Drug Study Drug Name Classifications Action Indication Adverse Effects Contraindication Nursing Responsibility Cns

DRUG STUDY Drug Name LOSARTAN POTASSIU M (lo-sar'tan) Cozaar Classifications cardiovascular agent; angiotensin ii receptor antagonist; antihypertensive
Action Angiotensin II receptor (type AT1) antagonist acts as a potent vasoconstrict or and primary vasoactive hormone of the renin angiotensin aldosterone system. Indication Hypertension Adverse Effects CNS: Dizziness, insomnia, headache. GI: Diarrhea, dyspepsia. Musculoskelet al: Muscle cramps, myalgia, back or leg pain. Respiratory: Nasal congestion, cough, upper respiratory infection, sinusitis. Contraindication Hypersensitivity to losartan, pregnancy [category C (first trimester), category D (second and third trimesters)], lactation Nursing Responsibility Monitor BP at drug trough (prior to a scheduled dose). Monitor drug effectiveness, especially in AfricanAmericans when losartan is used as monotherapy. Inadequate response may be improved by splitting the daily dose into twicedaily dose. Lab tests: Monitor CBC, electrolytes, liver & kidney function with long-term therapy.
Drug Name Amlodipine Norvasc
Classifications cardiovascular agent;
Action
Indication -Angina pectoris due to coronary artery spasm (Prinzmetal's variant angina) -Chronic stable angina, alone or in combination with other agents -Essential hypertension, alone or in combination with other antihypertensiv es
Inhibits calcium ion influx calcium channel across blocker; cardiac and smooth antihypertensive muscle agent cells, decreasing Prototype: myocardial Nifedipine contractility and oxygen Pregnancy demands Category: C
Adverse Effects Side effects of amlodipine are generally mild and reversible. The two most common side effects are headache and edema (swelling) of the lower extremities. Less common side effects include dizziness, flushing, fatigue, nausea, and palpitations
Contraindication NORVASC is contraindicated in patients with known sensitivity to amlodipine.
Nursing Responsibility Monitor BP for therapeutic effectiveness. BP reduction is greatest after peak levels of amlodipine are achieved 69 h following oral doses. Monitor for S&S of dose-related peripheral or facial edema Monitor BP with postural changes. Report postural hypotension. Monitor more frequently when additional antihypertensive s or diuretics are added.
Drug Name

Classifications
Action
Indication -Adjunct to diet in the treatment of elevated total cholestrol and LDL cholesterol with primary hypercholester olemia (types IIa and IIb) in those unresponsive to dietary restriction of saturated fat and cholesterol and other nonpharmacolo gic measures -To reduce the risk of coronary disease, mortality, and CV events,
simvastatin Zocor
Antihyperlipid Simvastatin is a prodrug emic, metabolised HMG-CoA in the liver to form the reductase active inhibitor hydroxy Pregnancy acid derivative. Category X This inhibits the conversion of HMGCoA to mevalonic acid by blocking HMG-CoA reductase, an early and ratelimiting step in cholesterol biosynthesi s. It reduces total cholesterol, LDL-
Adverse Contraindication Nursing Effects Responsibility Teaching points Headache, Acute liver Take drug in the nausea, disease or evening. Do not flatulence, unexplained drink grapefruit juice heartburn, persistent while using this abdominal elevations of drug. pain, serum diarrhea/co transaminases. Have periodic blood nstipation, Pregnancy, tests. dysgeusia; lactation. This drug cannot be myopathy Porphyria. taken during features pregnancy; using like barrier myalgia contraceptives is and recommended. muscle You may experience weakness; these side effects: serum Nausea (eat transamina frequent small ses and meals); headache, CPK muscle and joint elevations; aches and pains hypersensi (may lessen); tivity; lens sensitivity to light
cholesterol and triglycerides and increases HDLcholesterol levels.
including CVA, TIA, MI and reduction in need for bypass surgery and angioplasty in patients with coronary heart disease and hypercholester olemia

opacities; blurring of vision; dizziness; sexual dysfunctio n; insomnia; depression and upper respiratory symptoms. Potentially Fatal: Severe rhabdomyo lysis with acute renal failure.
(use a suncreen and wear protective clothing).
Report severe GI upset, changes in vision, unusual bleeding or bruising, dark urine or lightcolored stools, fever, muscle pain, or soreness.

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Drug Study Drug Name Classifications Action Indication Adverse Effects Contraindication Nursing Responsibility Cns

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DRUG STUDY Drug Name LOSARTAN POTASSIU M (lo-sar'tan) Cozaar Classifications cardiovascular agent; angiotensin ii receptor antagonist; antihypertensive

Drug Name Amlodipine Norvasc

Classifications cardiovascular agent;

Contraindication NORVASC is contraindicated in patients with known sensitivity to amlodipine.

cholesterol and triglycerides and increases HDLcholesterol levels.

(use a suncreen and wear protective clothing).

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