Entre diciembre 2006 y mayo 2007 se estudió la transmisión de un aislado del Tomato yellow leaf curl virus (TYLCV) por Bemisia tabaci a algunas especies de solanáceas cultivadas y silvestres para evaluarlas como posibles hospederas de... more
Entre diciembre 2006 y mayo 2007 se estudió la transmisión de un aislado del Tomato yellow leaf curl virus (TYLCV) por Bemisia tabaci a algunas especies de solanáceas cultivadas y silvestres para evaluarlas como posibles hospederas de dicho virus. Plantas de Solanum lycopersicum L., S. melongena L., S. hirtum Vahl, S. sisymbriifolium Lam., Datura stramonium L., D. inoxia Mill. Physalis angulata L. y P. ixocarpa Brot. se expusieron individualmente durante 48 horas a adultos de B. tabaci criados sobre plantas de tomate enfermas. Como control se utilizaron plantas de las mismas especies, expuestas a adultos criados sobre plantas de algodón libre del Begomovirus. Posteriormente, las plantas se mantuvieron dentro de jaulas a prueba de B. tabaci, sobre las cuales se hicieron observaciones para detectar síntomas hasta 30 días post-período de exposición al vector. Luego se tomaron muestras de ápices foliares para determinaciones del virus mediante PCR. Sólo se observaron síntomas de infecci...
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Buscamos com esse artigo suscitar uma analise critica dos objetivos da educacao presentes na Constituicao Federal de 1988 e os que estao previstos na LDB 9394/96 esta compreendida como norma infraconstitucional detalha como esses possa... more
Buscamos com esse artigo suscitar uma analise critica dos objetivos da educacao presentes na Constituicao Federal de 1988 e os que estao previstos na LDB 9394/96 esta compreendida como norma infraconstitucional detalha como esses possa estabelecer, vemos que as referidas leis apresentam ambiguidades quando objetivam uma educacao que tem como funcoes preparar para o mundo do trabalho e a pratica social, ao mesmo tempo, que deve fornecer condicoes para o pleno desenvolvimento. E a compreensao desses impasses a que se destina esse artigo. Para tanto, consideramos importante realizarmos uma breve contextualizacao historica da evolucao do pensamento humano para a constituicao do cartesianismo e sua influencia no sistema educacional brasileiro, a fim de questionar o impacto dessa perspectiva nas politicas educacionais para, por fim, refletir o sentido de “pleno desenvolvimento” na formacao das novas geracoes a partir da abordagem historico-cultural, buscando demonstrar a contradicao supra...
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A Comunicação Suplementar e/ou Alternativa (CSA) encontra-se em expansão no Brasil, sendo ainda, pouco documentada. Este trabalho trata-se da análise documental dos anais e livros dos quatro primeiros congressos brasileiros de CSA, com o... more
A Comunicação Suplementar e/ou Alternativa (CSA) encontra-se em expansão no Brasil, sendo ainda, pouco documentada. Este trabalho trata-se da análise documental dos anais e livros dos quatro primeiros congressos brasileiros de CSA, com o objetivo de mapear e conhecer a produção científica para levantar e identificar perspectivas e lacunas. Foram analisados 323 trabalhos, nas categorias: área do trabalho, tipo de instituição, população-alvo e ciclos de vida dos usuários. Os resultados mostram maior variedade nas categorias ao longo dos anos, evidenciando tendência de ampliação da CSA além da Saúde e Educação, abrangendo as áreas de Arte e Tecnologia; diversos ciclos de vida; outros interlocutores, como educadores e graduandos e outros ambientes além do aumento entre as parcerias de Centros especializados e Universidades. As mudanças abrem perspectivas de um novo olhar da CSA no país, abrangendo questões de funcionalidade, participação e inclusão em consonância com as políticas públic...
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This study describes the encapsulation of the local anesthetic lidocaine (LDC) in large unilamellar liposomes (LUV) prepared in a scalable procedure, with hydrogenated soybean phosphatidylcholine, cholesterol and mannitol. Structural... more
This study describes the encapsulation of the local anesthetic lidocaine (LDC) in large unilamellar liposomes (LUV) prepared in a scalable procedure, with hydrogenated soybean phosphatidylcholine, cholesterol and mannitol. Structural properties of the liposomes were assessed by dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and transmission electron microscopy (TEM). A modified, two-compartment Franz-cell system was used to evaluate the release kinetics of LDC from the liposomes. The in vivo anesthetic effect of liposomal lidocaine 2% (LUV) was compared to lidocaine 2% solution without (LDC) or with the vasoconstrictor epinephrine (1:100000) (LDC), in rat infraorbital nerve blockade model. The structural characterization revealed liposomes with spherical shape, average size distribution of 250 nm and low polydispersity even after LDC incorporation. Zeta potential laid around -30 mV and the number of suspended liposomal particles was in the range of 10 vesicles...
