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Immunizations

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IMMUNIZATIONS

DURING
PREGNANCY
 Immediate goal of
immunization is prevention of
disease in the individual and
eradication of the disease
itself
2 Types of Immunization
 Active immunization
Involves administration of
all or part of a microorganism
to elicit an immunologic
response
 Passive immunization

Administration of
preformed antibody to a
Live Attenuated Virus
Vaccine
 Meales
•Indication during pregnancy
-contraindicated
•Dosing schedule
- Single dose (MMR)
 Mumps
•Indication during pregnancy
- contraindicated
•Dosing schedule
- Single dose (MMR)
 Rubella
•Indication during pregnancy
- contraindicated
•Dosing schedule
- Single dose (MMR)
 Varicella
•Indication during pregnancy
- contraindicated, but no
adverse outcome reported
in pregnancy
•Dosing schedule
- 2 doses needed with 2nd
dose given 4-8 wk after 1st
dose
Inactivated Virus Vaccine
 Influenza
•Indication during pregnancy
- All women, regardless of
trimester, who will be
pregnant during the
influenza season
•Dosing schedule
- 1 dose IM every year
 Rabies
•Indication during pregnancy
- Indications for prophylaxis
not altered by pregnancy
•Dosing schedule
- To be consulted for
indications, dosage and
route of administration
 HepatitiB
•Indication during pregnancy
- Preexposure &
postexposure for women
at risk of infection
•Dosing schedule
- 3 doses series IM at 0, 1,
& 6 month
 HepatitisA
•Indication during pregnancy
- Preexposure &
postexposure if at risk
(international travel)
•Dosing schedule
- 2 doses schedule 6
months apart
Inactivated Bacterial
Vaccines
 Pneumococcus
•Indication during pregnancy
- Indications not altered by
pregnancy
•Dosing schedule
- 1 dose only; consider
repeat dose in 6 yrs for
high-risk women
 Meningococcus
•Indication during pregnancy
- Indications not altered by
pregnancy
•Dosing schedule
- 1 dose
 Typhoid
•Indication during pregnancy
- Not recommended
routinely
•Dosing schedule
- Primary: 2 injections > 4
wks apart
- Booster: 1 dose, schedule
not yet determined
Toxoids
 Tetanus-diphtheria
•Indication during pregnancy
-lack of primary series or
no booster within past 10
year
•Dosing schedule
- Primary: 2 doses at 1-2
mo interval w/ 3rd dose 6-
12 mo after the 2nd
- Booster: Single dose IM
every 10 year after
Specific Immune Globulins
 HepatitisB
•Indication during pregnancy
- Postexposure prophylaxis
•Dosing schedule
- Give along w/ hepatitis
vaccine, then vaccine
alone at 1 & 6 months
 Rabies
•Indication during pregnancy
- Postexposure prophylaxis
•Dosing schedule
- Half dose at injury site,
half dose in deltoid
 Tetanus

•Indication during pregnancy


- Postexposure prophylaxis
•Dosing schedule
- 1 dose IM
 Varicella
•Indication during pregnancy
- Considered for exposed
pregnant women to
protect against maternal
not congenital infection
•Dosing schedule
- 1 dose IM w/in 9 hrs of
exposure
Standard Immune Globulins
 Hepatitis
A
•Indication during pregnancy
- Postexposure prophylaxis
•Dosing schedule
- 0.02 ml/kg IM for 1 dose
of immune globulin
 Measles
•Indication during pregnancy
- Postexposure prophylaxis
•Dosing schedule
- .25 ml/kg for 1 dose

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