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    Git

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    Sabbir Ahmed
    The document discusses several hormones of the gastrointestinal tract including their origin, stimuli for secretion, and actions. It provides details on hormones like gastrin, cholecystokinin, secretin, motilin, GIP, VIP, ghrelin, peptide YY, and amylin. Ghrelin is noted as a hormone that stimulates appetite, acid secretion, and gastric emptying and is secreted by the stomach.

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    Git

    Uploaded by

    Sabbir Ahmed
    22 views4 pages
    The document discusses several hormones of the gastrointestinal tract including their origin, stimuli for secretion, and actions. It provides details on hormones like gastrin, cholecystokinin, secretin, motilin, GIP, VIP, ghrelin, peptide YY, and amylin. Ghrelin is noted as a hormone that stimulates appetite, acid secretion, and gastric emptying and is secreted by the stomach.

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    The document discusses several hormones of the gastrointestinal tract including their origin, stimuli for secretion, and actions. It provides details on hormones like gastrin, cholecystokinin, secretin, motilin, GIP, VIP, ghrelin, peptide YY, and amylin. Ghrelin is noted as a hormone that stimulates appetite, acid secretion, and gastric emptying and is secreted by the stomach.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    22 views4 pages

    Git

    Uploaded by

    Sabbir Ahmed
    The document discusses several hormones of the gastrointestinal tract including their origin, stimuli for secretion, and actions. It provides details on hormones like gastrin, cholecystokinin, secretin, motilin, GIP, VIP, ghrelin, peptide YY, and amylin. Ghrelin is noted as a hormone that stimulates appetite, acid secretion, and gastric emptying and is secreted by the stomach.

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    Digestive system(6-8)

    1.Hormones of git( Gastrin ,secretin, cck pZ)

    Causes of secretion, site of action and function

    2.Factors affecting saliva secretion

    3. Regulation of hcl secretion

    4.Amount, ph ,composition and regulation of digestive juice (GASTRIC juice)

    5.Cho, protein, fat digestion absorption and malabsorption

    6.Bile, micelli and emulcification

    7.Compositon of bile

    8. liver function

    9.fx of large gut

    10. gastric emptying

    11. Factors affecting fe absorption

    12. Absorption of water and electrolytes

    13.absorption of ca, bile, b12 in different part of intestine

    Ghrelin
    LOCAL HORMONES OF GIT

    Polypeptide in nature (amino acid less than 100)

    Secreted by nerve cells and gland cells in mucosa

    Act in paracrine fashion

    A. Gastrin family : gastrin ,cholecystokinin(CCK-PZ)

    B. Secretin family: secretin glucagon glicentin vip gip

    SBA: Gastrin: Stimulates pepsin secretion.

    Ach and cCk contracts- gall bladder.

    Ghrelin
    hormone Origin Stimulus Action
    Gastrin Antram G cell. Products of protein digestion Stimulates gastric acid
    Suppressed by acid and secretion
    somatostatin Stimulates growth of
    gastrointestinal mucosa
    insulin release
    somatostatin Throughout Gl tract & Fat ingestion Inhibits gastrin and insulin
    secretion
    Decreases acid secretion
    Inhibits pancreatic secretion
    Fat ingestion

    Cholecystokinin Duodenum and Products of protein simulates pancreatic enzyme


    Jejunum( S cell) digestion secretion
    Fat and fatty acids Suppressed Gallbladder contraction
    by trypsin Sphincter of Oddi relaxation
    Decreases gastric acid
    secretion
    Reduces gastric emptying
    Regulates pancreatic growth

    secretion Duodenum and Duodenal acid simulates pancreatic fluid and


    Jejunum( S cell) Fatty acids bicarbonate secretion - Ductal
    Decrease acid secretion
    Reduce gastric emptying
    Motilin Duodenum, small Fasting Regulates peristaltic activity,
    intestine and colon Dietary fat including,
    (Mo cells) migrating motor complexes
    (MMC)

    GIP Duodenum( K cells) and Glucose and fat Stimulates insulin release (also
    jejunum known as
    Glucose and fat
    glucose-dependent insulin-
    trophic
    polypeptide)
    Inhibits acid secretion

    VIP Nerve fibers Unknown Vasodilator


    throughout GI tract Smooth muscle relaxation
    Water and electrolyte
    secretion

    Ghrelin Stomach Fasting. Stimulates appetite, acid


    Inhibited by eating secretion and gastric emptying

    Ghrelin
    Peptide YY Ileum and colon feeding. Modulates satiety - decrease
    appetite.

    Amylin Pancreatic islet B-cells feeding. Glycemic control

    Stimuli that increase gastrin secretion:

    Luminal: Peptides ad amino acids, Distention

    Neural: Increased vagal discharge Vid GRP

    Blood borne: Calcium, Epinephrine

    Stimuli that inhibit Gastrin secretion:

    Luminal: Acid, Somatostatin

    Blood borne:

    Secretin, GIP, VIP, Glucagon, Calcitonin

    SBA - Ghelin the onty hormone which increase apelte.

    Leptin- Ioss appetite.

    In Acetle cholecystitis pain due to -CCK. - SBA.

    Ghrelin

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