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Nowadays different parameters were developed as indicators of animal nutritional status to know the balance between the nutrient supply of the diet and the nutrient requirements of an animal. Assessment of nutritional and health status of... more
Nowadays different parameters were developed as indicators of
animal nutritional status to know the balance between the nutrient supply
of the diet and the nutrient requirements of an animal. Assessment of
nutritional and health status of animals is valuable in present-day animal
husbandry. Determination of the nutritional status of an animal is useful
in quantifying the extent to which animal are affected by nutrition, disease
or other environmental factors, especially where seasonal fluctuations
in the quantity and quality of forages occur, as is common in dry tropical
and subtropical areas. Few data are available that document the effect
of feeding tropical poor fed stuffs to animals based on their nutrition
status for better rumen fermentation and supporting to the animal
health and performance. This review focuses on indicating the correct
animal nutritional status assessment techniques for better utilization
of existing huge number of livestock by improving their reproductive
and productivities performance through better feeding. Determining the
specific nutrient inclusion in a diet is important to know its negative or
positive effect on other nutrients metabolism. This is impossible without
metabolite analysis. Therefore, the technique metabolite analysis is not
only valuable for animal nutrient status assessment but also for knowing
the interaction of nutrients effect on proper metabolism of animals. In
research, information of nutrient status of farm animals is important in
studies focusing on establishing requirement values for nutrients and
for evaluating the effects of different feeding strategies.
animal nutritional status to know the balance between the nutrient supply
of the diet and the nutrient requirements of an animal. Assessment of
nutritional and health status of animals is valuable in present-day animal
husbandry. Determination of the nutritional status of an animal is useful
in quantifying the extent to which animal are affected by nutrition, disease
or other environmental factors, especially where seasonal fluctuations
in the quantity and quality of forages occur, as is common in dry tropical
and subtropical areas. Few data are available that document the effect
of feeding tropical poor fed stuffs to animals based on their nutrition
status for better rumen fermentation and supporting to the animal
health and performance. This review focuses on indicating the correct
animal nutritional status assessment techniques for better utilization
of existing huge number of livestock by improving their reproductive
and productivities performance through better feeding. Determining the
specific nutrient inclusion in a diet is important to know its negative or
positive effect on other nutrients metabolism. This is impossible without
metabolite analysis. Therefore, the technique metabolite analysis is not
only valuable for animal nutrient status assessment but also for knowing
the interaction of nutrients effect on proper metabolism of animals. In
research, information of nutrient status of farm animals is important in
studies focusing on establishing requirement values for nutrients and
for evaluating the effects of different feeding strategies.
Research Interests:
Asthma is one of the chronic inflammatory disease. The prevalence of asthma in the world is increasing. Although there are good controller drugs major concern about the side effects still remains. The asthma prevalence and clinical... more
Asthma is one of the chronic inflammatory disease. The prevalence
of asthma in the world is increasing. Although there are good controller
drugs major concern about the side effects still remains. The asthma
prevalence and clinical features showed gender related differences. It
is not clearly known whether the difference is due to sex steroids or
the way the drug is used or even multifactorial causes. But what about
responses to treatment? Are same treatments have same responses in
two gender? To answer this question, we obtained this study to evaluate
the effect of gender in new herbal formulation in mild asthma patients.
we selected one of the ancient prescriptions from Persian Medicine.
The participants divided to three groups randomly. One group received
fenugreek syrup one received honey syrup and the third received sugar
syrup as placebo. Duration of treatment was four weeks. 90 patients
with mild asthma entered the study but only 79 completed the study
duration. This number included 49 women and 30 men. Asthma control
test, St. Gorge questioner, spirometry parameters and IL4 were checked
before and after the study. At the beginning of the study women had
lower scores in St. Gorge and ACT results but at the end of the study
St. Gorge scores improved in men more than women but it was not
statistically significant. There weren’t significant differences between
men and women in IL4 and spirometry results. although the significant
response in fenugreek and honey syrup groups exist, sex didn’t have
significant effect on asthma treatment in this study.
of asthma in the world is increasing. Although there are good controller
drugs major concern about the side effects still remains. The asthma
prevalence and clinical features showed gender related differences. It
is not clearly known whether the difference is due to sex steroids or
the way the drug is used or even multifactorial causes. But what about
responses to treatment? Are same treatments have same responses in
two gender? To answer this question, we obtained this study to evaluate
the effect of gender in new herbal formulation in mild asthma patients.
we selected one of the ancient prescriptions from Persian Medicine.
The participants divided to three groups randomly. One group received
fenugreek syrup one received honey syrup and the third received sugar
syrup as placebo. Duration of treatment was four weeks. 90 patients
with mild asthma entered the study but only 79 completed the study
duration. This number included 49 women and 30 men. Asthma control
test, St. Gorge questioner, spirometry parameters and IL4 were checked
before and after the study. At the beginning of the study women had
lower scores in St. Gorge and ACT results but at the end of the study
St. Gorge scores improved in men more than women but it was not
statistically significant. There weren’t significant differences between
men and women in IL4 and spirometry results. although the significant
response in fenugreek and honey syrup groups exist, sex didn’t have
significant effect on asthma treatment in this study.
Research Interests:
Research on anticancer drugs focuses on agents that induce cell death in cancer cells leaving healthy cells unaffected. Our previous findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has beneficial potential as an... more
Research on anticancer drugs focuses on agents that induce cell
death in cancer cells leaving healthy cells unaffected. Our previous
findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has
beneficial potential as an anti-proliferative and anticancer agent. The
aim of the study is to evaluate anticancer activity of LPG against Human
Rhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF-
7) cells. This study focused on the death of cancer cells induced by
LPG with minimum effects on healthy CC1 and to evaluate molecular
mechanisms.
The levels of GSH, NO, and caspase, DNA fragmentation and
changes in morphology characteristic to apoptosis were investigated
after treatment with LPG in RD and MCF-7 cancer cells. The results
were compared with CC1 cells. A significant dose dependent decrease
in protein synthesis and increase in NO levels were observed in both
cancer cell types compared to CC1 cells. The reduction of GSH content
and elevation of cell survival with exogenous GSH proved that the
LPG caused cell death via induction of oxidative stress. Increase in
caspase activity and DNA fragmentation were observed only in RD cells.
The MCF-7 cells did not show any features of apoptosis.
Thus, the present study provides evidence for that LPG stimulates
oxidative stress by decreasing the levels of cellular total GSH levels and
depletion of MMP in RD cells which in turn switching on the caspase
cascade leads to apoptosis. Furthermore, the results reflect that MCF-
7 induces cell death in caspase independent pathway and less toxicity
against CC1 cells by LPG.
death in cancer cells leaving healthy cells unaffected. Our previous
findings proved that a poly herbal formulation, Le Pana Guliya (LPG) has
beneficial potential as an anti-proliferative and anticancer agent. The
aim of the study is to evaluate anticancer activity of LPG against Human
Rhabdomyosarcoma (RD) and human breast adenocarcinoma (MCF-
7) cells. This study focused on the death of cancer cells induced by
LPG with minimum effects on healthy CC1 and to evaluate molecular
mechanisms.
The levels of GSH, NO, and caspase, DNA fragmentation and
changes in morphology characteristic to apoptosis were investigated
after treatment with LPG in RD and MCF-7 cancer cells. The results
were compared with CC1 cells. A significant dose dependent decrease
in protein synthesis and increase in NO levels were observed in both
cancer cell types compared to CC1 cells. The reduction of GSH content
and elevation of cell survival with exogenous GSH proved that the
LPG caused cell death via induction of oxidative stress. Increase in
caspase activity and DNA fragmentation were observed only in RD cells.
The MCF-7 cells did not show any features of apoptosis.
Thus, the present study provides evidence for that LPG stimulates
oxidative stress by decreasing the levels of cellular total GSH levels and
depletion of MMP in RD cells which in turn switching on the caspase
cascade leads to apoptosis. Furthermore, the results reflect that MCF-
7 induces cell death in caspase independent pathway and less toxicity
against CC1 cells by LPG.
