- Endocrinology And Scienceedit
Research Interests: Endocrinology, Cardiovascular disease, Medicine, Cardiovascular Risk, Family history, and 15 moreInsulin Resistance, Internal Medicine, Insulin, First Degree Relatives, Homocysteine, Polycystic Ovary Syndrome, Cardiovascular Risk Factor, Oral Glucose Tolerance Test, Indexation, Area Under the Curve, Glucose Intolerance, Fasting Insulin, Glucose tolerance, Paediatrics and reproductive medicine, and Polycystic ovary
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- HLA-DR and DQ antigens positivity was searched in 27 patients with Hashimoto thyroiditis (HT) in and in 100 healthy control subjects. No significant difference was found at HLA-DR locus between HT patients and controls. However HLA-DQw3... more
- HLA-DR and DQ antigens positivity was searched in 27 patients with Hashimoto thyroiditis (HT) in and in 100 healthy control subjects. No significant difference was found at HLA-DR locus between HT patients and controls. However HLA-DQw3 antigen was found less frequent ...
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Introduction: Hashimoto's thyroiditis (HT) is common autoimmune thyroid disorder and is predominantly the clinical expression of cell-mediated immunity leading to destruction of thyroid cells. Vitamin D plays a role in the regulation... more
Introduction: Hashimoto's thyroiditis (HT) is common autoimmune thyroid disorder and is predominantly the clinical expression of cell-mediated immunity leading to destruction of thyroid cells. Vitamin D plays a role in the regulation of immunity and cell proliferation. So, do the serum levels ...
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Diphtheria is of great epidemiological concern. Although mainly observed during childhood, unvaccinated adults and relatively immunocompromised patients are at increased risk for acquiring diphtheria. We aimed to determine the rates and... more
Diphtheria is of great epidemiological concern. Although mainly observed during childhood, unvaccinated adults and relatively immunocompromised patients are at increased risk for acquiring diphtheria. We aimed to determine the rates and certain determinants of protection against diphtheria in adult hemodialysis (HD) patients. Protection rates of 322 HD patients were compared with 65 diabetes mellitus type 2 (DM) patients and 65 healthy controls. A questionnaire was held in regard to smoking habits and alcohol intake. Antibody levels against diphtheria were assessed by an in-house ELISA and a concentration of >or=0.1 IU/mL was regarded as protective. Effects of age, gender and time being on dialysis on protection were assessed by logistic regression. Ratios of individuals with protective antibody levels were found to be 36% (116/322), 27.7% (18/65), and 52.3% (34/65) for HD, DM, and control groups, respectively. Hemodialysis patients had a significantly (p < 0.05) lower protection rate than healthy controls. In all study groups, there was a tendency of higher protection rate with increasing age. These low ratios of protected individuals in both HD and DM patient groups are alarming, as these patients generally have defects in vaccine responses, and carriage is important in the perpetuation of diphtheria. The protection status of these patient groups might be improved with additional vaccinations.
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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in... more
In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a) General; b) Pharmacology; 9 Pathology: a) General; b) Cardiovascular; c) Neurological; d) Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (9 Weeks journals ‐ Search completed at 1st Aug 2001)
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Intracranial complications of pediatric sinusitis are rare but potentially life threatening. These complications include cavernous sinus thrombosis, orbital infection, meningitis, and subdural empyema. Children with these complications... more
Intracranial complications of pediatric sinusitis are rare but potentially life threatening. These complications include cavernous sinus thrombosis, orbital infection, meningitis, and subdural empyema. Children with these complications may experience significant morbidity from their infection. In such cases, delay in diagnosis and treatment may lead to severe brain damage or death. Emergency physicians, pediatricians, and otolaryngologists should maintain a high index of suspicion for this complication of disease when treating patients with sinusitis in the emergency department or outpatient clinic. Early and accurate diagnosis of subdural empyema will lead to prompt treatment and a favorable outcome for the patient. We report a case of subdural empyema secondary to frontal sinusitis in an otherwise healthy immunocompetent adolescent boy.
