Pawel Winter, Zbigniew I. Nowecki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer,; neoadjuvant chemotherapy; elederly; HER2- positive; pathological complete response; safety

Online: 12 January 2022 (13:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0039.v1

Part 2 – Roots to Grow and Wings to Fly: An Ethnography of Psychosocial Development in Adolescent Performance Sport.

Sergio Lara-Bercial, Jim McKenna

Subject: Social Sciences, Psychology Keywords: Positive youth development, youth sport, realist evaluation, life skills, personal development.

Online: 5 January 2022 (12:40:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0322.v1

Replication-Dependent Biogenesis of Turnip Crinkle Virus Long Noncoding RNAs

Shaoyan Zhang, Rong Sun, Limin Zheng, Feng Qu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Virus; plant virus; long noncoding RNA; replication; positive sense RNA virus

Online: 14 May 2021 (11:01:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0172.v1

Enhancing the Positive Impact Rating: A New Business School Rating in Support of a Sustainable Future

Kathleen Rodenburg, Taimoor Rizwan, Ruifeng Liu, Julia Christensen Christensen Hughes

Subject: Business, Economics And Management, Business And Management Keywords: Positive Impact Rating (PIR); Sustainable Development Goals (SDGs); Rankings; Ratings, Biases

Online: 10 May 2021 (11:05:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0197.v1

Stability and Stabilization of Ecosystem for Epidemic Virus Transmission Under Neumann Boundary Value Via Impulse Control

Ruofeng Rao

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Neumann boundary value; positive equilibrium point; Poincare inequality lemma; impulse control

Online: 8 February 2021 (12:05:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0491.v1

Cross-Sectional Study on Relationships Among FoMO, Social Influence, Positive Outcome Expectancy, Refusal Self-Efficacy and SNS Usage

KUNHUA LEE, Chia-Yu Lin, Jing Tsao, Lien Fang Hsieh

Subject: Social Sciences, Psychology Keywords: FoMO; Social Cognitive Theory; Social Influence; Self-efficacy; Positive Outcome Expectancy

Online: 21 July 2020 (12:57:49 CEST)

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Working Paper ARTICLE

Turkish Adaptation of the Positive-Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study

Arzu Araz, Duygu Güngör, Eda Aşçı

Subject: Social Sciences, Psychology Keywords: positive-negative relationship quality; reliability; validity; confirmatory factor analysis (CFA); bifactor

Online: 16 September 2019 (16:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0027.v1

Comparison of Smallest Eigenvalues for Nabla Fractional Boundary Value Problems

Jagan Mohan Jonnalagadda

Subject: Computer Science And Mathematics, Analysis Keywords: nabla fractional difference; boundary value problem; cone; u0- positive operator; eigenvalue

Online: 3 September 2019 (00:38:36 CEST)

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Working Paper ARTICLE

Interrogating Hope Theory

Jacob Shivley

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: interrogating hope theory, hope theory, hope, the hope scale, positive psychology

Online: 25 March 2019 (09:53:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0314.v1

From Individual Resource to Social Capital: The Mechanism of How Political Skill Affect Job Satisfaction and Turnover Intention

Yi Li, Mengqiu Ma

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: political skill; job satisfaction; turnover intention; popularity; positive affect; negative affect

Online: 26 December 2018 (12:16:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1409.v1

Multi-Dimensional Factors of Psychosomatic Health Disparities under the COVID-19 in Japan: Towards Communitarian Interventions

Masaya Kobayashi, Hikari Ishido, Jiro Mizushima, Hirotaka Ishikawa

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: well-being; psychological health; socio-economic factors; positive psychology; fairness; justice; psychosomatic

Online: 18 October 2024 (08:26:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0585.v1

Phylogenomic Signatures of a Lineage of Vesicular Stomatitis Indiana Virus Circulating During the 2019–2020 Epidemic in the United States

Selene Zarate, Miranda R. Bertram, Case Rodgers, Kirsten Reed, Angela Pelzel-McCluskey, Ninnet Gomez-Romero, Luis L Rodriguez, Christie Mayo, Chad Mire, Sergei L. Kosakovsky Pond, Lauro Velazquez-Salinas

Subject: Biology And Life Sciences, Virology Keywords: Vesicular stomatitis virus; evolution; positive selection; negative selection; epidemic lineages; natural selection