Research Interests:
Endometriosis is a chronic estrogen-dependent and inflammatory disease that affects the pelvic peritoneum as well as the ovaries and is one of the most commonly diagnosed gynecological conditions in women. It represents a debilitating... more
Endometriosis is a chronic estrogen-dependent and inflammatory
disease that affects the pelvic peritoneum as well as the ovaries and
is one of the most commonly diagnosed gynecological conditions in
women. It represents a debilitating condition for females and is a
challenging and complex disease for clinicians. While conventional
treatments are used, there is an unmet medical need for improving
treatment outcomes in providing treatments that have a reduced
risk of undesirable side effects. The need for a successful integrative
approach towards treating endometriosis is growing. The purpose of
this review is to conduct and summarize concisely and systematically,
the biological pathways involved in endometriosis using available
scientific data relating to endometriosis. As well as to provide possible
therapeutic recommendations that are clinically and science-based
using nutraceuticals and homeopathic medicines.
disease that affects the pelvic peritoneum as well as the ovaries and
is one of the most commonly diagnosed gynecological conditions in
women. It represents a debilitating condition for females and is a
challenging and complex disease for clinicians. While conventional
treatments are used, there is an unmet medical need for improving
treatment outcomes in providing treatments that have a reduced
risk of undesirable side effects. The need for a successful integrative
approach towards treating endometriosis is growing. The purpose of
this review is to conduct and summarize concisely and systematically,
the biological pathways involved in endometriosis using available
scientific data relating to endometriosis. As well as to provide possible
therapeutic recommendations that are clinically and science-based
using nutraceuticals and homeopathic medicines.
Research Interests:
Grenada - WI - Woman - 50 years’ old She had been treating herself for 22 years in the same hospital she had been a nurse in before her car accident, in New York. She had 12 surgeries related to the accident in her right arm, for it was... more
Grenada - WI - Woman - 50 years’ old
She had been treating herself for 22 years in the same hospital she
had been a nurse in before her car accident, in New York. She had 12
surgeries related to the accident in her right arm, for it was frozen. She
couldn’t even comb her hair and had constant pain in her limbs, head
and shoulders. Another big issue was her insomnias as she was under
heavy medication for a period of 22 years.
She arrived at the clinic carried by 2 male helpers, as she couldn’t
walk.
She had been treating herself for 22 years in the same hospital she
had been a nurse in before her car accident, in New York. She had 12
surgeries related to the accident in her right arm, for it was frozen. She
couldn’t even comb her hair and had constant pain in her limbs, head
and shoulders. Another big issue was her insomnias as she was under
heavy medication for a period of 22 years.
She arrived at the clinic carried by 2 male helpers, as she couldn’t
walk.
Research Interests:
Pistacia atlantica Desf. is very responsive in the Mediterranean countries and has various uses. The chemical composition of the essential oil (EOs) obtained by hydro distillation of the leaves of Pistacia atlantica Desf. was analyzed by... more
Pistacia atlantica Desf. is very responsive in the Mediterranean
countries and has various uses. The chemical composition of the
essential oil (EOs) obtained by hydro distillation of the leaves of
Pistacia atlantica Desf. was analyzed by gas chromatography and
gas chromatography coupled with mass spectroscopy (GC and GC/
MS). Forty-one compounds were identified, representing 98.51%
of total oil. The major compounds were α-pinene (34.04%), (Z)-
caryophyllene (12.01%), β-pinene (8.68%), δ-cadinene (5.75%),
Eudesma-3, 7 (11)-diene (5.06%) and 1,8-Cineole (4.62%). The yield
and the physico-chemical properties were determined. The study
of herbicidal activity of the EOs tested on Sinapis arvensis, Phalaris
canariensis and Triticum durum, indicated that the oil completely
inhibited the seed germination at a high concentration, while at low
doses the oil acted by decreasing and delaying the germination and
inhibiting the seedling growth of all tested weeds. Moreover, results
of the antifungal activity study by in vitro contact assay showed that P.
atlantica oil significantly inhibited the growth of five plant pathogenic
fungi. Our results showed that P. atlantica EOs could be valorized
and used as bio-pesticides for biocontrol of weeds and fungal plant
diseases.
countries and has various uses. The chemical composition of the
essential oil (EOs) obtained by hydro distillation of the leaves of
Pistacia atlantica Desf. was analyzed by gas chromatography and
gas chromatography coupled with mass spectroscopy (GC and GC/
MS). Forty-one compounds were identified, representing 98.51%
of total oil. The major compounds were α-pinene (34.04%), (Z)-
caryophyllene (12.01%), β-pinene (8.68%), δ-cadinene (5.75%),
Eudesma-3, 7 (11)-diene (5.06%) and 1,8-Cineole (4.62%). The yield
and the physico-chemical properties were determined. The study
of herbicidal activity of the EOs tested on Sinapis arvensis, Phalaris
canariensis and Triticum durum, indicated that the oil completely
inhibited the seed germination at a high concentration, while at low
doses the oil acted by decreasing and delaying the germination and
inhibiting the seedling growth of all tested weeds. Moreover, results
of the antifungal activity study by in vitro contact assay showed that P.
atlantica oil significantly inhibited the growth of five plant pathogenic
fungi. Our results showed that P. atlantica EOs could be valorized
and used as bio-pesticides for biocontrol of weeds and fungal plant
diseases.
Research Interests:
Background: Malaria anemia is a major public health problem and is the leading cause of death in sub-Saharan Africa, particularly in Togo. The recipes used in the traditional treatment of malaria resort to different combinations of plants... more
Background: Malaria anemia is a major public health problem and
is the leading cause of death in sub-Saharan Africa, particularly in
Togo. The recipes used in the traditional treatment of malaria resort
to different combinations of plants with anti-plasmodial, antipyretic,
analgesic and anti-anemic properties. Anti-anemic plants are poorly
documented in Togo. Aim of the study: The objective of this work was to
record the plants species used to treat malaria anemia in the Maritime
Region of Togo. Materials and Methods: Two complementary methods
of ethnopharmacological investigation were used: The Triplet Purchase
of Medicinal Recipes (ATRM) applied in 17 sales markets and the Semi
Structured Interview (SSI) conducted with traditional healers in the
study area. Results: In total, 206 recipes including 102 from 34 market
herbalists and 104 from 54 traditional healers were obtained. These
recipes are composed of 75 plant species. They belong to 37 botanical
families, of which the most represented are Fabaceae, Malvaceae,
Anacardiaceae, Annonaceae, Bignoniaceae and Euphorbiaceae. The
most cited species were Lannea kerstingii (39.32%), Sorghum caudatum
var. colorans (32.04%), Indigofera pulchra (16.50%), Uvaria chamae
(16.02%), Jatropha gossipifolia (15.04%), Cymbopogon citratus (13.59%),
Khaya senegalensis (12.62%)%), Hibiscus surattensis (10.19%).
Indigofera pulchra, Lannea kerstingii, Manihot esculenta and Occimum
gratissimum were selected for future laboratory tests. Conclusion: The
current results revealed that Togolese traditional medicine has various
plants species that could be used to produce improved traditional
medicines for an effective management of malaria anemia.
is the leading cause of death in sub-Saharan Africa, particularly in
Togo. The recipes used in the traditional treatment of malaria resort
to different combinations of plants with anti-plasmodial, antipyretic,
analgesic and anti-anemic properties. Anti-anemic plants are poorly
documented in Togo. Aim of the study: The objective of this work was to
record the plants species used to treat malaria anemia in the Maritime
Region of Togo. Materials and Methods: Two complementary methods
of ethnopharmacological investigation were used: The Triplet Purchase
of Medicinal Recipes (ATRM) applied in 17 sales markets and the Semi
Structured Interview (SSI) conducted with traditional healers in the
study area. Results: In total, 206 recipes including 102 from 34 market
herbalists and 104 from 54 traditional healers were obtained. These
recipes are composed of 75 plant species. They belong to 37 botanical
families, of which the most represented are Fabaceae, Malvaceae,
Anacardiaceae, Annonaceae, Bignoniaceae and Euphorbiaceae. The
most cited species were Lannea kerstingii (39.32%), Sorghum caudatum
var. colorans (32.04%), Indigofera pulchra (16.50%), Uvaria chamae
(16.02%), Jatropha gossipifolia (15.04%), Cymbopogon citratus (13.59%),
Khaya senegalensis (12.62%)%), Hibiscus surattensis (10.19%).
