Annotated by @bakulitathagata

ANTI-PLATELETS: PHARMACOLOGY

③ Aggregation TXA2-

TXAR
2
I
②
ab
> -

Activation

I
SE :

↑ uricemia
gont
-

↳ Ste : Pancytopenia,
-

Reye Sx (children) ~ revesible:

"'ending
①- Adhesion
- microvascular steatosis
&
O
O
Aspirin respirate a
I
Acute Liver of
HAMA
-

children
failure
'al l'ab'
S
in ba
indicate :
Hypokalemia only
monoclonal
Salbutamol 1) Kawasaki ds .
-

peptic ulces DAPT (De Antiplatelet drugs)

Insulin Rheumatic
Epinephrine
2) Amric
Fever
-
T
Prasugrel
A

Activated
Amphotericin B cp

S
Loop diuretics & thiazides
Acetazolamide Aspirin -
Sigagaelos (preferred)
Protease Receptor I
Hyperkalemia clopidogrel
Ace inhibitors
Beta blocker
PAR-1 INHIBITOR:
Cyclosporine/tacrolimus
Digoxin AtoPaxar
K sparing diuretics
VoraPaxar
 ANTICOAGULANTS-PHARMACOLOGY

NOAC

⑦ 11/X alsa pile to e Ex

prothrombotic state : Demal Shin necrosis

SE : -

renal
--
safe in

Heparin
induced
- faihre
Unorsbscyto↳

~
penix
25-10 days

~ Mi/stroke
post usage >

osteopenia HIT
risk)
DOC
For
Fondaparinux
-

DOC Ino Hit --

RTAIN
fantidote
-

->
-
PF4
↓ antidote
Teratogenic-
!
I d ar
cizumab
·
Th End an ant
in - -
ale
stippled cyp2c9
epiphysis) ·
ar sa
L

↓ Antidote
+ prosthetic
2) Preferred A Fib

I
a
protamme sulfate ↓ MS

stops breakdown
of dot'

Proteianueants
2) 2
,
7 , 9 , 20 , -
Trauma -

menorrhagia
(AT25)

alt Short #z C : always give wasfai

:
heparin cover)
blocks
first
 Glutamine-Valine

SICKLE CELL ANEMIA:

- -

Glutamic acid
Hydroxyurea sicling
Voxelotor I ↓

Crizanlizumab ⑦ Selectin
-
P

creasing)

Enzyme inducers Enzyme inhibitors

GPRS Cell Phone

Griseofulvin Imicrotubule &] Doc :

t
.

capilis Valproate Vit

Phenobarbitone ↑ duration of -
opening of GABA
Ketoconazole k
I DARbitone)
=

Pheno chains

Phenytoin Cimetidine cont CXP &

Rifampicin Ciprofloxacin(FD) F4
-

9 -

- cause

Carbamazepine Erythromycin, Clarithromycin

Enzyme (Manolide)
Smoking, Ethanol INH [I inhibitos]
inhibition
in

sulforyweas
Chronic Alcohol Acute Alcohol

Phenobarbitone
- ↓ ↓
Neonatal
Giggler Syndenham's
Sz chosea
wajs
·

as
 Hemorrhagic cystitis
-
Colchicine
Ifosphamide >Cyclo
Griserfuhin SIADH
↑
-

'Fan Stabilise
society' 4-hydroxyclycophosphamide: Active
↑ Compound: Acrolein
-

hypestabilise Prevention: Mesua

⑦
Treatment: suppress immunity (Steroids)
B
Cyclophosphamide
Busulfan
Pulmonary
Bleomycin
Carmustine fibrosis
I
I
sides to
Methotrexate
a

T
story'
Amiodarone
3) SIADH
neonspathy
Her (DOC)
↳esseine
DNA Vincristine peripheral
->

sparing
->
BM

MoA ↓
zickling Bleomycin flagellate
->
dumaliti
-

-> ribonucleotide reductase L-aspararginase pancreatitis

-
->
e

DHF reductase Perygium

~
-

d regimen

~Niko
lanal A)
acid rescue
folinis Stenosis
subgrollic
-

~ (cotton meyer)
Fludarabine DOC : CLL Mitomycin C ↳ topical VBCA Platinum
Temozolamide Nephrotoxic: ↓ Amifosline Displatin)
-

↳ Glioma (GBM)
Ototoxic
5FU s/e: Most emetogenic
Hand
foot Syndrome
DOC early- 5 H130 ondansetion
Anthracycline s/e: Al tonicity ->
↓
Demeagowane DOC delayed- NK10 Aprepitant
 Anticancer small molecule inhibitors
Filgrastim, Sargramostim GMCSF 4 Alectinib, crizotinib ALK Non-small cell lung
EPO anemia (8 RBC) &
cancer
Oprelevkin 12-11 analogue, (platelet +1) Erlotinib, gefitinib, EGFR Non-small cell lung
⑨

