Journal of Molecular Catalysis A: Chemical 233 (2005) 121–126

An efficient procedure for protection of carbonyls catalyzed

by sulfamic acid
Bo Wang a, c , Yanlong Gu a , Guoyong Song a , Tao Yang a ,
Liming Yang a, ∗ , Jishuan Suo b
a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics,
Chinese Academy of Sciences, Lanzhou 730000, China
b Chengdu Organic Chemicals Co. Ltd., Chinese Academy of Sciences, Chengdu 610041, China
c Graduate School of the Chinese Academy Sciences, Beijing 100039, China

Received 19 November 2004; received in revised form 2 February 2005; accepted 2 February 2005

Abstract

Sulfamic acid (H2 NSO3 H) has been used as an efficient and recyclable catalyst for acetalization and ketalization between carbonyl com-
pounds and diols. This system is reasonably general and can be applied to converting several carbonyl compounds to the corresponding acetals
and ketals using neopentyl glycol and other diols as protection reagents. The use of an inexpensive, green and stable catalyst, convenient
reaction operation and high selectivity to desired products are the features contained in this reaction. Sulfamic acid can be reused five times
in the reaction between benzaldehyde and neopentyl glycol without loss of activity.
© 2005 Elsevier B.V. All rights reserved.

Keywords: Sulfamic acid; Carbonyl compounds; Neopentyl glycol; Acetalization and ketalization; Green synthesis

1. Introduction tem that may be stable, easily separable, and reusable has
long been awaited.
The acetalization or ketalization reaction is a process that In the past 2 years, utilizations of a solid organic acid, sul-
is widely used in organic synthesis to protect the carbonyl famic acid (H2 NSO3 H), in catalytic and organic reactions as
group of aldehydes and ketones [1,2]. The acetals are im- an alternative for conventional acidic materials have received
portant reactants for synthesis of enantiomerically pure com- much attention due to its unique characters (nonvolatile, non-
pounds, which were widely used as steroids, pharmaceuti- hygroscopic, odorless, and white crystalline solid with out-
cals, and fragrances [3–13]. Previously, the catalysts used in standing stability) [19–23]. As a part of our ongoing studies
the acetalization or ketalization reactions were generally pro- on the use of sulfamic acid as a green catalyst in organic
tonic acids, Lewis acids, and a number of transitional metal transformations, we recently reported the tetrahydropyrany-
complexes including Rh, Pd, and Pt [14–17]. Although good lation of hydroxy compounds [24], acetolysis of cyclic ethers
results were obtained, the separation of the product from the [25], esterification of cyclic olefins with aliphatic acids un-
catalyst system after the reaction was still difficult and the der solvent-free conditions [26], the Beckmann rearrange-
noble metal catalysts used were quite expensive and usually ment of ketoxime in dried CH3 CN [27] and transesterifi-
unstable [18]. Therefore, the development of a catalytic sys- cation of ␤-ketoesters in ionic liquid [28]. We further re-
port here a practical procedure for protection of various car-
bonyl compounds by the formation of acetals or ketals in the
∗ Corresponding author. Fax: +86 931 8277088. presence of catalytic amount of sulfamic acid as depicted in
E-mail address: limy@lzb.ac.cn (L. Yang). Scheme 1.

1381-1169/$ – see front matter © 2005 Elsevier B.V. All rights reserved.
doi:10.1016/j.molcata.2005.02.006
122 B. Wang et al. / Journal of Molecular Catalysis A: Chemical 233 (2005) 121–126

for the next run after simple treatments including washing

with toluene (1 mL × 2) and drying under air.

