In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase... more
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-6-phosphate dehydrogenase deficiency (G6PDd), when treating patients with uncomplicated falciparum malaria. We sought to develop an age-based SLDPQ regimen that would be suitable for sub-Saharan Africa. Using data on the anti-infectivity efficacy and tolerability of primaquine (PQ), the epidemiology of anaemia, and the risks of PQ-induced acute haemolytic anaemia (AHA) and clinically significant anaemia (CSA), we prospectively defined therapeutic-dose ranges of 0.15-0.4 mg PQ base/kg for children aged 1-5 years and 0.15-0.5 mg PQ base/kg for individuals aged ≥6 years (therapeutic indices 2.7 and 3.3, respectively). We chose 1.25 mg PQ base for infants aged 6-11 months because they have the highest rate of baseline anaemia and the highest risks of AHA and CSA. We modelled an ...
Research Interests: Malaria, General Internal Medicine, Adolescent, Medicine, Humans, and 15 moreChild, Female, Male, Infant, Aged, Middle Aged, Adult, Antimalarials, Age Factors, Clinical Protocols, HUMAN MEDICINE, Child preschool, Glucosephosphate dehydrogenase deficiency, Malaria Falciparum, and Medical and Health Sciences
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The sectors of coffee and cocoa represented in Côte d?Ivoire, before the political crisis, approximately 15 % of the GDP and 40 % of exports. The production area of these two crops is the forest which is a malaria endemic area. The... more
The sectors of coffee and cocoa represented in Côte d?Ivoire, before the political crisis, approximately 15 % of the GDP and 40 % of exports. The production area of these two crops is the forest which is a malaria endemic area. The cultivation of these crops is less constraining than that of the food crops such as rice or yam
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Research Interests:
... Jean-François Brun du même auteur. ... The authors wish to thank Pierre Carnevale, at the time Head of the IPR/OCCGE in Bouaké, Côte d'Ivoire, for his ... Henry M.-C., Assi S.-B., Rogier C.,Nzeyimana I., Dossou-Yovo J., Audibert... more
... Jean-François Brun du même auteur. ... The authors wish to thank Pierre Carnevale, at the time Head of the IPR/OCCGE in Bouaké, Côte d'Ivoire, for his ... Henry M.-C., Assi S.-B., Rogier C.,Nzeyimana I., Dossou-Yovo J., Audibert M., Mathonnat J., Chandre F., Akodo E., Teuscher T ...
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The efficacy of nets treated with lambda-cyhalothrin, a pyrethroid insecticide, on malaria infection and disease was assessed for the first time at the community level in Anopheles gambiae pyrethroid resistance areas. The study was... more
The efficacy of nets treated with lambda-cyhalothrin, a pyrethroid insecticide, on malaria infection and disease was assessed for the first time at the community level in Anopheles gambiae pyrethroid resistance areas. The study was carried out in northern Côte d'Ivoire, which is an area of kdr resistance. Four pairs of villages were selected and matched according to demographic, sociological, and ecological criteria. Among each pair, a village was randomly allocated to receive mosquito nets. More than 80% of beds were covered with nets treated with lambda-cyhalothrin and retreated after 6 months. In each village, 54 children aged 0-59 months were randomly selected and clinically monitored for 8 periods of 7 days throughout the year. Results showed that the efficacy of treated nets was maintained with a reduction of the prevalence of asymptomatic malaria infection by 12% and an estimated protective efficacy against malaria disease of 56%.
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This article assesses the role of malaria and some social determinants on the agricultural development and more precisely on efficiency in the context of cotton crop in the Korhogo region in the North of Côte... more
This article assesses the role of malaria and some social determinants on the agricultural development and more precisely on efficiency in the context of cotton crop in the Korhogo region in the North of Côte d'Ivoire. Data envelopment analyses (DEA) was first applied for the purpose of calculating relative efficiencies in production. A Tobit regression model was then used to explain the variation in the DEA scores and check the hypotheses that the efficiency deviations between farmers can be explained by the disparity of malaria morbidity rate among the farmers and their family, by social cohesiveness and cultural behaviour. Field data were collected by the authors between March 1997 and February 1998 on 700 rural households living in three rice production systems differently exposed to the malaria risk. Two malaria indicators were used for the active (11-55 years old) family members of the farm: Plasmodium falciparum infection rate and high parasite density infection rate. The DEA model was applied on the sub-sample of cotton growers (about one third of the households of the full sample). Results of the different DEA and Tobit models (depending of the production process hypothesis) show that high parasite density infection has a direct and indirect negative effect on efficiency in the cotton crop. They also show that more cotton growers in the village improve efficiency, although villages where cotton is growing more widespread have weaker social cohesion.