Romiplostim , Eltrombopag Thromboportin agonist afatinib cancer

(m4)
IFN-α Chrheps enconte Imatinib, dasatinib, BCR-ABL CML, ALL, GISTs
IFN-β Brain)↳
MS Fibroblast nilotinib
IFN-γ Geamloma
CGD
TH1 cell Ruxolitinib ruko ja-ra JAK1/2 Polycythemia vera
Bortezomib, ixazomib, Proteasome Multiple myeloma,
-

Aldesleukin 12-2
against :
Red melanoma
carfilzomib ·
zom:
some (induce G2-M mantle cell
arrest -> lymphoma
Palivizumab REV
high
sish
↓viral apoptosis)
Cetuximab, Panitumumab E GFR G CA
color flung Vemurafenib, BRAF ~600E Melanoma
colorectal CA
tonic
encorafenib, The
-
-

SE
Trastuzumab, Pertuzumab
:
Her 2 new & -

Pilocytic astrocytoma
↳ Lapatin
&
dabrafenib - PTC
(Papillary Thyroid (1)
Emicizumab hemophilia (prevents by binding
to (a & X) Palbociclib Cyclin- dependent Breast cancer
factor
- Y -

Eculizumab C58 : PNH

breakdown
kinase 4/6
(induces arrest at
E

Natalizumab 24 nitegain & :

MS ; SE-Progressive Multifocal
Leukoemephalopathy GI-S phase →
VEGE ⑦ IPML)
me
apoptosis)
Bevacizumab R Olaparib Poly(ADP-ribose) Breast, ovarian,
Ranibizumab PDR /
polymerase (↓ pancreatic and
Brolucizumab RCC

Aflibercept DNA repair) prostate cancers

Pegaptanib
Rani
Berafa (ii) boo-lab) Peg (peeke) Holiday
& - (A .

fils)ip
 immuno activators

Advanced
melanoma, RCC
CTLA4G

Melanoma
HL 28
744
NSCLL
=

UB
Merkel cell ca
- A

-> Albie Moskel

L
289 trial
Keynote
-Now small cell
Lung A

-endometrial (A

-
 eychsporine)hyperplasia
:
sirtipania
L
dater SE ·

pan
gingihirsutiseh
val
~be
-

↑
-

Sa
onidase
Xanthine

SE
S
-

nephrotonic
48
-
-

hypertension
-
Allopurinol
TSC
I
-

dyslipidemia

y
 ~
din Liver failure
Safe in renal failure:
PMT Pe Mo Trova
B
Cyp inh, QT prolong, tendons, seizure
I
↳1 in
children

No
Macrolides
Cyp inh, QT prolong,
Prokinetic, Jaundice TMP : SMX

L 1
:
5 (Tab)
produces [Plasma)
MMC 1 : 20

SELCC
grey
baby
⑦ peptide-
&
Lianafence 0
0 23 S

L
DOC :
Anaerobes ->

above diaphragm

-
-
MCS
0 ~ Ecolocation
⑥
E

A F 30
Buy 50
syn 8
cell wall :
at
SEL(()
Fosfomycin: -> UT1

Muramic acid
Cycloserine: and line ATT
- AI
↳
SE Sz nemopsychiatric manifest
:

Pentapeptide (d-ALA)
,

-
Bacitracin: ↳
BPtopical
MRSA
⑦
Teachment

I
transporter
Vancomycin:
>

Transglycosylase wall ⑦
misreading
cell

elongation
-

B lactams: RNA
Transpeptidase wall

No ·cross-reactivity:
all
anaerobes
esslinking
↳ MRSA
Azi li batsch
nam toh
Monobactam
(Azteonam)
needoc - not
useful in
DOC TABLE IM Stat E
bacilli not
effective
negative
2 4 MU
12'-Benythin Gram
.

A
- white (Hit 3) GNB
• Syphilis -> Never
-

Acqueous Penicillin

• Actinomyces Penicillin

• Listeria
-
Ampicillin

• Mastitis donacillin
25t gen incision)
• SSI Celazolin (30m-1
m prior to
above
: Cindanim
- diaklagen

• Anerobes and
gen Cefnitin
Doc :
-> below :
Metronidazole dihydropeptidase
Imipenem+ Cilastatin:
• Neisseria, Lyme disease, Enteric fever Brd gen) Ceftrianone ↓
cause
Sy
• Pseudomonas cefoprazone leftaged wire
, [3ed/4in) with gen
also
effectivel
usifulin SHADH
(i) - I
• Enterobacter, Acinetobacter Mecopenem Ernie (
*
SE
Demeclocycline: D abso

