Congenital syphilis (CS) is a systemic infect contagious disease, sexually transmitted, easily diagnosed, with effective and low cost treatment. Thus, the existence of a paradox is detached, once infectious diseases of greater complexity... more
Congenital syphilis (CS) is a systemic infect contagious disease, sexually transmitted, easily diagnosed, with effective and low cost treatment. Thus, the existence of a paradox is detached, once infectious diseases of greater complexity have already been controlled. In its congenital form, syphilis in Brazil constitutes a sentry event of high magnitude that presents unfavorable indicators in terms of its control. In the State of Pará, Marabá is the municipality with the highest number of cases in the past years. The aimed of this study was describing a clinical-epidemiological profile of congenital syphilis in Marabá, from 2006 to 2015. This was a descriptive, retrospective and documental study which analyzed secondary data from SINAN/SMS/SVS/DATASUS/Marabá/PA. Between 2006 and 2015, 323 cases of CS were notified in Marabá. The incidence of congenital syphilis of 6.5 cases per 1,000 live births from 2006-2015 is 6.5 the Ministry of Health goal; from 2012 to 2015 the rates were 8, 9...
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Entre as ferramentas de prevenção no contexto da saúde pública, a vacinação merece destaque. Recentemente, entretanto, as imunizações passaram a enfrentar grandes obstáculos em território nacional, com o aumento dos índices de certas... more
Entre as ferramentas de prevenção no contexto da saúde pública, a vacinação merece destaque. Recentemente, entretanto, as imunizações passaram a enfrentar grandes obstáculos em território nacional, com o aumento dos índices de certas doenças infecciosas e a heterogeneidade da cobertura vacinal nas diferentes regiões brasileiras. Dessa forma, este estudo objetiva conhecer a cobertura das vacinas recomendadas pelo Ministério da Saúde para adolescentes, adultos e idosos, no município de Marabá, no período de 2015 à 2020. Trata-se de um estudo observacional, transversal e descritivo, onde foram entrevistados funcionários das salas de vacina das UBS (Unidade Básica de Saúde) da zona urbana de Marabá. Os dados foram coletados através de um questionário previamente elaborado pelos pesquisadores e por meio de informações advindas do Departamento de Informática do Sistema Único de Saúde (DATASUS). A pesquisa ofereceu riscos quanto à perda de sigilo de informações e constrangimento por parte ...
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O sarampo é uma doença infecciosa aguda de etiologia viral comum em crianças e que pode evoluir com complicações severas. O objetivo da atual pesquisa é analisar a prevalência do sarampo e correlacionar isto com a cobertura vacinal para a... more
O sarampo é uma doença infecciosa aguda de etiologia viral comum em crianças e que pode evoluir com complicações severas. O objetivo da atual pesquisa é analisar a prevalência do sarampo e correlacionar isto com a cobertura vacinal para a doença, no município de Marabá, Estado do Pará, no período de 2019 a 2020. Foi conduzido um estudo epidemiológico retrospectivo, descritivo, com abordagem analítica. Foram utilizados dados secundários disponíveis na Secretaria de Saúde do município de Marabá e Sistema de Informação de Agravos de Notificação (SINAN). Foram encontrados um total de 113 casos de saraeitompo no município de Marabá entre 2019 e 2020. Houve uma predominância dos casos de sarampo entre menores que um ano e entre 20 a 34 anos, o sexo mais frequente foi o masculino e a escolaridade mais frequente foi ensino médio completo. Quanto a cobertura vacinal, observou-se uma tendência de decrescimento entre os anos de 2000 a 2020. Deve-se intensificar as campanhas de vacinação no Mun...
