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SAFETY DATA SHEET

Version 5.5
Revision Date 02/24/2014
Print Date 03/21/2014

1. PRODUCT AND COMPANY IDENTIFICATION

1.1 Product identifiers
Product name : Toluene
Product Number : 244511
Brand : Sigma-Aldrich
Index-No. : 601-021-00-3
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 108-88-3
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Telephone : +1 800-325-5832
Fax : +1 800-325-5052
1.4 Emergency telephone number
Emergency Phone # : (314) 776-6555

2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
Reproductive toxicity (Category 2), H361
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
Specific target organ toxicity - repeated exposure (Category 2), H373
Aspiration hazard (Category 1), H304
Acute aquatic toxicity (Category 2), H401
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 GHS Label elements, including precautionary statements
Pictogram

Signal word Danger

Hazard statement(s)
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H361 Suspected of damaging fertility or the unborn child.
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 H373 May cause damage to organs through prolonged or repeated exposure.
H401 Toxic to aquatic life.
Precautionary statement(s)
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and
understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P303 + P361 + P353 IF ON SKIN (or hair): Remove/ Take off immediately all contaminated
clothing. Rinse skin with water/ shower.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position
comfortable for breathing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P321 Specific treatment (see supplemental first aid instructions on this label).
P331 Do NOT induce vomiting.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for
extinction.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
Formula : C7H8
Molecular Weight : 92.14 g/mol
CAS-No. : 108-88-3
EC-No. : 203-625-9
Index-No. : 601-021-00-3

Component Classification Concentration

Toluene
Flam. Liq. 2; Skin Irrit. 2; Repr. 90 - 100 %
2; STOT SE 3; STOT RE 2;
Asp. Tox. 1; Aquatic Acute 2;
H225, H304, H315, H336,
H361, H373, H401
For the full text of the H-Statements mentioned in this Section, see Section 16.

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4. FIRST AID MEASURES
4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available

5. FIREFIGHTING MEASURES
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all
sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive
concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Use explosion-proof equipment.Keep away from sources of ignition - No smoking.Take measures to prevent the build
up of electrostatic charge.
For precautions see section 2.2.
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7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
resealed and kept upright to prevent leakage.
Handle and store under inert gas.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters
Components with workplace control parameters
Component CAS-No. Value Control Basis
parameters
Toluene 108-88-3 TWA 100 ppm USA. OSHA - TABLE Z-1 Limits for
375 mg/m3 Air Contaminants - 1910.1000
STEL 150 ppm USA. OSHA - TABLE Z-1 Limits for
560 mg/m3 Air Contaminants - 1910.1000
TWA 200 ppm USA. Occupational Exposure Limits
(OSHA) - Table Z2
Remarks Z37.12-1967
CEIL 300 ppm USA. Occupational Exposure Limits
(OSHA) - Table Z2
Z37.12-1967
Peak 500 ppm USA. Occupational Exposure Limits
(OSHA) - Table Z2
Z37.12-1967
TWA 20 ppm USA. ACGIH Threshold Limit Values
(TLV)
Visual impairment
Female reproductive
Pregnancy loss
2010 Adoption
Substances for which there is a Biological Exposure Index or Indices
(see BEI® section)
Not classifiable as a human carcinogen
TWA 100 ppm USA. NIOSH Recommended
375 mg/m3 Exposure Limits
ST 150 ppm USA. NIOSH Recommended
560 mg/m3 Exposure Limits
Biological occupational exposure limits
Component CAS-No. Parameters Value Biological Basis
specimen
Toluene 108-88-3 Toluene 0.02 mg/l In blood ACGIH - Biological
Exposure Indices
(BEI)
Remarks Prior to last shift of workweek
Toluene 0.03 mg/l Urine ACGIH - Biological
Exposure Indices
(BEI)
End of shift (As soon as possible after exposure ceases)
o-Cresol 0.3 mg/g Urine ACGIH - Biological
Exposure Indices
(BEI)
End of shift (As soon as possible after exposure ceases)

