Dunning, P., Kim, HA and Mullineux, G., 2010. Loading Magnitude Uncertainty in Level-Set Based Topology Optimization. Submitted to: 12th AIAA non-Deterministic Approaches Conference, 12-15 April 2010, Orlando, Florida, USA. ... Full text... more
Dunning, P., Kim, HA and Mullineux, G., 2010. Loading Magnitude Uncertainty in Level-Set Based Topology Optimization. Submitted to: 12th AIAA non-Deterministic Approaches Conference, 12-15 April 2010, Orlando, Florida, USA. ... Full text not available from this repository.
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Topology optimisation is the most general form of structural optimisation, capable of calculating the optimal arrangement of material in a loaded structure. Low weight efficient structures are vital to aircraft performance making... more
Topology optimisation is the most general form of structural optimisation, capable of calculating the optimal arrangement of material in a loaded structure. Low weight efficient structures are vital to aircraft performance making aerospace structures an ideal field for the application of topology optimisation. In this investigation 3D level set topology optimisation is developed to optimise the internal structure of an aircraft wing with coupled aerostructural interaction. The results suggest that an alternative configuration of I-beam like wing with columns may be an optimal solution for wing structures. They also show the importance of considering the relationship between the internal wing structure and its aerodynamic performance. The paper thus, demonstrates potential benefits of Aerostructural 3D level set topology optimisation for a design of aircraft wing.
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We report a case of disseminated Kikuchi disease (KD) associated with Hemophagocytic syndrome (HS) in a 9-month-old boy with recurrent fever and tender cervical and inguinal lymphadenopathy. Disseminated necrotizing lymphadenopathies can... more
We report a case of disseminated Kikuchi disease (KD) associated with Hemophagocytic syndrome (HS) in a 9-month-old boy with recurrent fever and tender cervical and inguinal lymphadenopathy. Disseminated necrotizing lymphadenopathies can be observed on whole-body MR imaging.
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The objective of this study was to examine the prevalence and risk factors for widespread pain and its influence on quality of life in residents of Korean communities. A rural and an urban community were selected, and 5,037 subjects were... more
The objective of this study was to examine the prevalence and risk factors for widespread pain and its influence on quality of life in residents of Korean communities. A rural and an urban community were selected, and 5,037 subjects were surveyed. Participants were asked if they had pain, aching, or stiffness in any of their joints on most days. Widespread pain was defined as pain above the waist, below the waist, on both sides of the body and in the axial region. The prevalence of widespread pain was 12% (16.2% and 5.5% in females and males, respectively). It was more frequent among females and increased with age in both genders. Age, female gender, and the presence of hand or knee arthritis were significantly associated with widespread pain after multivariate analysis. Except for mental health, all the items in the SF-12 were adversely affected in the widespread pain group after adjustment for confounding factors. Our findings show that the prevalence of widespread pain among resi...
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: John Merbecke's The Booke of Common Praier Noted (BCPN) is a musical manifestation of the English Reformation—the vernacular liturgical chants extensively utilized by the Victorian Anglicans as a key source for re-establishing the... more
: John Merbecke's The Booke of Common Praier Noted (BCPN) is a musical manifestation of the English Reformation—the vernacular liturgical chants extensively utilized by the Victorian Anglicans as a key source for re-establishing the musical foundation of the Church. Since then, Merbecke's chants have spread throughout the Anglican churches and were adopted by many denominations of English-speaking countries and, furthermore, used for the English liturgy of the Roman Catholic Church after the Second Council. While the historical importance of BCPN is evident, however, the music and its remarkable popularization in later centuries have been misunderstood, especially because of the musical hybridity of Merbecke's chants that reflect the liturgical transition of the late 1540s. In light of more recent studies of Merbecke that elucidate the essential characteristics of his chants as musica rhetorica, this essay seeks to re-evaluate the Victorian motivation for and contribution to the rediscovery of Merbecke's chants. It examines how and why BCPN came to be viewed as a paradigm for the post-Tractarian revival of choral service, whose theological aesthetics of music is best manifested in The Ecclesiologist and Parish Choir and recapitulates the core of Christian music polemics articulated by the Church Fathers and the key Reformers. The essay thus argues for the historical and theological continuity between the Tudor Anglican ideal of “sacred music” underlying BCPN and its Victorian counterpart that views BCPN as a musical means for the realization of a via media in Christian antiquity—an icon of Anglican plainchant.