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Platelet-rich plasma (PRP) has emerged as a significant therapy used in medical conditions with heterogeneous results. There are some important classifications to try to standardize the PRP procedure. The aim of this report is to describe... more
Platelet-rich plasma (PRP) has emerged as a significant therapy used in medical conditions with heterogeneous results. There are some important classifications to try to standardize the PRP procedure. The aim of this report is to describe PRP contents studying celular and molecular components, and also propose a new classification for PRP. The main focus is on mononuclear cells, which comprise progenitor cells and monocytes. In addition, there are important variables related to PRP application incorporated in this study, which are the harvest method, activation, red blood cells, number of spins, image guidance, leukocytes number and light activation. The other focus is the discussion about progenitor cells presence on peripherial blood which are interesting due to neovasculogenesis and proliferation. The function of monocytes (in tissue-macrophages) are discussed here and also its plasticity, a potential property for regenerative medicine treatments.
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Antimicrobial resistance is a current public health concern, limiting the available therapeutic options used for the treatment of common bacterial infections. The development of new drug entities via biotechnological processes is however... more
Antimicrobial resistance is a current public health concern, limiting the available therapeutic options used for the treatment of common bacterial infections. The development of new drug entities via biotechnological processes is however expensive and time-consuming. Therefore, old antimicrobial agents have been recovered for clinical use. An example of these drugs is polymyxin, which is known for its serious adverse side effects, such as nephrotoxicity, neurotoxicity and promotion of skin pigmentation. To overcome these limitations, the use of biodegradable nanoparticles has been proposed to allow site-specific targeting, increasing the drug's bioavailability and decreasing its side effects. The aim of this work was the development of an optimized pharmaceutical formulation composed of solid lipid nanoparticles (SLN) loading polymyxin B sulphate (PLX) for the treatment of bacterial infections. The PLX-loaded SLN were produced by a double emulsion method (w/o/w), obtaining parti...
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Nearly all respondents to survey say they use research. But the extent of emphasis on research by colleges and universities may be exaggerated.
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Research Interests: Art and non blocking I/O
Research Interests: Philosophy and Humanities
O presente trabalho objetiva compreender o uso que professores e alunos fazem do computador fora dos limites da escola, a fim de buscar novas formas de utilizacao desse instrumento nos limites escolares. Realizamos tambem um levantamento... more
O presente trabalho objetiva compreender o uso que professores e alunos fazem do computador fora dos limites da escola, a fim de buscar novas formas de utilizacao desse instrumento nos limites escolares. Realizamos tambem um levantamento bibliografico, com base em Masetto, Behrens, Rinaldi, entre outros e aplicamos um questionario a professores e alunos de duas escolas da cidade de Paranaiba-MS, sendo uma publica e uma privada. Dentre os professores pesquisados, grande maioria possui microcomputador em suas casas, utilizando-o frequentemente para realizacao de diversas atividades. E consenso entre os profissionais da educacao, no que relaciona-se ao uso desse instrumento para a melhoria de sua atuacao. Com relacao aos alunos, entrevistamos alunos do 3° ao 5° ano, de um total de 17, apenas 6 possuem computador em casa, restando aos demais o acesso e uso apenas na escola, mesmo assim os alunos ainda possuem uma visao diferenciada com relacao ao do computador. Palavras-chave : Professor. Aluno. Computador.