Indigofera pulchra, Lannea kerstingii, Manihot esculenta and Occimum
gratissimum were selected for future laboratory tests. Conclusion: The
current results revealed that Togolese traditional medicine has various
plants species that could be used to produce improved traditional
medicines for an effective management of malaria anemia.
Research Interests:
Food is an instinctive need but since nowadays science has proceeded a lot, we should eat according rules based on the food features. For these reasons, i would like to describe some foods to learn eating better, to empower. I will... more
Food is an instinctive need but since nowadays science has proceeded
a lot, we should eat according rules based on the food features. For these
reasons, i would like to describe some foods to learn eating better, to
empower. I will describe rich in tyrosine foods, negative calories foods,
mediterrenean diet, then coffee tea, stevia, chocolate. In this way we can
eat better in quality and quantity and lead an healthier and happier life.
a lot, we should eat according rules based on the food features. For these
reasons, i would like to describe some foods to learn eating better, to
empower. I will describe rich in tyrosine foods, negative calories foods,
mediterrenean diet, then coffee tea, stevia, chocolate. In this way we can
eat better in quality and quantity and lead an healthier and happier life.
Research Interests:
Healthcare delivery is transitioning away from a volume-based reimbursement model to an efficiency-and-quality-oriented model. The balance between high quality, evidence-based and value-based care is posing a challenge for healthcare... more
Healthcare delivery is transitioning away from a volume-based
reimbursement model to an efficiency-and-quality-oriented model.
The balance between high quality, evidence-based and value-based
care is posing a challenge for healthcare systems. Reducing the risk of
patient harm during the process of healthcare delivery is at the forefront
of policy and practice. The present health care model is in a political,
financial and social crisis. Personalized and Precision Medicine (PPM)
offers an opportunity to reframe and reassess the control over patient
morbidity, mortality and disabling outcome rates as well as significantly
optimize the cost and efficacy of treatment for those who have fallen ill.
PPM is a new model of healthcare services that illustrates how we can
apply new sets of thinking for the population, community, and individual
citizen.
reimbursement model to an efficiency-and-quality-oriented model.
The balance between high quality, evidence-based and value-based
care is posing a challenge for healthcare systems. Reducing the risk of
patient harm during the process of healthcare delivery is at the forefront
of policy and practice. The present health care model is in a political,
financial and social crisis. Personalized and Precision Medicine (PPM)
offers an opportunity to reframe and reassess the control over patient
morbidity, mortality and disabling outcome rates as well as significantly
optimize the cost and efficacy of treatment for those who have fallen ill.
PPM is a new model of healthcare services that illustrates how we can
apply new sets of thinking for the population, community, and individual
citizen.
Research Interests:
Metastases to the paranasal sinuses and anterior cranial base are rarely found; among them, Renal Cell Carcinoma (RCC) is the most common cancer to metastasize to this region with almost 21 cases of ethmoid metastases reported. We present... more
Metastases to the paranasal sinuses and anterior cranial base are
rarely found; among them, Renal Cell Carcinoma (RCC) is the most
common cancer to metastasize to this region with almost 21 cases
of ethmoid metastases reported. We present a 63-year-old female
patient with a previous history of right nephrectomy for clear cell
renal carcinoma 9 years ago and surgery for thyroid metastases 3
years ago. She suffered a 9-month history of a nasal obstruction and
recurrent massive spontaneous epistaxis. Computed Tomography (CT)
revealed a well-circumscribed 5.2 × 4.9 cm isodense tumor with avid
contrast enhancement and some necrotic zones in the right ethmoid and
maxillary sinuses, extended in to the orbital apex and anterior cranial
base invasion. A left external carotid ligature was performed in order to
reduce the blood flow of the lesion and them an endonasal endoscopic
approach extended to the anterior cranial base and right orbit was
performed. Histological findings confirmed a clear cell renal carcinoma
metastases. Unless anterior cranial base RCC metastases are unusual
might be considered in any vascularized tumor of the region with severe
epistaxis, with or without history of renal cancer. Preoperative ligature/
embolization of external carotid/maxillary artery can diminish the blood
flow and facilitate the tumor resection. Endonasal endoscopic surgery
constitutes a good option with minimal morbidity and faster recovery
facilitating early adjuvant treatment.
rarely found; among them, Renal Cell Carcinoma (RCC) is the most
common cancer to metastasize to this region with almost 21 cases
of ethmoid metastases reported. We present a 63-year-old female
patient with a previous history of right nephrectomy for clear cell
renal carcinoma 9 years ago and surgery for thyroid metastases 3
years ago. She suffered a 9-month history of a nasal obstruction and
recurrent massive spontaneous epistaxis. Computed Tomography (CT)
revealed a well-circumscribed 5.2 × 4.9 cm isodense tumor with avid
contrast enhancement and some necrotic zones in the right ethmoid and
maxillary sinuses, extended in to the orbital apex and anterior cranial
base invasion. A left external carotid ligature was performed in order to
reduce the blood flow of the lesion and them an endonasal endoscopic
approach extended to the anterior cranial base and right orbit was
performed. Histological findings confirmed a clear cell renal carcinoma
metastases. Unless anterior cranial base RCC metastases are unusual
might be considered in any vascularized tumor of the region with severe
epistaxis, with or without history of renal cancer. Preoperative ligature/
embolization of external carotid/maxillary artery can diminish the blood
flow and facilitate the tumor resection. Endonasal endoscopic surgery
constitutes a good option with minimal morbidity and faster recovery
facilitating early adjuvant treatment.
Research Interests:
Background: Repair of the inguinal hernia either laparoscopic or open repair is one of the most common procedures worldwide. Prosthetic mesh for repair of inguinal hernia is widely used, it decreases the rate of recurrence, and however,... more
Background: Repair of the inguinal hernia either laparoscopic
or open repair is one of the most common procedures worldwide.
Prosthetic mesh for repair of inguinal hernia is widely used, it decreases
the rate of recurrence, and however, infection of the mesh remains
one of the challenging surgical management. Definitive treatment of
infected mesh is removal of the infected mesh; posterior inguinal wall
is reinforced using cremasteric apparatus; which is used as autogenous
flap reconstruction for posterior inguinal wall.
Patients and methods: Twelve patients were included in the study,
between January 2014 to January 2018. Those patients with refractory
mesh infection after open repair of inguinal hernia, with either a sinus
discharging pus or exposed mesh.
Results: All twelve patients (100%) recruited in our study get rid of
their infection. Eleven patients (91%) had no recurrence after 3 years
follow up, while one patient (0.08%) had recurrence after 2 months;
which was supra vesicasl type of inguinal hernia. Operative time was
70 ± 10 minutes, bleeding was minimal and no major complication was
recorded.
Conclusion: Infected mesh removal and reinforcement of the
posterior inguinal wall by cremasteric apparatus as autogenous flap is
a safe and effective one step surgical treatment for infected mesh post
repair of inguinal hernia.
or open repair is one of the most common procedures worldwide.
Prosthetic mesh for repair of inguinal hernia is widely used, it decreases
the rate of recurrence, and however, infection of the mesh remains
one of the challenging surgical management. Definitive treatment of
infected mesh is removal of the infected mesh; posterior inguinal wall
is reinforced using cremasteric apparatus; which is used as autogenous
flap reconstruction for posterior inguinal wall.
Patients and methods: Twelve patients were included in the study,
between January 2014 to January 2018. Those patients with refractory
mesh infection after open repair of inguinal hernia, with either a sinus
discharging pus or exposed mesh.
Results: All twelve patients (100%) recruited in our study get rid of
their infection. Eleven patients (91%) had no recurrence after 3 years
follow up, while one patient (0.08%) had recurrence after 2 months;
which was supra vesicasl type of inguinal hernia. Operative time was
70 ± 10 minutes, bleeding was minimal and no major complication was
recorded.
Conclusion: Infected mesh removal and reinforcement of the
posterior inguinal wall by cremasteric apparatus as autogenous flap is
a safe and effective one step surgical treatment for infected mesh post
repair of inguinal hernia.