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The study aimed to examine leukocyte telomere length (LTL) and serum neuregulin-4 levels and their relationship with disease activity, co-morbidities and body fat distribution in female acromegaly patients. Forty female patients with... more
The study aimed to examine leukocyte telomere length (LTL) and serum neuregulin-4 levels and their relationship with disease activity, co-morbidities and body fat distribution in female acromegaly patients. Forty female patients with acromegaly and thirty-nine age and body mass index (BMI) similar healthy female volunteers were included in the study. Patients were classified into two groups: active acromegaly (AA) and controlled acromegaly (CA). The quantitative polymerase chain reaction (PCR) method was used to study LTL, and T/S ratio < 1 was accepted as shortened telomere length. Neuregulin-4 was studied by ELISA. There was no difference in median LTL between acromegaly and the control group (p = 0.530). The percentage of T/S < 1 in patients with acromegaly (60.0%) was similar to that of the control group (43.6%) (p = 0.144). However, serum neuregulin-4 was significantly higher in patients with acromegaly than those in the control group (p = 0.037). There were no significan...
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Bu calismanin amaci, Tip 2 Diyabetes Mellitus (T2DM) hastalarinda ayak taban duyusunun fonksiyonel ambulasyon duzeyi ile iliskisini incelemektir. Calismaya 38 T2DM hastasi (yas ort±ss=54,60±16,19 yil) ve 17 saglikli (yas... more
Bu calismanin amaci, Tip 2 Diyabetes Mellitus (T2DM) hastalarinda ayak taban duyusunun fonksiyonel ambulasyon duzeyi ile iliskisini incelemektir. Calismaya 38 T2DM hastasi (yas ort±ss=54,60±16,19 yil) ve 17 saglikli (yas ort±ss=52,35±8,25 yil) birey alindi. Bireylerin ayak tabani hafif dokunma-basinc esigi (Semmes-Weinstein monoflament) ve iki nokta ayrimi mesafesi (esteziometre) ayak tabaninin 6 farkli bolgesinden (basparmak, 1. metatars, 5. metatars, orta ayak mediali ve laterali, topuk) bilateral olarak degerlendirildi. Fonksiyonel ambulasyon duzeylerinin belirlenmesinde ise Sureli kalk ve yuru testi kullanildi. Saglikli kontroller ile karsilastirildiginda, T2DM hastalarinin hafif dokunma-basinc duyu esiginin ve iki nokta ayrimi mesafesinin anlamli derecede arttigi belirlendi (p<0,05). T2DM hastalarinda ayak tabani hafif dokunma-basinc duyu esigi (r=0,400-0,569, p<0,05) ve iki nokta ayrim mesafesi arttikca (r=0,329-0,414, p<0,05), fonksiyonel ambulasyon duzeyinin azaldi...
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Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes... more
Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes mellitus (T2DM).Materials and methods: Peripheral blood samples were obtained from 125 patients with T2DM and 112 healthy volunteers. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There were no statistically significant differences found between the allele and genotype frequencies of CAPN10 SNP-19, CAPN10 SNP-44, and NR3C1 N363S polymorphisms and T2DM development (P > 0.05). The CAPN10 SNP-19 del-allele, CAPN10 SNP-44 C-allele, and NR3C1 N363S G-allele were determined to be risk factors for T2DM development. In T2DM patients an association was identified between the CAPN10 SNP-19 del-allele, homozygous del/del genotype, SNP-44 C-allele, heterozygous TC genotype, NR3C1 N...
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Nasal mucociliary clearance has an important role in voiding the airways from inhaled foreign substances. This activity could be disturbed by environmental factors such as radiofrequency radiation. The aim of the present study was to... more
Nasal mucociliary clearance has an important role in voiding the airways from inhaled foreign substances. This activity could be disturbed by environmental factors such as radiofrequency radiation. The aim of the present study was to investigate short-term and relatively long-term effects of 2100-MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone, on the nasal septal mucosa and mucociliary clearance in rats. Thirty Wistar albino rats were divided into 4 groups. There were 6 rats in Group A and Group B, which served as the control groups (10-day and 40-day groups, respectively). Groups C (10-day exposure) and D (40-day exposure) were both composed of 9 rats; they comprised the radiofrequency radiation exposure groups. The rats in groups C and D were exposed to 2100-MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone, 6 hours/day, for 10 or 40 days, respectively. After exposure, nasal mucociliary clearance was measured by rh...