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Research Interests: Chemistry, Organic Chemistry, Nanoparticles, Pharmaceutical Chemistry, Medicine, and 15 moreLipids, Cell line, Humans, Differential scanning calorimetry, Permeability, Dynamic Light Scattering, Drug Delivery Systems, Skin, Skin Diseases, Molecules, Particle Size, Permeation, Drug Carriers, skin disorders, and Dispersity
This work evaluated the effects of UV irradiation, plasma radiation, steam and 70% ethanol treatments on the sterilization and integrity of auto-crosslinked hyaluronic acid (HA-ACP) scaffolds structured in microparticles and sponges... more
This work evaluated the effects of UV irradiation, plasma radiation, steam and 70% ethanol treatments on the sterilization and integrity of auto-crosslinked hyaluronic acid (HA-ACP) scaffolds structured in microparticles and sponges aiming in vivo applications for regenerative medicine of bone tissue. The integrity of the microparticles was characterized by rheological behavior, while for the sponges, it was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry. The effectiveness of the sterilization treatment was verified by the number of microorganism colonies in the samples after the treatments. In conclusion, plasma radiation was the best treatment for the sponges, while steam sterilization in the autoclave at 126°C (1.5 kgf/cm2) for 5 min was the best treatment for the microparticles.
Research Interests: Chemistry, Biomedical Engineering, Radiation, Tissue Engineering, Nanoparticles, and 15 moreScanning Transmission Electron Microscopy, Medicine, Differential scanning calorimetry, Ethanol, Sterilization, Disinfection, Hyaluronic Acid, Scanning Electron Microscope, Fourier transform infrared spectroscopy, Etanol, STEAM, Microspheres, Bone and Bones, Chemical Phenomena, and Tissue Scaffolds
The objective was to identify the scientific production about domestic violence by means of the descriptors ElderAbuse and Family and to classify the articles found in national and international journals according to the thematicfocus,... more
The objective was to identify the scientific production about domestic violence by means of the descriptors ElderAbuse and Family and to classify the articles found in national and international journals according to the thematicfocus, the time, and the place of publication, research scenario, and description of the first author. Themethodological approach was a bibliographic review in the databases LILACS and MEDLINE for the period from1997 to 2009. In 2006, the biggest number of publications occurred, especially in Brazil and in the United States.The prevalence of choice among the researchers was the context of government and assistance agencies with apredominance of the qualitative approach. The object of the study followed the most varied themes: state ofmaltreatment and associated factors; understanding about the abuse, and perspectives of occurrence. It can beconcluded that this state of victimization is complex and represents a challenge both for the investigation and forthe policies regarding how to deal with family maltreatment in this population group.
Research Interests: Psychology and Gerais
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Bacillus thuringiensis (Bt) is a valuable biopesticide that is being used for the control of agricultural plagues of economic importance. Their insecticide properties are attributed to the presence of δ-endotoxins, Cry toxins, which are... more
Bacillus thuringiensis (Bt) is a valuable biopesticide that is being used for the control of agricultural plagues of economic importance. Their insecticide properties are attributed to the presence of δ-endotoxins, Cry toxins, which are synthesized during the phase of sporulation of the bacterium. These toxins, when ingested by the larvae of the target insect, generate a set of physiological reactions that cause their death. The objective of the present work was the isolation and characterization of Bt strains from soils of the Guayana Region (Venezuela). Soils of different locations of Guayana were collected, dried and processed until the isolation of colonies with Bacillus spp. morphology. These colonies were grown in agar-water until sporulation and observed under the microscope for the verification of the presence of crystals, having identified 94 strains with Bacillus morphology. These strains were characterized for the presence of genes cry by the use of the PCR technique and the use of general primers for cry1 and cry2. Of the total of analyzed strains, 75% presents the genetic profile cry1/cry2, which is toxic against Lepidoptera and Diptera and may have important applications in the agricultural and health fields.
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Research Interests: Chemical Engineering, Chemistry, Biomedical Engineering, Chromatography, Drug delivery, and 15 moreNanoparticles, Medicine, Lipids, Humans, Keratinocytes, Mice, Animals, Microbial genetic and drug resistance, Alginates, Particle Size, Drug Carriers, Cell Survival, fibroblasts, Dispersity, and polymyxin B sulphate
Growing evidence suggests that for many treatments, a relationship exists between provider volume and patient outcomes. This relationship is less clear in injury management. We sought to evaluate whether a relationship exists between... more
Growing evidence suggests that for many treatments, a relationship exists between provider volume and patient outcomes. This relationship is less clear in injury management. We sought to evaluate whether a relationship exists between trauma center volume and the nature of quality improvement (QI) programs. This is a survey of 154 verified adult trauma centers in the United States, Canada, Australia, and New Zealand (76% response rate) regarding their QI programs. Centers were classified according to American College of Surgeons annual volume requirements for a Level I center (low volume vs. high volume) and QI programs compared. All participating trauma centers reported using a trauma registry and measuring quality of care. Low-volume centers were more likely than high-volume centers to use quality indicators for evaluating triage and patient flow (18% vs. 13%, p < 0.001), effectiveness of care (33% vs. 30%, p = 0.016), and efficiency of care (29% vs. 23%, p < 0.001). High-vol...