2.3. Qualitative and quantitative analysis

The qualitative analysis of liquid reaction mixture was

carried out on a Hewlett-Packard 6890/5793 GC/MS sys-
Scheme 1. Sulfamic acid catalyzed formation of acetals or ketals.
tem equipped with a HP 5MS column (30 m) with helium as
carrier gas. The column temperature was raised from 80 to
2. Experimental 260 ◦ C at a heating rate of 10 ◦ C min−1 .
The quantitative analysis of the extract solution was car-
2.1. Materials and reagents ried out on a temperature-programmed Hewlett-Packard GC-
5790 apparatus equipped with a ϕ3 × 3000 mm PTFE col-
All solvents and chemicals used were commercially umn. The concentration of reactant and product was directly
available and used without further purification. Bu- given by the system of GC chemstation according to the area
tanone, 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, of each chromatograph peak.
4-nitrobenzaldehyde, 4-hydroxybenzaldehyde, hexanal,
neopentyl glycol, 2,3-butandiol, 1,3-propandiol and 2-pyri-
dinecarboxaldehyde were purchased from Aldrich. Di- 3. Results and discussion
isobutylketone, piperonal, vanillin, benzyl methyl ketone,
crotonaldehyde were bought from Acros Organics. 2-Fural- 3.1. Optimization of reaction conditions
dehyde, benzaldehyde, sulfamic acid, ethylene glycol,
acetophenone, cinnamaldehyde, 1,2-propanediol, cyclo- Initially, neopentyl glycol has been used to react with ben-
hexanone, cyclopentanone, 2-mercaptoethanol and pentaery- zaldehyde over sulfamic acid catalyst in toluene solution, and
thritol were obtained from Shanghai Chemicals Co. Toluene the results are listed in Table 1. When equivalent amount
was distilled over sodium-benzophenone prior to use. of benzaldehyde and neopentyl glycol was used, the con-
version of benzaldehyde was unsatisfactory (entry 1). For
2.2. Acetalization or ketalization of carbonyl the improvement of benzaldehyde conversion, slightly ex-
compounds with diols cess alcohol must be used. When the ratio of neopentyl gly-
col to benzaldehyde increased from 1.0 to 1.2, conversion of
All the reactions (Scheme 1) were performed in a 25 mL benzaldehyde correspondingly increased from 77% to 97%
round-bottom flask equipped with a magnetic stirrer and a dis- (entry 2). When the reaction time was shortened to 3 h or
tillation condenser. For a typical experiment, 0.29 g sulfamic 10 mmol% sulfamic acid dosage was used, the conversions
acid (3 mmol) and benzaldehyde (20 mmol) were put into were only 84% and 87%, respectively (entries 3 and 5). The
15 mL toluene, and 24 mmol neopentyl glycol were succes- subsequent condition optimization experiments revealed that
sively charged into the reactor. Then the content was stirred both the 4 h reaction time and 15 mmol% catalyst dosage
for 4 h at 110 ◦ C. After the desired reaction time, the reaction were necessary to complete the reaction. Further prolonga-
mixture was cooled to room temperature (15 ◦ C). The solid tion of reaction time and increase in the catalyst dosage seems
sulfamic acid was separated by filtration, and could be reused to be ineffective for the improvement of the acetalization

Table 1
Conditions optimization of the reaction between benzaldehyde and neopentyl glycol over sulfamic acida

Entry Benzaldehyde/neopentyl Amount of sulfamic Reaction time (h) Reaction Conentration (%) Selectivity (%)
glycol (M/M) acid (%) temperature (◦ C)
1 1:1 15 4 110 77 ∼100
2 1:1.2 15 4 110 97 ∼100
3 1:1.2 10 4 110 84 ∼100
4 1:1.2 20 4 110 97 ∼100
5 1:1.2 15 3 110 87 ∼100
6 1:1.2 15 5 110 98 ∼100
7 1:1.2 15 4 80 68 ∼100
8 1:1.2 15 4 50 42 ∼100
a Reaction conditions: benzaldehyde, 2.12 g (20 mmol); toluene, 15 mL.
 B. Wang et al. / Journal of Molecular Catalysis A: Chemical 233 (2005) 121–126 123

reaction (entries 4 and 6). When the reaction was conducted Table 2
at 80 or 50 ◦ C, the benzaldehyde cannot be completely con- Sulfamic acid catalyzed reaction between carbonyl compounds and
sumed and the conversions were only 68% and 42%, re- neopentyl glycola
spectively (entries 7 and 8). Thus, the optimized conditions
should be 1.2 for the ratio of neopentyl glycol to benzalde-
hyde, 15 mmol% sulfamic acid, 4 h for the reaction time and
110 ◦ C for the reaction temperature. It should be pointed out Entry Carbonyl compounds Reaction time (h) Conentrationb (%)
here, the selectivity to the desired acetalization product was 1 4 99
close to 100% in any condition as shown in Table 1, indicat-
ing the specific activity of sulfamic acid for the acetalization 2 4 97
reaction.
3 4 96
3.2. Sulfamic acid catalyzed reactions between various
carbonyl compounds and neopentyl glycol 4 4 92