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A anticoncepção feminina abrange desde aspectos socioeconômicos até aspectos políticos. As Nações Unidas consideram que o acesso ao planejamento familiar seguro e voluntário é um direito humano, pois é essencial para a promoção da... more
A anticoncepção feminina abrange desde aspectos socioeconômicos até aspectos políticos. As Nações Unidas consideram que o acesso ao planejamento familiar seguro e voluntário é um direito humano, pois é essencial para a promoção da igualdade de gênero, avanço da autonomia das mulheres e redução da pobreza. Nesse contexto, o objetivo deste estudo foi analisar o conhecimento, uso e falha dos métodos contraceptivos dentre as mulheres residentes em Marabá (PA), assim como a utilização dos serviços de saúde pública. Trata-se de um estudo observacional e transversal, na qual um questionário elaborado pelas pesquisadoras foi aplicado em entrevistas presenciais e por formulário eletrônico. Foram incluídas 394 mulheres residentes na área urbana de Marabá, alfabetizadas e com idade de maior ou igual a 18 anos. Os resultados mostraram que 21% (83) das entrevistadas já tiveram algum aborto e, destas, 8.43% nunca foram ao ginecologista/obstetra, sendo que a maioria afirma conhecer e saber usar pr...
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The theme medication/self-diagnosis presents contrary opinions about what is right or wrong, in addition to being scarce the quantitative studies with the purpose to clarify the causes of these two dangerous practices. For both, the... more
The theme medication/self-diagnosis presents contrary opinions about what is right or wrong, in addition to being scarce the quantitative studies with the purpose to clarify the causes of these two dangerous practices. For both, the objective of this study was to identify the causes that influence the self-diagnosis and medication, as well as analyze failures in public assistance in health, which can be promoting the avoidance of the patient to search for an alternative medicine, evidencing the risk that this done can promote. It was a descriptive and cross-sectional study, of qualitative nature, carried out in all health centers in the urban area of Marabá (Pará State, Brazil), through the application of forms and having the data analyzed and tabulated, making use mainly of Chi-square statistical test. The results showed that education is not directly related to the medication, which before was vacant in literature, but the main result highlighted expressed that the motivation for ...
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Malaria is a tropical disease caused by protozoa of the genus Plasmodium (Aconoidasida: Haemosporida: Plasmodiidae). The Brazilian Amazon is the area with the highest risk of malaria transmission in the country. The aim of this study was... more
Malaria is a tropical disease caused by protozoa of the genus Plasmodium (Aconoidasida: Haemosporida: Plasmodiidae). The Brazilian Amazon is the area with the highest risk of malaria transmission in the country. The aim of this study was to trace the epidemiological profile of malaria patients between 2010 and 2015, in the Municipality of Marabá, State of Pará, North Brazil. Secondary data were used, of Sivep-malaria of the Municipal Health Department of the municipality. The variables analyzed were the incidence autochthonous or imported cases, genus, species of the causative parasite infection during pregnancy and parasitic annual index. Data analysis used the Chi-Square Test, in the Biostat 5.0. The annual parasitic index (IPA) of malaria cases in Marabá in 2010 was 3.7, followed by the year of 2011 with 2.7, from the year 2012 the IPA drops sharply to 0.68, followed by the years 2013, 2014 and 2015, which presented an IPA of 0.1, 0.07 and 0.01 respectively. Data on the contamina...
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In the early 17th century, French and Portuguese colonizers and Jesuit priests settled in the state of Maranhão and made contact with the Guajajara, an ethnic group that lived along the margins of the Pindaré River. The Guajajara... more
In the early 17th century, French and Portuguese colonizers and Jesuit priests settled in the state of Maranhão and made contact with the Guajajara, an ethnic group that lived along the margins of the Pindaré River. The Guajajara maintained contact with Brazilian national society over the centuries, including with Brazilian admixed populations, and with African slaves that flocked towards the region from the 18th century onwards. The present study investigates the origins of this admixture using mitochondrial genetic variability. The bones of 12 individuals investigated, which are currently part of the collection of theNational Museum, were tested for genetic diversity. aDNA was extracted by the phenol-chloroform method and by DNA IQ (Promega, Madison, WI, USA). Amplification of the HVS I region was performed by PCR, followed by direct sequencing using the Big Dye kit (Life Technologies, Foster City, CA, USA). This region was found to represent haplogroups of Amerindians (A, C, and ...