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Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder. Although its etiopathogenesis is obscure, there are many findings about the relationship between other autoimmune diseases and HT. The reason for this association is a... more
Hashimoto's thyroiditis (HT) is an autoimmune thyroid disorder. Although its etiopathogenesis is obscure, there are many findings about the relationship between other autoimmune diseases and HT. The reason for this association is a topic of interest, but in our study we searched for the concurrence of autoimmune hepatitis (AH) with HT, which is a relatively new autoimmune disorder for this association. Forty-six patients (44 female, 2 male) with HT were included in the study. Liver function tests, viral hepatitis markers, autoantibody panels, ultrasonography and liver biopsy were performed in certain cases. All patients were hepatitis B negative, only two patients were hepatitis C positive (4.3%). Smooth muscle antibody (SMA) was 21.7% positive, ANA was 26% positive, Anti-Liver kidney microsomal antibody-1 (LKM-1) was 13.4% positive. Anti-mitochondrial antibody (AMA) was not detected. Liver biopsy performed on six patients. Two of them had (+++) positive LKM-1 antibody titer, th...
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In this study, we aimed to investigate the effects of 1800 and 2100 MHz Radio Frequency (RF) radiation on the number of micronucleus (MN) in exfoliated bladder cells of rat which shows the genotoxic damage. Exposure period was 30 min/day,... more
In this study, we aimed to investigate the effects of 1800 and 2100 MHz Radio Frequency (RF) radiation on the number of micronucleus (MN) in exfoliated bladder cells of rat which shows the genotoxic damage. Exposure period was 30 min/day, 6 days/week for a month and two months exposure periods. Thirty male wistar albino rats were used for five groups: Group I (n = 6): 1800 MHz RF exposed animals for one month, Group II (n = 6): 2100 MHz RF exposed animals for one month, Group III (n = 6): 2100 MHz RF exposed for two months, Group IV (n = 6): control group for one month, Group V (n = 6): control group for two months. Rats of the control groups were housed in their home cages during the entire experimental period without subjecting to any experimental manipulation. 1800 and 2100 MHz RF exposures did not result in any significant MN frequencies in rat bladder cells with respect to the control groups (p &gt; 0.05). There was no statistically significant difference between 2100 MHz RF exposed groups, either. Further studies are needed to demonstrate if there is any genotoxic effect, micronucleus formation in other tissues of rats.
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Research Interests: Medicine and Gynecology
Research Interests: Endocrinology, Biology, Medicine, Insulin Resistance, Humans, and 15 moreInternal Medicine, Blood Glucose, Female, Clinical Sciences, Polycystic Ovary Syndrome, Calpain, Pcos, Adult, Single Nucleotide Polymorphism, Androgen, Hirsutismus, Pcr Rflp, Androstenedione, Polycystic ovary, and dehydroepiandrosterone sulfate
Medullary thyroid carcinoma (MTC) frequently occurs in a sporadic form, but a substantial number of cases are hereditary and appear as part of the multiple endocrine neoplasia type 2 (MEN2) syndromes. Germline mutations in ret... more
Medullary thyroid carcinoma (MTC) frequently occurs in a sporadic form, but a substantial number of cases are hereditary and appear as part of the multiple endocrine neoplasia type 2 (MEN2) syndromes. Germline mutations in ret proto-oncogene have been shown to be the underlying cause of MEN2 syndromes. We carried out a multi-center study that aimed to perform mutational analysis of so called sporadic MTC patients. Fifty-six MTC patients verified by histopathologic examination were subjected to genetic analysis. Exon 10, 11, 13, 14, 15 and 16 of the ret gene were analyzed by DNA sequencing and restriction enzyme digestion method. Among 56 apparently sporadic MTC patients, we identified 6 (10.7%) ret germline mutation carriers. Three individuals carried mutations at codon 634 in exon 11, one at codon 618 in exon 10, and two at codon 804 in exon 14. Identification of the predisposition gene mutation has allowed DNA-based strategy for direct mutation detection in patients with apparently sporadic MTCs. A substantial number of patients with apparently sporadic MTC carried germline mutations and 50% of their first degree relatives are expected to have or to develop MTC and/or other endocrine tumors. These results indicate the importance of careful genetic surveillance of any patient with apparently sporadic MTCs.