Online: 8 October 2024 (14:02:48 CEST)

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For the first time, we describe phylogenomic signatures of an epidemic lineage of vesicular stomatitis Indiana virus (VSIV). We applied multiple evolutionary analyses to a dataset of full-length genome sequences representing the circulation of an epidemic VSIV lineage in the US between 2019 and 2020. Based on phylogenetic analyses, we predicted the ancestral relationship of this lineage with a specific group of isolates circulating in the endemic zone of Chiapas, Mexico. Subsequently, our findings indicate that the lineage diversified into at least four different subpopulations during its circulation in the US. We identified single nucleotide polymorphisms (SNPs) that differentiate viral subpopulations and assessed their potential relevance using comparative phylogenetic methods, highlighting the preponderance of synonymous mutations during the differentiation of these populations. Purifying selection was the main evolutionary force favoring the conservation of this epidemic phenotype, with P and G genes as the main drivers of the evolution of this lineage. Our analyses identified multiple codon sites under positive selection and the association of these sites with specific functional domains at P, M, G, and L proteins. Based on ancestral reconstruction analyses, we showed the potential relevance of some of the sites identified under positive selection to the adaptation of the epidemic lineage at the population level. Finally, using a representative group of viruses from Colorado, we established a positive correlation between genetic and geographical distances, suggesting that positive selection on specific codon positions might have favored the adaptation of different subpopulations to circulation in specific geographical settings. Collectively, our study reveals the complex dynamics that accompany the evolution of an epidemic lineage of VSIV in nature. Our analytical framework provides a model for conducting future evolutionary analyses. The ultimate goal is to support the implementation of an early warning system for vesicular stomatitis virus in the US, enabling early detection of epidemic precursors from Mexico.

Preprint ARTICLE | doi:10.20944/preprints202409.2063.v1

Positive Childhood Experiences and Subjective Well-being Among Chinese University Students: The Mediating Role of Resilience

Yanni Huang, Fuhua Yang, Keli Yin

Subject: Social Sciences, Psychology Keywords: Positive Childhood Experiences; Subjective Well-being; Psychological Resilience; College Students; Mental Health

Online: 26 September 2024 (04:35:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1348.v1

Nuancing 'Emotional' Social Play: Does Play Behaviour Always Underlie a Positive Emotion?

Giada Cordoni, Ivan Norscia

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: cooperation; competition; positive/negative emotions; aggressive play; play signals; rapid motor mimicry

Online: 17 July 2024 (02:58:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0249.v1

A Positive Experience Design Model: The Product Attachment Perspective

Chunmao Wu, Lili Chen

Subject: Arts And Humanities, Other Keywords: internalising positive experiences; product attachment; designing for well-being; systematic design models

Online: 5 February 2024 (13:28:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1877.v1

Nonlinear Differential Equation and SIS Epidemiological Model with a Time Delay Bounded by Two Positive Functions

Iveta Ilavská, Zuzana Malacká

Subject: Computer Science And Mathematics, Mathematics Keywords: nonlinear differential equation with time delay; SIS model; epidemiological model; positive solution

Online: 26 January 2024 (09:38:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1059.v1

Human Resources Management Development Regarding Work-Related Flow in Contrast to Either Happiness or PERMA Factors for Career Sustainability

Carol Nash

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: HRM; career sustainability; work-related flow; Csikszentmihalyi; happiness; PERMA; positive psychology; MDPI

Online: 15 January 2024 (10:27:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0437.v1

HER2 Positive Early Breast Cancer: Time for Ultimate De-escalation?

Nikolas Tauber, Christoph Cirkel, Anna Claussen, Franziska Fick, Emmanuel Kontomanolis, Natalia Krawczyk, Achim Rody, Maggie Banys-Paluchowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2 positive; Breast Cancer; Systemic De-Escalation; Chemo-free therapy; Targeted Therapy

Online: 5 January 2024 (06:47:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2328.v1

EMS for Active and Reactive Power Management in a Polygenerative Microgrid feeding a PED

Abhinav Sawhney, Federico Delfino, Barbara Bonvini, Stefano Bracco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Microgrids; Optimization; EMS; E-mobility; V2G; Smart Grid; MILP; Positive Energy District