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O presente trabalho teve como objetivo traçar o perfil das formas de identificação e/ou reconhecimento post mortem mais ocorrentes no IML de Marabá/PA nos anos de 2016 e 2017. Trata-se de um estudo científico, transversal, nominal do tipo... more
O presente trabalho teve como objetivo traçar o perfil das formas de identificação e/ou reconhecimento post mortem mais ocorrentes no IML de Marabá/PA nos anos de 2016 e 2017. Trata-se de um estudo científico, transversal, nominal do tipo observacional, de caráter descritivo, voltado para análises documentais de laudos periciais no Centro de Perícias Renato Chaves nas quais foram identificação antropológica, documental e em última instância a identificação por DNA. Os dados foram analisados mediante gráficos de dispersão (ANOVA) e uma representação de comparação das médias (teste de Tukey) no software R Studio®. Foram analisados 735 laudos do ano de 2016 e 758 laudos de 2017. Em 2016 os métodos de identificação/reconhecimento mais utilizados foram Para identificação por meio de documentos do cadáver e identificação por meio de documentos combinados com reconhecimento familiar; a identificação por DNA correpondeu a 3,12%. Em 2017 os métodos mais utilizados também foram documentos do ...
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Cobertura vacinal para adolescentes, adultos e idosos em Marabá (PA), no período de 2015 a 2020 Vaccination coverage for adolescents, adults and the elderly in Marabá (PA), from 2015 to 2020 Cobertura de vacunación para adolescentes,... more
Cobertura vacinal para adolescentes, adultos e idosos em Marabá (PA), no período de 2015 a 2020 Vaccination coverage for adolescents, adults and the elderly in Marabá (PA), from 2015 to 2020 Cobertura de vacunación para adolescentes, adultos y ancianos en Marabá (PA), en el período de
Conhecimento, uso e falha de métodos contraceptivos dentre as mulheres marabaenses que já tiveram aborto Knowledge, use and failure of contraceptive methods among women from Marabá who have had abortions Conocimiento, uso y falla de... more
Conhecimento, uso e falha de métodos contraceptivos dentre as mulheres marabaenses que já tiveram aborto Knowledge, use and failure of contraceptive methods among women from Marabá who have had abortions Conocimiento, uso y falla de métodos anticonceptivos entre mujeres de Marabá que han tenido abortos
Desde os primórdios da sociedade, a questão do aborto é fonte de reflexões e demanda diligências para a tentativa de seu enquadramento social. Por atravessar um emaranhado de aspectos sociais, culturais, econômicos, jurídicos, religiosos... more
Desde os primórdios da sociedade, a questão do aborto é fonte de reflexões e demanda diligências para a tentativa de seu enquadramento social. Por atravessar um emaranhado de aspectos sociais, culturais, econômicos, jurídicos, religiosos e ideológicos, é tema que incita passionalidade e dissensão, parecendo distante de saída. Assim, esta pesquisa visa integrar essas principais questões relacionadas à temática apresentada, proporcionando uma visão geral do aborto na saúde pública brasileira. Trata-se de uma revisão integrativa de literaturas, as quais foram selecionadas por meio da Scielo, Lilacs e BVS. Foram incluídos 38 artigos publicados entre 1900 e 2020, que correspondiam aos questionamentos utilizados. O estudo evidenciou que mesmo com os esforços parcialmente bem sucedidos em reduzir o número de abortos provocados no Brasil e no mundo, as estimativas não têm mudado consideravelmente. Sendo assim, as mulheres mais vulneráveis são adolescentes e jovens adultas, negras e pardas e mulheres com menor poder aquisitivo, sendo os problemas financeiros, relações interpessoais instáveis, violências e estrutura familiar comprometida alguns dos principais motivos para abortar. Também ressalta-se a utilização incorreta e conhecimento deficiente das mulheres acerca dos métodos contraceptivos. Conclui-se que a informação e o planejamento devem ser chaves no combate ao abortamento provocado e suas consequências. Palavras-chave: abortamento, aborto provocado, aborto no Brasil, consequências do aborto.