Various carbonyl compounds have been used as sub- 5 4 91

strates to react with neopentyl glycol over sulfamic acid cat-
alyst. The results in Table 2 clearly demonstrate that the 6 4 99
method of protecting carbonyls using neopentyl glycol as
protect reagent is efficient, with almost quantitative conver- 7 4 95
sion and exclusive selectivity in most cases. The molar ra-
tio of aldehyde or ketone to neopentyl glycol is 1:1.2. Hex-
8 4 85
anal reacted with neopentyl glycol in 99% conversion and
100% selectivity (Table 2, entry 1). Aromatic aldehydes,
such as p-chlorobenzaldehyde, p-methoxybenzaldehyde, p- 9 4 97
nitrobenzaldehye, p-hydroxybenzaldehyde could also be ac-
etalized to afford the corresponding 1,3-dioxolanes with
96%, 92%, 91% and 99% conversions respectively in the
same conditions (entries 3–6). Cinnamaldehyde and croton- 10 4 99
aldehyde were converted to the corresponding products with-
out any damage of the double bond (entries 7 and 8). The ke-
talization reactions were also examined over the H2 NSO3 H 11 6 96
system. The linear chain ketones such as butanone and di-
isobutyl ketone can also be converted to the correspond-
12 10 81
ing ketals in moderate yields (entries 13 and 14). Cyclo-
hexanone and cyclopentanone are also worked well, but
13 8 89
the reactivity of cyclopentanone seems to be slightly lower
than that of cyclohexanone (entries 15 and 16). When ace-
tophenone and benzyl methyl ketone were used as sub- 14 8 68
strates, the ketalization products were obtained in con-
versions of 84% and 70%, respectively (entries 17 and 15 6 89
18).
Protection of carbonyls with neopentyl glycol is also a use- 16 6 96
ful tool for the heterocyclic compounds. 2-Furaldehyde and
2-pyridinecarboxaldehyde were consequently used as sub-
17 8 84
strates in our system and the results are listed in Table 2.
These two aldehydes have been successfully acetalized, and
conversions of the two aromatic aldehydes were 96% and 18 8 70
81%, respectively (entries 11 and 12), further expanding the
generality of this catalytic system to heterocyclic aromatic a Reaction conditions: aldehyde or ketone, 20 mmol; neopentyl glycol,

aldehydes. 24 mmol; toluene, 15 mL; sulfamic acid, 3 mmol; reaction temperature,

In our system, many acid-labile substrates such as 110 ◦ C.
b The corresponding selectivities were all ca. 100%.
4-methoxybenzaldehyde, cinnamaldehyde, crotonaldehyde,
vanillin and piperonal all worked well (entries 4, 7–10). Es-
pecially, the reaction of nitrogen-containing substrates, for
example, 2-pyridinecarboxaldehyde, which has been consid-
124 B. Wang et al. / Journal of Molecular Catalysis A: Chemical 233 (2005) 121–126

ered being very difficult over protonic acids or Lewis acids 3.4. Sulfamic acid catalyzed condensation of carbonyls
catalysts, because the acidic catalyst is readily trapped by and pentaerythritol
nitrogen atom, can also be performed in the sulfamic acid
system. These results indicated the usefulness of sulfamic Like the acetalization or ketalization of carbonyl com-
acid as catalyst for the title reactions. pounds, the reactions of carbonyl compounds with pentaery-
thritol to form the diacetals or diketals are also commonly
3.3. Sulfamic acid catalyzed reaction between carbonyl used in the protection of carbonyls [29]. Many conventional
compounds and different protection reagents acidic catalysts including mineral acid [30], solid acid or p-
toluene sulfonic acid [31–33] are all examined; however, they
Table 3 shows the results of sulfamic acid catalyzed suffered from disadvantages such as corrosion of equipment,
acetalizations between benzaldehyde and different protec- the difficulty of catalyst separation from product and low ac-
tion reagents, including ethylene glycol, 1,2-propanediol, tivity. Here, sulfamic acid has subsequently been used as cat-
2,3-butandiol, 1,3-propandiol, 1,4-butandiol and 2- alyst to evaluate the reactivity of carbonyl compounds with
mercaptoethanol. Under identical conditions, the con- pentaerythritol.
versions of benzaldehyde were increased as follows: Under our optimized conditions, the conversion of ben-
1,4-butandiol < 2-mercaptoethanol < ethylene glycol < 1,3- zaldehyde was only 26% even at prolonged reaction time
propandiol < 1,2-propanediol < 2,3-butandiol < neopentyl (Table 4, entry 1). In this reaction, the by-product, water, was
glycol. It shout be pointed out here that selectivities to formed in twofold amount of product; immediate removal of
desired products are all close to 100% over the sulfamic water should be helpful for the improvement of benzaldehyde
acid catalyst. In consequent investigations, another diol, conversion. Thus, this reaction was conducted at a round bot-
2,3-butandiol, has been used as protection reagent of a tom flask equipped with a water separator under reflux condi-
variety of carbonyl compounds and the results are listed tions. Here, toluene was used as water-carrying reagent. The
in Table 3. Conversions of 4-chlorobenzaldehyde, hexanal, content was stirred vigorously for 4 h. GC analysis indicated
cyclohexanone and 2-furaldehyde are all more than 90% that the conversion of substrate could be efficiently improved,
after certain periods. These good results may profit from and dibenzalpentaerythitol was obtained in 84% benzalde-
the hindrance of two methyl groups in 2,3-butandiol hyde conversion and 96% selectivity (Table 4, entry 2). Un-
molecule. der the same conditions, similar reactions of cyclohexanone