Online: 29 December 2023 (16:26:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1826.v1

Oral SERD, A Novel Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer

Niraj Neupane, Sawyer Bawek, Sayuri Gurusinghe, Elham Moases Ghaffary, Omid Mirmosayyeb, Sangharsha Thapa, Carla Falkson, Ruth O’Regan, Ajay Dhakal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; Estrogen receptor-positive; endocrine therapies; resistance; selective estrogen degrades; Oral

Online: 29 November 2023 (08:15:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1720.v1

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

Samantha Greaves, Caroline Harvey, Yashuhiro Kotera

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate change; positive and negative affect; pro-environmental behavioural intentions; climate anxiety

Online: 28 November 2023 (08:15:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1857.v1

Effect of Chest Physiotherapy with Threshold Valve in Hospitalized Adults with COVID-19 Pneumonia

Julia Estela, Emilio José Sánchez, Georgina Mateu, Elena Fernandez, Eva Robert, Silvia Pozo, Mariona Noray, Joan Carles Oliva, Fernanda Caballero, Manel Luján

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; pneumonia; hospitalized patients; chest physiotherapy; positive expiratory pressure; threshold valve

Online: 27 July 2023 (07:24:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0014.v1

Participating in HIV Prevention Clinical Trial: Reasons and Experiences among Female Participants in Antibody Mediated Prevention Study at UNC Project, Lilongwe, Malawi

Ruth Holla, Adamson Muula

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: HIV/AIDS; community health worker; clinical trial; informed consent; HIV positive; STI

Online: 2 May 2020 (13:45:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0003.v1

Ventilation Positive Pressure Intervention Effect on IAQ in a School Building with Moisture Problems

Camilla Vornanen-Winqvist, Kati Järvi, Sander Toomla, Kaiser Ahmed, Maria A. Andersson, Raimo Mikkola, Tamas Marik, Laszlo Kredics, Heidi Salonen, Jarek Kurnitski

Subject: Engineering, Civil Engineering Keywords: ventilation; positive pressure; indoor air quality; mycobiota; indoor air questionnaire; moisture damage

Online: 1 December 2017 (07:06:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0206.v1

Genome Characterization of a Novel Binary Toxin-Positive Strain of Clostridium difficile and Comparison with the Epidemic 027 and 078 Strains

Zhong Peng, Sidi Liu, Xiujuan Meng, Wan Liang, Biao Tang, Yuanguo Wang, Juping Duan, Chenchao Fu, Bin Wu, Anhua Wu, Chunhui Li

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Clostridium difficile; ST201; binary toxin-positive; whole genome sequencing; comparative genomic analysis

Online: 30 May 2017 (06:15:11 CEST)

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A novel binary toxin-positive non-027, non-078 Clostridium difficile strain designated LC693 whose sequence type was ST201 was isolated from the fecal sample of a patient with severe diarrhea in China. To understand the pathogenesis basis of C. difficile ST201, this recently recovered isolate LC693 was then chosen for whole genome sequencing. The project finally generated an estimated genome size of approximately 4.07 Mbp. The genome sequence was then analyzed together with the other two ST201 strains VL-0104 and VL-0391 and compared to the epidemic 027/ST1 and 078/ST11 strains. Phylogenetic analysis demonstrated that the ST201 strains belonged to clade 3. Genome size of the three ST201 strains ranged from 4.07 Mb~4.16 Mb, with an average GC content between 28.5%~28.9%. The ST201 genomes contained more than 40 antibiotic resistance genes and 15 of them were predicted to be associated with vancomycin-resistance, suggesting that they may have a strong antibiotic resistance. The ST201 strains contained a typical clade 3 specific PaLoc with a Tn6218 element inserted, and those genes harbored on their PaLoc that participated in the toxin expression and regulation were highly homologues to the epidemic 027 and 078 strains, with the exception of tcdC. A truncated TcdC was found in the ST201 strains, which is suggestive to have a contribution to the toxin production of the ST201 strains. In addition, the ST201 strains contained intact binary toxin coding and regulation genes, which is also proposed to contribute to the virulence. Genome comparison of the ST201 strains with the epidemic 027 and 078 strain identified 641 genes specific for the C. difficile ST201, and a number of them were predicted as fitness and virulence associated genes. The identification of those genes also contributes to the pathogenesis of the ST201 strain. To our knowledge, this is the first study that the genome sequence of C. difficile ST201 was discussed in detail, and the present study would have a contribution to understanding the pathogenesis basis of C. difficile ST201.