Gansamihistamine
I

raptans

• C.difficile, MRSA Vancomycin SPE

:

NO
T RED
↳ Micocycline:
↳
Fidonamy en Nephnotorie black

migro
vestibular unition
• Plague,Tularemia streptomy en Thrombophlebitis
S

• Ricketsia, Cholera Donycychne

• Atypical pneumonia, Legionella, Mycoplasma, Chlamydia, Pertussis, Diphtheria Macrolides

• Nocardia, PCP, Burkholderia, Cyclospora, Isospora IMP : SMX

• Meningococcal (Rx and prophylaxis), Anthrax, UTI, Travelers diarrhea FI

 TABLE OF DRUGS NOT EFFECTIVE AGAINST MICROORGANISMS
CIDAL DRUGS
BEVAFA STREPTOGRAMINS MYCOPLASMA Cell wall inhibitors (beta-lactams, vancomycin)
-
- PSEUDOMONAS Vancomycin
-

↓
Blackam
↳ FD
e
Aminoglycoside
-concentiation dep
ANAEROBES Aminoglycosides On
for
activation
need rol'
ceftaroline
e
Vanco
killing EDK
MRSA Beta lactams (except fifth generation cephalosporins)
-
TDK
dependent
I time
hitting)
doses
-
single dose SALMONELLA Aminoglycosides
-

frequent
Resistance: Enzyme Altered target Efflux pump
(PBP 2 a)
Bile secretion: SAFE IN RENAL FAILURE:
ABC
·

Blactamase · MRSA
Tetracycline
Nafcillin, Ampicillin ·

Aminoglycoside ·
URSA (D
-ala)
·

Chloramphenicol D-Lac

③
Ceftriaxone, Cefoperazone
VRSA:
Tigecycline, Doxycycline Linezolid VRSA Pneumonia
DOC

Daptomycin DOC
IRSA

Clindamycin Quinpristine-Dalfopristine
Ceftarolin
PMT

Rifampicin
DOC: Cestodes, Trematodes- praziquantel
• LIVER FLUKE- Trichaberdage
• HYDATID, Nematodes Albendazole
• FILARIA- DEC

• ONCHOCERCA, STRONGYLOIDES- Ivermectin

• Cryptosporidium- Nita
zow

n enter atte
Me ment
Antifungals
*

Thitin &
cardiasis
~

onychomycosis Invasive
I mail lacquess) ~

poses
B
RA 1
-
-

Ampho
-

CA =
1)
2 -
Acetazolamide
4 - UFH

• Systemic severe infection, Mucor, Kalaazar DOC: Amphotericin B

• Infusion reaction, Nephrotoxicity, RTA type 1, hypokalemia, BM supression: Amphotericin
=
B

• Cryptococcal DOC: smp B Ihrytesine (A 1)

: maintain
• Candida DOC, Max oral / CNS BA: -
fluconazole
I man oral) nemal BA)

• Aspergillus DOC, Transient visual changes: Voriconazole

• Histoplasmosis, Sporothrix, Blastomyces DOC: Itraconazole
• Azole useful in mucor: Posal Isave
• Azole with antipruritc/ anti-inflammatory action Setzaconazole
ATT

-Siderblasti
-
Sz
B6
A

neurons
attaglis
⑦
mp ART (
ATT 2 whe then

~
ARTT ATT (1st

-
Bat G -
acchilation
SHIP
->
->

SECT i
e

like symplois)
(fle
I
SX
N
-
slow lator
aceliy
-

neuropathy Pulmonary
H
-
fast -

hepatotoxic

SE hypericemia
:

L hepatotonicity
⑦ Intracellular
FA
synthase
static

as
Static
-thums A
 ⑨

BAL1
=

I bas made
Khas

[cilastation -
ImipenemI

- rest needed

-
↳
Si El

Nerirafine S2 Ez

Sy Es
-

Entricitabine

(dadaji)

o
⑧

non
competitive

effervescent vivid dreams

myopting

↑A 2

0
0

-
I'm Rien
 Sente
congestive Glaucoma
ACG
'cidazolamide
I

mountain sidees A so used in

Do
acting HOW/ HE
:

long
+

e ->
-
>

(ROC)
-

d RE except 'Metalazone'
Thiazide-not safe in :

-> entra /E : Da

Mannitof
use :
ACG/edema
C11 annsial CHE
↑ et
:

h
B
RA 1 -

Ampho
A 1s=

divities ~ Acetazolamide
Loop
2
-

4 - UFH

short/ ceiling
uses : slieve edema

Gynaecomastia
·
Aldosterone
mastion
·

↓
⑫ antagonists agree Athalos
↑

loses Cat ↓ Ca2

Loop
:

