Research Interests: Complementary and Alternative Medicine, Cancer, Biology, Cell Adhesion, Ethnopharmacology, and 15 moreCancer Research, Cell line, Humans, Immunoprecipitation, Du, Cancer Cell, Cell Proliferation, Cell Cycle Arrest, Cadherin, Lymph Node, Abdominal Pain, Cell Motility, Cadherins, Cell invasion, and Expression pattern
Gene expression values
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Oral cancer is a common neoplasm in both male and female worldwide; the incidence and mortality of this cancer have increased over the past decades. Cancer metastasis is a major cause of morbidity and mortality in oral cancer patients,... more
Oral cancer is a common neoplasm in both male and female worldwide; the incidence and mortality of this cancer have increased over the past decades. Cancer metastasis is a major cause of morbidity and mortality in oral cancer patients, which is associated with the translocation of tumor cells from the initial neoplastic focus into neighboring host tissues. The E-cadherin/catenin complex plays an important role in maintaining epithelial integrity, thus disrupting this complex affect several signaling pathways including Wnt as well as the adhesive repertoire and consequently incites motility and invasion. Aberrant expression patterns of the E-cadherin/catenin complex are associated with a wide variety of human malignancies including oral cancer resulting from epithelial to mesenchymal transition (EMT). In this chapter we will overview the clinical description of oral metastatic cancer; furthermore, we will discuss the role of E-cadherin/catenin complex and its signaling pathways as well as EMT in the progression of this cancer.
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Oral cancer is the most frequent type of malignancy of the head and neck area worldwide. This cancer is a major cause of mortality in several parts of the world especially in certain Asian countries. In fact, the majority of cancer deaths... more
Oral cancer is the most frequent type of malignancy of the head and neck area worldwide. This cancer is a major cause of mortality in several parts of the world especially in certain Asian countries. In fact, the majority of cancer deaths are the result of metastasis, either directly due to tumor involvement of critical organs or indirectly due to therapeutic side effects. On the other hand, it is estimated that 10–20% of human cancers are linked to virus infections including Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) especially types 16, 18, and 33, which cumulatively infect 80–90% of the population worldwide. Moreover, it has been reported that oncoproteins of high-risk HPV type 16 can covert noninvasive and nonmetastatic human cancer cells into invasive and metastatic form. It was pointed out that high-risk HPVs and EBV are important etiological factors in human oral cancer, since around 35 and 55% of these cancers are positive for these viruses, respectively. In addition, it was recently revealed that high-risk HPVs and EBV can be copresent in human oral cancer, and their copresence is associated with high-grade invasive carcinomas. Thus, it is evident that high-risk HPVs and EBV oncoproteins play an important role in the initiation and progression of human oral cancer. In this chapter, we will overview the presence and role of HPVs and EBV in this frequent malignancy, more specifically; we will focus on the role of their oncoproteins and their interactions with other oncogenes in human oral carcinogenesis.
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Metastatic breast cancer disease is one of the leading causes of cancer-related death among women worldwide. Meanwhile, it is well-established that the epithelial-mesenchymal transition (EMT) is a major event in the development of cancer... more
Metastatic breast cancer disease is one of the leading causes of cancer-related death among women worldwide. Meanwhile, it is well-established that the epithelial-mesenchymal transition (EMT) is a major event in the development of cancer metastases. On the other hand, recent studies revealed that Aspirin could play an important role in preventing cancer development and its progression. Herein, we explored the effect of aspirin on breast cancer cells and EMT. We found that aspirin-treatment initiates mesenchymal to epithelial transition, which is the opposite event of EMT; thus, aspirin-treatment can potentially inhibit cancer invasion and metastasis. These data suggest that aspirin could be useful to prevent breast cancer progression as well as other human carcinomas and their metastases.
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Water-pipe smoking (WPS) is the most widespread tobacco use in the Middle-East, and is rapidly spreading globally. Smoke from WP contains most of the compounds present in cigarette smoke, although in different proportions. WPS is... more
Water-pipe smoking (WPS) is the most widespread tobacco use in the Middle-East, and is rapidly spreading globally. Smoke from WP contains most of the compounds present in cigarette smoke, although in different proportions. WPS is associated with the risk of several human diseases; however, its impact on the early stage of normal development has not been investigated yet. Thus, in this investigation, we assess the effect of WPS on the embryo at the early stage of development. Chicken embryos at three days of incubations were used in this study. Meanwhile, we explored the outcome of WPS on angiogenesis using the chorioallantoic membrane (CAM) of the chicken embryos. Finally, quantitative real-time PCR was used to study the regulation of some key control genes of cell proliferation, apoptosis and migration. Our data reveal that WPS inhibits angiogenesis of the CAM and in embryos in comparison with their matched controls; in addition, WPS-exposed embryos show slight reduction in their sizes. We also noted that around 80% of WPS-exposed embryos die before ten days of incubation. More significantly, WPS induces up-regulations of BCL-2, Caspase-8, ATF-3, INHIB-A and Cadherin 6 genes, which are important key regulators of cell apoptosis, proliferation and migration. Our data reveal, for the first time, that WPS has very toxic effects during the early stage of embryogenesis. Thus, we believe that further studies are required to elucidate the pathogenic effect of WPS on human health especially on the embryo at the early stage of its development. This investigation addresses an important gap on the outcome of WPS during the early stage of embryogenesis. Data of this study point out that WPS can have a very toxic effect on the embryo at this stage. Additionally, results from this report display for the first time that WPS can damage normal angiogenesis of the embryo thus provoking a significant number of embryonic death. Moreover, this study reveals that this effect can occur via the deregulation of several genes related to cell apoptosis, proliferation and migration.