Research Interests:
Laparoscopic revolution made inguinal hernioplasty a topic of intense study again. Most crucial step in laparoscopic total extraperitoneal preperitoneal (TEPP) repair is creation of an avascular preperitoneal space. Preperitoneal access... more
Laparoscopic revolution made inguinal hernioplasty a topic of intense
study again. Most crucial step in laparoscopic total extraperitoneal
preperitoneal (TEPP) repair is creation of an avascular preperitoneal
space. Preperitoneal access requires balloon dissection or telescopic
dissection with/without prior needle insufflation. Present study
prospectively evaluated sixty adult male patients undergoing TEPP
hernioplasty (N=65) for inguinal hernia (N=68). Standard 3-midlineport
technique with mainly direct telescopic dissection was utilized.
Patients were evenly distributed across the 3rd to 8th decade of life
and across their professional occupation. Mean patient age was 50.1
± 17.2 years with a range of 18-80 years, and their mean BMI was
22.6 ± 2.0 kg/m2 with a range of 19.3-31.2 kg/m2). There occurred
early conversion to open anterior repair (n=1), open preperitoneal
repair (n=1) and transabdominal laparoscopic repair (n=1). Access to
avascular preperitoneal plane was made at or just below the level of
the middle working port by surgically creating a transverse opening
either through transversalis fascia in presence of a classical incomplete
posterior rectus sheath with a primary Arcuate line (N=41), or through
both posterior rectus sheath and transversalis fascia in presence of a
complete posterior rectus sheath without a primary Arcuate line (N=14)
or a long incomplete posterior rectus sheath with a low primary Arcuate
line (N=10). No conversion was forced secondary to the so-called
difficult dissection, and there was no major complication. Unhurried
telescopic dissection provided accurate recognition of morphology
of posterior wall of posterior rectus canal for its judicious division,
invariably resulting in successful access to preperitoneal space for
joyful completion of TEPP repair, and the technique with all steps under
direct vision, the most fundamental principle of modern laparoscopy,
is strongly recommended. Sound understanding of variable multilayered
anatomy of preperitoneal access is essential for seamless TEPP
hernioplasty and widespread popularization.
study again. Most crucial step in laparoscopic total extraperitoneal
preperitoneal (TEPP) repair is creation of an avascular preperitoneal
space. Preperitoneal access requires balloon dissection or telescopic
dissection with/without prior needle insufflation. Present study
prospectively evaluated sixty adult male patients undergoing TEPP
hernioplasty (N=65) for inguinal hernia (N=68). Standard 3-midlineport
technique with mainly direct telescopic dissection was utilized.
Patients were evenly distributed across the 3rd to 8th decade of life
and across their professional occupation. Mean patient age was 50.1
± 17.2 years with a range of 18-80 years, and their mean BMI was
22.6 ± 2.0 kg/m2 with a range of 19.3-31.2 kg/m2). There occurred
early conversion to open anterior repair (n=1), open preperitoneal
repair (n=1) and transabdominal laparoscopic repair (n=1). Access to
avascular preperitoneal plane was made at or just below the level of
the middle working port by surgically creating a transverse opening
either through transversalis fascia in presence of a classical incomplete
posterior rectus sheath with a primary Arcuate line (N=41), or through
both posterior rectus sheath and transversalis fascia in presence of a
complete posterior rectus sheath without a primary Arcuate line (N=14)
or a long incomplete posterior rectus sheath with a low primary Arcuate
line (N=10). No conversion was forced secondary to the so-called
difficult dissection, and there was no major complication. Unhurried
telescopic dissection provided accurate recognition of morphology
of posterior wall of posterior rectus canal for its judicious division,
invariably resulting in successful access to preperitoneal space for
joyful completion of TEPP repair, and the technique with all steps under
direct vision, the most fundamental principle of modern laparoscopy,
is strongly recommended. Sound understanding of variable multilayered
anatomy of preperitoneal access is essential for seamless TEPP
hernioplasty and widespread popularization.
Research Interests:
Introduction: Different pancreatic pathologies, needs resection of pancreatic tissue. Adenocarcinoma of the pancreatic duct is the most frequently seen malignancy, presenting with early metastasis and seen as resistant to alternative... more
Introduction: Different pancreatic pathologies, needs resection of
pancreatic tissue. Adenocarcinoma of the pancreatic duct is the most
frequently seen malignancy, presenting with early metastasis and seen
as resistant to alternative treatment regimens currently available [1,2].
Management and handling of such tumors is a complex and challenging
task for a surgeon [1-3]. surgical resection offers improved prognosis,
with a median survival after resection of 14-20 months and up to 25%
5-year survival rates [4,5]. This study is aimed at presenting data of 75
pancreatic resections for various malignant pancreatic lesions.
Methods: This is an ongoing longitudinal study which started in 2009
at teaching institute in central India. Though we had 122 patients for
pancreatic resection, only 75 patients were considered suitable for the
present study. All patients after admission were thoroughly investigated
and then considered for surgery. 53 patients were male and 22 patients
were female. Age group was ranging from 34 to 67 years with mean age
between 46 to 56 yrs. Spectrum of various malignancies and different
types of pancreatic resections were done and results are presented in
this study.
Results: Pancreatic adenocarcinoma is one of the most aggressive
malignancy, responds to surgical treatment better than other alternative
modalities. In our series out of 75 patients 32 patients with pancreatic
head cancer, 28 patients with Periampullary cancer, 2 patients
with duodenal cancer, 8 patients with distal cholangio carcinoma, 1
patient with mucinous cystadenocarcinoma. 4 patients with body and
tail of pancreas cancer. Average age 34 to 67 years, 53 males and 22
females. Commonest procedure was Whipple’s operation, and distal
pancreatectomy. Survival in our series was 18 -24 months and 5-year
survival was 12 % that is seen mainly with Periampullary cancer.
Conclusion: Surgery is the only chance of cure or long term
survival in pancreatic cancer. Chemo radiation as a primary therapy is
ineffective. But some reports suggest the improved quality of life with
palliative chemotherapy. Biology of the disease is the king and dictates
the outcome, the type of surgical procedure had no impact on survival,
nor on morbidity and mortality.
pancreatic tissue. Adenocarcinoma of the pancreatic duct is the most
frequently seen malignancy, presenting with early metastasis and seen
as resistant to alternative treatment regimens currently available [1,2].
Management and handling of such tumors is a complex and challenging
task for a surgeon [1-3]. surgical resection offers improved prognosis,
with a median survival after resection of 14-20 months and up to 25%
5-year survival rates [4,5]. This study is aimed at presenting data of 75
pancreatic resections for various malignant pancreatic lesions.
Methods: This is an ongoing longitudinal study which started in 2009
at teaching institute in central India. Though we had 122 patients for
pancreatic resection, only 75 patients were considered suitable for the
present study. All patients after admission were thoroughly investigated
and then considered for surgery. 53 patients were male and 22 patients
were female. Age group was ranging from 34 to 67 years with mean age
between 46 to 56 yrs. Spectrum of various malignancies and different
types of pancreatic resections were done and results are presented in
this study.
Results: Pancreatic adenocarcinoma is one of the most aggressive
malignancy, responds to surgical treatment better than other alternative
modalities. In our series out of 75 patients 32 patients with pancreatic
head cancer, 28 patients with Periampullary cancer, 2 patients
with duodenal cancer, 8 patients with distal cholangio carcinoma, 1
patient with mucinous cystadenocarcinoma. 4 patients with body and
tail of pancreas cancer. Average age 34 to 67 years, 53 males and 22
females. Commonest procedure was Whipple’s operation, and distal
pancreatectomy. Survival in our series was 18 -24 months and 5-year
survival was 12 % that is seen mainly with Periampullary cancer.
Conclusion: Surgery is the only chance of cure or long term
survival in pancreatic cancer. Chemo radiation as a primary therapy is
ineffective. But some reports suggest the improved quality of life with
palliative chemotherapy. Biology of the disease is the king and dictates
the outcome, the type of surgical procedure had no impact on survival,
nor on morbidity and mortality.