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Research Interests: Medicine and Gynecology
The aim of this study was to investigate the relationship of alpha1-acid glycoprotein (AGP, orosomucoid), which is an acute-phase reactant, in patients with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM), with the metabolic parameters... more
The aim of this study was to investigate the relationship of alpha1-acid glycoprotein (AGP, orosomucoid), which is an acute-phase reactant, in patients with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM), with the metabolic parameters and complications of diabetes mellitus. A total of 119 diabetic patients (89 T2DM, 30 T1DM) and 33 healthy controls were included in the study. The mean AGP level in the diabetic group was not different from the control group (82.4 +/- 28.9 and 81.6 +/- 16.6 mg/dl, respectively), but it was higher in T2DM than in T1DM subjects (86.6 +/- 28.3 and 69.7 +/- 26.9, respectively). AGP plasma levels showed a significant correlation with age and body mass index (r = +0.348 and r = +0.296, respectively). AGP plasma levels resulted higher in obese diabetic patients (97.7 +/- 28.0) than in non-obese diabetic patients (77.6 +/- 28.7 mg/dl) and controls (81.6 +/- 16.6), and also higher in diabetic subjects with poor glycaemic control (85.1 +/- 33.3 mg/dl) than in diabetic subjects with optimal glycaemic control (79.5 +/- 23.1 mg/dl). A relationship between AGP and macro- and microvascular complications of diabetes mellitus was not found. In conclusion, inflammatory findings were more prominent in obese diabetic patients.
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This study was designed to examine the relationship between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and insulin resistance (IR) in first-degree relatives of subjects with... more
This study was designed to examine the relationship between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and insulin resistance (IR) in first-degree relatives of subjects with polycystic ovary syndrome (PCOS). One hundred and twenty family members of 55 patients with PCOS and 80 unrelated healthy control subjects without a family history of diabetes or PCOS were studied. IR was assessed by homeostatic model assessment (HOMA-IR) and area under the curve (AUC) for insulin during an oral glucose tolerance test in subjects with normal glucose tolerance and controls. Genetic analysis of the PPAR-gamma gene Pro12Ala polymorphism was performed by restriction fragment length polymorphism. Fasting insulin, HOMA-IR and AUC insulin were significantly higher in first-degree relatives of PCOS subjects than in controls. A significantly different allele distribution of the Pro12Ala polymorphism of PPAR-gamma was observed between the two groups, with the frequency of the variant Ala isoform being significantly reduced in the first-degree relatives of PCOS subjects (10.8%, 13 subjects) compared with the control group (22.5%, 18 subjects). All Pro12Ala polymorphisms of the PPAR-gamma gene were heterozygous. Compared with first-degree relatives of PCOS subjects with the Pro12Pro polymorphism of PPAR-gamma, first-degree relatives of PCOS subjects with the Pro12Ala polymorphism had low fasting insulin, HOMA-IR and AUC insulin levels. The combined prevalence rate for impaired glucose tolerance, impaired fasting glucose and diabetes was 40% (16 subjects) in mothers and 52% (20 subjects) in fathers of PCOS women. Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.
Research Interests: Endocrinology, Family, Biology, Adolescent, Insulin Resistance, and 15 moreHumans, Internal Medicine, Insulin, Fasting, Diabetes mellitus, Female, First Degree Relatives, Body Mass Index, Homeostasis, Adult, Glucose Tolerance Test, Gynecological Diseases, Glucose Intolerance, alleles, and Gene frequency
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The study was designed to examine serum IL-18 level and its relation to metabolic control parameters and microvascular complications in type 1 diabetes mellitus (DM). Sixty two patients with type 1 DM and 30 healthy individuals were... more
The study was designed to examine serum IL-18 level and its relation to metabolic control parameters and microvascular complications in type 1 diabetes mellitus (DM). Sixty two patients with type 1 DM and 30 healthy individuals were enrolled in the study. Serum IL-18 levels of patients with type 1 DM were significantly increased compared to controls (293.4+/-133.4 vs 211.2+/-63.9 pg/ml, P=0.003). Patients with poor glycemic control had higher levels of IL-18 than patients with well glycemic control (329.9+/-141.0 vs 226.3+/-89.6 pg/ml, P=0.02). There was no significant difference between the serum IL-18 levels of patients with microvascular complications and those of patients without microvascular complications (307.6+/-127.6 vs 293.2+/-145.6 pg/ml, P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05). IL-18 correlated positively with HbA(1c) (r=0.32, P=0.01) and postprandial blood glucose (PPBG) (r=0.26, P=0.02); and negatively with HDL-cholesterol (HDL-C) (r=-0.38, P=0.007). By linear regression analysis, PPBG was determined as the most explanatory parameter for the alterations in serum IL-18 levels (P=0.02). High levels of IL-18 in patients with type 1 DM is related to short and long term glycemic control and HDL-C levels but not to microvascular complications.
