Escape Room EDU

Teacher Instructions
Print out question cards and decoder cards for each level
Important Note: The final level (Level 5) comes in two
versions (Normal or Hard). Use either one, both end
with the same code. The digital escape room uses the
normal difficulty only.
Make copies of the recording sheet for each student or group

Print answer key to check student answers

Digital Escape Room: http://bit.ly/2Sn1HXH

– Students receive a completion code after the
last level to show you they have broken out.
Click here for a Force copy of the Google Form
– You will be able to change the settings to
collect student responses (e-mails).
 Escape Room EDU
How to Use
Escape Room for Teams:
Version 1: Place each level at different stations – Requires
each team to cycle at predetermined times
Version 2: Place all levels at each station – Requires
students to remain at one station

Escape Room for Individual Students:

Place levels around the room for students to
answer. Students receive the completion code
from teacher when all 5 levels are completed

Optional:
Hide the cards throughout the room to
make the game extra challenging
Use physical boxes and locks to make
the game feel more “real”
 Escape Room EDU
Decoding the Puzzles
All levels work in the same fashion: (Answer Key is on Pg. 13)
- Students solve the answer to the 4 multiple choice questions
- Students use the A, B, C, D answers with the decoder for that level

Example: How to solve Level 1

-The answers to level 1, in order, are BACD

- Using these answers with the Level 1 puzzle:
- B leads to 3
- A leads to 4
- C leads to 2
- D leads to 1
- If you put these in the same order it
becomes 3421, which is the code for level 1.
- The other puzzles are solved the same way
 Escape Room EDU
FAQ
My school’s internet does not allow me to use shortened links.
Long Link:
https://docs.google.com/forms/d/e/1FAIpQLSf79Ws3TErS-
D_LJH8F1HpwFTYmhPwTFJJ2ybYj_xQVgBTzyg/viewform
How can I see what they did based off the Google form?
Answer: You can’t. Students must input the correct answer
to move on. The completion code is used to know
when they have completed it.
How long does this take to complete?
Answer: Usually about 45 minutes, sometimes up to an hour,
which can be broken into two class periods
Are electronic devices needed to complete this activity?
Answer: No, this can be done without a device

Does this require Google Classroom?

Answer: No, just access to the internet

How long does this take to set up?

Answer: Hardly any time at all; just print the Question cards, Level cards
and recording sheet, the Google form is already ready to use
 ESCAPE ROOM EDU Mission Objective
A mad professor trapped your whole class in the

DNA classroom. In order to escape, you must use your

knowledge of DNA replication to convince him to let
you go. Answer the questions at each level and be sure

Replication to record each answer. Once all levels are

complete, retrieve the completion
code to break out and save the day.
You must hurry and escape before you
remain trapped in class forever!
Digital Link: bit.ly/2Sn1HXH

Level 1 Level 2
A B C D
8
6
Digits
4
2
0
1 3 4 A B C D
2 Answers
 Level 3 Level 4
A= A B C D
Q1 = 9
B=
Q2 = 2
C= Q3 = 5
D= Q4 = 7

Level 5 Level 5: Hard

3 2 A + = 8 A=
+ = 9 B=
1 C 4
+ = 8 C=

D 5 B + = 12 D=
 Level 1 Q1 Level 1 Q2
What shape does a DNA molecule have? Which of the following is the correct
name of DNA?

A. Alpha helix A. Deoxyribonucleic acid

B. Double helix B. Deoxoribonuclear acid
C. Single helix C. Denatured ribonucleic acid
D. Ringed helix D. Deoxynucleic acid

Level 1 Q3 Level 1 Q4
Which organelle contains DNA? What are the building blocks of DNA?
A. Golgi C. Nucleus

A. Codons
B. Amino Acids
B. Rough ER D. Smooth ER
C. Fatty Acids
D. Nucleotides
 Level 2 Q1 Level 2 Q2
What type of bond holds a DNA molecule What is the process by which DNA
together? makes a copy of itself called?