Research Interests:
Meckel’s diverticulum is a congenital anomaly of the gastrointestinal tract, occurring in 2-3% of the population. It is generally asymptomatic and only manifests in a specific way when complications exist. The most common complications... more
Meckel’s diverticulum is a congenital anomaly of the gastrointestinal
tract, occurring in 2-3% of the population. It is generally asymptomatic
and only manifests in a specific way when complications exist. The
most common complications are obstruction of the small intestine,
hemorrhage from ectopic gastric ulceration and diverticulitis. An
unusual complication is entrapment of Meckel’s diverticulum in hernia,
known as Littre’s hernia representing 10% of all complications of
Meckel’s diverticulum. Clinically it is difficult to distinguish between
involvement of a small bowel loop and Meckel’s in an inguinal hernia
and accurate preoperative diagnosis is seldom made. Most of them are
clinically silent and often incidentally found during laparotomy or in an
inguinal incision. We present a case of strangulated inguinal hernia with
Meckel’s diverticulum as content and discussed the options of surgical
management of asymptomatic/incidentally detected diverticula.
tract, occurring in 2-3% of the population. It is generally asymptomatic
and only manifests in a specific way when complications exist. The
most common complications are obstruction of the small intestine,
hemorrhage from ectopic gastric ulceration and diverticulitis. An
unusual complication is entrapment of Meckel’s diverticulum in hernia,
known as Littre’s hernia representing 10% of all complications of
Meckel’s diverticulum. Clinically it is difficult to distinguish between
involvement of a small bowel loop and Meckel’s in an inguinal hernia
and accurate preoperative diagnosis is seldom made. Most of them are
clinically silent and often incidentally found during laparotomy or in an
inguinal incision. We present a case of strangulated inguinal hernia with
Meckel’s diverticulum as content and discussed the options of surgical
management of asymptomatic/incidentally detected diverticula.
Research Interests:
Background and purpose: Carcinosarcoma is an extremely rare biphasic tumor of oral cavity with both malignant epithelial & mesenchymal components. It has carcinomatous as well as specific differentiated sarcomatous elements with hallmarks... more
Background and purpose: Carcinosarcoma is an extremely
rare biphasic tumor of oral cavity with both malignant epithelial &
mesenchymal components. It has carcinomatous as well as specific
differentiated sarcomatous elements with hallmarks of malignancy.
Methodology: This is a prospective study of three patients admitted
in a tertiary care teaching institutions of Kolkata between June 2014 to
May 2015 with a histopathological diagnosis of carcinosarcoma of oral
cavity.
Result & Discussion: Age of patients varied between 42 to 68 years.
All patients were male and all of them had primary lesion within oral
cavity. All the patients had recurrence (one immediately after surgery
and two after radiotherapy) and were treated with palliative therapy.
Conclusion: Carcinosarcoma is a rare and aggressive neoplasm
with poor survival outcomes. The study concludes surgery as primary
modality of treatment and radiotherapy as adjuvant or palliative.
rare biphasic tumor of oral cavity with both malignant epithelial &
mesenchymal components. It has carcinomatous as well as specific
differentiated sarcomatous elements with hallmarks of malignancy.
Methodology: This is a prospective study of three patients admitted
in a tertiary care teaching institutions of Kolkata between June 2014 to
May 2015 with a histopathological diagnosis of carcinosarcoma of oral
cavity.
Result & Discussion: Age of patients varied between 42 to 68 years.
All patients were male and all of them had primary lesion within oral
cavity. All the patients had recurrence (one immediately after surgery
and two after radiotherapy) and were treated with palliative therapy.
Conclusion: Carcinosarcoma is a rare and aggressive neoplasm
with poor survival outcomes. The study concludes surgery as primary
modality of treatment and radiotherapy as adjuvant or palliative.
Research Interests:
Background: We described an operative surgical repair of abdominal aortic aneurysms in patients with Behçet’s disease followed by the application of an outer layer of the same used graft material wrapped around the vascular anastomoses in... more
Background: We described an operative surgical repair of abdominal
aortic aneurysms in patients with Behçet’s disease followed by the
application of an outer layer of the same used graft material wrapped
around the vascular anastomoses in combination with pre- and postoperative
immunosuppressive therapy to protect it from postoperative
pseudoaneurysm formation.
Methods: We retrospectively evaluated both the open surgical
repair of abdominal aortic aneurysms repair and immunosuppressive
medication as an adjuvant treatment in patients with Behçet’s disease,
during the period from January 2010 to December 2013. Patients’ data
were collected, and clinically evaluated. The imaging investigations,
the surgical procedure, graft selection, graft-related complications
were analyzed. Operative intervention was performed for symptomatic
patients, and patients with expanding aneurysms ≥ 5.5 cm. Those
patients who had having Behçet’s carotid aneurysms, patients with
thoraco-abdominal aortic aneurysms, patients with peripheral arterial
aneurysms and those patients with venous system involvement were
excluded from the study.
Results: Ten patients included in the study. There were 8 males and 2
females; the male-to-female ratio, (4:1) with the mean age of 34 ± 2 years
(range 25-40 years old). Nine out of 10 patients were presented with
concomitant infrarenal abdominal aortic aneurysms and bilateral iliac
artery aneurysms and the remaining patient presented with an isolated
infrarenal abdominal aortic aneurysm. Immunosuppressive therapy
was given pre- and post-operatively. Heparin-bonded synthetic Dacron®
Y-shaped graft was used for patients with concomitant abdominal aortic
and iliac aneurysms (n=9) and tube graft was used for the isolated
infrarenal abdominal aortic aneurysm (n=1). None of the postoperative
complications were observed especially, anastomotic pseudoaneurysm,
however, no other graft-related complications were observed after 2
years of follow up.
Conclusion: Surgical repair of abdominal aortic aneurysms in
patients with Behçet’s disease using the wrapping technique at the
site of vascular anastomoses as a prophylactic measure to prevent
postoperative pseudoaneurysm formation, in combination with
immunosuppressive therapy is feasible, safe and effective technique
associated with low morbidity and mortality.
aortic aneurysms in patients with Behçet’s disease followed by the
application of an outer layer of the same used graft material wrapped
around the vascular anastomoses in combination with pre- and postoperative
immunosuppressive therapy to protect it from postoperative
pseudoaneurysm formation.
Methods: We retrospectively evaluated both the open surgical
repair of abdominal aortic aneurysms repair and immunosuppressive
medication as an adjuvant treatment in patients with Behçet’s disease,
during the period from January 2010 to December 2013. Patients’ data
were collected, and clinically evaluated. The imaging investigations,
the surgical procedure, graft selection, graft-related complications
were analyzed. Operative intervention was performed for symptomatic
patients, and patients with expanding aneurysms ≥ 5.5 cm. Those
patients who had having Behçet’s carotid aneurysms, patients with
thoraco-abdominal aortic aneurysms, patients with peripheral arterial
aneurysms and those patients with venous system involvement were
excluded from the study.
Results: Ten patients included in the study. There were 8 males and 2
females; the male-to-female ratio, (4:1) with the mean age of 34 ± 2 years
(range 25-40 years old). Nine out of 10 patients were presented with
concomitant infrarenal abdominal aortic aneurysms and bilateral iliac
artery aneurysms and the remaining patient presented with an isolated
infrarenal abdominal aortic aneurysm. Immunosuppressive therapy
was given pre- and post-operatively. Heparin-bonded synthetic Dacron®
Y-shaped graft was used for patients with concomitant abdominal aortic
and iliac aneurysms (n=9) and tube graft was used for the isolated
infrarenal abdominal aortic aneurysm (n=1). None of the postoperative
complications were observed especially, anastomotic pseudoaneurysm,
however, no other graft-related complications were observed after 2
years of follow up.
Conclusion: Surgical repair of abdominal aortic aneurysms in
patients with Behçet’s disease using the wrapping technique at the
site of vascular anastomoses as a prophylactic measure to prevent
postoperative pseudoaneurysm formation, in combination with
immunosuppressive therapy is feasible, safe and effective technique
associated with low morbidity and mortality.
Research Interests:
A 46 years old Male was diagnosed with penis fracture due to sexual intercourse. A 72 years old Male was diagnosed as having a tumor on the upper pole of the femur.A 41 years old Female had a Cesarean section. All of them underwent spinal... more
A 46 years old Male was diagnosed with penis fracture due to sexual intercourse. A 72 years old Male was diagnosed as having a tumor on the upper pole of the femur.A 41 years old Female had a Cesarean section. All of them underwent spinal anesthesia for their operations. All of them underwent at the end of their operations Local anesthesia reversal (LAR) of Spinal anesthesia by Lipid Emulsion (Lipofundin 20%) using Bolus and Infusion. The local anesthesia reversal was started in approximately 3 minutes after starting the bolus injection and completed in approximately 30 minutes afterwards.This new modality of LAR can make a great change in the use of spinal anesthesia in day case surgery facilities.
