All rights reserved ISBN 978-92-9223-421-8 (Electronic version) The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning... more
All rights reserved ISBN 978-92-9223-421-8 (Electronic version) The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The authors are responsible for the choice and the presentation of the facts contained in this book and for the opinions expressed therein, which are not necessarily those of UNESCO and do not commit the Organization. UNESCO Bangkok is committed to widely disseminating information and to this end welcomes enquiries for reprints, adaptations, republishing or translating this or other publications. Please contact ikm.bgk@ unesco.org for further information. Edited by Darryl R.J. Macer Design/Layout by Alessandra Blasi (cover), Darryl Macer and Sirisak Chaiyasook (content) Cover photo by © UNESCO/S. Chaiyasook P...
Muslim jurisprudents and muftis issue fatwas on abortion based on Ijtihad. Three fundamental principles of Ijtihad indicate that jurisprudence has to consider the changes of the time and place, the public interest, and the least harm in... more
Muslim jurisprudents and muftis issue fatwas on abortion based on Ijtihad. Three fundamental principles of Ijtihad indicate that jurisprudence has to consider the changes of the time and place, the public interest, and the least harm in issuing fatwas. However, many ignore these principles since they stick to the traditional concept of health which is their basis to issue fatwas. In this paper, we analyze how Islamic jurisprudence, through using these principles in perception of the concept of health, can help to solve the illegal abortion crisis in Muslim countries.
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ISBN 978-92-9223-378-5 (Print Version) ISBN 978-92-9223-377-8 (Electronic version) The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of... more
ISBN 978-92-9223-378-5 (Print Version) ISBN 978-92-9223-377-8 (Electronic version) The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. The authors are responsible for the choice and the presentation of the facts contained in this book and for the opinions expressed therein, which are not necessarily those of UNESCO and do not commit the Organization. Edited by Darryl R. J. Macer Design/Layout by Alessandra Blasi (cover) and Sirasak Chaiyasook Cover photo by © UNESCO/S. Chaiyasook Printed in Thailand
The purpose of this meeting is to engage in an interactive dialogue over the priorities for bioethics and ethics of science and technology in Asia and the Pacific, with global implications. How can we apply bioethics declarations and... more
The purpose of this meeting is to engage in an interactive dialogue over the priorities for bioethics and ethics of science and technology in Asia and the Pacific, with global implications. How can we apply bioethics declarations and international agreements to enhance the realities of communities across a divided and diverse world? As we develop networks of researchers and policymakers we are bringing together persons from over 30 countries and a wide range of specialties for this roundtable as a further step in the reflection and action on ethics of science and technology.
Quality of life and palliative care needs of patients with Niigata Minamata disease: A complete survey after
Naming and being named, listening and being listened to: Opening one’s heart to others- Thoughts
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This conference was held in the context of Working Group 2: Ethical Worldviews of Nature, in the Ethics of Energy Technologies in Asia and the Pacific (EETAP) project. It was held at the time of the 22 World Congress of Philosophy, in... more
This conference was held in the context of Working Group 2: Ethical Worldviews of Nature, in the Ethics of Energy Technologies in Asia and the Pacific (EETAP) project. It was held at the time of the 22 World Congress of Philosophy, in Seoul, to take advantage of the large number of philosophers present, and to gather wider diversity of views and feedback on the range of worldviews there are of nature.
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The Convention on Biological Diversity emerged out of a universal consensus that biodiversity is of immense value to humankind. Although the report adopted the definition of the Convention on Biological Diversity, it reviews the concept... more
The Convention on Biological Diversity emerged out of a universal consensus that biodiversity is of immense value to humankind. Although the report adopted the definition of the Convention on Biological Diversity, it reviews the concept of biodiversity as applied to genes, microbes, ecosystems and the planet as a whole. There are a number of accepted scientific measurements to allow recording of biodiversity, although all show that it is being reduced at rates that are unprecedented, due to anthropogenic activity. A variety of ethical approaches to human relationships to biodiversity are described in the report, but despite the range of ideas that they include, most would argue that human beings should modify their behaviour to slow the rate of biodiversity loss. Even an anthropocentric argument would also show the high value of biodiversity for current and future human generations, as exceeding the short-term gains that are the cause of most biodiversity loss. There is an extensive...