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8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Full contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Splash contact
Material: Fluorinated rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method:
EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the
supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an
industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It
should not be construed as offering an approval for any specific use scenario.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of
protective equipment must be selected according to the concentration and amount of the dangerous substance
at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-
purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourless
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: -93 °C (-135 °F)
point
f) Initial boiling point and 110 - 111 °C (230 - 232 °F)
boiling range
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 g) Flash point 4.0 °C (39.2 °F) - closed cup
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower Upper explosion limit: 7 %(V)
flammability or Lower explosion limit: 1.2 %(V)
explosive limits
k) Vapour pressure 29.1 hPa (21.8 mmHg) at 20.0 °C (68.0 °F)
l) Vapour density no data available
m) Relative density 0.865 g/mL at 25 °C (77 °F)
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition 535.0 °C (995.0 °F)
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
9.2 Other safety information
no data available

10. STABILITY AND REACTIVITY

10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Vapours may form explosive mixture with air.
10.4 Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - rat - > 5,580 mg/kg
LC50 Inhalation - rat - 4 h - 12,500 - 28,800 mg/m3
LD50 Dermal - rabbit - 12,196 mg/kg
no data available
Skin corrosion/irritation
Skin - rabbit
Result: Skin irritation - 24 h
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 Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
rat
Liver
DNA damage
Carcinogenicity
IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene)
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
Damage to fetus possible
Suspected human reproductive toxicant
Reproductive toxicity - rat - Inhalation
Paternal Effects: Spermatogenesis (including genetic material, sperm morphology,motility, and count).
Experiments have shown reproductive toxicity effects in male and female laboratory animals.
Developmental Toxicity - rat - Oral
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: XS5250000
Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the development of
inflammatory and ulcerous lesions of the penis, prepuce, and scrotum in animals.
Stomach - Irregularities - Based on Human Evidence
Stomach - Irregularities - Based on Human Evidence

12. ECOLOGICAL INFORMATION

12.1 Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 7.63 mg/l - 96 h
NOEC - Pimephales promelas (fathead minnow) - 5.44 mg/l - 7 d
Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 8.00 mg/l - 24 h
other aquatic
invertebrates
Immobilization EC50 - Daphnia magna (Water flea) - 6 mg/l - 48 h
Toxicity to algae EC50 - Chlorella vulgaris (Fresh water algae) - 245.00 mg/l - 24 h
EC50 - Pseudokirchneriella subcapitata (green algae) - 10.00 mg/l - 24 h
12.2 Persistence and degradability
Biodegradability Result: - Readily biodegradable.

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12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Toxic to aquatic life.

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a
licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION

DOT (US)
UN number: 1294 Class: 3 Packing group: II
Proper shipping name: Toluene
Reportable Quantity (RQ): 1000 lbs
Marine pollutant: No
Poison Inhalation Hazard: No

IMDG
UN number: 1294 Class: 3 Packing group: II EMS-No: F-E, S-D
Proper shipping name: TOLUENE
Marine pollutant: No

IATA
UN number: 1294 Class: 3 Packing group: II
Proper shipping name: Toluene

15. REGULATORY INFORMATION

REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
The following components are subject to reporting levels established by SARA Title III, Section 313:
CAS-No. Revision Date
Toluene 108-88-3 2007-07-01
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
CAS-No. Revision Date
Toluene 108-88-3 2007-07-01
Pennsylvania Right To Know Components
CAS-No. Revision Date
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 Toluene 108-88-3 2007-07-01
New Jersey Right To Know Components
CAS-No. Revision Date
Toluene 108-88-3 2007-07-01
California Prop. 65 Components
WARNING: This product contains a chemical known to the CAS-No. Revision Date
State of California to cause birth defects or other reproductive 108-88-3 2009-02-01
harm.
Toluene

16. OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3.
Aquatic Acute Acute aquatic toxicity
Asp. Tox. Aspiration hazard
Flam. Liq. Flammable liquids
H225 Highly flammable liquid and vapour.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H336 May cause drowsiness or dizziness.
H361 Suspected of damaging fertility or the unborn child.
H373 May cause damage to organs through prolonged or repeated exposure.
H401 Toxic to aquatic life.
Repr. Reproductive toxicity
Skin Irrit. Skin irritation
HMIS Rating
Health hazard: 2
Chronic Health Hazard: *
Flammability: 3
Physical Hazard 0
NFPA Rating
Health hazard: 2
Fire Hazard: 3
Reactivity Hazard: 0
Further information
Copyright 2014 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling
or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing
slip for additional terms and conditions of sale.

Preparation Information
Sigma-Aldrich Corporation
Product Safety – Americas Region
1-800-521-8956
Version: 5.5 Revision Date: 02/24/2014 Print Date: 03/21/2014

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