Research Interests:
Local anesthesia reversal(LAR) is a new idea based on the history of Local Anesthetic Systemic Toxicity (LAST). If Intralipid and other specific Lipid emulsions can reverse the cardiac toxicity, why it cannot reverse other features... more
Local anesthesia reversal(LAR) is a new idea based on the history of Local Anesthetic Systemic Toxicity (LAST). If Intralipid and other specific Lipid emulsions can reverse the cardiac toxicity, why it cannot reverse other features connected to the local anesthesia toxicity?It is a very logical idea. The illogical issue is why it took almost 20 years from the first article on Intralipid and bupivacaine to invent it…? In our 3 cases the first patient " after finishing the lipofundin bolus injection after 4 mins (137 min after the brachial plexus block), she could move slightly her right finger.The patient could move her hand at 34 mins after the lipofundin bolus injection (166 mins after the brachial plexus block), and she could move her forearm 102 mins after the lipofundin bolus injection ". In the 2nd case " after 80-84 mins of the LE bolus injection (180 min after the brachial plexus block) the patient could move slightly his left thumb.After 184 mins since the lipid emulsion bolus injection (290 mins after the brachial block) the patient could move his hand and arm easily ". In the 3rd case " 85-87 mins after the LE bolus injection (220 min after the brachial plexus block), the patient could move slightly his arm. 128 mins after the lipid emulsion bolus injection (261 mins after the brachial plexus block), the patient could move his hand easily ". In all the 3 cases the reversal of the sensory and motor blocks were much faster than in the non-LAR cases as described in the medical literature. In that regards the LAR by Intralipid, Lipofundin and other similar lipid emulsions is a new method for postoperative care of patients after brachial plexus block. A 37 years old female was diagnosed an ununion radial bone. She performed a radial bone surgery on 1 st March 2018 at Military Hospital 103,Vietnam Military Medical University:http://www.csen.com/ upper4.JPG Patient was anesthetized by ultrasound guided brachial plexus block, upper clavicular approach with lidocaine 4 mg/kg combined with ropivacaine 1mg/kg and epinephrine 1/200.000 in a total volume of 30 ml.
Research Interests:
These 3 case reports are the first reports in the medical literature regarding the Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofundin which is similar to Intralipid having soybean oil fatty acids including... more
These 3 case reports are the first reports in the medical literature regarding the Local Anesthesia Reversal (LAR) of Total Spinal Anesthesia (TSA) by Lipofundin which is similar to Intralipid having soybean oil fatty acids including Linoleic acid. A 22 years old, 158 cm of height, 40 kg weight, female, was under Spinal Anesthesia for tibia reconstruction on the right leg. Past medical history was normal. The patient had a right tibia fracture, scheduled for tibia fixation.
Research Interests:
A 25 years old male was diagnosed as having natural stump in left forearm due to detonator. He needed an emergency surgery for cutting damaged tissue and repair of the stump. The patient was anesthetized by Ultrasound guided brachial... more
A 25 years old male was diagnosed as having natural stump in left forearm due to detonator. He needed an emergency surgery for cutting damaged tissue and repair of the stump. The patient was anesthetized by Ultrasound guided brachial plexus block through the Supra Clavicular approach with Lidocaine 4 mg/kg combined with Ropivacaine 1mg/kg and Epinephrine 1/200.000 in total of 30 ml solution. Lipid emulsion (Lipofundin 20%, B. Braun) bolus injection was given 70 min after the Brachial plexus block over 2 min in a dose of 1.5 mg/kg (patient's weight is 60 kg). After 2 min of the Lipid emulsion bolus injection he could move slightly his left arm. Full Local Anesthesia Reversal (LAR) was achieved after 255 min from the Brachial plexus block performance. It is the first case report in the medical literature of Local Anesthesia Reversal (LAR) of the upper arm Brachial plexus block by Lipid Emulsion. A 25 years old male was diagnosed as having natural stump in left forearm due to detonator. (Photo: http://www.csen.com/stump1.jpg) (X-ray: http://www.csen.com/stump2.jpg) He needed an emergency surgery for cutting damaged tissue and repair of the stump.The operation was done on Feb 16th, 2018 at the Military Hospital 103, Vietnam Military Medical University. The patient was anesthetized by Ultrasound guided brachial plexus block through the Supra Clavicular approach with Lidocaine 4 mg/kg combined with Ropivacaine 1mg/kg and Epinephrine 1/200.000 in total of 30 ml solution. • Onset time of Anesthesia: 5 min. • Anesthesia effect was very good for the surgery. • Duration of surgery: 50 min Surgery was accomplished in 65 min after the Brachial plexus block. Sensory and motor function of the left hand that were assessed before injection were absent completely. Lipid emulsion (Lipofundin 20%, B. Braun) bolus injection was given 70 min after the Brachial plexus block over 2 min in a dose of 1.5 mg/ kg (patient's weight is 60 kg). The patient was monitored closely in the
Research Interests:
Calcium, Aspirin, antihypertensive drugs and Magnesium sulfate are drug Interventions that are recommended for prevention or treatment of pre-eclampsia and eclampsia by WHO [20]. This article suggests a new intervention of using... more
Calcium, Aspirin, antihypertensive drugs and Magnesium sulfate are drug Interventions that are recommended for prevention or treatment of pre-eclampsia and eclampsia by WHO [20]. This article suggests a new intervention of using Intralipid (fat emulsion) as a sole treatment or combined with the current drugs. Intralipid is an emerging treatment for local anesthetic systemic toxicity as well as for other types of intoxications and it is also suggested for treatment in certain diseases. Intralipid treatment of Preeclamsia/Eclampsia is first suggested in the medical literature. Animal studies should be done in order to evaluate this new treatment modality.
Research Interests:
A 71-year-old woman was scheduled for total knee replacement on left side. Combined Spinal Epidural Anesthesia (CSEA) was performed at L3-4 and L2-3 separately and was technically uneventful. Epidural Anesthesia (EA) with levobupivacaine... more
A 71-year-old woman was scheduled for total knee replacement on left side. Combined Spinal Epidural Anesthesia (CSEA) was performed at L3-4 and L2-3 separately and was technically uneventful. Epidural Anesthesia (EA) with levobupivacaine 0.1%+fentanyl (2mcg/ml) was effective at 5 ml/h for postoperative analgesia. Eight hours post-op, she complained of having lost all feeling on the non-operative leg. On examination, she had diminished both touch sensory and motor power on the non-operative leg, but intact on the operative side with VAS at 2/10. Epidural catheter was receded 2 cm and the dose was lowered and paused. Despite of these adjustments after 4 hours, her experience was not improved. It was decided to use lipid emulsion as a challenging therapy. After completion of the lipid therapy, the sensory and movement of the non-operative leg regained normal after 60 min. The severe pain recurred which needed IV morphine titration. The EA of 2-5ml/h was recontinued and effective for pain control for 3 days without no incident. It is the first time in the medical literature that Lipid Emulsion is used for the purpose of LAR (Local Anesthesia Reversal) not connected to LAST (Local Anesthetic Systemic Toxicity). A 71-year-old woman was scheduled for total knee replacement on left side. Past medical history was hypertension, type 2 diabetes, bilateral degenerative knee pain. Combined Spinal Epidural Anesthesia (CSEA) was performed at L3-4 and L2-3 separately and was technically uneventful. Spinal Anesthesia (SA) with 10 mg bupivacaine 0.5% heavy+20mcg fentanyl was effective for surgery. Epidural Anesthesia (EA) with levobupivacaine 0.1%+fentanyl (2mcg/ml) was effective at 5ml/h for postoperative analgesia. She was sent back to ward after free movement of both knees. Eight hours post-op, she complained of having lost all feeling on the non-operative leg. On examination, she had diminished both touch sensory and motor power on the non-operative leg, but intact on the operative side with VAS at 2/10. After Local Anesthetic Systemic Toxicity (LAST) was ruled out, epidural catheter was receded 2cm and the dose was lowered and paused. Despite of these adjustments after 4 hours, her experience was not improved. It was decided to use lipid emulsion as a challenging therapy. A vial of 250ml of Lipidem 20% (B. Braun) was infused over 30 min as regimen in ASRA's checklist for treatment of LAST. After completion of the lipid therapy, the sensory and movement of the non-operative leg regained normal after 60min. The severe pain recurred which needed IV morphine titration. The EA of 2-5ml/h was recontinued and effective for pain control for 3 days without no incident.