Resumo O sarampo é uma doença infecciosa aguda de etiologia viral comum em crianças e que pode evoluir com complicações severas. O objetivo da atual pesquisa é analisar a prevalência do sarampo e correlacionar isto com a cobertura vacinal... more
Resumo O sarampo é uma doença infecciosa aguda de etiologia viral comum em crianças e que pode evoluir com complicações severas. O objetivo da atual pesquisa é analisar a prevalência do sarampo e correlacionar isto com a cobertura vacinal para a doença, no município de Marabá, Estado do Pará, no período de 2019 a 2020. Foi conduzido um estudo epidemiológico retrospectivo, descritivo, com abordagem analítica. Foram utilizados dados secundários disponíveis na
Este trabalho buscou conhecer a importância da inclusão de crianças com autismo ainda na educação infantil, mostrando os empecilhos encontrados pelos docentes e pela escola durante o processo de inclusão dentro da sala de aula,... more
Este trabalho buscou conhecer a importância da inclusão de crianças com autismo ainda na educação infantil, mostrando os empecilhos encontrados pelos docentes e pela escola durante o processo de inclusão dentro da sala de aula, considerando seus conhecimentos e seus ajustes curriculares. Fez uma análise da inclusão de forma consciente, mostrando que não basta só incluir, é preciso que a escola ofereça paradigmas para que a inclusão abranja todos os envolvidos de forma precisa. Foi realizado um estudo bibliográfico qualitativo, exploratório, documental e de revisão bibliográfica narrativa, onde os autores serviram como base para fundamentação teórica deste artigo. Durante a pesquisa, vários artigos sobre o tema foram escolhidos através de palavras chaves no Google acadêmico e selecionados apenas os mais relevantes para a construção do estudo. Os resultados de pesquisa mostraram que existem muitos empecilhos tanto da escola, quanto do professor para incluir, que acaba refletindo sobre o aluno. Com este estudo pretende-se contribuir para reflexão da importância da Inclusão na Educação Infantil.
Resumo A Epidemiologia Forense une os princípios e técnicas da epidemiologia e as ciências forenses e possibilita o preenchimento de lacunas entre questões jurídicas que envolvam situações clínicas (saúde-doença) e epidemiológicas,... more
Resumo A Epidemiologia Forense une os princípios e técnicas da epidemiologia e as ciências forenses e possibilita o preenchimento de lacunas entre questões jurídicas que envolvam situações clínicas (saúde-doença) e epidemiológicas, estabelecendo o nexo causal em ações civis e processos criminais e defesa. O objetivo deste trabalho foi fornecer uma breve revisão geral dos métodos e aplicações da epidemiologia forense, pois a epidemiologia forense é de interesse para aqueles que trabalham e estudam nas áreas de medicina legal, epidemiologia e direito. Trata-se de um estudo qualitativo, descritivo, do tipo revisão narrativa da literatura. A busca bibliográfica foi desenvolvida nas bases de dados. Scielo, Google Scholar, desde o final dos anos 1990, quando o termo epidemiologia forense foi cunhado. Como resultado, foram geradas situações relativas às aplicações da epidemiologia forense, tais como áreas de Toxicologia forense; Benefícios (auxílio-doença e aposentadoria por invalidez); Suicídio; Acidentes de trânsito e álcool; Violência doméstica; Infanticídio. Este estudo apresentou limitações, dentre elas a busca de artigos em português, com o escopo voltado para epidemiologia forense propriamente dita. No entanto, podemos destacar que este estudo mostrou a importância de se investigar esse tema e faz-se necessário ampliar as pesquisas tanto no âmbito nacional como internacional.
Aluminum (Al) is the most abundant metal and the third common chemical element on earth. It is known that Al is toxic, especially its trivalent form (Al(3+)), that represents the its most soluble form. Al intoxication is related to some... more
Aluminum (Al) is the most abundant metal and the third common chemical element on earth. It is known that Al is toxic, especially its trivalent form (Al(3+)), that represents the its most soluble form. Al intoxication is related to some pathogenic disorders, principally neurodegeneratives ones as Parkinson and Alzheimer diseases. The present study aimed to evaluate the mutagenic potential of aluminum chloride (AlCl(3)). Comet assay and chromosome aberrations analysis were applied to evaluate the DNA-damaging and clastogenic effects of AlCl(3), respectively, in different phases of the cell cycle. Cultured human lymphocytes were treated with 5, 10, 15 and 25 microM aluminum chloride during the G1, G1/S, S (pulses of 1 and 6h), and G2 phases of the cell cycle. All tested concentrations were cytotoxic and reduced significantly the mitotic index in all phases of cell cycle. They also induced DNA damage and were clastogenic in all phases of cell cycle, specially in S phase. AlCl(3) also induced endoreduplication and polyploidy in treatments performed during G1 phase. The presence of genotoxicity and polyploidy on interphase and mitosis, respectively, suggests that aluminum chloride is clastogenic and indirectly affects the construction of mitotic fuse in all tested concentrations.
