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    Folinic Acid

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    Muhammad Arsalan
    Folinic acid is a reduced folic acid derivative that is administered after methotrexate treatment to rescue bone marrow and gastrointestinal cells from methotrexate effects. It is readily converted to other reduced folic acid derivatives like tetrahydrofolate and has equivalent vitamin activity to folic acid. Common adverse reactions when combined with fluorouracil include leukopenia, nausea, vomiting, and diarrhea. Folinic acid should not be administered intrathecally due to risk of severe adverse effects or death, and may obscure diagnosis of pernicious anemia.

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    Folinic Acid

    Uploaded by

    Muhammad Arsalan
    295 views1 page
    Folinic acid is a reduced folic acid derivative that is administered after methotrexate treatment to rescue bone marrow and gastrointestinal cells from methotrexate effects. It is readily converted to other reduced folic acid derivatives like tetrahydrofolate and has equivalent vitamin activity to folic acid. Common adverse reactions when combined with fluorouracil include leukopenia, nausea, vomiting, and diarrhea. Folinic acid should not be administered intrathecally due to risk of severe adverse effects or death, and may obscure diagnosis of pernicious anemia.

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    Drug monogragh

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    Folinic acid is a reduced folic acid derivative that is administered after methotrexate treatment to rescue bone marrow and gastrointestinal cells from methotrexate effects. It is readily converted to other reduced folic acid derivatives like tetrahydrofolate and has equivalent vitamin activity to folic acid. Common adverse reactions when combined with fluorouracil include leukopenia, nausea, vomiting, and diarrhea. Folinic acid should not be administered intrathecally due to risk of severe adverse effects or death, and may obscure diagnosis of pernicious anemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    295 views1 page

    Folinic Acid

    Uploaded by

    Muhammad Arsalan
    Folinic acid is a reduced folic acid derivative that is administered after methotrexate treatment to rescue bone marrow and gastrointestinal cells from methotrexate effects. It is readily converted to other reduced folic acid derivatives like tetrahydrofolate and has equivalent vitamin activity to folic acid. Common adverse reactions when combined with fluorouracil include leukopenia, nausea, vomiting, and diarrhea. Folinic acid should not be administered intrathecally due to risk of severe adverse effects or death, and may obscure diagnosis of pernicious anemia.

    Copyright:

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    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    FOLINIC ACID

    Therapeutic class: Vitamer Pharmacologic class: Reduced folic acid derivative Use\ Indications Folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. There is no apparent effect on preexisting methotrexate-induced nephrotoxicity. Pharmacological Effects Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. Adverse Reactions Leucovorin in combination with fluorouracil: leukopenia, nausea, vomiting, diarrhea, stomatitis, lethargy/malaise/fatigue, alopecia, dermatitis, anorexia. Precautions/Warnings/Contraindication Folinic acid should not be administered intrathecally. This may produce severe adverse effects or even death Pernicious anemia or other megaloblastic anemias secondary to lack of vitamin B12; such use may obscure diagnosis of pernicious anemia by alleviating hematologic manifestations while allowing neurologic complications to progress. Interactions: Anticonvulsants, Fluorouracil, Glucarpidase, Co-trimoxazole Dosing Adults and children: Not more than 25mg dose is recommended Brand Names Parenteral: Kunyrin 15mg, 50mg Leucovorin 15mg Tablet: Kunyrin 15mg Tablet.

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