Research Interests:
Multiple sclerosis is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. Trigeminal neuralgia involves loss of the myelin around the trigeminal nerve. Myelin is a phospholipid... more
Multiple sclerosis is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. Trigeminal neuralgia involves loss of the myelin around the trigeminal nerve. Myelin is a phospholipid membrane that wraps around axons to provide them with insulation. It is produced by Schwann cells in the PNS, and by oligodendrocytes in the CNS. Intralipid treatment is first suggested in the medical literature as a way for myelin sheath repair in multiple sclerosis and trigeminal neuralgia.
Research Interests:
Two case reports of myoclonus of legs post spinal anesthesia treated successfully by IV lipid emulsion are first described in the medical literature. A review of cases of myoclonus post regional anesthesia (spinal or epidural) are... more
Two case reports of myoclonus of legs post spinal anesthesia treated successfully by IV lipid emulsion are first described in the medical literature. A review of cases of myoclonus post regional anesthesia (spinal or epidural) are discussed with the hypothesis that the Lipid Emulsion effects are on the mitochondria and the intracellular calcium.
Research Interests:
One in every seven pregnancies ends with meconium-stained amniotic fluid (MSAF). MSAF can be harmful to the newborn with short and long-term sequelae. A new treatment of Intravenous Intralipid is first suggested for MSAF.
Research Interests:
This study examined the roles of care (ECEC) in supporting children, who receive home medical care, to use outpatient facilities through participation in play. Based on the results, one of the roles of ECEC may be parenting support,... more
This study examined the roles of care (ECEC) in supporting children, who receive home medical care, to use outpatient facilities through participation in play. Based on the results, one of the roles of ECEC may be parenting support, covering child development and the shift toward community-based care. In order to ensure children's right to play based on their own intrinsic motivation, it may be necessary to support their participation in play through collaboration with them from the perspective of the living.
Research Interests:
Tubal disease is the cause of female infertility in approximately 30% of women and 10-25% of these are due to proximal tubal obstruction. Selective salpingography represent an approach in the diagnosis and treatment of proximal tubal... more
Tubal disease is the cause of female infertility in approximately 30% of women and 10-25% of these are due to proximal tubal obstruction. Selective salpingography represent an approach in the diagnosis and treatment of proximal tubal abnormalities. Intralipid (IL) is a synthetic product composed of 10% soybean oil, 1,2% egg yolk phospholipids, 2.25% glycerin, and water. When indicated, IL is infused 7-10 days prior to embryo transfer (ET), Rates of ongoing pregnancy and live births were higher among women who underwent hysterosalpingography with oil contrast than among women who underwent this procedure with water contrast. It is the first time that intralipid-iodine is suggested to be used for hysterosalpingography in infertile women.
Research Interests:
The popularity of espresso coffee (EC) is based on the greater sensory satisfaction it gives to the consumer when compared with coffees prepared through alternative brewing methods. The quality of an EC is largely governed by the... more
The popularity of espresso coffee (EC) is based on the greater sensory satisfaction it gives to the consumer when compared with coffees prepared through alternative brewing methods. The quality of an EC is largely governed by the relationship between the extraction process and the controllable size distribution of the ground roast beans. This research presents an experimental study on two methods for measuring the particle size distribution. It was concluded that permeability of the water through the coffee is highly influenced by the ratio of grind sizes and fine tuning of the grind for EC extraction. Finally, the results demonstrate that there is variation in the precision control of particle size distribution due to damage and wear of the grinding burrs, and by monitoring this distribution a prediction of burr replacement can be made.
Research Interests:
The effect of high pressure treatment and conventional thermal processing on the various quality attributes of onion paste was studied. Thermal processing not only caused significant reduction (p<0.05) in enzyme activity and microbial... more
The effect of high pressure treatment and conventional thermal processing on the various quality attributes of onion paste was studied. Thermal processing not only caused significant reduction (p<0.05) in enzyme activity and microbial count, but also resulted in the significant (p<0.05) degradation of phytochemicals and antioxidant activity. At lower pressures, polyphenol oxidase and peroxidase were found to increase significantly (p<0.05), but they decreased at higher pressures; whereas, total phenolics, flavonoids and antioxidant activities showed a slight increasing trend due to high pressure processing. The CIE L* values decreased while a* and b* values were found to increase significantly (p<0.05) with increase in the pressure. The microbial counts in terms of total plate count, yeast and mold count as well as total coliform counts were also reduced significantly (p<0.05) with increase in pressure. High pressure processed samples were rated better as compared to thermal processed one in terms of sensory attributes.
Research Interests:
Probiotics including Lactobacillus, Bifidobacteria, Enterococcus, Streptococcus, Bacillus, Lactococcus and some yeasts are usually present in the human gastrointestinal tract, fermented milk and other dairy products, human faeces and... more
Probiotics including Lactobacillus, Bifidobacteria, Enterococcus, Streptococcus, Bacillus, Lactococcus and some yeasts are usually present in the human gastrointestinal tract, fermented milk and other dairy products, human faeces and breast milk. Source of strains and the ability to reach the target site in the gastrointestinal tract are important. Strains must be able to survive on different physiochemical, enzymatic and microbial stresses throughout the gastrointestinal transit before they can exhibit beneficial effects on the host's health. They can improve the intestinal microbial equilibrium and stimulate butyrate production, which promotes the growth of epithelial cells that lead to an increase in the thickness of the cecal and colonic mucosa for a better absorption of nutrients. They also produce a variety of metabolic end products with antagonistic properties against pathogens. These products include bactericidal proteins and antibiotic-like metabolites termed bacteriocins (such as nisin). The inhibitory spectra of several bacteriocins include food spoilage microorganisms and/or food-borne pathogens. Bacteriocins are considered to be safe natural preservatives or bio-preservatives because it is assumed that they can be degraded by the proteases present in the gastrointestinal tract. The joint working group of Food Aid Organization/World Health Organization made guidelines that can be used for assessing probiotics in food. The minimum requirements include assessment of strain identity and safety, and studies of health benefits in the target host. The continuous search for novel probiotics of importance in medical, industrial and agricultural environments is ongoing around the word. This review summarizes the current state of evaluation criteria for determining the candidacy of novel probiotics.
Research Interests:
The study was conducted to produce and characterize beer from Kodome Varity of sorghum. The sorghum was collected from Enderta which is located in southern part of Tigray, with complete randomization sampling technique. The beer was... more
The study was conducted to produce and characterize beer from Kodome Varity of sorghum. The sorghum was collected from Enderta which is located in southern part of Tigray, with complete randomization sampling technique. The beer was produced from sorghum grain with brewing process involves malting, mashing, wort boiling, fermentation and packaging. The gelatinization temperature of sorghum starch samples was determined and results ranged between 80 °C. The experimental design was designed using randomized block design to investigate the effects of temperature, time and pH on quality attributes bitterness of the product. The products were beer with and ort without caramel. Hence, the effects of process variables on finished beer were conducted such as pH, bitterness, color, polyphenols, alcohol content (v/v), and carbon dioxide (CO 2), Original extract (OE), density, real extract, alcohol (w/w), haze value, Ea (app extract), and Concentration of sugar. The results showed that 4.53, 9.854BU, 7.5EBC, 59.8272mg/L, 4.78%v/v, 3.803mg/L, 10.36%, 1.0049g/cm3, 2.92%w/w, 4.78%v/v, 0.165EBC, 2.15%w/w and 0.99 °brix respectively. Generally, the beer produced at grist malt size 0,2mm and mash temperature of 80 °C had great sensory acceptance. Finally, it can be concluded that the mash for 1.30 hrs. 250 gram of 0.2 mm size malt grist and 2000ml hot water at the end of the mashing add 4 g of hop and ferment then a flavored and tasty beer can drink and get all the nutritional values of sorghum.