↳ no
-

- -
~
Thiazide/Furosemide)
Aliskiren kills renin.
I awa-
GINA 2021: DOC-
Formoterol + ICS
MR 5'

I SA
>a

JLA
ab just acting e

wonder need
~
2
more in COPD

metabolised by Cyp

↑Na
Aminophylline: CYP
↓
PDE-4 inhibition Bronchodilation
-

adenosine

↓
L
GFR
PDE-3 inhibition arrythmia
Adenosine antagonism dirresis
Histone deacetylase activation inflammation epigenetion
(deactivates)
 'Dinner for 2

H-2 Blockers:Cimetidine, famotidine, nizatidine

> >

Cimetidine: CYPO gynaecomastia

/

->
PGES : Misoprostor
d
NSAID induced peptinker
specific for

d
~
immediate

Antacids: -
stica
e
ueroprotective
PPI: Omeprazole, lansoprazole, pantoprazole-DOC
Al OH + Mg OH
:con Hit and run
L
constipati ③

milk-alkali - C.difficile, AIN, B12 deficiency, Fracture risk

SE #CC
Triple drug therapy:
CaCO3 Sx

I
Omeprazole: CYP2C19-Clopidogrel
Interstitial nephritis
CAP: Clarithromycin + Amoxicillin + PPI

Allergic
 CONSTIPATION DIARRHEA
Bulk forming: Methylcellulose u Agonist: Loperamide
'race
. K(co Stop'
Osmotic: Lactulose, PEG Enkephalinase inhibitor: Racecodotril
-
-

- opoid
-

Stimulant: Senna, Bisacodyl Melanosis col

Cl channel activator: Lubiprostone CLUB'

·

Guanylate cyclase Agonist: cGMP-Linaclotide, Plecanatide

Li Please Gana
I Procinetic)
·

5HT-4 agonist: Prucalopride

sa
S(e) unao"
-
-

D2 blockers: -> SHE-EPS/I

PRL
⑨

NHE3 inhibitor: Tenapanor Metoclopramide: BBBV Benzhenat DOC:

L
(Prokinetic
5HT agonist
Peripheral opioid inhibitor: For post-op ileus ↑
Domperidone: BBB X

I dopa
induced vointing
Alvimopan, Naloxegol, Methylnaltrexone DOC :

Anti-obesity Approved drugs:

Morning sickness: Donylamine/B6 Irefractory) Phentermine + topiramate
cases
only
Sea sickness: Medizine ⑤ Bupropion + zonisamide
Motion sickness: Myosine ) Pro methazine Liraglutide
Semaglutide
Mountain sickness: A
idazolamide Tirzepatide
Orlistat, Cetilistat ⑦ lipase pancreas-
->
⑦ likid met .
 &
Agonist: BETHANECHOL
flaccid UB

Antagonist: Solifenacin, Oxybutynin, Flavoxate, Tolterodine, Darfenacine

SOFT D' I
urge incontinence
Overactive bladder
I

mera bladder
gone
MIRABEGRON t

Finisherde
-

also
I stops prostaric growth)
M Static component
TAMSULOSIN ⑧ BPH

IXLAE 7 - (no
hypotension)
only dynamic BPH symploins)
I only for
[21B -

acts on

blood

vessels]
 Anticholinergies Cholinergic dings

Atropine, Donepezil, s
~patch
Homatropine,
->
mydriasis f Rivastigmine,
Tropicamide cycloplegia Galantamine
A chEG
Benztropine, EPS SIE (WOC)
Neostigmine
-

snake bit
Trihexyphenidyl ↓
-

-> several of NMA

sections
Glycopyrrolate poat intin op post
op items
-

->

Hyoscyamine, Pyridostigmine
->
motion sickness Honger acting) Myasthenia gravis
Dicyclomine initable Bowel Sy

Physostigmine
Ipratropium, -> COPD) Asthine Crosses
used in Dhalia poison
BBB)
Tiotropium Varenicline
antismoting
 Agonists
↓ est
Astra SE : -

Temoss
hypoglycemial
-

↑
1x
Ritodrine, Isosuxprine glycemia
·

-
Tocolytic (BC)
-
-

Tachycardia
shock
-
2-18 718
A shock +
olignin 21-VC

Huntinglein
Es
<2
↓
BI
<2
Jug1kg/um
~
Sympatholytics

-
-
ADHD

Fowler gray
HTN
I
HIN ER

Pregnancy
-

e
Dundee (PIN)
- ~ relarant

evahtest
show
sanely electiophysiological
-
muscle

used
&
I
V

for poalical hypotension masal

S
Doc

decongestant

Shock
Septic
=sympathomimetic

NC

anaesthesia
Nor for spinal
induced B ?
 L
Glaucoma
inseveisible :

