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    1 - Pharmaceutical Dosage Forms-Amneded

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    hefikurniasari
    This document discusses different drug dosage forms and their composition. It describes solid dosage forms like tablets, capsules, and powders. Tablets can be enteric coated, film coated, or sugar coated. Sustained release forms provide gradual drug release. Liquid forms include solutions, suspensions, emulsions, and elixirs. Semi-solid forms are ointments, creams, gels, and pastes. Different routes of administration are also covered like oral drops, nasal sprays, injections, and suppositories. The purpose of various formulations is to deliver drugs in a manner that is stable, convenient for patients, and optimizes drug absorption and effects.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd

    1 - Pharmaceutical Dosage Forms-Amneded

    Uploaded by

    hefikurniasari
    149 views53 pages
    This document discusses different drug dosage forms and their composition. It describes solid dosage forms like tablets, capsules, and powders. Tablets can be enteric coated, film coated, or sugar coated. Sustained release forms provide gradual drug release. Liquid forms include solutions, suspensions, emulsions, and elixirs. Semi-solid forms are ointments, creams, gels, and pastes. Different routes of administration are also covered like oral drops, nasal sprays, injections, and suppositories. The purpose of various formulations is to deliver drugs in a manner that is stable, convenient for patients, and optimizes drug absorption and effects.

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    1- Pharmaceutical Dosage Forms-Amneded

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    This document discusses different drug dosage forms and their composition. It describes solid dosage forms like tablets, capsules, and powders. Tablets can be enteric coated, film coated, or sugar coated. Sustained release forms provide gradual drug release. Liquid forms include solutions, suspensions, emulsions, and elixirs. Semi-solid forms are ointments, creams, gels, and pastes. Different routes of administration are also covered like oral drops, nasal sprays, injections, and suppositories. The purpose of various formulations is to deliver drugs in a manner that is stable, convenient for patients, and optimizes drug absorption and effects.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    149 views53 pages

    1 - Pharmaceutical Dosage Forms-Amneded

    Uploaded by

    hefikurniasari
    This document discusses different drug dosage forms and their composition. It describes solid dosage forms like tablets, capsules, and powders. Tablets can be enteric coated, film coated, or sugar coated. Sustained release forms provide gradual drug release. Liquid forms include solutions, suspensions, emulsions, and elixirs. Semi-solid forms are ointments, creams, gels, and pastes. Different routes of administration are also covered like oral drops, nasal sprays, injections, and suppositories. The purpose of various formulations is to deliver drugs in a manner that is stable, convenient for patients, and optimizes drug absorption and effects.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 53

    Drug formulation

    Dosage forms or pharmaceutical preparation

    Drug formulation

    Why to use different formulation Types of dosage forms Composition of each dosage form

    Why to use different formulation?


    The physical nature of the drug Drug size Drug solubility Drug taste Drug absorption, first pass effect Drug side effects Drug half life Site of disease or infection Patient compliance

    Drug forms

    Solid dosage forms

    Liquid dosage forms

    Semi-solid dosage forms

    Others Nasal Inhalational

    Solid dosage forms

    Tablets

    Capsules Lozenges

    Powders

    I-Solid dosage forms

    Capsules, sustained-release capsules, tablets, pills, are used to divide a drug or mixture of drugs into definite doses and avoid the inconvenience of preparing the dose from dry powders. Tablets are a convenient way of giving drugs that have an unpleasant taste

    Capsules
    the most popular dosage forms for the oral administration of powders, oils, and liquid They dissolve readily in the stomach and make the contents available for absorption only slightly less quickly than a liquid medicament Are usually made of gelatin and may be hard or soft - Hard gelatin capsule : contains powder - Soft gelatin capsule : contains Liquids Gelatin capsules may be coated with a substance that resists the action of gastric juice and so will not disintegrate until they reach the alkaline secretions of the intestine. Such capsules are said to be enteric coated

    Tablets

    Tablets are preparations of powdered drug that are compressed or molded into small disks. They may be made with or without a diluent (dextrose, lactose, starch), And they may differ greatly in size, weight, and shape. Compressed tablets are made with heavy machinery.