Research Interests: Religion, Sociology, Anthropology, Health Behavior, Occupational Health, and 21 moreAgricultural Development, Family, Culture, Agriculture, Social Science & Medicine, Social cohesion, Humans, Social Environment, Incidence, Efficiency, Prevalence, Production Process, Regression Model, Public health systems and services research, Tobit Model, Plasmodium falciparum, Seasons, Production System, Field Data, Relative Efficiency, and Cote D Ivoire
The genetic variability and population structure of Plasmodium falciparum are key factors in malaria control strategies. Studies have suggested no P. falciparum population structure although linkage disequilibrium was observed in some... more
The genetic variability and population structure of Plasmodium falciparum are key factors in malaria control strategies. Studies have suggested no P. falciparum population structure although linkage disequilibrium was observed in some African areas. We have assessed length polymorphism at 6-22 microsatellites in four urban and rural sites (Djibouti, Dakar, Niamey, and Zouan-Hounien, n = 240 blood samples). Results have shown a P. falciparum population structure in Africa (Fst = 0.17-0.24), lower genetic diversity in Djibouti (He = 0.53) than in the other sites (He = 0.73-0.76), and 3) significant linkage disequilibrium in Djibouti. These results could be related to geographic isolation and low flow of parasites between sites. They also suggest a potential effect of rural suburbs to generate genetic diversity in towns. This could affect the dispersal of selected drug resistance and should be considered when adapting urban malaria control strategies.
Research Interests: Geography, Polymorphism, Africa, Genetic Diversity, Population structure, and 14 moreHumans, Animals, Drug Resistance, Blood sampling, Polymerase Chain Reaction, Genotype, Control Strategy, Plasmodium falciparum, Linkage Disequilibrium, Urban Population, Genetic variation, Rural Area, Genetic Variability, and The American
Research Interests: Engineering, Geography, Physics, Chemistry, Biology, and 15 moreMalaria, Medicine, Multidisciplinary, Humans, Benin, Female, Male, Infant, Droughts, Risk factors, PLoS one, Newborn Infant, Western Africa, Risk Factors, and Seasons
Background:Intrauterinegrowthretardationisamajorpredictorof child health in developing countries. Objective: We tested whether providing pregnant women with the UNICEF/WHO/UNU international multiple micronutrient prepara- tion (UNIMMAP),... more
Background:Intrauterinegrowthretardationisamajorpredictorof child health in developing countries. Objective: We tested whether providing pregnant women with the UNICEF/WHO/UNU international multiple micronutrient prepara- tion (UNIMMAP), rather than iron and folic acid alone, improved fetal growth and its correlates. Design: An intention-to-treat, double-blind, randomized controlled trial including 1426 pregnancies was carried out in rural Burkina Faso. Tablet intake was directly observed. Results: Pregnancy outcome
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Research Interests: West Africa, Medical Microbiology, Low Frequency, Insecticide Resistance, Spatial Heterogeneity, and 9 moreAcetylcholinesterase, Vector control, Parasit, Public health systems and services research, Randomized Controlled Trial, Plasmodium falciparum, Intervention study, Indexation, and Allele Frequency
Research Interests: Polymorphism, Africa, Medical Microbiology, Malaria, Sequence Analysis, and 13 moreMitochondrial DNA, Humans, Animals, Drug Resistance, Asia, French Guiana, South America, Cytochrome B, Geographic distribution, Plasmodium falciparum, Amino Acid Substitution Rates, Central African Republic, and Full Length Movies
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Research Interests: Geography, Medical Microbiology, Malaria, Cameroon, Senegal, and 24 moreMultivariate Analysis, Drug Use, Humans, Child, Burkina Faso, Female, Animals, Drug Resistance, Male, Fever of Unknown Origin, Urine, High Performance Liquid Chromatography, High Pressure Liquid Chromatography, Questionnaires, Pyrimethamine, Random sampling, Plasmodium falciparum, Antimalarials, Random-Effects Models, Age Factors, Chloroquine, Logistic Regression Model, General Population, and Socioeconomic Factors
Research Interests: Geography, Medical Microbiology, Malaria, Cameroon, Senegal, and 24 moreMultivariate Analysis, Drug Use, Humans, Child, Burkina Faso, Female, Animals, Drug Resistance, Male, Fever of Unknown Origin, Urine, High Performance Liquid Chromatography, High Pressure Liquid Chromatography, Questionnaires, Pyrimethamine, Random sampling, Plasmodium falciparum, Antimalarials, Random-Effects Models, Age Factors, Chloroquine, Logistic Regression Model, General Population, and Socioeconomic Factors
Research Interests:
Research Interests: Land tenure, Medical Microbiology, Malaria, Ecology, Multivariate Analysis, and 26 moreSeasonality, Humans, Child, Burkina Faso, Female, Animals, Male, Infant, Risk factors, Access to Health Care, Prevalence, Questionnaires, Health Problems, Cross Section, Plasmodium falciparum, Random-Effects Models, Urban Population, Risk Factors, Rural Area, Protozoan Proteins, Urban Ecosystem, Dried Blood Spot, Cross Sectional Studies, Logistic Models, Urban Area, and Socioeconomic Factors
... But briefly, the district has an annual population growth rate of 2.4% and a total fertility rate of 7.2 [24]. It is bordered by Kayunga district in the North and Lake Victoria in the South. ... Areas on the shores of Lake Victoria... more
... But briefly, the district has an annual population growth rate of 2.4% and a total fertility rate of 7.2 [24]. It is bordered by Kayunga district in the North and Lake Victoria in the South. ... Areas on the shores of Lake Victoria are holo-endemic. ...