Research Interests: Sociology, Literature, Liturgy, Hybridity, Vernacular, and 3 moreChoir, Anglican Studies, and Musical
Wireless sensor networks are being increasingly accepted as an effective tool for structural health monitoring. The ability to deploy a wireless array of sensors efficiently and effectively is a key factor in structural health monitoring.... more
Wireless sensor networks are being increasingly accepted as an effective tool for structural health monitoring. The ability to deploy a wireless array of sensors efficiently and effectively is a key factor in structural health monitoring. Sensor installation and management can be difficult in practice for a variety of reasons: a hostile environment, high labour costs and bandwidth limitations. We present and evaluate a proof-of-concept application of virtual visual sensors to the well-known engineering problem of the cantilever beam, as a convenient physical sensor substitute for certain problems and environments. We demonstrate the effectiveness of virtual visual sensors as a means to achieve non-destructive evaluation. Major benefits of virtual visual sensors are its non-invasive nature, ease of installation and cost-effectiveness. The novelty of virtual visual sensors lies in the combination of marker extraction with visual tracking realised by modern computer vision algorithms. ...
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STUDY DESIGN.: An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation effect of a reporter or therapeutic gene expression by an oxygen-dependent degradation (ODD) domain in a... more
STUDY DESIGN.: An in vitro neural hypoxia model and rat spinal cord injury (SCI) model were used to assess the regulation effect of a reporter or therapeutic gene expression by an oxygen-dependent degradation (ODD) domain in a hypoxia-inducible gene expression system with or without the erythropoietin (EPO) enhancer. OBJECTIVE.: To increase vascular endothelial growth factor (VEGF) gene expression in SCI lesions but avoid unwanted overexpression of VEGF in normal sites, we developed a hypoxia-inducible gene expression system consisting of the EPO enhancer upstream of the SV promoter and an ODD domain C-terminally fused to VEGF. SUMMARY OF BACKGROUND DATA.: ODD domain plays a major role in the degradation of hypoxia-inducible factor 1alpha and has been used in a hypoxia-specific gene expression system as a post-translational regulatory factor. METHODS.: The hypoxia-inducible luciferase or VEGF plasmid was constructed using the EPO enhancer combined with or without the ODD domain. The constructed plasmid was transfected into mouse Neuro 2a (N2a) neuroblastoma cells by Lipofectamine 2000, followed by a 24-hour incubation in hypoxia or normoxia. For in vivo analysis, the naked plasmid DNA was directly injected into the injured rat spinal cord. The gene expression was evaluated by luciferase activity assay, enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, and immunofluorescence staining. RESULTS.: The EPO enhancer/ODD domain-combined hypoxia-inducible gene expression system clearly increased the expression of the reporter luciferase gene and therapeutic VEGF gene specifically under hypoxic conditions and SCI, and quickly downregulated protein expression to a very low level after reoxygenation. CONCLUSION.: These results strongly suggest the potential applicability of this EPO enhancer/ODD domain-based hypoxia-inducible gene expression system in the development of a safer and more effective VEGF gene therapy for SCI.