    Tablets

    Compressed tablets usually contain in addition to the drug a Diluents, are used when the amount of active ingredient is small A binder are substances that give adhesiveness to the powdered drug. A disintegrator , such a starch, helps the tablet to dissolve readily when it is placed in water, because the starch expands when it gets wet and a lubricant keep the tablet from sticking to the machines

    Tablets

    Tablets are sometimes scored (marked with an indented line across the surface) so-that they can be broken easily if half a tablet is the dose required. Tablets may be coated with sugar or chocolate to enhance their palatability. They may be covered with a colored coating to make them more attractive to patients, easier to swallow, or identifiable by the use of distinctive colors. Both tablets and capsules may be enteric coated,

    to protect the drug from the effect of the gastric secretions to prevent drug irritation of the gastric mucosa

    Tablets

    Normal tablets Effervescent Chewable Delayed release Film coated Sugar coated

    Sustained-release dosage forms

    Dosage forms providing for gradual but continued release of drug . Sustained-release dosage forms contain small particles of the drug coated with materials that require a varying amount of time to dissolve.. This provides for a long continuous period of absorption and effect. Some particles dissolve and-are absorbed almost immediately, others require 2 or 3 hours

    Lozenges

    Troches or lozenges are flat, round, or rectangular preparations that are held in the mouth until they dissolve, liberating the drug or drugs involved. They usually contain water, sugar, and a mucilage in addition to the drug and are dried in hot air. They temporarily produce a high concentration of the drug in the oral cavity. They are held in the mouth until entirely dissolved.

    Pills

    Pills are mixtures of a drug or drugs with some cohesive materials. The mass is molded into globular, oval, or flattened bodies convenient for swallowing. They have been replaced to a great extent by capsules and tablets.

    Powders

    Powders are finely divided solid drugs or mixtures of drugs for internal or external use. Dusting powders Granules Cachets

    Chewable Tablets

    Effervescent Tablets

    Lozenges

    Capsules

    Pills

    II-Liquid dosage forms

    Solutions ((

    Aqueous solutions have one or more substances dissolved in water. Examples are strong iodine solution (Lugol's Solution), epinephrine nasal solution Syrups

    For their demulcent(soothing) effect on irritated membranes of the throat e.g Promethazina hydrochloride syrup

    Suspensions ( )

    are defined as preparations of finely divided drugs either intended for suspension or already in suspension in some suitable liquid vehicle

    Liquid dosage forms

    Emulsions ( (

    are suspensions of fats or oils in water with the aid of an, emulsifying agent, which lowers the interfacial tension between the two susbtances, masking its oily feel. These oils are more easily digested than undispersed oils. Emulsions are stabilized by agents such as acacia and gelatin, which coat the tiny droplets of oil and prevent them from coming in direct contact with water. An example is cod liver oil emulsion

    Liquid dosage forms

    Elixirs ( (

    are aromatic, sweetened, alcoholic preparations, frequently used as flavored vehicles, such as aromatic elixir, or as active medicinal agents if they are medicated elixirs, such as phenobarbital elixir.

    Liquid dosage forms


    Liquid forms are composed of Solvents Sweeting agents Flavoring and coloring agent Stabilizers Preservatives and antioxidant

    Liquid dosage forms


    -Drops eye (ophthalmic ) ear (otic) nose (Nasal) oral (commonly for infants) - Paints )( Lotions )( -Tinctures )( -Sprays - nasal oral - local

    Liquid dosage forms

    -Ampoules and the like

    1-Ampoules ( Single Dose). 2- vials ( multi -dose containers with rubber capped stopper ). 3- Bottles. 4- Disposable syringes.

    Solution

    Suspension

    Ampoule

    Vials

    Drops

    III-Semi-solid dosage forms

    1- Ointments and the like - Ointments )( - Creams )( - Gels )( - Pasts )( 2- Transdermal therapeutic system 3- Suppositories and the like - Rectal supp. - Vaginal inserts ( tablets ovules supp. pessary )

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