Research Interests: Immunology, Gastroenterology, Microcirculation, Medicine, Humans, and 15 moreInternal Medicine, Blood Glucose, Diabetes mellitus, Diabetic Retinopathy, Female, Male, IL, Cytokine, Adult, Glycemic Control, Linear Regression, Metabolic control, Interleukin, Diabetic Neuropathies, and Diabetic nephropathies
Background and Objective: Recent studies have revealed that circulating ghrelin levels seem to play a role in energy homeostasis. The effect of hyperthyroidism on ghrelin levels is not fully known. Methods: Serum levels of ghrelin and its... more
Background and Objective: Recent studies have revealed that circulating ghrelin levels seem to play a role in energy homeostasis. The effect of hyperthyroidism on ghrelin levels is not fully known. Methods: Serum levels of ghrelin and its relationship with insulin resistance were evaluated in 48 patients with hyperthyroidism and 43 euthyroid healthy controls. Thyroid hormones, insulin, glucose, ghrelin levels and lipid parameters were measured in all subjects. Insulin sensitivity was determined using the homeostasis model assessment. Results: Serum ghrelin levels were significantly decreased in hyperthyroid patients than in controls (32.5 ± 23.3 vs. 54.1 ± 35.5 pg/ml, p &lt; 0.001). Circulating ghrelin levels significantly correlated with age (r = –0.26, p = 0.01), fasting glucose (r = –0.21, p = 0.01), free triiodothyronine (r = –0.18, p = 0.04), free thyroxine (r = –0.23, p = 0.02) and thyroid stimulating hormone (r = 0.21, p = 0.04), but not with blood pressure, body mass index, lipid parameters, insulin and homeostasis model assessment (p &gt; 0.05). Multiple regression analysis revealed glucose level to be the most important predictor of circulating ghrelin level. Conclusion: These results indicate that hyperthyroidism has effect on serum ghrelin levels. Further studies are needed for the exact mechanism.
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The purpose of this study was to evaluate insulin sensitivity, beta-cell function and islet-cell-directed autoimmunity in pregnant women with normal glucose tolerance and gestational diabetes mellitus (GDM). A total of 21 women with... more
The purpose of this study was to evaluate insulin sensitivity, beta-cell function and islet-cell-directed autoimmunity in pregnant women with normal glucose tolerance and gestational diabetes mellitus (GDM). A total of 21 women with normal glucose tolerance and 21 women with GDM were evaluated at 24-36 weeks&#39; gestation. Insulin resistance and beta-cell function were evaluated using the continuous infusion of glucose with model assessment (CIGMA) method, which aims to give a near-physiological stimulus and to evaluate the endogenous insulin and glucose response. Islet-cell autoantibody was positive in one woman with GDM, and glutamic acid decarboxylase autoantibodies were negative in both groups. The calculated CIGMA insulin resistance (CIGMA IR) was 2.04 +/- 1.74 and 1.08 +/- 1.22 in patients with GDM and in control subjects, respectively (p &lt; 0.05). CIGMA percentage beta-cell values were 64.04 +/- 44.55% and 87.07 +/- 52.77% in patients with GDM and control subjects, respectively (p &gt; 0.05). Decreased insulin sensitivity in late pregnancy was more evident in lean GDM subjects with mild hyperglycemia who did not require insulin therapy, and beta-cell function was partially preserved in this group of patients.
