- Redirect neuroscientist active as advisor.edit
Research Interests:
Research Interests: Cognitive Science, Regeneration, Gene Therapy, Microsurgery, Nanotechnology, and 15 moreMolecular Mechanics, Peripheral Nerve Injury, Clinical Practice, Humans, Animals, Nerve Regeneration, Functional Recovery, Peripheral nerves, Peripheral Nerve, Neurotrophic Factors, Neurosciences, Nerve Injury, Peripheral nerve injuries, Axon Outgrowth, and Genetic Therapy
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests: Cognitive Science, Ethics, Deep Brain Stimulation, Clinical Trial, Informed Consent, and 15 morePlacebo Effect, Humans, Animals, Central Nervous System, Placebos, Study design, Controlled Clinical Trial, Large Scale, Double Blind, Neurosciences, Parkinson Disease, Test Bed, Adrenal Medulla, Clinical Trials as Topic, and Patient selection
Research Interests:
Research Interests: Heart Failure, Left Ventricular Assist Device, Animals, Male, Heart rate, and 9 moreHeart, Single Photon Emission Computed Tomography, Nuclear Cardiology, Rabbits, Structure activity Relationship, Tissue distribution, Left Ventricular, Cardiovascular medicine and haematology, and In Vitro Techniques
Research Interests:
Research Interests:
Research Interests: Positron Emission Tomography, Heart Failure, Asymmetric Synthesis, Left Ventricular Assist Device, Animals, and 14 moreMale, Structural Change, Clinical Sciences, Hydrogen Peroxide, Single Photon Emission Computed Tomography, Chronic Heart Failure, Radioligand Assay, Rabbits, Ligands, Left Ventricle, Molecular Structure, Binding affinity, Tissue distribution, and Left Ventricular
Research Interests:
Research Interests: Psychology, Cerebellum, Cerebral Cortex, Female, Animals, and 15 moreMale, Genetic modification, Central Nervous System, Nerve Regeneration, Clinical Sciences, Experimental, Rats, Peripheral Nerve, Experimental Neurology, In Vitro Studies, Schwann Cell, Neurosciences, Gene Transfer, Brain injuries, and Reporter gene
Research Interests:
Spinal root avulsions result in paralysis of the upper and/or lower extremities. Implanting a peripheral nerve bridge or reinsertion of the avulsed roots in the spinal cord are surgical strategies that lead to some degree of functional... more
Spinal root avulsions result in paralysis of the upper and/or lower extremities. Implanting a peripheral nerve bridge or reinsertion of the avulsed roots in the spinal cord are surgical strategies that lead to some degree of functional recovery. In the current study lentiviral (LV) vector-mediated gene transfer of a green fluorescent protein (GFP) reporter gene was used to study the feasibility of gene therapy in the reimplanted root to further promote regeneration of motor axons. A total of 68 female Wistar rats underwent unilateral root avulsion of the L4, L5 and L6 ventral lumbar roots. From 23 rats intercostal nerves were dissected before ventral root avulsion surgery, injected with a lentiviral vector encoding GFP (LV-GFP) and inserted between the spinal cord and avulsed rootlet. In the remaining 45 rats, the avulsed ventral root was injected with either LV-GFP or a lentiviral vector encoding a fusion between a GlyAla repeat and GFP (LV-GArGFP), and reinserted into the spinal c...
Research Interests:
In this review, recent studies using pharmacological treatment, cell transplantation, and gene therapy to promote regeneration of the injured spinal cord in animal models will be summarized. Pharmacological and cell transplantation... more
In this review, recent studies using pharmacological treatment, cell transplantation, and gene therapy to promote regeneration of the injured spinal cord in animal models will be summarized. Pharmacological and cell transplantation treatments generally revealed some degree of effect on the regeneration of the injured ascending and descending tracts, but further improvements to achieve a more significant functional recovery are necessary. The use of gene therapy to promote repair of the injured nervous system is a relatively new concept. It is based on the development of methods for delivering therapeutic genes to neurons, glia cells, or nonneural cells. Direct in vivo gene transfer or gene transfer in combination with (neuro)transplantation (ex vivo gene transfer) appeared powerful strategies to promote neuronal survival and axonal regrowth following traumatic injury to the central nervous system. Recent advances in understanding the cellular and molecular mechanisms that govern neu...
Research Interests:
The potential of both stereoisomers of 11 beta-methoxy-17 alpha-[123I] iodovinylestradiol (E- and Z-[123I]MIVE) as suitable radioligands for imaging of estrogen receptor (ER)-positive human breast tumours was studied. The 17... more
The potential of both stereoisomers of 11 beta-methoxy-17 alpha-[123I] iodovinylestradiol (E- and Z-[123I]MIVE) as suitable radioligands for imaging of estrogen receptor (ER)-positive human breast tumours was studied. The 17 alpha-[123I]iodovinylestradiol derivatives were prepared stereospecifically by oxidative radioiododestannylation of the corresponding 17 alpha-tri-n-butylstannylvinylestradiol precursors. Both isomers of MIVE showed high in vitro affinity for dimethylbenzanthracene-induced rat and fresh human mammary tumour ER, that of Z-MIVE however being manyfold higher than that of E-MIVE. In vivo distribution studies with E- and Z-[123I]MIVE in normal and tumour-bearing female rats showed ER-mediated uptake and retention in uterus, ovaries, pituitary, hypothalamus and mammary tumours, again the highest for Z-[123I]MIVE. The uterus- and tumour-to-nontarget tissue (far, muscle) uptake ratios were also highest for Z-[123I]MIVE. Additionally, planar whole body imaging of two bre...