A. Hydrogen bonds ? A. Reproduction

B. Covalent bonds ? B. Translation
C. Metallic bonds C. Replication
D. Ionic bonds ? D. Transcription

Level 2 Q3 Level 2 Q4
Which nitrogen base is not found in DNA? If the sequence of a DNA strand is
A. Guanine C. Uracil AAGCCA, what are the bases on
its complimentary strand? DNA
A
A. C C A T T C A
B. Cytosine D. Adenine B. T T C G G T G
C. A C C G A A C
D. A A G C C A C
A
 Level 3 Q1 Level 3 Q2
The enzyme that unwinds the double helix The open area of DNA where replication or
of DNA in preparation for DNA replication is transcription can take place is called
called

A. DNA Ligase A. Replication bubble

B. DNA Primase B. Replication fork
C. DNA Polymerase C. Replication strand
D. DNA Helicase D. Replication origin

Level 3 Q3 Level 3 Q4
The enzyme involved in DNA replication Once the two strands of DNA are
that joins individual nucleotides to produce separated, what prevents them from
a DNA molecule is called assuming their double-helical shape?

A. Other proteins hold the strands apart

A. DNA Ligase B. They are too far away from each other
B. DNA Primase C. Each strand has opposing charges,
C. DNA Polymerase which keep them repelled
D. DNA Helicase D. All of the above
 Level 4 Q1 Level 4 Q2
How does DNA polymerase move along How can each copy of DNA at the end of
each strand of DNA? replication be compared?

A. Both move towards the replication fork

B. Both move away from the replication fork A. Each copy is identical to each other
C. One moves towards from the replication B. Each copy is different from each other
fork and the other moves away from it C. They are 90% similar
D. There is only one DNA polymerase on D. They are 50% similar
the DNA at a time

Level 4 Q3 Level 4 Q4
What are damages or changes to a DNA In the event of a mismatched nucleotide,
sequence called? which molecule is able to backtrack,
“proofread,” and correct the nucleotide
sequence?
A. Adaptations
B. Carcinogens A. DNA Proofreadase
C. Mutagens B. DNA Polymerase
D. Mutations C. DNA Helicase
D. DNA Primase
 Level 5 Q1 Level 5 Q2
DNA replication occurs How many DNA strands exist after one
during which phase molecule of DNA has been replicated?
of the cell cycle?

A. 1
A. G1 B. 2
B. S: Synthesis C. 4
C. G2 D. 8
D. Mitosis

Level 5 Q3 Level 5 Q4
Which correctly pairs the organism with the Which correctly pairs the organism with the
DNA and replication forks in the picture? DNA and replication forks in the picture?
A. Prokaryotic DNA: A. Prokaryotic DNA:
Example: Bacteria Example: Bacteria
B. Prokaryotic DNA: B. Prokaryotic DNA:
Example: Human Example: Human
C. Eukaryotic DNA: C. Eukaryotic DNA:
Example: Bacteria Example: Bacteria
D. Eukaryotic DNA: D. Eukaryotic DNA:
Example: Human Example: Human
 Make Your Escape! Name ________________

DNA Replication Digital Link: bit.ly/2Sn1HXH

Level 1 Level 2 Level 3

Codes Answers

Codes Answers

Codes Answers
Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4

Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4

Level 4 Level 5
Codes Answers

Codes Answers

Congratulations!
Enter the completion code
Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 to make your escape!

Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4

 Key: DNA Replication

Level 1 Level 2 Level 3

Codes Answers

Codes Answers

Codes Answers
B A C D A C C B D B C A
Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4

3 4 2 1 5 8 8 1 5 8 8 6
Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4

Level 4 Level 5
Codes Answers

Codes Answers

Congratulations!
C A D B B C A D Enter the completion code
Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 to make your escape!

5 2 9 7 9 3 5 4 3 2 6 0
Digit 1 Digit 2 Digit 3 Digit 4 Digit 1 Digit 2 Digit 3 Digit 4
Large Cards
 ESCAPE ROOM EDU

DNA
Replication
Digital Link: bit.ly/2Sn1HXH
 Mission Objective
A mad professor trapped your whole class in the
classroom. In order to escape, you must use your
knowledge of DNA replication to convince him to let
you go. Answer the questions at each level and be
sure to record each answer. Once all
levels are complete, retrieve the
completion code to break out and save
the day. You must hurry and escape before
you remain trapped in class forever!
 Level 1 Q1
What shape does a DNA molecule have?

A. Alpha helix
B. Double helix
C. Single helix
D. Ringed helix
 Level 1 Q2
Which of the following is the correct name of DNA?