Research Interests: Endocrinology, Autoimmunity, Insulin Resistance, Gestational diabetes, Humans, and 15 moreInternal Medicine, Insulin Sensitivity, Blood Glucose, Insulin, Insulin Secretion, Diabetes mellitus, Female, Body Mass Index, Adult, Gestational Age, Glucose Tolerance Test, Gestation, Autoantibodies, Glutamate decarboxylase, and gestational diabetes mellitus
Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each... more
Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM). In the present study we investigated levels of adiponectin and TNF-alpha and their relationships with each other and metabolic factors in women with gestational DM (GDM). Thirty-four pregnant women with GDM and 31 pregnant women with normal glucose tolerance (NGT) were included in the study. Plasma adiponectin levels were lower in GDM than in NGT (36.9 +/- 6.7 vs. 61.3 +/- 13.0 ng/ml, p = 0.028). Serum TNF-alpha levels were increased in GDM compared with NGT (20.5 +/- 2.4 vs. 14.0 +/- 1.5 pg/ml, p = 0.042). After adjustment for pre-pregnancy and current body mass index (BMI), adiponectin levels correlated negatively with insulin resistance by homeostasis model assessment-insulin resistance (HOMA-IR) and 0-h and 1-h glucose both at glucose challenge test and oral glucose tolerance test in GDM. Adiponectin levels were correlated only with very low-density lipoprotein cholesterol and triglyceride levels in NGT. TNF-alpha levels were correlated with glycated hemoglobin in GDM. There was a significant positive correlation between TNF-alpha levels and pre-pregnancy and current BMI in GDM as well as NGT. HOMA-IR for adiponectin and pre-pregnancy BMI for TNF-alpha remained as significant determinants in multiple regression analyses. In conclusion, these data suggest that reduced adiponectin and increased TNF-alpha may be involved in the pathogenesis of GDM.
Research Interests: Endocrinology, Medicine, Insulin Resistance, Gestational diabetes, Pregnancy, and 14 moreHumans, Internal Medicine, Female, Body Mass Index, Adiponectin, Adult, Tumor necrosis factor-alpha, Glucose Tolerance Test, Gynecological Diseases, Hemoglobins, Triglyceride, Tumor necrosis factor, Paediatrics and reproductive medicine, and gestational diabetes mellitus
Research Interests: Endocrinology, Family, Cardiovascular disease, Cardiovascular Risk, Family history, and 15 moreHuman, Blood Pressure, Female, First Degree Relatives, Homocysteine, Family Health, Adiponectin, Adult, Cardiovascular Risk Factor, Assessment Model, Cardiovascular Diseases, Area Under the Curve, Glucose Intolerance, Fasting Insulin, and Glucose tolerance
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Research Interests: Medicine and Dyslipidemia
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Loss of appetite affects one‐third of patients with CKD and is the leading cause of malnutrition in this population. Orexigenic Agouti‐related peptide (AgRP) with neuropeptide‐Y (NPY) and anorexigenic melanocyte‐stimulating hormone‐α... more
Loss of appetite affects one‐third of patients with CKD and is the leading cause of malnutrition in this population. Orexigenic Agouti‐related peptide (AgRP) with neuropeptide‐Y (NPY) and anorexigenic melanocyte‐stimulating hormone‐α (MSH‐α) with cocaine‐ and amphetamine‐regulated transcript (CART) are known to regulate appetite. In this study, we aimed to evaluate the levels of these peptides in CKD patients compared to healthy subjects and demonstrate the effects of dialysis treatment and erythropoiesis‐stimulating agent (ESA) therapy. The cross‐sectional study is composed of consecutive inclusion of 20 healthy individuals, 20 predialysis CKD patients, 20 HD, and 20 peritoneal dialysis (PD) patients. Exclusion criteria were an active infection, history of malignancy, hypo‐ or hyperthyroidism, and diabetes. Patients on dialysis had targeted Kt/Vs. Demographic features and BMIs of the four groups were similar. Levels of AgRP, NPY, AMSH, and CART were significantly different between ...