Research Interests: Chemistry, Biology, Cell Cycle, DNA damage, Medicine, and 15 moreMitosis, Humans, Genotoxicity, Comet Assay, Food Sciences, Environmental Pollutants, Lymphocytes, Food and Chemical Toxicology, Alzheimer Disease, Cell Survival, Mitotic Index, Interphase, Chlorides, Chromosome aberrations, and human lymphocyte
Fibroadenoma (FA) is a benign breast tumour that occurs in about 25% of women. Cytogenetic studies suggest that numerical chromosomal aberrations may contribute to tumorigenesis, but chromosomal instability is still poorly characterised... more
Fibroadenoma (FA) is a benign breast tumour that occurs in about 25% of women. Cytogenetic studies suggest that numerical chromosomal aberrations may contribute to tumorigenesis, but chromosomal instability is still poorly characterised in breast cancer. The aim of this study was to investigate numerical alterations of chromosome 21 in 15 breast FAs. All samples were analysed by classical cytogenetics and by fluorescence in situ hybridisation (FISH) for chromosome 21 DNA sequences. Classical cytogenetics analysis showed that all cells were diploidies with modal number varying between 43 and 47 chromosomes, and clonal chromosome alterations in 46.7% of tumours. Clonal numerical alterations involved, preferentially, chromosomes 8, 10, 12, 16 and 21. FISH analysis showed a statistically significant difference for chromosome 21 monosomy between seven samples and control group. This monosomy varied from 24.5% to 43.5% of analysed cells. The presence of chromosomal alterations in FAs may be a consequence of the proliferation process and is probably not related to the aetiology of this type of lesion. The study of benign proliferations and comparison with chromosome alterations in their malignant counterparts should result in an understanding of the genes acting in cell proliferation alone and those that cause these cells to both undergo malignant transformation and become invasive.
Research Interests: Breast Cancer, Biology, Adolescent, Cytogenetics, Humans, and 15 moreFluorescence in situ hybridization, Female, Aneuploidy, Clinical Sciences, Chromosome, Adult, Cell Proliferation, Chromosomal Instability, Control Group, Fibroadenoma, DNA sequence, Breast Neoplasms, chromosome instability, Chromosome aberrations, and Breast tumour
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Congenital syphilis (CS) is a systemic infect contagious disease, sexually transmitted, easily diagnosed, with effective and low cost treatment. Thus, the existence of a paradox is detached, once infectious diseases of greater complexity... more
Congenital syphilis (CS) is a systemic infect contagious disease, sexually transmitted, easily diagnosed, with effective and low cost treatment. Thus, the existence of a paradox is detached, once infectious diseases of greater complexity have already been controlled. In its congenital form, syphilis in Brazil constitutes a sentry event of high magnitude that presents unfavorable indicators in terms of its control. In the State of Pará, Marabá is the municipality with the highest number of cases in the past years. The aimed of this study was describing a clinical-epidemiological profile of congenital syphilis
The theme medication/self-diagnosis presents contrary opinions about what is right or wrong, in addition to being scarce the quantitative studies with the purpose to clarify the causes of these two dangerous practices. For both, the... more
The theme medication/self-diagnosis presents contrary opinions about what is right or wrong, in addition to being scarce the quantitative studies with the purpose to clarify the causes of these two dangerous practices. For both, the objective of this study was to identify the causes that influence the self-diagnosis and medication, as well as analyze failures in public assistance in health, which can be promoting the avoidance of the patient to search for an alternative medicine, evidencing the risk that this done can promote. It was a descriptive and cross-sectional study, of qualitative nature, carried out in all health centers in the urban area of Marabá (Pará State, Brazil), through the application of forms and having the data analyzed and tabulated, making use mainly of Chi-square statistical test. The results showed that education is not directly related to the medication, which before was vacant in literature, but the main result highlighted expressed that the motivation for the choice of ingesting medication without prescription, are the difficulties encountered in SUS, the poor quality of care and failures in the relationship doctor patient of the public health service.