Pheochromocytoma

reversible wine

·
abo
~
cheese ratn
-

Iysamine
(Md00)
-
donidine with drawal

al
↳
HAN

157 doss/Postin
bite (SE :

Scorpion mypotension)
I1A8 : no HTN)

CI:
Bradycardia

Jamie semua se e
AV block
Acute CHF
Asthma
mediated by sympathetic gic
choliner
depression PVD
DM mash hypoglycemia enept -
surcation

Prinzmetal angina vasospasm

- ye

DOC for toxicity: Glucagon

 >

DOC :
open
angle glamour vasodilator
↳ keep DA patent Dinnes for 2

Cervi
prime
(102) ↓ Woral
↳ ger
medical abortion ? PH
agonist
S
-
PPH I
PAH
250
jug
x 8 closes constipation
(CUB)
2 mg)

I
I man :
 nitrate
PDE-5 inhibitors -
PAH
x I

Sildenafil , vardenafil , tadalafil -> erectile dysfunction /

vasodilation
tPDEGO
B burn/cycopia

PDE-4 inhibitor
~ milestone
COPD

Roflumilast
L

PDE-3 inhibitor ↑ irvolioply/UD

Milrinone used in CHE

“Platelet inhibitors”
Cilostazol PDEO
now specific
Dipyridamole I
Sticke Peripheral
aterial de.
Anti-Glaucoma Drugs
Decrease Aqueous Increase Trabecular Increase Uveoscleral
Production Outflow Outflow

Ocular Beta Blockers

Cholinomimetic Drugs PGF2∝ Analogues
1. Timolol
SE ↓ corneal Pilocarpine 1. Lantanoprost
2. Betaxolol
=

sensation 2. Bimatoprost
3. Levobunolol
4. Carteolol

Nonselective Alpha Agonist Rho kinase inhibitor

Dipivefrine I black conjunctival Netrasudil
vorien herato
Alpha-2 Agonist palling
1. Apraclonidine I
2. Brimonidine all
dings except
MTX

Carbonic Anhydrase Inhibitors &

1. Acetazolamide
2. Brinzolamide ·
Yeh Past 1 wa

3. Dorzolamide end hai , pichire

abhi baki hai
'
dost
mere ip
 cough v no
cough
-

CCB Hydralazine Nitroprusside Digoxin ACE-: angioedema ARB: edema -

no

asteriolar dilator Nitrates Captopril, Losartan,

contraction
Amlodipine, clevidipine, Diltiazem, L
↑
Lisinopril, Valsartan
↓
aftiload venodilators I is ionoliophy)
nicardipine, nifedipine, verapamil
-
↳ used in CHF

preload) Enalapril
blood ↓ CHE
I pool used
-
:. in

O prevent vasospasm
nimodipine post
is
SAH SE-reflex tachy vessel & AV modal
t

conduction
intervention now-DAP - Headache (cranial
vasodilat") SE-reflex tachy I leads to
-
DH P Headache
eacts ~
D arythmia
-

↓ HR
drug (Acetylation)
on -> ↓BP
SHIP verticular
& act on vascular smooth muscle
SE me :

bigenm GFR
d
cyanide toxicly ↓
-

L
induced lupus Niteoprside
-

vasodilators SE :
reflen tachycardia
-

Ding d
AFib/fltlic/MAT
·

-
R : -
R
↑kt
D -

predominantly
.

Angina (B) cholinergic DOC

:

DM+ Hi
SE :
symploins
-
Muster headache Nitroli-meth
SIE
Ab -

xanthopisi (yellow vision)

DM nephropaling
edema
Alt
generalised L
d
-

↳
-causes & it
blue
flushing meltingline Cyanopsia
SE-bradykinin
vasodilti
hyperkalemia)
-

I I
(block) + PDEGG
Monday PDE50 alf It
prevent efflue ACEi)
digonin) Sildenafil)
x
SE AV # Clike

cony
- in

(blies)
:

Disease I
use : HAN
I
-

d
constipation
&

vasospasm headache
-

↓
L

vecapami cougl Angioedema

argina I
print metal schew derma

PDES & -

es in pregnancy
I venal agenesis)
Stenosis
preventsNatefflux di-x in B venal
Stenosis
-

~ ~ U11
abo ca effle
in
F but, cautions
ge K
W PCM I
↓ Fluid overload
Day e
prevent
Sx
Tur
lysis : -

+3
I Ca

↑ kt tonicity :
RIF for Digonin -

Phenytoin Quinidine b
2

↳re
Mg+
My+2
-

POy3-
cyclospore I

IPCX verapanil
unique SE
Uric Acid

v
Verapamil q Ca
- +2

Gingival hyperplasia V Amiodarone

verapanil Thiazide
Hyperprolactinemia
WAT
Queen (Sin)
Ki
-

Steride Macrolides
-

⑰ziltial
 NEW DRUGS: ~ funny SE
Visual SE
Ivabradine: If Naft
~
bradycardia
t
-

Misiko-trh Rho-ge
- >

Nicorandil: K opennes dis

doge
·

- in
Fas jaoge" ans

Rho kinase inhibitor: Fasedil Time) .

