Endocrine System
Endocrine System
Endocrine System
Cell
Tissue
Organism
Organ
System
System
Endocrine System
Endocrine System:
is a
collection of glands that
produce/secrete hormones that
regulate metabolism, growth,
development, reproduction etc.
Chemical co-ordination
Exocrine system
Endocrine system
20 glands (endocrine system)
Endocrinology
Hormones
Feedback mechanism
Thyroid Gland
In the neck(below the
larynx)
Two lobes and isthmus
SECRETION:
Thyroxin
Tri- iodo thyronin
Calcitonin
Thyroxin
and stress
somatotropin + thyroid
Brain cell
differentiation
metamorphism
Hypothyroidism
cretinism:
Retardation
Dry skin
Puffy eye lids
Scanty brittle hair
S.S.C failure
Goiter:
Iodine deficiency
Myxedema:
Weight gain
Loss of hair
Slow pulse rate
Lethargy
Low body temperature
Skin and hand puffy
Hypothyroidism
Hyperthyroidism
Graves disease:
Cause: TSH
Nervousness
High heart rate and B.P
Weight loss
High O2 consumption
Bulging eyes
Cardiac failure
Treatment:Drugs
Surgery
Calcitonin
Parathyroid
parathormone
Deficiency
Muscular Tetany
Fatal
Efficiency
Bones weakening
(rickets)
Kidney stone
Fatal
Pancreas
(Islets of langerhans)
SECRETION:
Insulin (beta cells)
Glucagon (alpha cells)
Insulin
Glucose Glycogen
Glucose Cells
Glucose consumption
Glucose Protein/lipids
Glucose production
Insulin
Deficiency
Diabetes mellitus
Conc. Urine
Abnormal thirst
Weakness
Fatigue
Efficiency
Hypoglycemia
Dilute urine
Reduced muscle and
impulse functioning
Glucagon
Hypothalamus
Part of forebrain
Thirst center
Posterior pituitary
(oxytocin and
vasopressin)
Anterior pituitary (tropic
hormones)
Pituitary gland
(hypophysis cerebri)
Base of brain
Connected to brain
Infundibulum
Anterior pituitary
1.Somatotropin (GH)
.Hypothalamus
.SRF
.Anterior pituitary
.STH
.Liver
.Somatomedins
.Efficiency
Gigantism
Acromegaly
Deficiency
Dwarfism
HPT axis
Hypothalamus
TRF
Anterior pituitary
TSH
Thyroid gland
Thyroxin
Tri-iodothyronin
Calcitonin
HPA axis
Hypothalamus
CRH
Anterior pituitary
ACTH
Adrenal cortex
Cortisol / stress hormone (glucocorticoid and
mineralocorticoid)
Released under influence of stress conditions
Cotisol deficiency
Addisons disease
Cortisol efficiency
Cushing s disease
Gonadotrophic hormones
4.Follicle stimulating hormone (FSH)
5.Leuteinising hormone (LH/ICSH)
.HPG axis
.Hypothalamus
.GnRH
.Anterior pituitary
.FSH (estrogen secretion/sperm)
.LH (progesterone secretion)
ICSH (testosterone)
6.Prolactin (LTH)
.Stimulates milk production
.PIH (Dopamine)
Median pituitary
1.Melanophore stimulating hormone
(MSH)
. Sunlight
. MSH
. Melanocytes
. Melanin
. Causes darkening of skin and hair
. More production during pregnancy and Addison's
disease
. Protection from UV rays of sun
Posterior pituitary
1.Antidiuretic (ADH) or vasopressin
.Deficiency
Diabetes insipidus
Dilute urine
Great thirst
in collecting duct
2.Oxytocin
Acts on smooth muscles
Causes contraction of uterus during birth
And ejection of milk from mammary glands
Artificially used to induce labor
Stimulation (positive feedback)