Research Interests: Nursing, Emergency Medicine, Quality Management, Australia, Quality Improvement, and 15 moreBenchmarking, Medicine, Trauma, Canada, Humans, Triage, United States, New Zealand, Clinical Sciences, Trauma Center, Wounds and Injuries, Trauma Centers, Injury Severity Score, Health Care Surveys, and Quality of health care
To describe the quality indicators (QIs) that trauma centers use for quality measurement and performance improvement. Measuring and reporting quality of care is a critical step to improve the quality of care. QIs compare actual trauma... more
To describe the quality indicators (QIs) that trauma centers use for quality measurement and performance improvement. Measuring and reporting quality of care is a critical step to improve the quality of care. QIs compare actual trauma care against ideal criteria and identify patients in whom care may have been suboptimal and should be further reviewed. Three hundred thirty verified trauma centers in the United States, Canada, Australia, and New Zealand had their websites reviewed and leadership surveyed regarding QI use. The indicators identified were classified according to definition specifications, phase of care, Institute of Medicine aims, and contents. Two hundred fifty-one centers responded to the survey (76%) and the majority (97%) indicated that they use QIs. We obtained 10,587 QIs from 262 centers (survey responses and website review) of which 1,102 were unique indicators. The QIs primarily assessed the safety (49%), effectiveness (32%), efficiency (27%), and timeliness (22...
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To assess the effects of an Iyengar yoga program (IYP) on patients with chronic respiratory diseases. Patients attending lung transplant clinics in a tertiary institution were invited to participate in a two-phase, 12-week IYP that... more
To assess the effects of an Iyengar yoga program (IYP) on patients with chronic respiratory diseases. Patients attending lung transplant clinics in a tertiary institution were invited to participate in a two-phase, 12-week IYP that included 2 h biweekly classes. Doctors completed a formal physical and clinical assessment on candidates before enrollment. Patients with New York Association Class III or IV, or dyspnea grade IV were excluded. At baseline and at the end of 12-weeks, patients completed the Hospital Anxiety and Depression Scale (HADS), Chronic Respiratory Questionnaire (CRQ) and Health Utilities Index (HUI). Medication(s), 6 min walk test results and other clinical parameters were also recorded. Patients recorded the effects of the IYP on their daily living in journals. Nonparametric and qualitative methods were used to analyze the data. Twenty-five patients diagnosed with pulmonary arterial hypertension and chronic obstructive pulmonary disease (mean age 60 years) were in...
Research Interests: Quality of life, Fatigue, Medicine, Pulmonary Hypertension, Physical Therapy, and 15 moreAnxiety, Humans, Female, Male, Health Status, Aged, Middle Aged, Questionnaires, Adult, Chronic obstructive pulmonary disease, ANXIETY, Pilot Projects, Exercise Test, Cohort Studies, and Pulmonary Disease Chronic Obstructive
Patient-reported outcome measures (PROs) were originally developed for comparing groups of people in clinical trials and population studies, and the results were used to support treatment recommendations or inform health policy, but there... more
Patient-reported outcome measures (PROs) were originally developed for comparing groups of people in clinical trials and population studies, and the results were used to support treatment recommendations or inform health policy, but there was not direct benefit for the participants providing PROs data. However, as the experience in using those measures increased, it became obvious the clinical value in using individual patient PROs profiles in daily practice to identify/monitor symptoms, evaluate treatment outcomes and support shared decision-making. A key issue limiting successful implementation is clinicians' lack of knowledge on how to effectively utilize PROs data in their clinical encounters. Using a change management theoretical framework, this paper describes the development and implementation of three programs for training clinicians to effectively use PRO data in routine practice. The training programs are in three diverse clinical areas (adult oncology, lung transplant...
