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    Unit-2 (Part-2) : Herbs/Food - Drug Interactions

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    Mamta Pant
    Herbs can interact with drugs through pharmacokinetic and pharmacodynamic pathways. Some herbs increase drug absorption while others decrease it. This can impact the effectiveness and safety of medications. Common herb-drug interactions include garlic, ginger, black pepper, ginkgo, ginseng, and ephedra potentially interacting with drugs like anticoagulants, antihypertensives, antacids, antidepressants, and more. More research is still needed due to a lack of knowledge about combinations and varying potency of herbal products. Clinicians should be aware of potential herb-drug interactions.

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    Unit-2 (Part-2) : Herbs/Food - Drug Interactions

    Uploaded by

    Mamta Pant
    2K views14 pages
    Herbs can interact with drugs through pharmacokinetic and pharmacodynamic pathways. Some herbs increase drug absorption while others decrease it. This can impact the effectiveness and safety of medications. Common herb-drug interactions include garlic, ginger, black pepper, ginkgo, ginseng, and ephedra potentially interacting with drugs like anticoagulants, antihypertensives, antacids, antidepressants, and more. More research is still needed due to a lack of knowledge about combinations and varying potency of herbal products. Clinicians should be aware of potential herb-drug interactions.

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    5-Herb-drug -interaction

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    Herbs can interact with drugs through pharmacokinetic and pharmacodynamic pathways. Some herbs increase drug absorption while others decrease it. This can impact the effectiveness and safety of medications. Common herb-drug interactions include garlic, ginger, black pepper, ginkgo, ginseng, and ephedra potentially interacting with drugs like anticoagulants, antihypertensives, antacids, antidepressants, and more. More research is still needed due to a lack of knowledge about combinations and varying potency of herbal products. Clinicians should be aware of potential herb-drug interactions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    2K views14 pages

    Unit-2 (Part-2) : Herbs/Food - Drug Interactions

    Uploaded by

    Mamta Pant
    Herbs can interact with drugs through pharmacokinetic and pharmacodynamic pathways. Some herbs increase drug absorption while others decrease it. This can impact the effectiveness and safety of medications. Common herb-drug interactions include garlic, ginger, black pepper, ginkgo, ginseng, and ephedra potentially interacting with drugs like anticoagulants, antihypertensives, antacids, antidepressants, and more. More research is still needed due to a lack of knowledge about combinations and varying potency of herbal products. Clinicians should be aware of potential herb-drug interactions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 14

    Unit- 2 (Part-2)

    HERBS/FOOD – DRUG INTERACTIONS

    B. Pharm 6th Sem.

    1
    INTRODUCTION
    When Herbal Medicinal Products and Western drugs
    administered together may interact each other in body
    leading to kinetic and dynamic alterations

    Herbs are often administered in combination with


    therapeutic drugs, raising the potential of herb-drug
    interactions.

    An estimated 5-20% of general people consume


    herbal medicines because
    1. Naturally available
    2. Consideration of safe to use
    3. Ready available
    HERB-DRUG INTERACTIONS

    PHARMACOKINETIC PHARMACODYNAMIC

    Modify metabolic Herb and drug


    pathways in body Interactions can be
    ❖Mainly occur in predicted:
    ❖Antagonism or
    GIT
    Synergism
    Kidney
    Liver
    INCREASED DECREASED

    ABSORPTION Ginger Fibres


    Green Tea Mucilage herbs
    Black Pepper

    Guggul Grape fruit

    Laxative Liquorice
    Diuretic herbs
    Reason for Herbs/ food- drug interaction

    1. Clinicians lack of adequate knowledge


    of combinations

    2. No quality assurance for purity and


    potency

    3. No advancement in research
    GARLIC:
    – May ↑ bleeding times with
    anticoagulants
    – ↓ blood levels and toxicity of protease
    inhibitors like ritonavir, indinavir….etc

    GINGER:
    ❑ May ↑ bleeding with anticoagulants
    ❑↓ effect of antacids
    ❑Ginger might decrease blood sugar
    Insulin, Chlorpropamide , Glipizide, Tolbutamide
    ❑High blood pressure (Calcium channel blockers)
    interacts with GINGER
    verapamil , felodipine , amlodipin
    ▪Black and white pepper might decrease
    how quickly the liver breaks down some
    medications
    ❑ lovastatin (Mevacor)
    ❑ ketoconazole (Nizoral)
    ❑ Itraconazole (Sporanox), …etc.

    ▪It will decrease the action of antacids


    ▪The black pepper majorly shows interaction and
    increase the AUC of The drugs are:
    ❖Phenytoin (Dilantin)
    ❖Carbamazepine (Tegretol) tranquilizers
    in healthy volunteers
    ❖Propranolol (Inderal)

    ❖Rifampin
    ❖Theophylline in patients with pulmonary tuberculosis.
    Ginkgo:
    ➢May ↑ bleeding with anticoagulants
    ➢ May ↑ activity and side effects of
    MAO inhibitors
    ➢ Increases blood pressure when
    combined with a thiazide diuretic and
    even caused coma.
    ➢ Increases the digoxin plasma levels
    GINSENG
    (PANAX GINSENG):
    Increases the AUC of digoxin
    Decreased activity of opioids – clear
    mechanism is unknown
    Increased CNS side effects due to
    additive effect of
    ▪MAO inhibitors
    ▪Phenelzine
    ❖Produce sadation with barbiturates
    &benzodiazepines
    ❖– Contraindicated with hepatotoxic
    drugs and alcohol
    ❖– ↓ efficacy of Parkinson drugs
    (L-Dopa)
    EPHEDRA

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