Theoretical Framework

Theoretical Framework
COVID-19 (Coronavirus) has affected day to day life and slowing down the global economy. As
the outbreak of coronavirus disease 2019 (COVID-19) progresses, epidemiological data are
needed to guide situational awareness and intervention strategies. Here we describe efforts to
compile and disseminate epidemiological information on COVID-19 from news media and
social networks.
As the outbreak of coronavirus disease 2019 (COVID-19) is rapidly expanding in China and
beyond, with the potential to become a worldwide pandemic, real-time analyses of
epidemiological data are needed to increase situational awareness and inform interventions.
Previously, real-time analyses have shed light on the transmissibility, severity, and natural
history of an emerging pathogen in the first few weeks of an outbreak, such as with severe acute
respiratory syndrome (SARS), the 2009 influenza pandemic, and Ebola. Analyses of detailed line
lists of patients are particularly useful to infer key epidemiological parameters, such as the
incubation and infectious periods, and delays between infection and detection, isolation, and
reporting of cases. However, official individual patient data rarely become publicly available
early on in an outbreak, when the information is most needed.
Building on our previous experience collating news reports to monitor transmission of Ebola
virus, here we present an effort to compile individual patient information and subnational
epidemic curves on COVID-19 from a variety of online resources. Data were made publicly
available in real time and were used by the infectious disease modeling community to generate
and compare epidemiological estimates relevant to interventions. We describe the data
generation process and provide an early analysis of age patterns of COVID-19, case counts
across China and internationally, and delays between symptom onset, admissions to hospital, and
reporting, for cases reported until Jan 31, 2020.
To our knowledge, this is the first study that uses crowd sourced data from social media sources
to monitor the COVID-19 outbreak. We searched DXY.cn, a Chinese health-care-oriented social
network that broadcasts information from local and national health authorities, to reconstruct
patient-level information on COVID-19 in China. We also queried international media sources
and national health agency websites to collate data on international exportations of COVID-19.
We describe the demographic characteristics, delays between symptom onset, seeking care at a
hospital or clinic, and reporting for 507 patients infected with COVID-19 reported until Jan 31,
2020. The overall cumulative progression of the outbreak is consistent between our line list and
an official report published by the Chinese national health authorities on Jan 28, 2020. The
estimated incubation period in our data aligns with that of previous work. Our dataset was made
available in the public domain on Jan 21, 2020.
Crowdsourced line-list data can be reconstructed from social media data, especially when a
central resource is available to curate relevant information. Public access to line lists is important
so that several teams with different expertise can provide their own insights and interpretations
of the data, especially in the early phase of an outbreak when little information is available.
Publicly available line lists can also increase transparency. The main issue with the quality of
patient-level data obtained during health emergencies is the potential lack of information from
locations overwhelmed by the outbreak (in this case, Hubei province and other provinces with
weaker health infrastructures). Future studies based on larger samples of patients with COVID-
19 could explore in more detail the transmission dynamics of the outbreak in different locations,
the effectiveness of interventions, and the demographic factors driving transmission.
Conceptual Framework
The outbreak of coronavirus disease 2019 (COVID-19) has created a global health crisis that has
had a deep impact on the way we perceive our world and our everyday lives. Not only the rate of
contagion and patterns of transmission threatens our sense of agency, but the safety measures put
in place to contain the spread of the virus also require social distancing by refraining from doing
what is inherently human, which is to find solace in the company of others. Within this context,
physical threat, social and physical distancing, and public alarm.
The conceptualization of this research is framed under three (3) underlying ideas. These ideas are
the foundation that guides the researcher in this investigation.
INPUT OUTPUT PROCESS
1. The natural origin and

the probable Pangolin Understanding
origin of SARS-CoV-2 COVID-19: A
Interview
associated with the Questionnaire Qualitative
Exploratory
COVID-19 outbreak. Research
2. The epidemiology and
pathogenesis of
coronavirus disease
(COVID-19) outbreak.
Proposed
3. The symptoms, intervention to
transmissibility, and prevent COVID-19
characteristics
of coronavirus disease
2019 (COVID-19).
FEEDBACK
Figure 1. Conceptual Paradigm of the Study

Theoretical Framework

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Theoretical Framework

1. The natural origin and

Figure 1. Conceptual Paradigm of the Study

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