Research Interests: Biomedical Engineering, Molecular Biology, Gene Therapy, Medicine, Gene expression, and 15 moreAnoxia, Animals, Male, Luciferase, Neurons, Astrocytes, Clinical Sciences, Fluorescent Antibody Technique, Rats, Enhancer, Genetherapy, Enzyme Linked Immunosorbent Assay, Genetic Therapy, reverse transcriptase polymerase chain reaction, and Reporter gene
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Research Interests: Rheumatology, Immunology, Molecular Biology, Biology, Apoptosis, and 15 moreMedicine, Osteoarthritis, Humans, Nitriles, NF-kappa B, Clinical Sciences, Kinase, Public health systems and services research, Articular Cartilage Wear, Chondrocytes, Matrix Metalloproteinases, Knee Joint, Matrix Metalloproteinase, Interleukin, and reverse transcriptase polymerase chain reaction
There are few data available regarding the association between hallux valgus and pain or functional limitation. We determined the prevalence of hallux valgus in a rural Korean population aged between 40 and 69 years, and its association... more
There are few data available regarding the association between hallux valgus and pain or functional limitation. We determined the prevalence of hallux valgus in a rural Korean population aged between 40 and 69 years, and its association with pain and function. A total of 563 subjects was examined using the foot health status questionnaire, the Short Form-36 questionnaire and weight-bearing anteroposterior radiographs. Hallux valgus was present in 364 subjects (64.7%). It did not significantly correlate with age and was more common in women. Of the 364 subjects, 48 (13.2%) had moderate or greater deformity, defined as a hallux valgus angle > 25°. This was significantly associated with pain, worse function and worse foot health. The putative risk factors associated with painful hallux valgus were female gender, low educational attainment and the presence of pain in the knee.
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ABSTRACT During the last decades, many studies have been conducted on performing reliable prediction for high-dimensional data that are usually non-linearly correlated with complex patterns. In this paper, we propose a novel Bayesian... more
ABSTRACT During the last decades, many studies have been conducted on performing reliable prediction for high-dimensional data that are usually non-linearly correlated with complex patterns. In this paper, we propose a novel Bayesian regression method via non-linear dimensionality reduction. The method incorporates prior information on the underlying structure of original input features to preserve input–output patterns on reduced features, and to provide distributions of predicted values. To verify the effectiveness of the proposed method, we conducted simulations on benchmark and real-world data. Results showed that the method not only better predicts a distribution of forecast estimates compared with other methods, but also more robust and consistent performance on prediction.
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ABSTRACT The performances of the pretreatment facilities were analyzed on the basis of 5-week-long continuous experiments using sea water. The results confirmed that the newly constructed pretreatment equipment could be used for the... more
ABSTRACT The performances of the pretreatment facilities were analyzed on the basis of 5-week-long continuous experiments using sea water. The results confirmed that the newly constructed pretreatment equipment could be used for the pretreatment of sea water reverse osmosis as evidenced by silt density index 15 values below two for a long period and measured turbidities of about 0.4 NTU. The membrane fouling could be removed by using chemical enhanced backwash. Trans-membrane pressure and the permeability could be returned to the initial conditions. It reveals that UF membrane performances of the pretreatment were dependent on the sea water conditions and operating conditions.
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Research Interests: Engineering, Mechanical Engineering, Aerospace Engineering, Materials Science, Composite Materials and Structures, and 13 moreSmart Materials, Shape Memory Alloys, Smart Morphing Structures, Piezoelectric material, Composite Material, Shape Memory Alloy, Alloy, Aircraft, Bistability, Piezoelectricity, Design of Electronics, Actuators and Sensors, and Computational and Mathematical Modeling
Kim, HA, Betts, D., Giddings, P., Fong, YTT, Salo, A. and Bowen, C., 2010. Study of an arbitrary bistable composite laminates. Submitted to: 51st AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference, 12-15... more
Kim, HA, Betts, D., Giddings, P., Fong, YTT, Salo, A. and Bowen, C., 2010. Study of an arbitrary bistable composite laminates. Submitted to: 51st AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference, 12-15 April 2010, Orlando, Florida, USA. ... Kim, HA, Betts, D., Giddings, P., Fong, YTT, Salo, A. and Bowen, C.