Preprint ARTICLE | doi:10.20944/preprints202409.2338.v1

The Effects of Service Quality on an Online Shopping Mall on Consumption Behavior of Sporting Goods Consumers: Moderating Effects of Positive Emotion

Feng Yang, Yuanyan Tong, Jie Wu

Subject: Business, Economics And Management, Business And Management Keywords: Online Shopping Mall; Service Quality; Sporting Goods; Positive Emotion; Shopping Value; Consumer Behavior

Online: 30 September 2024 (09:41:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0585.v1

Comparitive Chloroplast Genomics of Nine Endangered Habenaria Species and Phylogenetic Relationship of Orchidaceae

Jinkui Zhang, Dangwei Zhou, Weidong Chen, Pengcheng Lin, Suqin Zhao, Min Wang, Huan Wang, Shengbo Shi, Farrukh Mehmood, Xing Ye, Jing Meng, Yuanwen Zhuang

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: ; Habenaria; chloroplast genome; molecular marker; positive selection; Orchidaceae; phylogenomic ;

Online: 10 June 2024 (13:51:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1458.v1

Rapid Review on the Concept of Positive Health and Its Implementation in Practice

Marja Van Vliet, Miriam De Kleijn, Karolien Van den Brekel, Tim Huijts, Sandra van Hogen-Koster, Hans Peter Jung, Machteld Huber

Subject: Public Health And Healthcare, Health Policy And Services Keywords: positive health; health; rapid review; shared decision making; health concept; transition; sustainable healthcare

Online: 19 January 2024 (07:53:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0054.v1

Play Behavior as a Positive Welfare Indicator for Farmed Spotted Paca (Cuniculus paca)

Allison Ferreira de Lima, Stella Guedes Calazans Lima, Sérgio L G Nogueira-Filho, Suzanne D. E. Held, Michael Mendl, Selene Siqueira da Cunha Nogueira

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: animal welfare; applied ethology; animal emotions; farmed animals; play behavior; positive welfare indicator

Online: 1 November 2023 (10:34:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0907.v1

Continuation of Radial Positive Definite Functions and Their Characterization

Fethi Bouzeffour

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Positive definite functions; completely monotone functions; Fractional integral and derivative; Fractional diffusion equation

Online: 11 August 2023 (12:54:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1601.v1

Antimicrobial Potential of the Microalgae Extracts

Alexander Lykov, Alexei Salmin, Ruslan Gevorgiz, Svetlana Zheleznova, Lyubov Rachkovskaya, Maria Surovtseva, Olga Poveshchenko

Subject: Biology And Life Sciences, Life Sciences Keywords: diatoms; cyanobacter; green microalgae; Gram-positive and Gram-negative bacteria; Mycobacteria; antimicrobial potential

Online: 24 July 2023 (10:46:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0380.v1

Li-Rich Layered Oxides: Structure and Doping Strategies to Enable Co-poor/Co-free Cathodes for Li-Ion Batteries

Laura Silvestri, Mariarosaria Tuccillo, Arcangelo Celeste, Sergio Brutti

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: lithium rich layered oxides; secondary aprotic batteries; positive electrode materials; Li-ion; cathodes.

Online: 21 December 2022 (03:36:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0038.v1

Part 1 - Looking Back and Looking Around: How Parents, Coaches and Athletes See Psychosocial Development in Adolescent Performance Sport.

Sergio Lara-Bercial, Jim McKenna

Subject: Social Sciences, Psychology Keywords: Positive youth development, youth sport, realist evaluation, life skills, personal development, psychosocial development.