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The "Quality of Trauma Care Patient-Reported Experience Measure" is the first measure of patient experiences with overall injury care. The objective of this study was to use cognitive interviews to inform revision of the measure... more
The "Quality of Trauma Care Patient-Reported Experience Measure" is the first measure of patient experiences with overall injury care. The objective of this study was to use cognitive interviews to inform revision of the measure into a parsimonious set of items that function as intended, in preparation for multicenter testing. Concurrent and retrospective cognitive interviews with injured patients (n = 17) and family members (n = 13) using semi-structured interview guides. Responses were analyzed using thematic analysis. Six broad themes were identified and guided revisions: (1) participants did not have the information to answer items (n = 9); (2) items were ambiguous or were inconsistently interpreted (n = 13); (3) items did not measure the intended constructs (n = 6); (4) items included assumptions about healthcare processes (n = 4); (5) items measured non-priority aspects of injury care (n = 8); and (6) items were redundant (n = 5). Two issues resulted in key conceptua...
Research Interests: Psychology, Cognition, Content Analysis, Family, Quality of Mental Health Care, and 15 moreMedicine, Thematic Analysis, Hospitals, Humans, Female, Male, Middle Aged, Adult, Public health systems and services research, Retrospective Studies, Cognitive interview, Quality Life, Trauma Centers, Surveys and Questionnaires, and Quality of health care
The purpose of this study was to assess physicians' perceptions on a newly developed electronic transfer of care (e-TOC) communication tool and identify barriers and opportunities toward its adoption. The study was conducted in a... more
The purpose of this study was to assess physicians' perceptions on a newly developed electronic transfer of care (e-TOC) communication tool and identify barriers and opportunities toward its adoption. The study was conducted in a tertiary care teaching center as part of a randomized controlled trial assessing the efficacy of an e-TOC communication tool. The e-TOC technology was developed through iterative consultation with stakeholders. This e-TOC summary was populated by acute care physicians (AcPs) and communicated electronically to community care physicians (CcPs). The AcPs consisted of attending physicians, resident trainees, and medical students rotating through the Medical Teaching Unit. The CcPs were health care providers caring for patients discharged from hospital to the community. AcPs and CcPs completed validated surveys assessing their experience with the newly developed e-TOC tool. Free text questions were added to gather general comments from both groups of physici...
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This study aimed to evaluate thein vitroperformance of activated platelet-rich plasma associated with porous sponges of chitosan as a composite scaffold for proliferation and osteogenic differentiation of human adipose tissue-derived... more
This study aimed to evaluate thein vitroperformance of activated platelet-rich plasma associated with porous sponges of chitosan as a composite scaffold for proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. The sponges were prepared by controlled freezing (−20, −80, or −196°C) and lyophilization of chitosan solutions (1, 2, or 3% w/v). The platelet-rich plasma was obtained from controlled centrifugation of whole blood and activated with calcium and autologous serum. The composite scaffolds were prepared by embedding the sponges with the activated platelet-rich plasma. The results showed the performance of the scaffolds was superior to that of activated platelet-rich plasma alone, in terms of delaying the release of growth factors and increased proliferation of the stem cells. The best preparation conditions of chitosan composite scaffolds that coordinated the physicochemical and mechanical properties and cell proliferation were 3% (...
Research Interests: Chemistry, Tissue Engineering, Chitosan, Scanning Transmission Electron Microscopy, Regenerative Medicine, and 15 moreMedicine, Cell Differentiation, Humans, Porosity, Scaffold, Mesenchymal Stem Cell, Platelet Rich Plasma, Osteogenesis, Cell Proliferation, Materials Testing, Freezing, Biocompatible Materials, Mesenchymal Stromal Cells, In Vitro Techniques, and Quitosana
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The focus in this chapter is an evaluation, based in data from the literature, of the use of Platelet-Rich Plasma (PRP) in cell culture for treatment of bone and cartilage defects. For the preparation of this chapter the data bank from... more
The focus in this chapter is an evaluation, based in data from the literature, of the use of Platelet-Rich Plasma (PRP) in cell culture for treatment of bone and cartilage defects. For the preparation of this chapter the data bank from PubMed, developed by the National Center for Biotechnology Information, U.S. National Library of Medicine was used as a tool. Key words used were: platelet-rich plasma, mesenchymal stem cells, biomaterials, tissue engineering; cartilage repair; bone healing. The role of PRP on tissue regeneration, cell proliferation and mesenchymal stem-cells is emphasized. In vitro and in vivo studies of PRP in bone and cartilage regeneration are described and referenced.
