168-Article Text-511-1-10-20151214
168-Article Text-511-1-10-20151214
168-Article Text-511-1-10-20151214
A CRITICAL REVIEW ON GUGGULU [COMMIPHORA WIGHTII (ARN.) BHAND.] & ITS MIRACULOUS
MEDICINAL USES
D.C. Singh1, Srishti Dhyani2*, Gagandeep Kaur2
1Professor and HOD, *2P.G. Scholar, P.G. Dept. of Dravyaguna, Rishikul Govt. P.G. Ayurvedic College &
Hospital, Haridwar, Uttarakhand, India.
Received on: 28/12/2014 Revised on: 12/01/2015 Accepted on: 28/01/2015
ABSTRACT
Guggulu has been a key component in ancient Indian Ayurvedic system of medicine. It has
been used extensively by Ayurvedic physicians for centuries to treat a wide variety of
disorders, besides its use in pharmaceutical and perfumery industries. Guggulu is a gum or
resin extracted from the plant Commiphora wightii (Arn.) Bhand. (Syn. Commiphora mukul
Hook. ex. Stocks) or Guggulu tree. Guggulu is a shrub or small tree belonging to Burseraceae
family. Guggulu contains volatile oil, gum resin, gugulipids, guggulsterones, guggulsterols,
mukolol and other steroids. Guggulu is very much used in Ayuvedic system of medicine as
astringent, anti-septic, expectorant, aphrodisiac, carminative, anti-spasmodic,
emmenagogue. In Ayurveda, Guggulu is the best among herbs that are used for Medoroga and
Vata disorders. It is widely used for obesity and it is also known as fat burning agent all over
the world. It helps to lower cholesterol and triglycerides level. Guggulu is very effective in
rheumatoid arthritis, gout and sciatica. It is also one of the most important Rasayana of
Ayurveda. In addition it treats sluggish liver, stimulates libido, nervous diseases, bronchial
congestion, cardiac and circulatory problems, weak digestion, wounds, abscess, foetid ear,
fractures, gynaecological problems and various skin diseases. Guggulu is a very important
and trustworthy herb in Ayurvedic medicine. Basically it is used almost in every kind of
illness due to its amazing treating power. This review is an attempt to describe the
pharmacological activities of Guggulu and variable uses of Guggulu in several diseases.
KEYWORDS: Guggulu, Guggul, Commiphora wightii, Commiphora mukul, Burseraceae, Gum,
Resin, Medicinal use, Anti-inflammatory, Obesity.
INTRODUCTION
Commiphora wightii (Arn.) Bhand. (Syn. analgesic, cleaning of wound and healing due to its
Commiphora mukul Hook. ex. Stocks), with antibacterial action. Guggulu is a natural health
common names Indian bdellium tree, Gugal, product used primarily to reduce elevated blood
Guggul, Guggulu, is a flowering plant belonging to cholesterol levels. It has been used for many years
family Burseraceae. The Guggul plant may be as a hypocholesterolaemic agent in India. Guggulu
found from northern Africa to central Asia, but is is one of the best rewarding herbs for Vata
most common in Northern India. It prefers arid diseases. Various preparations of Guggulu used in
and semi-arid climates and is tolerant of poor soil. sciatica, hemiplegia, gout, rheumatic diseases,
It is a shrub or small tree, reaching a maximum facial paralysis etc. Guggulu is beneficial in
height of 3m, with thin papery bark. Guggul cleansing and healing of wounds and to reduce
produces a resinous sap known as gum Guggul. oedema due to its anti-inflammatory and anti-
The extract of this gum, called gugulipid or septic properties. In digestive ailments also like
guglipid, has been used in Ayuvedic medicine anorexia, flatulence, worm infestations, piles etc, it
abundantly. Guggulu contains essential oil, resin, works well.
gum, and bitter compounds. The major chemical Vernacular Names
constituents of gugglu are Z- guggulsterone, E- Table 1: Showing vernacular names of Guggulu
guggulsterone, guggullignans I & II, gugglu tetrols;
Arabic Aflatan, Moql, Moqlearzaqi,
mukulol; allylcembrol; c-27 guggulusterols I, II, III;
Mukulearabi
Z-guggulusterol; E-guggulusterol etc. These
Bengal Gugal, Guggul, Mukul, Ranghanturb
constituents are responsible for several
Canarese Guggala
pharmacological activities like anti-inflammatory,
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Srishti Dhyani et al. A Critical Review on Guggulu [Commiphora Wightii (Arn.) Bhand.]
Cutch Gugal used for Rasayan karma8. Dhanwantari Nighantu
Deccan Gugal, Guggal, Mukul, Ranghaturb included it under “Chandanadi Varga”9. Madanpala
Gujarat Gugal, Gugali, Gugar, Guggul, Mukul, Nighantu included it under “Karpooradi Varga”10.