Online: 5 January 2022 (12:39:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0050.v1

Positive Deviance for Dual-Method Promotion among Women in Uganda: A Qualitative Study

Hodaka Kosugi, Akira Shibanuma, Junko Kiriya, Ken Ing Cherng Ong, Stephen Mucunguzi, Conrad Muzoora, Masamine Jimba

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: positive deviance; dual-method use; contraception; unintended pregnancy; sexually transmitted infection; HIV/AIDS

Online: 5 July 2020 (07:04:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0076.v1

Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complex

Diego Forni, Alessandra Mozzi, Manuela Sironi, Rachele Cagliani

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Structural Maintenance of Chromosomes; meiotic cohesins; positive selection; host-pathogen arms race; intragenomic conflict

Online: 1 August 2024 (14:13:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0112.v1

A 3D Numerical Model to Estimate Lightning Types for PyroCb Thundercloud

Surajit Das Barman, Rakibuzzaman Shah, Syed Islam, Apurv Kumar

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: cloud-to-ground lightning; lower positive charge structure; pyrocumulonimbus; surface charge density; tripole thundercloud

Online: 2 May 2024 (09:38:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1861.v1

Expressed in HPV 16 Infected Epidermoid Carcinoma Cells, HIV‐1 Reverse Transcriptase Shifts Their Metabolism towards aerobic Glycolysis, Induces Hybrid E/M Cell Phenotype and Increases Expression of E6 Transcripts

Alla S Zhitkevich, Ekaterina O Bayurova, Daria V Avdoshina, Natalia F Zakirova, Galina A Frolova, Juris Jansons, Sona Chowdhury, Alexander V Ivanov, Ilya V Gordeychuk, Joel M. Palefsky, Maria G Isaguliants

Subject: Biology And Life Sciences, Virology Keywords: HIV-1; reverse transcriptase; HPV16-positive cells; E6*I isoform expression; glycolysis; mitochondrial respiration

Online: 25 December 2023 (13:18:26 CET)

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High incidence of epithelial malignancies in HIV-1 infection is associated with co-infection with oncogenic viruses, such as high-risk human papillomaviruses (HR HPVs), most often HPV16. A collaboration between HIV-1 and HR HPVs in the malignant transformation of epithelial cells exposed to both viruses have long been anticipated. Here, we delineated the effects on in vitro and in vivo properties of HPV16-infected cervical cancer cells of HIV-1 reverse transcriptase. Epidermoid carcinoma Ca Ski cells were made to express RT of HIV-1 clade A (RT_A) or Green Fluorescence Protein (GFP) by lentiviral transduction, subclones with one or six copies of RT_A and six copies of GFP DNA were generated. Expression by subclones of GFP was assessed by flow cytometry, and of RT_A, by Western blotting. Cells were assessed for the levels of mRNA of the RT_A, E6 and its isoforms, and cellular factors characterizing oxidative stress, and EMT by the real-time PCR. Parameters of glycolysis and mitochondrial respiration were assessed by Seahorse technology. Subclones were surveyed for the changes in cell cycle, doubling time, migration capacity, clonogenic activity and for the capacity to form tumors in nude mice. Ca Ski RT_A produced 20-55 fg of RT_A per cell. Expression of RT_A caused a proportional increase in the expression of E6*I isoform. In Ca Ski, RT_A suppressed mitochondrial respiration and oxygen consumption, and increased glycolysis. Compared to parental cells and GFP control, transcription in Ca Ski RT_A of epithelial (E-CADHERIN) state marker was increased, and of mesenchymal (VIMENTIN) decreased, indicating acquisition by cells of the hybrid epithelial/mesenchymal (E/M) phenotype. While Ca Ski GFP and Ca Ski RT_A with one gene insert had reduced migration rate, decreased clonogenic activity in vitro, and diminished capacity to form tumors in nude mice, increase in RT_A copicity/expression mitigated these effects. Altogether, expression of HIV-1 RT_A gave Ca Ski cells the plasticity required to overcome negative effects of lentiviral transduction and potentially increased their tumorigenicity.

Preprint ARTICLE | doi:10.20944/preprints202311.1430.v1

Polyphasic Characterization of Brucella spp. in Livestock Slaughtered from Abattoirs in Eastern Cape, South Africa

Koketso Desiree Mazwi, Francis B Kolo, Ishmael Festus Jaja, Charles Byaruhanga, Ayesha Hassim, Henriette Van Heerden

Subject: Public Health And Healthcare, Other Keywords: Brucellosis; Livestock; Tissue samples; culture positive; AMOS-PCR; Brucella abortus; Brucella melitensis; South Africa

Online: 23 November 2023 (17:32:54 CET)

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