↑ Bradijkian
-

CHE
-
1St m

Neprilysin inhibitor: Sacubitit SE-4Kt ,

+
4
-> 1

Se
Metabolic modulators: Trimetazidine EE :
-

in
(cautions)
also
MM + Late inward Na blocker: Ranolagine constipation
->
:

verapamil
spironolactone Gynac v
:

X
Eplerenone
-,
·

PPAR8 + -

Glitazone
PPAR8 - -> Telmisartan
M

statin induced

L
wills

intestine

[HC-2A)
③

⑰.
⑯
⑱
)
④
 I

1a : Queen Proclaims Diso

Pyramid
Antiarrhythmic drugs
indurd)
9I
Ic : Pass
fries
I einchoni
headache I Janice
I
sm
- Nat
↑

#
SHIP
Frien
&
-

additional -
-
-

IA: K-: Quinidine, Procainamine, Disopyramide *

#

E
k

ventriculas I
IB: K +: LLignocaine, Phenytoin only
.

⑨ Tt :

conyltmia
Doc For
Digosin anythimial before Digibind) 9 T44 1
IC: K no: Fleicanide, Propafenone

-
1 a 111
,
↳el
⑧I in MI ↓ -
*
2
WPW ↳ SHIP
II # pro anythines
B

III-Amiodarone, Ibulitide Dofetilide, Sotalol k+-

1
d
mech

IV
all
-
& CB dose reentrant circuit
~
SE
Adenosine ↑
Hefflun -> Al mode conduction ↓ - PSVT -

flushing doom'
line
-
short
acting feeling of 'impending
I
interval
& central & 10 see
given

Bronchospasin
-

Ein
Secs)
-

(10

SE Blue man 3x
Amiodarone: Red man Vancountain
Pls photosensitivity , Peripheral neuropathy
Grey baby Chloramphenicol
Check auto deposits
corneal ,
also +
ungocardial
derma
depression purple toe wasfain
PFT fibrosis
Put

LFT dysfunction
liver orange
wine Rifampicin
TFT hypo/hyperthyroid 140 % Iz) yellow -
brown Phenytoin
swin Do wis x
RA: Acute Gout
Indomethin NSAIDS Dos except-Airin
↳ PCM
Microtubule 8 :

Griseofulvin
-
-

Colchicine microtubule
UC
-
also in
- ⑨G
neutiophi chemotaxis -
mebendazole
Tanane'Far Stabilise
↳
refractory
diasshea d
MO society'
DOC in pregnancy:
↑

SE
sulfusalague
Hi I
Chronic gout DOC: Alopurinot↳ infections
- -
Vinca

Grise
Alkaloids
⑦
polymeris
'Better

BIOLOGICALS in RA supplement Jolinis ) - A

HLA B5*801 hypersensitivity in also mebendazole
-

41 :
.

I do 1st
NSAIDS/MTX Montown test / IGRA- Quantiferon Gold Kalaaga Colchicine

TNF-apha inhibitors: 40
-

-
- (Blood Test)
AVOID WITH: MP/ Ayathiopsine
6
-

TB

Adalimumab exposure TNEXO

before giving
Certolizumab
Etanercept ACE Inhibitors (lifts flare up -
be

Gol
Infliximab ↳ granuloma

Golimumab
IL-1R Antagonist: An ali a

Sariliummab
IL-6 inhibitor: Tocilizumab ,

B-cell depletor/CD20-: Rinzimab

Co-stimulation inhibitor/CTLA4-: A but acept
JAK inhibitors: Tofacitinib, Baricitinib BATA= 4 im
lysis
Sx
- ~
9
12-2R :
Basiliximab
↳
(C 250) gont
uricosuric agents
- 200 : O crelizumab Ms
5 CProgressive
& in primary
R
20:p)
~

cost
:
Rs
hai" (Mnemonic
·
Oh Riti ! In sleep

variant)
laggressive

↓44 SE
MIGRAINE CLUSTER HEADACHE
DOC: Triptans / 100 % On
First line: NSAIDS
Prophylaxis: Verapanil
DOC: 5HT1B/1D+ : Triptans
Prophylaxis: propanolos TENSION HEADACHE
Ditans) DOC: NSAIDS
5HT1F + : LASMIDITAN I Fac Lats .