Ranghanturb Kaiydev Nighantu has mentioned it under “Aushadi
Hindi Gogil, Gugal, Guggul, Mukul, Varga”11. Bhavprakash Nighantu has described it
Ranghanturb in “Karpooradi Varga”12. Raj Nighantu included it
Marathi Guggala, Gulag, Mukul under “Chandanadi Varga”13. Mahaushadi
Persian Boejahudan Nighantu included it under “Chandanadi Varga”14.
Porebunder Gugal, Gugali, Gugar Shaligram Nighantu has mentioned it under
Sanskrit Bhavabhishtha, Bhutahara, “Karpooradi Varga”15.
Devadhupa, Deveshta, Dhurta, Varities of Guggulu
Divya, Durga, Guggulu, Jatala, Bhavmishra described five varieties of
Jatayu, Kalaniriyasa, Kaushika, Guggulu - 1). Mahishaksha - Mahishaksha has the
Kumbha, Kumbhi, Kumbholu, colour of honey-bee or Anjana (antimony sulphide).
Kumbholukhalaka, Kunti, 2). Mahanila - Mahanila is similar to its name and
Mahishaksha, Mahishakshaka, looks like a Sapphire, a precious stone. 3). Kumuda -
Marudishta, Nishadhaka, Kumuda resembles Kumuda flower (white) in
Palankasha, Pavandvishta, Pura, colour. 4). Padma - Padma resembles Manikya (ruby
Puta, Rakshoha, Sarvasaha, red). 5). Hiranya - Hiranya is like gold in colour.
Shambhava, Shiva, Uddipta, Mahikshaksh and Mahanila varieties are beneficial
Ulukhalaka, Usha, Vayughna to elephants, Kumuda and Padma bestow health to
Sind Gugal, Guggul, Mukul, Ranghanturb horses, Hiranya variety is best suited for humans.
Sinhalese Gugula, Jatayu, Javayu, Mahishaksha is also good for humans16.
Ratadummula Other two varieties of Guggulu has
Tamil Gukkal, Gukkulu, Maishakshi mentioned in the texts books of Ayurveda: 1). Nava
Telugu Gugul, Mahisaksh, Maisakshi.1 Guggulu 2). Purana Guggulu The freshly collected
Guggulu is known as Marudeshya because Guggulu is tissue builder and aphrodisiac and if
it is a plant which grows in arid zone. It exudes a stored for more than one year, it is a depletory of
gum resin coming out of cavities (Kaushika, tissues. The characters of fresh one are, it is oily,
Ulukhala, Kumbholukhala) in form of particles yellowish looks like a ripen Jambu fruit, fragnant
(Kananiryasa) reddish black in colour and gummy in nature. Purana or old decayed
(Mahishaksa, Kalaniryasa). It removes a number of Guggulu is dry, emitting bad smell, devoid of natural
ailments (Guggulu) particularly obesity colour and potency.
(Palankasa) and is antiseptic (Rakshoha) as Nav Guggulu is useful in debility, whereas
fumigation. It is also used as incense in god’s the old variety - Purana Guggulu is salutary in
worship (Devadhupa)2. obesity and diabetes17,18.
Guggulu is known as Ulukhala because it According to Kaiydeva Nighantu, Guggulu
exudes a gum-resin which comes out from cavities. are of five types: Mahishaksha, Mahanila, Kumuda,
The resin is the best medicine, so it is known as Padma, Hiranaya. Kaiydeva mentioned that
Pura. It is also known as Durg because it is a plant Guggulu trees habituated in the Maru bhumi
which grows in arid zone3. pradesh (Vata pradhan desh) will yield five types
Classical Review of gum-resin during Grishmritu as well as
In Atharvaveda it is mentioned that Shaityaritu. According to Kaiydeva Nighantu -
Yakshma and other diseases will not spread to the Krishna varna Guggulu - best for Rakta-pitta dosh
areas fumigated by Guggulu. Sayana also Pingal varna Guggulu - best for Kapha-pitta dosh
introduced it as a well known “Dhupana dravaya”. Sweta varna Guggulu - best for Vata-pitta dosh19.
It was used for the treatment of diseases of cattle. Other five types of Guggulu, according to Unani
It is observed that the internal usage of Guggulu system of medicine:
increased during Samhita period only4. Charaka Mukle Saklabi - Brown in colour Mukle
has mentioned it in “Sangyasthapana arabi - It is reddish brown or purpulish in colour
mahakashaya” (Su.4/48) and in “Kashaya and found in Yaman pradesh. Mukle ajarak -
Skandha” (Vi.8/144)5. Sushruta has described reddish in colour Mukle Yahud - yellowish in
Guggulu in “Eladi gana” (Su.38/24)6. Vagbhata colour Mukle hindi - It is found in India20.
included Guggulu in “Eladi gana”. (Su.16/37)7.