Research Interests: Ethics and Biodiversity
A brief review of some of the key issues in policy relating to the ethical issues raised by medical biotechnology in developing countries is presented, using India as an example. A series of some key issues is discussed, including... more
A brief review of some of the key issues in policy relating to the ethical issues raised by medical biotechnology in developing countries is presented, using India as an example. A series of some key issues is discussed, including information obtained from interviewing Indian government policy makers. Some of the issues discussed include: Economic and social incentives to encourage biotechnology; Health policy and ethics review; Patents on drugs; Medical genetics; Relationship to traditional medical practices; Positive public attitudes to biotechnology; Limited public participation; Infrastructural hurdles; Indian progress in stem cell research; and dilemmas of expensive technologies. The results show that although the needs of developing countries are different to those of rich countries, government policy utilizing guidelines and ethics committees has evolved as mechanisms to aid ethical health care delivery in India. In all countries there may be some of these concerns that are r...
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Note: The designations employed and the presentation of material throughout the publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or... more
Note: The designations employed and the presentation of material throughout the publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or of its authorities, or concerning its frontiers or boundaries. ... 1This is draft 8 of the report of the Ethics and Climate Change in Asia and the Pacific (ECCAP) Project WG7; Please refer to: http://www.unescobkk.org/rushsap/energyethics / ... Energy Equity and Environmental Security (ECCAP WG7 report draft 8)
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Georgetown University Home. Is Human Reproductive Cloning Inevitable: Future Options for UN Governance. DSpace/Manakin Repository. ...
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Rapid advances in medical technology may in the near future make " natural " aging and old age diseases the main causes of human death in affluent societies (apart from accidents). When dealing with end of life issues, medical sociology... more
Rapid advances in medical technology may in the near future make " natural " aging and old age diseases the main causes of human death in affluent societies (apart from accidents). When dealing with end of life issues, medical sociology will need to focus more on life and death in seniors. Understanding the attitudes of older persons toward life and death is important for both performing end-of-life medical care and in developing end-of-life policies. Descriptive bioethical analysis of attitudes in different cultures can aid a fuller understanding of the views inside each culture and the trajectories of conflict situations within each culture. In-depth interviews were conducted with 112 senior citizens in Taiwan and with 25 senior citizens in New Zealand. All interviews were transcribed verbatim; qualitative data analysis was used to examine people's views on life and death. Their images of life and end of life attitudes were compared. Analysis of the key concepts they mentioned revealed distinctive views in life attitudes between these two groups. However, in spite of differences in culture and traditions, most life and end-of-life attitudes among elderly people in the two groups were rather similar. According to these similarities, an interpretation of these values was made within a Confucian and Taoist framework that might be applicable to non-Eastern cultures as well.
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Public engagement in science and technology has grown in importance as developments in science and technology make increasingly significant impacts on people's lives. Now, efforts to engage publics in social decision-making or... more
Public engagement in science and technology has grown in importance as developments in science and technology make increasingly significant impacts on people's lives. Now, efforts to engage publics in social decision-making or consensus-building regarding science and technology involve participation, learning or deliberation opportunities, as well as interactive or coproductive efforts among various sectors in society based on the recognition of scientific activities as a part of social operations-even those performed by scientific communities. We have conducted a community engagement program in the HapMap project, the international human genome program, in Japan since 2002. Consequent upon our various approaches to engage Japanese publics, a range of observations were made, such as that: public engagement is not yet recognized or institutionalized in Japan; there is a wide gap between science and society; and the implications of public engagement in a Japanese context have not been examined enthusiastically, especially from the perspectives of political decision making, social consensus-building or self-determination. In this paper, we provide an overview of public engagement in Japan, and discuss issues and challenges raised by the HapMap community engagement project. We also discuss the implications of public engagement for social decision-making and self-determination, and explore the prospects for public engagement in science and technology in Japan.