Prophylaxis: TCA
CGRP-: RimeGIPANT
ERENUMAB, GALANEZUMAB
·
ne/un

-
Suttar
pio NDRI Antidepressant

(GAD)
 Phenomenon
Syndopa-onel off
1 Levo +
↓ dopamine availability
carbil dystlinesia -
↑

metabolised
Doc : Amantadine
reticularis
515-Livedo ↳
v
edema
peripheral
-

-> cential -

↓
withdrawn
:
hepatotonic

induced
Drug
Benztropine, Trihexphenidyl Canticholinergic
X

↑2 (Two)
MAOA- antidepresent Istradefylline: Adenosine [A2A] receptor
>
> )
- -

antagonist
->

DBS:brain Subthalamic > Globus

- neu protective
2-DOPA
1
Deep nucleus Pallidus
->
Pref aflei
- Stimulation)

young any impube

disorders

SIE-pathological gambling --
Atomoxetine
R

Rotigotine (patch)
 ~crebility cyp+

-
BAyPet V

en
R :
Typical absence
signze

L
*
ON
warning !
PCN N
Black BOX
exp activator NO GABi
e ->
- ↓ W
Antidepressant
Lamotrigine Celecoxib
E
woman' SE
yellow
psychiatric manifest
- sni eide sists
never
hemaphagocytic MI
esp
in 'children'
lymphonistocytosis

Barbi DURAtes
-
X-
i duration
↓

↑ freq -> prevent L-carnitions

-
2 MOA
Wat #

GABA
against

&
PCOD
a Gabapentin
SIE
Doe :
-
gender
Specific
- post herpetic Pregabalin
nemalgia
-diabetic nemopaltiy
Ex
- Restless Leg Lamotrigine

Iial
~ "phase 4 Clinical

visual S/E
-
ANTI-EPILEPTIC DRUGS

DOC GTCS/ Atonic/ Myoclonic/Atypical absence JME/ LGS erebellular #

Valproate
DOC focal seizure BE (SIE-SIS cell C1/SADH) count Ess ....

DOC focal seizure in elderly Lamotrigine

Gamma knife
DOC trigeminal neuralgia ~

Ca * #
CBE -

type ~> T-

DOC typical absence

-
sz Ethosunimide >

DOC infantile spasm

-
ACTH
-

DOC infantile spasm in TSC vigabatin Lorazepam

-

DOC neonatal sz Phenobarbitone wayepar

~ Temazepam
O

DOC febrile sz Diazepam (PIR)

DOC status epilepticus Locagepamaloha with dramat factory it

DOC
-

Et

BZD approved in LGS Rob again valproate) IDOC -

DOC in pregnancy Leviscetar Lamotrigene

-

2 SE , 2MOA

S/e stones / ACG: Stopiraweight (wt loss)

-

-
- -

=>

Topircurate)
S
⑤ op-vision I

Valproate antidote: L-carnitine

OPIOIDS
Close presynaptic Ca2+ channels, open postsynaptic K+ channels.
Inhibit release of ACh, norepinephrine, 5-HT, glutamate, substance P
(depresents)
Fullnashm
agonist: Morphine, Pethidine, Heroin, Meperidine, Methadone, ↓
d
~

Codeine, Fentanyl ↓ help Op abese in

O

ST4 withdrawal
↳ in
cough suppressants

E
- n e e

2P

Partial agonist: Buprenorphine -

↳

-mined
Mixed agonist/antagonist: Nalbuphine, Pentazocine, Butorphanol - -

1P

Antagonist: Natocone/Naltionene
↑
Atiacus-Landosine
↓BP ↓ GCS ↓ HR miosis
:

↓RR
TOXICITY C/F: m acceptor
L

AVOID IN: biliary colic pain I head injury seap for analgesia
↳ sphincter contraction
Mydriasis: Meperidineagons)
f
Oddi
of
only darg full
Isko in vanco Alia cisalia)
Mistamine
Pruritus:
, ,

No tolerance to: miosis/ constipation

Tramadol (dual mech)

Serotonin syndrome: ->
predisposes
to snotonin 3x

S
Wooden chest syndrome:
chest
Fentanyl Also Line zolid

mp sigidity &
 (MM Sclerosis)
.

ITCA analogue)
Insulin
ullia . 'S'host acting S/e:
Degludec: longest Weight gain
↑ Lipoatrophy
basal I peakless
K: ↓ hypokalemia
S I
iv others S/c

~intermediate

pH: 24
OHG
Agent Mechanism of action Side effects
Sulfonylureas Increases insulin secretion by inhibiting B- Hypoglycemia , Weight gain
Chlorpropamide cell K+ ATP channels Chlorpropamide: S1ADH
↓ ↓
Glipizide, Glyburide D1
R
BM
# shaddha
Meglitinides 'neutical PPI
*
D Later
abo >
Repaglinide, Nateglinide 5)
~
.