A. Deoxyribonucleic acid
B. Deoxoribonuclear acid
C. Denatured ribonucleic acid
D. Deoxynucleic acid
 Level 1 Q3
Which organelle contains DNA?
A. Golgi C. Nucleus

B. Rough ER D. Smooth ER
 Level 1 Q4
What are the building blocks of DNA?

A. Codons
B. Amino Acids
C. Fatty Acids
D. Nucleotides
 Level 1
A B C D

1 2 3 4
 Level 2 Q1
What type of bond holds a DNA molecule together?

?
A. Hydrogen bonds ?
B. Covalent bonds
C. Metallic bonds ?
D. Ionic bonds
 Level 2 Q2
What is the process by which DNA makes
a copy of itself called?

A. Reproduction
B. Translation
C. Replication
D. Transcription
 Level 2 Q3
Which nitrogen base is not found in DNA?
A. Guanine C. Uracil

B. Cytosine D. Adenine
 Level 2 Q4
If the sequence of a DNA strand is AAGCCA,
what are the bases on its complimentary strand?
DNA

A
A
A. C C A T T C G
B. T T C G G T C
C. A C C G A A C
D. A A G C C A A
 Level 2

6
Digits

0
A B C D
Answers
 Level 3 Q1
The enzyme that unwinds the double helix of DNA
in preparation for DNA replication is called

A. DNA Ligase
B. DNA Primase
C. DNA Polymerase
D. DNA Helicase
 Level 3 Q2
The open area of DNA where replication
or transcription can take place is called

A. Replication bubble
B. Replication fork
C. Replication strand
D. Replication origin
 Level 3 Q3
The enzyme involved in DNA replication that
joins individual nucleotides to produce a
DNA molecule is called

A. DNA Ligase
B. DNA Primase
C. DNA Polymerase
D. DNA Helicase
 Level 3 Q4
Once the two strands of DNA are separated,
what prevents them from assuming their
double-helical shape?

A. Other proteins hold the strands apart

B. They are too far away from each other
C. Each strand has opposing charges, which
keep them repelled
D. All of the above
 Level 3
A=
B=
C=
D=
 Level 4 Q1
How does DNA polymerase move along each
strand of DNA?

A. Both move towards the replication fork

B. Both move away from the replication fork
C. One moves towards from the replication
fork and the other moves away from it
D. There is only one DNA polymerase on
the DNA at a time
 Level 4 Q2
How can each copy of DNA at the end of
replication be compared?

A. Each copy is identical to each other

B. Each copy is different from each other
C. They are 90% similar
D. They are 50% similar
 Level 4 Q3
What are damages or changes to a DNA
sequence called?

A. Adaptations
B. Carcinogens
C. Mutagens
D. Mutations
 Level 4 Q4
In the event of a mismatched nucleotide, which
molecule is able to backtrack, “proofread,” and
correct the nucleotide sequence?

A. DNA Proofreadase
B. DNA Polymerase
C. DNA Helicase
D. DNA Primase
 Level 4
A B C D
Q1 = 9
Q2 = 2
Q3 = 5
Q4 = 7
 Level 5 Q1
DNA replication occurs during which phase
of the cell cycle?

A. G1
B. S: Synthesis
C. G2
D. Mitosis
 Level 5 Q2
How many DNA strands exist after one molecule
of DNA has been replicated?

A. 1
B. 2
C. 4
D. 8
 Level 5 Q3
Which correctly pairs the organism with the
DNA and replication forks in the picture?

A. Prokaryotic DNA:
Example: Bacteria
B. Prokaryotic DNA:
Example: Human
C. Eukaryotic DNA:
Example: Bacteria
D. Eukaryotic DNA:
Example: Human
 Level 5 Q4
Which correctly pairs the organism with the
DNA and replication forks in the picture?

A. Prokaryotic DNA:
Example: Bacteria
B. Prokaryotic DNA:
Example: Human
C. Eukaryotic DNA:
Example: Bacteria
D. Eukaryotic DNA:
Example: Human
 Level 5
3 2 A

1 C 4

D 5 B
 Level 5: Hard

+ = 8 A=
+ = 9 B=
+ = 8 C=
+ = 12 D=