Research Interests:
In the present work, chilling injury (CI) incidence and quality parameters were analyzed in peaches stored at 0 °C, 2 °C, 5 °C and 8 °C for 28 days, to evaluate the effects of four different temperatures on the keeping quality of 'Okubao'... more
In the present work, chilling injury (CI) incidence and quality parameters were analyzed in peaches stored at 0 °C, 2 °C, 5 °C and 8 °C for 28 days, to evaluate the effects of four different temperatures on the keeping quality of 'Okubao' peach. The extreme susceptibility of 'Okubao' peach to CI at 5 °C was confirmed by extensive woolliness and decay. Peaches stored at 5 °C develop noticeable CI symptom after one to two weeks, while significantly less woolliness occurred after storage 8 °C, the temperature at which the highest rate of decay was found. Minimum loss of weight and firmness, optimum sensory quality were obtained by the prolonged storage at 0 °C. 0 °C was the most effective treatment in alleviating chilling injury by controlling membrane permeability, inhibiting respiration rate and slowing down polyphenol oxidase (PPO) and peroxidase (POD) activities. Results indicated that fruit held at 0 °C can be stored for at least four weeks, and possibly five weeks without much injury.
Research Interests:
Fluorescence studies are one of the methods which can potentially be used for in situ monitoring cooking foods or off line understanding changes occurring during cooking process. Most of the time, fluorescence experiments are conducted... more
Fluorescence studies are one of the methods which can potentially be used for in situ monitoring cooking foods or off line understanding changes occurring during cooking process. Most of the time, fluorescence experiments are conducted using laboratory equipment like laser sources, monochromators and more or less integrated optical spectrometers. This allows developing classification algorithms based on various statistical analyzes. However, the use of laboratory equipment prohibits the direct transposition of fluorescence monitoring to application in industrial or domestic kitchens. In this communication, we present an in situ, integrated and low-cost fluorescence monitoring sensor based on synchronous detection of the auto-fluorescence emitted by several food products. Experiments were conducted with beef, chicken, veal, pork, trout, cod and salmon. Results show that the evolution of the emitted fluorescence can be used to assess the core temperature during the cooking process.
Research Interests:
At present time, the concentrates of juice produce by the separation of the water from fresh juice. For producing of the concentrates of juice is used one of the following methods: the evaporation either the freezing water or the... more
At present time, the concentrates of juice produce by the separation of the water from fresh juice. For producing of the concentrates of juice is used one of the following methods: the evaporation either the freezing water or the diaphragm method. In the evaporation method the juice is heated in the vacuum in the special trays, but this heat is not led to the boiling point, since during the process of boiling all useful substances will be destroyed. The mass, obtained after evaporation, is similar to more viscous the jam, to the honey or the thick syrup. The process of the freezing water completely repeats evaporation, with exception of temperature parameters. The water is moved away under the action of cold. In the diaphragm method the juices pass through the membrane with the smallest membrane 's holes. The water infiltrates, and the large molecules of other substances of juice remain. All these methods are connected with the high expenditures. The paper represents the use of a new developed method for producing of the concentrate of the juice, where the water was not moved away, but the water by itself provides the producing of the high concentrate of juice, which permits to produce of the high-quality concentrates by simple, fast and economically advantageous (it does not require the application of evaporation, freezing and membranes) method. Electric field influence on the water solutions, Hydrogen electrolysis gas bubbles.
Research Interests:
Today, grains, spices, nuts, breakfast cereals, dry fruits and vegetables, pasta, noodles, tea, dry herbal products, and other durable agricultural commodities are commonly stored in synthetic polythene bags. Fungi and insect infestations... more
Today, grains, spices, nuts, breakfast cereals, dry fruits and
vegetables, pasta, noodles, tea, dry herbal products, and other durable
agricultural commodities are commonly stored in synthetic polythene
bags. Fungi and insect infestations cause significant damage to the quality
of grains during storage and tend to speed up undesirable chemical
changes and accumulation of fugal toxins among stored crops and their
food products [1,2]. Therefore, quality deterioration of durable food
commodities is unavoidable under common package or storage systems. Physical control techniques such as high pressure, vacuum, controlled/modified atmospheres (CA/MA), radio frequency, microwave and high temperature have the advantages of being free of chemical residues, although there is variation in insect and fungal susceptibility to physical control techniques [3,4].
vegetables, pasta, noodles, tea, dry herbal products, and other durable
agricultural commodities are commonly stored in synthetic polythene
bags. Fungi and insect infestations cause significant damage to the quality
of grains during storage and tend to speed up undesirable chemical
changes and accumulation of fugal toxins among stored crops and their
food products [1,2]. Therefore, quality deterioration of durable food
commodities is unavoidable under common package or storage systems. Physical control techniques such as high pressure, vacuum, controlled/modified atmospheres (CA/MA), radio frequency, microwave and high temperature have the advantages of being free of chemical residues, although there is variation in insect and fungal susceptibility to physical control techniques [3,4].
Research Interests:
Cereals such as wheat and barley have always been a valuable source of food, for humans and animals. Wheat is mostly used as a raw material for the baking industry, although malting and brewing industries take up a significant portion of... more
Cereals such as wheat and barley have always been a valuable source
of food, for humans and animals. Wheat is mostly used as a raw material
for the baking industry, although malting and brewing industries take
up a significant portion of cereals production. These cereals are very
sensible towards Fusarium infections of cereals intended for malting.
Wheat and barley intended for malting have to fulfil strict limits and
recommendations on the quality of raw material used for malting and
brewing. Some of the main quality parameters for malt are: protein
content, β-glucan content, Kolbach index, malt extract, extract difference,
saccharification time, wort colour, viscosity, FAN (free amino nitrogen)
etc. [1]. Protein content is one of the most important parameters and
the ideal range is between 11-12% [2]. Protein content higher than
12% results in heighten soluble proteins content in wort, releasing
undesirable flavours in final beer. On the other hand, lower protein
content is correlated with low carbohydrate levels, lower extract values
[3], and may adversely affect the fermentation due to the poor amino
acid content available for yeast nutrition.
of food, for humans and animals. Wheat is mostly used as a raw material
for the baking industry, although malting and brewing industries take
up a significant portion of cereals production. These cereals are very
sensible towards Fusarium infections of cereals intended for malting.
Wheat and barley intended for malting have to fulfil strict limits and
recommendations on the quality of raw material used for malting and
brewing. Some of the main quality parameters for malt are: protein
content, β-glucan content, Kolbach index, malt extract, extract difference,
saccharification time, wort colour, viscosity, FAN (free amino nitrogen)
etc. [1]. Protein content is one of the most important parameters and
the ideal range is between 11-12% [2]. Protein content higher than
12% results in heighten soluble proteins content in wort, releasing
undesirable flavours in final beer. On the other hand, lower protein
content is correlated with low carbohydrate levels, lower extract values
[3], and may adversely affect the fermentation due to the poor amino
acid content available for yeast nutrition.
Research Interests:
The use of renewable energy sources is a fundamental factor for a possible energy policy in the future. Considering the sustainable character of most of renewable energy technologies, they are able to preserve resources and to provide... more
The use of renewable energy sources is a fundamental factor for a possible energy policy in the future. Considering the sustainable character of most of renewable energy technologies, they are able to preserve resources and to provide security, diversity of energy supply and services, virtually without environmental impact. Sustainability has acquired great importance due to the negative impact of various developments on environment. The rapid growth during the last decade has been accompanied by active construction, which in some instances neglected the impact on the environment and human activities. Policies to promote the rational use of electric energy and to preserve natural non-renewable resources are of paramount importance. Low energy design of urban environment and buildings in densely populated areas requires consideration of wide range of factors, including urban setting, transport planning, energy system design and architectural and engineering details. The focus of the world's attention on environmental issues in recent years has stimulated response in many countries, which have led to a closer examination of energy conservation strategies for conventional fossil fuels. One way of reducing building energy consumption is to design buildings, which are more economical in their use of energy for heating, lighting, cooling, ventilation and hot water supply. Consumption of the primary energy will be reduced by following natural or hybrid ventilation, some Passive measures compared to airconditioning. Fossil fuels dependency will be reduced by the utilization of renewable energy in agricultural greenhouses and buildings. Thus, promotion of the novel renewable applications and its fortification resulting in the preservation of the ecosystem. This will also contribute to the amelioration of environmental conditions by replacing conventional fuels with renewable energies that produce no air pollution or greenhouse gases. Present study described about various low energy building designs and explains the effects of dense urban building on energy consumption and in the climatic changes. Moreover, this study outlines some measures to save energy in buildings.