New sequencing technologies such as Illumina/Solexa, SOLiD/ABI, and 454/Roche, revolutionized the biological researches. In this context, the SOLiD platform has a particular sequencing type, known as multiplex run, which enables the... more
New sequencing technologies such as Illumina/Solexa, SOLiD/ABI, and 454/Roche, revolutionized the biological researches. In this context, the SOLiD platform has a particular sequencing type, known as multiplex run, which enables the sequencing of several samples in a single run. It implies in cost reduction and simplifies the analysis of related samples. Meanwhile, this se-quencing type requires an additional filtering step to ensure the reliability of the results. Thus, we propose in this paper a probabilistic model which considers the intrinsic characteristics of each sequencing to characterize multiplex runs and filter low-quality data, increasing the data analysis reliability of mul-tiplex sequencing performed on SOLiD. The results show that the proposed model proves to be satisfactory due to: 1) identification of faults in the se-quencing process; 2) adaptation and development of new protocols for sample preparation; 3) the assignment of a degree of confidence to the data generated; and 4) guiding a filtering process, without discarding useful sequences in an arbitrary manner.
Mercury is a xenobiotic metal that is a highly deleterious environmental pollutant. The biotransformation of mercury chloride (HgCl 2) into methylmercury chloride (CH 3 HgCl) in aquatic environments is well-known and humans are exposed by... more
Mercury is a xenobiotic metal that is a highly deleterious environmental pollutant. The biotransformation of mercury chloride (HgCl 2) into methylmercury chloride (CH 3 HgCl) in aquatic environments is well-known and humans are exposed by consumption of contaminated fish, shellfish and algae. The objective of the present study was to determine the changes induced in vitro by two mercury compounds (HgCl 2 and CH 3 HgCl) in cultured human lymphocytes. Short-term human leukocyte cultures from 10 healthy donors (5 females and 5 males) were setup by adding drops of whole blood in complete medium. Cultures were separately and simultaneously treated with low doses (0.1 to 1000 µg/l) of HgCl 2 and CH 3 HgCl and incubated at 37ºC for 48 h. Genotoxicity was assessed by chromosome aberrations and polyploid cells. Mitotic index was used as a measure of cytotoxicity. A significant increase (P < 0.05) in the relative frequency of chromosome aberrations was observed for all concentrations of CH 3 HgCl when compared to control, whether alone or in an evident sinergistic combination with HgCl 2. The frequency of polyploid cells was also significantly increased (P < 0.05) when compared to control after exposure to all concentrations of CH 3 HgCl alone or in combination with HgCl 2. CH 3 HgCl significantly decreased (P < 0.05) the mitotic index at 100 and 1000 µg/l alone, and at 1, 10, 100, and 1000 µg/l when combined with HgCl 2 , showing a synergistic cytotoxic effect. Our data showed that low concentrations of CH 3 HgCl might be cytotoxic/genotoxic. Such effects may indicate early cellular changes with possible biological consequences and should be considered in the preliminary evaluation of the risks of populations exposed in vivo to low doses of mercury.
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In the early 17th century, French and Portuguese colonizers and Jesuit priests settled in the state of Maranhão and made contact with the Guajajara, an ethnic group that lived along the margins of the Pindaré River. The Guajajara... more
In the early 17th century, French and Portuguese colonizers and Jesuit priests settled in the state of Maranhão and made contact with the Guajajara, an ethnic group that lived along the margins of the Pindaré River. The Guajajara maintained contact with Brazilian national society over the centuries, including with Brazilian admixed populations, and with African slaves that flocked towards the region from the 18th century onwards. The present study investigates the origins of this admixture using mitochondrial genetic variability. The bones of 12 individuals investigated, which are currently part of the collection of the National Museum, were tested for genetic diversity. aDNA was extracted by the phenol-chloroform method and by DNA IQ (Promega, Madison, WI, USA). Amplification of the HVS I region was performed by PCR, followed by direct sequencing using the Big Dye kit (Life Technologies, Foster City, CA, USA). This region was found to represent haplogroups of Amerindians (A, C, and D) and Africans (L, L1b, L1c, and L3). The presence of African haplogroups in Guajajara bones from as early as the 18th century is consistent with historical and anthropological data, suggesting the admixture with Africans and/or Afrodescendants. Therefore, this study demonstrates that women with African haplogroups were introduced into the Guajajara population.