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This study aims to offer a general idea of the current progress and discussions about the aspects of technical preparation and biological foundation of PRP for clinical application. We seek to gather the best therapeutic indications that... more
This study aims to offer a general idea of the current progress and discussions about the aspects of technical preparation and biological foundation of PRP for clinical application. We seek to gather the best therapeutic indications that have a scientific foundation on the use of this new tool of Regenerative Medicine. The articles of this study were acquired from the leading data bases of medical literature.
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Platelet-rich plasma (PRP) is currently used in regenerative medicine and has opened up an exciting field of study. In this chapter, we present the main challenges limiting the study and standardization of PRP, based on variables and... more
Platelet-rich plasma (PRP) is currently used in regenerative medicine and has opened up an exciting field of study. In this chapter, we present the main challenges limiting the study and standardization of PRP, based on variables and interactions involved in its preparation. Furthermore, we present and discuss some approaches to basic science studies of PRP from the simplest case to the most complex or real scenario. A feasible strategy for studying P-PRP (Pure-PRP) preparation in a real situation is also illustrated. The key point of the strategy is the predictive description of the main steps of PRP preparation, based on the physicochemical events. Within the expected variability for an autologous product, the quality of PRP can be modulated by preparation conditions and also tailored for evaluation of biological responses. The interconnected characterization and standardization of the quality and biological properties of PRP are the basis for further clinical studies
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Introduction. Platelet-Rich Plasma (PRP) is rich in growth factors, playing important role in tissue healing. The wide variation of reported protocols for preparation of PRP leads to variable compositions, which induce different... more
Introduction. Platelet-Rich Plasma (PRP) is rich in growth factors, playing important role in tissue healing. The wide variation of reported protocols for preparation of PRP leads to variable compositions, which induce different biological responses and prevent results comparison. This study aims to highlight relevant aspects of the centrifugation step to obtain reproducible results and overall quality. Material and Methods. Samples of blood were collected from 20 healthy donors that have signed free informed consent. Two centrifugation steps (spins) were analyzed for the influence of centrifugal acceleration, time, processed volume, and platelet gradient. The Pure Platelet-Rich Plasma (P-PRP) was characterized as platelet concentration, integrity, and viability (sP-selectin measurement). Results. Lower centrifugal accelerations favour platelet separation. The processing of 3.5 mL of blood at 100 ×g for 10 min (1st spin), 400 ×g for 10 min (2nd spin), withdrawing 2/3 of remnant plas...
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The in vivo absorption of didanosine was studied, focusing on the performance of a novel pharmaceutical formulation for didanosine, composed of chitosan granules containing didanosine incorporated in chitosan microspheres. This novel... more
The in vivo absorption of didanosine was studied, focusing on the performance of a novel pharmaceutical formulation for didanosine, composed of chitosan granules containing didanosine incorporated in chitosan microspheres. This novel formulation is aimed at oral administration in AIDS therapy. The experimental results in male adult dogs showed controlled delivery of didanosine along 36 h, with a 2-fold increase in the absorption time of didanosine compared to the commercial granules, gastro-resistant didanosine and tablets. The higher absorption is due to adhesion to the intestinal membrane, improving absorption through increase of residence time, permeation and release. Furthermore, the novel formulation facilitates handling and deglutition, especially in the elderly and children, as well as enhances the taste and reduces the frequency of doses and collateral effects associated with a high concentration of the buffer agents usually used in other formulations.
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OBJECTIVE: To describe the clinical impact of the first year treatment with dornase alfa, according to age groups, in a cohort of Brazilian Cystic Fibrosis (CF) patients. METHODS: The data on 152 eligible patients, from 16 CF reference... more
OBJECTIVE: To describe the clinical impact of the first year treatment with dornase alfa, according to age groups, in a cohort of Brazilian Cystic Fibrosis (CF) patients. METHODS: The data on 152 eligible patients, from 16 CF reference centers, that answered the medical questionnaires and performed laboratory tests at baseline (T0), and at six (T2) and 12 (T4) months after dornase alfa initiation, were analyzed. Three age groups were assessed: six to 11, 12 to 13, and >14 years. Pulmonary tests, airway microbiology, emergency room visits, hospitalizations, emergency and routine treatments were evaluated. Student's t-test, chi-square test and analysis of variance were used when appropriated. RESULTS: Routine treatments were based on respiratory physical therapy, regular exercises, pancreatic enzymes, vitamins, bronchodilators, corticosteroids, and antibiotics. In the six months prior the study (T0 phase), hospitalizations for pulmonary exacerbations occurred in 38.0, 10.0 and ...