David Erazo

A mouse model of cutaneous leishmaniasis (CL) by Leishmania (Viannia) panamensis (L(V)p) that reproduces the characteristics of the human disease remains elusive. Here we report the development of a CL model that uses a mouse-adapted L(V)p isolate to reproducibly induce a dermal disease with a remarkable similarity to human CL. BALB/c mice infected intradermally in the ear with 105 stationary UA-946 L(V)p promastigotes develop a progressive cutaneous disease that exhibits the typical ulcerated lesions with indurated borders observed in CL patients. Although most of parasites in the inoculum die within the first week of infection, the survivors vigorously multiply at the infection site during the following weeks, paralleling disease appearance and aggravation. Regional lymphadenopathy as well as lymphatic dissemination of parasites to draining lymph nodes (dLN) was evidenced early after infection. Viable parasites were also isolated from spleen at later timepoints indicating systemic...

Los esfuerzos ocasionados al trabajar con tension emocional y malas posturas sin preparacion fi­sica adecuada, pueden traer como consecuencia fatiga, accidentes y lesiones graves para el trabajador. El programa de Fisioterapia de la Universidad Mariana, comprometido con la salud y seguridad en el trabajo, realiza diversas actividades en pro del cuidado de los funcionarios y la prevencion de lesiones por tareas repetitivas o posturas inadecuadas en el desarrollo de sus tareas, para esto, como estrategia, se ha planteado la realizacion de la gimnasia laboral en las diferentes sedes, las cuales se benefician con este programa, el cual esta a cargo de los estudiantes de fisioterapia, que cursan actualmente la practica formativa de salud ocupacional y bajo la directriz de la docente Karina Rodri­guez Espinosa. Sin duda estos espacios, son de suma importancia para los trabajadores, ya que ayudan a prevenir los desordenes musculoesqueleticos, derivados de la jornada laboral.

Resumen :Los rayos cosmicos (CR) son particulas energeticas que provienen de fuentes galacticas y extragalacticas. Estas particulas al interactuar con el campo magnetico y la atmosfera terrestre generan chubascos atmosfericos extensos (EAS). En este articulo se realizaron simulaciones con el paquete computacional  CORSIKA de los chubascos de particulas secundarias generados por protones (), particulas alfa (), fotones () y nucleos de hierro (Fe) con energias de 10 GeV, 100 GeV, 1 TeV, 10 TeV y 100 TeV, considerando la rigidez magnetica en la region ecuatorial y una altitud de  m.s.n.m. para la calibracion de un Detector Cherenkov de Agua (WCD). Se obtuvo la distribucion longitudinal de particulas secundarias y la distribucion longitudinal de la energia de las particulas secundarias creadas respecto a la profundidad atmosferica. Los resultados muestran que el numero de muones secundarios generados es menor comparado con el numero de electrones; sin embargo, de acuerdo con las simulac...

The final work of the Bachelors of Arts in Teaching demands teachers be well prepared not only by practice but also by a deep theory study. English language teachers must be led from theory to practice and vice versa when it comes to improve the art of teaching on a daily basis. It is very necessary for teachers to analyse as well as contrast what happens on the classrooms every day. The importance of not taking for granted issues that seem simple leads to critical thinking teachers who, in turn, can keep on contributing to the discussion of complex matters such as the one presented in this paper work. If teachers go beyond theory and become able to contrast it with accurate supporting after real world practice, they can whether revoke what somebody says, or reinforce and support what somebody establishes. Just by doing this, teachers can contribute to the changes our educational society requires when teaching a foreign language

Se plantea la pericopa del encuentro de Jesus con los mercaderes del templo en la version de Mateo como critica a la liturgia actual en busqueda de aportes para la renovacion de los espacios cultuales desde la realidad de los pueblos. Una celebracion liturgica autentica y correcta eticamente, desde la originalidad de la Alianza y la proclamacion del Reinado de Dios, debe estar a favor de los vulnerables de la historia, anticipando el anhelo de la paz, desde la practica de la justicia.

One of the interventional strategies to reestablish the immune effector/regulatory balance, that is typically altered in chronic inflammatory diseases (CID), is the reinforcement of endogenous immunomodulatory pathways as the one triggered by interleukin (IL)-10. In a recent work, we demonstrated that the subcutaneous (sc) administration of an IL-10/Treg-inducing small molecule-based formulation, using a repetitive microdose (REMID) treatment strategy to preferentially direct the effects to the regional immune system, delays the progression of atherosclerosis. Here we investigated whether the same approach using other IL-10-inducing small molecule, such as the safe, inexpensive, and widely available polyphenol curcumin, could induce a similar protective effect in two different CID models. We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying o...