M I Dilip Sir
.

-
Biguanides Stimulates AMP kinase, decreasing insulin Lactic acidosis,? Weight loss, Vit B12 deficiency
(Doc)
Metformin resistance Max reduction in HbA1c C11 in CKD

Thiazolidinediones Activates transcription regulator PPAR-g, Weight gain, Heart failure, Hepatotoxic, Fractures
pees L *

Pioglitazone decreasing insulin resistance ·

Abacais Risk of bladder cancer - Bioglitazone
I
in PPI also

Rosiglitazone MI- Rosiglitazone

-

GLP-1 agonists Incretins - Increases glucose- dependent insulin Increase satiety, Weight loss (approved)
L
Exenatide, Liraglutide-SC insidin↑ secretion, decreases glucagon secretion, Pancreatitis – GLP1+ ~ ocal drugs
MT2
eating
~
on

Semaglutide-Oral delays gastric emptying Nasopharyngitis- DPP4-

DPP4 inhibitors : ORAL GLP2 + :
TeduglutideBowel Sx
DPP4 - : CI in renal failure except: zinaglitstie
Short
DOC : ·
hai
Sitagliptin, Saxagliptin, Linagliptin Lena

Amylin Analogue Decreases glucagon secretion, delays Increase satiety

Pramlintide : Approved for T2DM gastric emptying

α-glucoside inhibitors Reduces intestinal disaccharide absorption Diarrhea, Flatulence

Acarbose , Miglitol CI in IBD
SGLT2 Inhibitors Increases renal glucose excretion · in Urinary tract infections
glucose -
, Polyuria (osmotic diuresis)
L
flozeuss
Canagliflozin, Dapagliflozin &
wine Weight loss candiacis too !
*
Fournieis
↓ & CHE
mortality
Gangrene
Osteoporosis treatment
Inhibit Osteoclasts Stimulate Osteoblasts Dual Action

BISPHOSPHONATES: DOC
Adverse effect- flonger chain-cast)

1. Esophagitis PTH 1-34 (Shorter) SE : Romosozumab

Osteosarcoma
-

mandible
2. Oster of
necrosis Teriparatide Scherostin ⑦
44 tide
↑
-

3. Stypical NOF #I Abaloparatide

-
- -

Max: 2yrs I stop after 2 years)

Longest acting- Strontium
Zotendronate (IV , once
yearly)
SE : Renal failure O
anis

Lemprolide
I
Prostatic CA

A menorshoea Nagar RELIN↓

Delayed puberty ,
-of Antag
SERM
N
SIE DVT stimulate
Rabonifers against Agonist
: ↳
GnRH
+

cont
=

than
Cetso RELIY-Belles
.

rate
(V2G)
x =

Away . no
flare up
Denosumab Lig
and
Vaptans
or be med
cycline
1
RANK -

Octeotide
:
Somatostating
y D20 used
(Preg Bromocriptine)
Dopamine Cabergoline
e
:

↓
PRL
Methimazole / Carbien
ayole
Calcitonin: Intranasal PTN

↑ TU l'Pehle'T'eimesliv'se)
Cinacalcet-CasR agonist But Die :

(SE : -choanal
atresia
Methimazole
Used in HyperPTH I 3T2/Ts :
PTH release in T1
-entis
aplasial
⑰
PFH
 Man ACC
Pro
Summary thanks to Ravenclaw for this page !

--
 Rangesa sabrener
~

↳ Histamme
4PG
R Denazowame
~

Bedaquiline
-
~
Thiori dazone
setinal

pigment

D1SC40"

Cyclosporine
D2

(On)

Ethionamide ~
[Ee'thambutol is not hepatotonic]
R H Z HP Z E

-
Didanosine (Dadaji') -
GLP1+

L-asparaginase

Ab + PP1

30
cis'o'platin

↳ car retinitis

[cold (19M)
L

wai type ATMA (1gG) Mycoplasma

EBU]

(DRESS)

Megeneric Acid (Meftal)

Metformin
P4 I

4 (H17)
manga platelet
MRSA-URSA :"
-
 'Poy

Aspirin
↳ low dose

Cpremenopausal ansah
↳ Tamoxifen) ,7
glitazones
·

postment ER/PRt
↳
Thiazolidinediones
E
?? ↑ #
SGLT 20 -
# shaddha

Seizure

Wit A
Teliacycme
D
,

TOAD ou GH
-
Pethidine -
Alacurium
-
FQ
D) 2 #

ACGs
(v)
-

Efavirenz -
-

Degrisomant Bull's
eye
-

vigabatin machlopaltry
-

voriconazole

Earn will atteast Acceptance

No
by
:
-

Denial
:

Jas will hi
Hope :
say : No hi
Only sigh!
say bye
↑

friends -