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ABSTRACT Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin, Id-1 and P-cadherin genes are... more
ABSTRACT Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin, Id-1 and P-cadherin genes are important regulators of cell invasion and metastasis in several human carcinomas, including colorectal. In order to investigate the correlation between the presence of high-risk HPVs and Fascin, Id-1, and P-cadherin genes in human colorectal cancer (CRC) in the Syrian population, we examined the incidence of high-risk HPV types (16, 18, 31, 33 and 35) and their association with Fascin, Id-1 and P-cadherin expression. Materials and Methods: A total of 78 blocks from CRC Syrian patients were used in this study. These blocks were analyzed using polymerase chain reaction (PCR) and tissue microarray (TMA) analyses for the presence of high-risk HPVs and Fascin, Id-1 as well as P-cadherin expression, respectively. Results: We found that high-risk HPVs were present in 42 samples (53.84%), which represent the majority of invasive CRC cases; the most frequent high-risk HPV types in the Syrian population are 16, 33, 18, 35 and 31 respectively. Furthermore, the expression of E6 onco-protein of high-risk HPVs was found to be correlated with Fascin, Id-1 and P-cadherin expression/over-expression in the majority of CRC tissue samples. Conclusion : These data reveal that high-risk HPVs are present in human CRCs in the Syrian population, and their presence is associated with invasive and metastatic phenotype.
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ABSTRACT We recently performed two studies exploring the presence of Epstein–Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we... more
ABSTRACT We recently performed two studies exploring the presence of Epstein–Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (~17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis.
Research Interests: Cancer, Virology, Medicine, Colorectal cancer, Population, and 4 moreVirus, EBV, Epstein-Barr virus, and Carcinogenesis
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The ErbB family of receptor tyrosine kinases have important roles in maintaining normal epithelial cell function. The ErbBs are involved in the interaction between cells and cell–matrix adhesion molecules and have proven critical in... more
The ErbB family of receptor tyrosine kinases have important roles in maintaining normal epithelial cell function. The ErbBs are involved in the interaction between cells and cell–matrix adhesion molecules and have proven critical in maintaining the integrity of the epithelial cell environment. Deregulation of these tyrosine receptors has been associated with several human diseases. In particular, the expression or activation of epidermal growth factor receptor (EGFR) and ErbB2 is altered in many epithelial tumors. Epithelial (E)-cadherin is another major molecule expressed by epithelial cells. To create efficient cell–cell adhesion, E-cadherin couples its cytoplasmic domain to catenins and the actin cytoskeleton. The loss of intercellular adhesion appears to be a fundamental aspect of the neoplastic phenomena. In addition, EGFR and ErbB2 signaling associated with the E-cadherin–catenin complex has been demonstrated in normal and cancer cells. This signaling is involved in regulating cell adhesion and the invasive growth of cancers. This article provides an overview of the interaction between the ErbB tyrosine receptors and the E-cadherin–catenin complex in human carcinomas.
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Differential expression results
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Research Interests: Oncology, Clinical Trial, Cancer, Breast Cancer, Biology, and 15 moreOvarian Cancer, Medicine, Humans, Insulin, Female, Clinical Sciences, Carcinogenesis, Review article, Insulin Receptor, Antineoplastic Agents, Molecular Targeted Therapy, Insulin Like Growth Factor, Clinical Trials as Topic, Breast Neoplasms, and epithelial ovarian cancer
Research Interests: Pharmacology, Chemistry, Clinical Trial, Cancer, Medicine, and 12 moreHumans, Metformin, Female, Adenylate Kinase, Transporter, Antineoplastic Agents, Biochemistry and cell biology, Biguanides, epithelial ovarian cancer, Medical biochemistry and metabolomics, Ovarian Neoplasms, and organic cation transporter 1
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Supplementary Figure 1: Log-transformed Quantile-Quantile plots of the Univariate Survival Analysis p-values. P-values derived from the univariate survival analysis of the effects of each individual gene was plotted for each fold in which... more
Supplementary Figure 1: Log-transformed Quantile-Quantile plots of the Univariate Survival Analysis p-values. P-values derived from the univariate survival analysis of the effects of each individual gene was plotted for each fold in which the analysis took place. The horizontal line at 2.52 represents -log(0.003), which was the cutoff for variable selection in the final modeling of survival in the test cohort. Supplementary Figure 2: Abridged representation of the FOXM1 regulatory network. See references [2-5]
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Patient characteristics