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ORCID number: Ibrahim Demirci 0000-0003-0498-3115; Cem Haymana 0000-0002-6866-2364; Serpil Salman 0000-0003-4867-3725; Ilker Tasci 0000-0002-0936-2476; Demet Corapcioglu 0000-0002-2103-9866; Ali Kirik 0000-0001-5129-4430; İlhan Yetkin... more
ORCID number: Ibrahim Demirci 0000-0003-0498-3115; Cem Haymana 0000-0002-6866-2364; Serpil Salman 0000-0003-4867-3725; Ilker Tasci 0000-0002-0936-2476; Demet Corapcioglu 0000-0002-2103-9866; Ali Kirik 0000-0001-5129-4430; İlhan Yetkin 0000-0001-8905-3771; Mustafa Altay 0000-0003-2074-4384; Tevfik Sabuncu 0000-0001-65045355; Fahri Bayram 0000-0002-96376744; Ilhan Satman 0000-0001-86131797; Alper Sonmez 0000-0002-93097715.
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Recent studies have indicated that polymorphisms of the interleukin-18 (IL-18) and interleukin- 12 (IL-12) genes are associated with the development of Type 1 diabetes mellitus (T1DM) in some populations, but not all. The present study... more
Recent studies have indicated that polymorphisms of the interleukin-18 (IL-18) and interleukin- 12 (IL-12) genes are associated with the development of Type 1 diabetes mellitus (T1DM) in some populations, but not all. The present study was designed to examine the roles of polymorphisms in the IL-18 promoter and IL-12p40 with respect to susceptibility to T1DM in Turkish patients. Ninety-one patients with T1DM and 87 unrelated healthy subjects were included in the study. The IL-18 polymorphisms at positions -607 and -137 were detected by a sequence-specific PCR method. The single nucleotide polymorphism in the IL-12p40 3&#39; untranslated region (3&#39;-UTR) at position +1188 was analyzed by the PCR-restriction fragment length polymorphism (RFPL) method. The allelic and genotypic frequencies of the IL-18 and IL-12p40 polymorphisms did not differ significantly between subjects with T1DM and the controls (p&gt;0.05). However, diabetic patients with the -137 (CC) genotype showed a younger onset age compared to patients with the -137 (GG) genotype (p=0.02). In addition, patients with the -607 (CC) genotype had higher levels of glycated hemoglobin (HbA1c) than patients with the -607 (AC) genotype (p=0.004). Furthermore, patients with the IL-12p40 (AC) genotype had higher HbA(1c) levels than patients with the IL-12p40 (AA) genotype (p=0.01). The results of the present study show that the IL- 18 and IL-12p40 polymorphisms may have some effect on the onset age and deterioration of glycemic control in Turkish patients with T1DM.
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Background The efficacy of dapagliflozin has been less extensively studied in the real-life context, limiting the comparability of observational real-world evidence with results from dapagliflozin clinical trials. This study aimed to... more
Background The efficacy of dapagliflozin has been less extensively studied in the real-life context, limiting the comparability of observational real-world evidence with results from dapagliflozin clinical trials. This study aimed to evaluate HbA1c, blood pressure (BP), and weight outcomes in dapagliflozin-treated patients with type 2 diabetes (T2D) treated in a real-world setting. Methods A total of 1683 T2D patients (mean (SD) age: 54.6 years (9.1), 56.6% were females) initiating dapagliflozin were included in this multicenter retrospective observational cohort study. Data on patient demographics, comorbidities, duration of diabetes, and concomitant antidiabetic treatment were recorded. Change in glycated hemoglobin (HbA1c), body weight, body mass index (BMI), and BP levels with dapagliflozin treatment and dapagliflozin discontinuation rates were evaluated based on baseline, 3rd-month, and 6th-month data. Results At the end of 6-month dapagliflozin treatment (discontinued in 4.3% of patients), HbA1c levels were ≤7% in 30.1% of patients, BP was ≤140/90 mmHg in 95.9% of patients, and >5% weight loss was evident in 38.0% of patients. Less than 5-year diabetes duration was associated with significantly higher rate of achieving HbA1c ≤7% ( p = 0.032), BP ≤140/90 mmHg ( p = 0.001), and BP ≤130/80 mmHg ( p < 0.001) targets at the 6th month ( p = 0.032) as compared with longer diabetes duration. Conclusion In conclusion, this nationwide observational study in T2D patients treated with dapagliflozin in Turkey provided real-life evidence on significant and clinically meaningful reductions in HbA1c, body weight, and BP within 6-month therapy.