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Koch G.L.E., Macer DRJ. & Wooding F.B.P. (1989) "The major 55kDa calcium-binding Stains-all positive protein in mammalian cells is in the reticuloplasm of the endoplasmic reticulum", pp. 159-167 in Biochemical Approaches to Cellular... more
Koch G.L.E., Macer DRJ. & Wooding F.B.P. (1989) "The major 55kDa calcium-binding Stains-all positive protein in mammalian cells is in the reticuloplasm of the endoplasmic reticulum", pp. 159-167 in Biochemical Approaches to Cellular Calcium (Methodological Surveys in Biochemistry and Analysis), eds., R.E. Reid, G.M.W. Cook & J.P. Luzio, Vol. 19 (London: Royal Society Chemistry 1989).
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A procedure was developed for the isolation of reticuloplasm, the luminal material of the endo-plasmic reticulum (ER). A reticuloplasm-rich extract was prepared from a murine plasmacytoma cell line that contains large amounts of ER, by... more
A procedure was developed for the isolation of reticuloplasm, the luminal material of the endo-plasmic reticulum (ER). A reticuloplasm-rich extract was prepared from a murine plasmacytoma cell line that contains large amounts of ER, by first extracting the cytoplasmic contents using hypotonic lysis to yield ER-rich 'shells' followed by mechanical lysis to release the ER contents. The extract contains five major proteins with apparent molecular weights of 100, 75, 60, 58 and 55 (xlO 3)M r by SDS— polyacrylamide gel electrophoresis. The 100, 75 and 58 (Xl0 3)M r species were identified as the known ER proteins endoplasmin, BiP and PD1, respectively. The ER association of the 60 and 55 (X10 3) M r proteins was confirmed by conf ocal fluor-escence microscopy with affinity-purified anti-bodies. Equilibrium dialysis with isolated reticuloplasm gave a calcium-binding capacity of 300 nmoles calcium per mg protein with half-maximal binding at 3 mM-Ca 2+. Purified endoplasmin bound 280 nmoles calcium per mg protein at a calcium concentration of 5mM-Ca 2+. A calcium overlay test revealed that, in addition to endoplasmin, reticuloplasm contained at least three other calcium-binding proteins: i.e. BiP, PDI and the 55xlO 3 M r protein, respectively, with endoplasmin and the 5 5 x 1 0 ^ , protein (CRP55) accounting for the major proportion of the calcium-binding activity. Treatment of cells with calcium ionophore led to the specific over-expression of the major calcium-binding reticuloplasmins endoplasmin, BiP and CRP55. These studies show that the lumen of the ER contains a family of proteins with the capacity to bind significant amounts of calcium in the millimo-lar range and thereby to confer upon the ER the ability to perform a calcium storage function analogous to that of the sarcoplasmic reticulum in muscle cells.
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The location of endoplasmin in the endoplasmic reticulum was investigated by biochemical and immunoelectron microscopic analyses. The protein could be obtained in a soluble form by procedures that do not involve the use of any detergents.... more
The location of endoplasmin in the endoplasmic reticulum was investigated by biochemical and immunoelectron microscopic analyses. The protein could be obtained in a soluble form by procedures that do not involve the use of any detergents. The soluble protein has the amino-and carboxy-terminal sequences of the intact molecule, showing that it has not been proteo-lysed. Application of the Triton X-114 phase-separation test does not reveal significant hydrophobicity in the molecule. Immunogold labelling studies on cells with a dilated endoplas-mic reticulum (ER) lumen show that endoplas-min is uniformly distributed throughout the lumen, with no evidence of a preferential association with the membrane. These studies clearly demonstrate that endoplasmin is a luminal protein of the ER, i.e. a reticuloplasmin, and not an integral membrane protein.