Table 3
Sulfamic acid catalyzed reaction between carbonyl compounds and different protection reagentsa
Entry Carbonyl compounds Protection reagents Products Reaction time (h) Concentrationb (%)

1 10 43

2 10 78

3 10 90

4 10 30

5 10 75

6 10 23

7 6 94

8 8 92

9 8 97

10 8 91

a Reaction conditions: aldehyde or ketone, 20 mmol; diol, 24 mmol; toluene, 15 mL; sulfamic acid, 3 mmol; reaction temperature, 110 ◦ C.
b The corresponding selectivities were all ca. 100%.
 B. Wang et al. / Journal of Molecular Catalysis A: Chemical 233 (2005) 121–126 125

Table 4
Sulfamic acid catalyzed condensation of carbonyls and pentaerythritola

Entry Carbonyl compounds Reaction time (h) Concentration (%) Selectivity (%)

1 18 26 94

2 4 84 96

3 4 87 99

4 4 88 97
a Reaction conditions: aldehyde or ketone, 20 mmol; pentaerythritol, 12 mmol; toluene, 15 ml; sulfamic acid, 3 mmol; reaction temperature, 110 ◦ C.

and hexanal with pentaerythritol occurred with comparative 4. Conclusion

results (entries 3 and 4).
Sulfamic acid has been used as an efficient and recyclable
catalyst for acetalization and ketalization between carbonyl
3.5. Recovery and reuse of sulfamic acid
compounds and diols. After optimizing reaction conditions,
various aldehydes and ketones were successfully converted
One of special properties of sulfamic acid is immisciblility
to corresponding acetals and ketals using neopentyl glycol
with non-polar organic compounds or solvents. Thus, recov-
and 2,3-butandiol as protection reagents. Inexpensive, incor-
ery of catalyst is very convenient in sulfamic acid catalyzed
rosive and stable catalyst, convenient operation and high se-
reactions when a non-polar solvent was used as a medium. In
lectivity to desired product are the features contained in the
the present acetalization and ketalization reactions, sulfamic
H2 NSO3 H system. Sulfamic acid showed a higher catalytic
acid seems to be a heterogeneous acid catalyst because it is
activity perfectly maintained after four recyclings. The sim-
insoluble in the reaction medium, toluene. After reaction, by
ple procedures as well as easy recovery and reuse of this novel
cooling the reaction mixture to room temperature (15 ◦ C),
catalytic system are expected to contribute to the development
sulfamic acid catalyst was recovered by filtration. To rule
of more benign acetalization and ketalization reactions.
out the possibility of catalyst leaching, the activity of the re-
covered catalyst in each reaction was investigated carefully.
The experimental results revealed that sulfamic acid could
Appendix A. Supplementary data
be recycled in 99.9%. Therefore, loss resulting from catalyst
leaching is negligible. In the condensation of benzaldehyde
Supplementary data associated with this article can
with neopentyl glycol, H2 NSO3 H could be reused for five
be found, in the online version, at 10.1016/j.molcata.
times without visible loss of activity (Fig. 1).
2005.02.006.

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