Sharangdhara quoted it among the drugs to be
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Int. J. Ayur. Pharma Research, 2015;3(1):1-9 SSN: 2322 - 0910
Botanical Description when fresh viscid and golden coloured, odour;
Guggulu [commiphora wightii (Arn) aromatic, taste is bitter and astringent.
Bhand.] is a woody shrub or a small tree which b) Microscopic Foreign matter Not more than 4 %;
grows to the height of 2-3 metres, much branched Total Ash Not more than 5 %; Acid-insoluble ash
with characteristics silvery and paper like bark- Not more than 1%; Alcohol-soluble extractive
peelings. Branches are knotty and crooked, Not less than 27 %; Water-soluble extractive
divaricate, usually ending in a sharp spine. Not less than 53%; Volatile oil Not less than 1%,
Leaves: The leaves are rhomboid-ovate, 1-3 v/w.25
foliate, serrate-toothed in the upper part, smooth Distribution
and shinning, the lateral leaflets when present less The Guggul plant may be found from
than half the size of the terminal ones. northern Africa to central Asia, but is most common
Flowers: Flowers in the fascicles of 2-3; pedicles in Northern India. It is also found in the tracts of
very short. Calyx campanulate, glandular, hairy; Western India and found extensively in Rajasthan,
lobes are 4-5 in number, triangular, as long as the Gujrat, and Maharashtra. It is propagated by seeds
tube. Petals are brownish red, broadly linear, and root cuttings26,27,28.
nearly thrice the length of the calyx, reflexed at the Cultivation
apex. Stamens are 8-10 in number, alternatively Guggulu is sought for its gummy resin, which
long and short, half the length of the petals. Disk, is harvested from the plant’s bark through the
8-10 lobed, the alternate sinuses deeper and in process of tapping. In India, Guggulu is cultivated
these are inserted the shorter stamens. Ovary commercially. It can successively be propagated by
oblong-ovoid, attenuated into the style. vegetative means. The rooting initiates 21 days after
Fruits: The fruits are small, red in colour when sprouting and 300mm, long 15 and 15mm diameter
ripe, ovoid drupes. Each plant produces about 0.5 cutting gives the maximum rooting. As it is a plant of
to 1kg of oleo-gum resin which is collected from arid zone, there is no necessity of irrigation upto the
January to March. middle of November except during drought.
Gum Resin: Pale yellow to brown aromatic gum However, if there is the winter shower, there is a
resin obtained from the bark of the plant. necessity of irrigation to plants of one to five years
Agglomerated tears of resin are somewhat of age group. The plants of 6-7 years of age group
transparent, with waxy surface and brittle in require irrigation only in summer season. Irrigation
nature. Gum-resin is thick, scented, burnt on fire, can be done either by head load method or water
liquifies in sun heat. When dissolved in water, it tank method29,30.
turns milky white21,22,23. Endangerment and Rescue
Chemical Constituents Because of its medicinal properties, guggul
In its chemical composition volatile oil, has been overharvested in much of its habitat, and
resins, gum and a bitter compound is found. Five has been listed on the IUCN Red List of threatened
types of guggul sterols, Z-guggul sterone, E- species. Several efforts are in place to address this
guggulsterone, guggul sterol - I, II, III, sesamine, situation. India’s National Medicinal Plants Board
cholesterol, mucolol and other steroids are also launched a project in Kutch District to cultivate 500
found. Monocyclic diterpenes- alpha - camphorene to 800 hectares (1,200 to 2,000 acres) of Guggal,
and cembrene isolated from resin; allylcembrol while a grass-roots conservation movement, led by
isolated from plant and characterized (Chem IUCN associate Vineet Soni, has been started to
Abstr. 1972,77, 111554 t). Three new steroids - educate Guggul growers and harvesters in safe,
guggulsterols I,II,III are isolated from gum resin sustainable harvesting methods31.
(Tetrahedron 1972, 28, 2341). Cembrene A Substitutes and Adulterants
isolated from resin and characterized Oleo-gum resin obtained from Boswellia
(Tetrahedron 1973, 29, 341). Isolation and serrata Roxb. (Salai guggulu) is the major
structure elucidation of two aliphatic tetrols - adulterant. It is distinguished by its yellowish
octadecan - 1, 2, 3, 4 and eicosan - 1, 2, 3, 4 - tetrol green, golden or milky tears, seldom amalgamated
from gum resin (Tetrahedron 1973, 29, 1595). into lumps and a characteristic terpentine like
Guggulsterol VI and Z - guggulsterol isolated from odour. Gum-oleo-resin of Commiphora myrrha
gum resin (Tetrahedron 1982, 38, 2949)24. (Nees) Engl., imported from Africa and
Macroscopic and Microscopic Features constituting the drug Hirabole or bole of
a) Macroscopic Drug occurs in vermicular pieces commerce is sometimes mixed with Guggulu.
of pale yellow or brown coloured mass, makes Similarly, gum-oleo-resin obtained from
milky emulsion in hot water and readily burns, Commiphora roxburghii (Arn) Engl., Occurring in