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    Artificial Pancreas

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    rameshjey
    The document discusses improvements that could help enable a successful closed-loop artificial pancreas (AP). It proposes greater emphasis on model predictive controllers that use mathematical models of patient physiology. Whole-body models integrating the hypothalamus-pituitary-adrenal axis and gastrointestinal tract could help make controllers practical for daily care, but developing accurate submodels will require collaboration between experimentalists and modelers. Developing dual insulin and glucagon control could also help by relaxing accuracy requirements on the controller.

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    Artificial Pancreas

    Uploaded by

    rameshjey
    32 views2 pages
    The document discusses improvements that could help enable a successful closed-loop artificial pancreas (AP). It proposes greater emphasis on model predictive controllers that use mathematical models of patient physiology. Whole-body models integrating the hypothalamus-pituitary-adrenal axis and gastrointestinal tract could help make controllers practical for daily care, but developing accurate submodels will require collaboration between experimentalists and modelers. Developing dual insulin and glucagon control could also help by relaxing accuracy requirements on the controller.

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    a research view on artificial pancreas

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    The document discusses improvements that could help enable a successful closed-loop artificial pancreas (AP). It proposes greater emphasis on model predictive controllers that use mathematical models of patient physiology. Whole-body models integrating the hypothalamus-pituitary-adrenal axis and gastrointestinal tract could help make controllers practical for daily care, but developing accurate submodels will require collaboration between experimentalists and modelers. Developing dual insulin and glucagon control could also help by relaxing accuracy requirements on the controller.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    32 views2 pages

    Artificial Pancreas

    Uploaded by

    rameshjey
    The document discusses improvements that could help enable a successful closed-loop artificial pancreas (AP). It proposes greater emphasis on model predictive controllers that use mathematical models of patient physiology. Whole-body models integrating the hypothalamus-pituitary-adrenal axis and gastrointestinal tract could help make controllers practical for daily care, but developing accurate submodels will require collaboration between experimentalists and modelers. Developing dual insulin and glucagon control could also help by relaxing accuracy requirements on the controller.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Advanced Generation Optimization and Synthesis

    Artificial Pancreas

    Based on glucose regulatory mechanisms known to date, their impairment in the diabetic state,
    and fundamental principles of control theory, some corrections to the present course of research
    are proposed to facilitate the removal of this barrier. A greater emphasis on model predictive
    controllers or controllers that exploit a mathematical representation, or model, of the patient's
    own physiology is proposed. Whole-body physiologically based pharmacokinetics–
    pharmacodynamics-type models hold the best odds for enabling a successful closed-loop AP.
    However, two major improvements to the diabetes modeling state of the art are required to make
    them practical for daily care: integrating hypothalamus–pituitary–adrenal axis and
    gastrointestinal tract submodels. Although there are simple representations of these in current
    existence, large concerted efforts between experimentalists and modelers will be required to
    enhance their accuracy. Finally, changes in hardware that complements controller performance
    are suggested. For instance, the development of dual control inputs of insulin and glucagon could
    relax tolerances on controller accuracy.

    Keywords: artificial pancreas, control, diabetes, glucagon, meal, model, stress

    Introduction

    A biological cure, which would require either regeneration or transplantation of normal β cells with
    long-term success. In the normal pancreas, a significant variety of hormonal, substrate, and neuronal
    signals are continuously transduced (sensed), and the appropriate responses in the form of insulin,
    amylin, glucagon, and somatostatin are continuously secreted. In the current approach, the AP proposes
    to mimic those functions by linking a glucose sensor to an insulin pump via a computer control
    algorithm.1,2 The goal is to obtain a safe, effective, and affordable device that operates continuously by
    mimicking the pancreas, requiring minimal patient or professional intervention.

    Reference Lib Folder AP

    NIH: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769707/

    Hillol.Sarkar@ago-inc.com | April 8, 2015

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