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Rajae TOUZANI

    Rajae TOUZANI

    BACKGROUND The development of telehealth and telemedicine, in the form of increased teleconsultation and medical telemonitoring, accelerated during the COVID-19 health crisis in France to ensure continued access to care for the... more
    BACKGROUND The development of telehealth and telemedicine, in the form of increased teleconsultation and medical telemonitoring, accelerated during the COVID-19 health crisis in France to ensure continued access to care for the population. Since these new information and communication technologies (ICTs) are diverse and likely to transform how the health care system is organized, there is a need better to understand public attitudes toward them and their relationship with peoples’ current experience of health care. OBJECTIVE This study aimed to determine the French general population’s perception of the usefulness of video recording/broadcasting (VRB) and mobile Health (mHealth) apps for medical consultations in France during the COVID-19 health crisis and the factors associated with this perception. METHODS Data were collected for 2003 people in 2 waves of an online survey alongside the Health Literacy Survey 2019 (1003 in May 2020 and 1000 in January 2021) based on quota sampling. The survey collected sociodemographic characteristics, health literacy levels, trust in political representatives, and perceived health status. The perceived usefulness of VRB in medical consultations was measured by combining 2 responses concerning this technology for consultations. The perceived usefulness of mHealth apps was measured by combining 2 responses concerning their usefulness for booking doctor appointments and for communicating patient-reported outcomes to doctors. RESULTS The majority (1239/2003, 62%) of respondents considered the use of mHealth apps useful, while only 27.6% (551/2003) declared VRB useful. The factors associated with the perceived usefulness of both technologies were younger age (≤ 55 years), trust in political representatives (VRB: adjusted odds ratio [aOR] 1.68, 95% CI 1.31-2.17; mHealth apps: aOR 1.88, 95% CI 1.42-2.48), and higher (sufficient and excellent) health literacy. The period of the beginning of the COVID-19 epidemic, living in an urban area, and being limited in daily activities were also associated with perceiving VRB positively. The perceived usefulness of mHealth apps increased with the level of education. It was also higher in people who had 3 or more consultations with a medical specialist. CONCLUSIONS There are important differences in attitudes toward new ICTs. Perceived usefulness was lower for VRB than for mHealth apps. Moreover, it decreased after the initial months of the COVID-19 pandemic. There is also the possibility of new inequalities. Hence, despite the potential benefits of VRB and mHealth apps, people with low health literacy considered them to be of little use for their health care, possibly increasing their difficulties in accessing health care in the future. As such, health care providers and policy makers need to consider those perceptions to guarantee that new ICTs are accessible and beneficial to all.
    e17093 Background: Active surveillance (AS) is a standard of care for low-risk prostate cancer (PCa). However, it is not yet clear whether AS may be a source of anxiety in patients (pts) compared to pts receiving treatment. The objective... more
    e17093 Background: Active surveillance (AS) is a standard of care for low-risk prostate cancer (PCa). However, it is not yet clear whether AS may be a source of anxiety in patients (pts) compared to pts receiving treatment. The objective of this study is to compare anxiety in pts receiving apalutamide monotherapy plus AS versus AS alone in pts with low and intermediate-risk PCa. Methods: The study was conducted, in pts enrolled in a multicenter randomized phase 2 trial comparing AS with apalutamide (240 mg) 6 months versus AS alone. Participants completed questionnaires at baseline, 3, 6, and 12 months after diagnosis. We assessed anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and prostate-specific anxiety using the Memorial Anxiety Scale for Prostate Cancer (MAX-PC). Results: Patients were randomized to AS alone (n = 40) or AS + apalutamide (n = 51). Anxiety questionnaire, response rates, were 98%, 88%, 92%, and 82%, respectively, at baseline, 3 months, 6 months, and 12 months. HADS scores were similar between treatment groups (p > 0.05 at each assessment point) and did not change significantly over time (p > 0.05 for each comparison over time). By analyzing the general MAX-PC anxiety score, we observed that for pts on treatment, anxiety decreased significantly at 3 months compared to baseline (p = 0.01), then remained stable between 3 and 6 months. For pts on AS, anxiety remained stable during the first 3 months and decreased significantly after 3 months (p = 0.018). At the end of treatment (6 months), anxiety increased significantly in pts in the apalutamide arm (p = 0.05) while it remained stable for pts on AS alone. One year after inclusion, the MAX-PC general anxiety levels returned to baseline for both groups of pts. However, for the prostate cancer anxiety subscale, scores decreased significantly from baseline to 12 months in the AS alone group (p = 0.031). Conclusions: Anxiety was reduced in the apalutamide arm after the start of treatment, but this effect was transient and disappeared at the end of treatment. The decrease in anxiety appears to be delayed over time for AS patients, but after a few months, these patients experience a decrease in anxiety levels, suggesting that patients have become accustomed to not being treated. Better detection of PCa specific anxiety was observed, with disease-specific tools such as MAX-PC compared with generic anxiety detection with HADS. Clinical trial information: NCT03088124 .
    Introduction Dans le but de réduire le nombre de personnes infectées par la COVID-19, plusieurs pays ont mis en œuvre des applications mobiles pour retracer les contacts étroits de la personne infectée par le SARS-CoV-2. Cependant, cette... more
    Introduction Dans le but de réduire le nombre de personnes infectées par la COVID-19, plusieurs pays ont mis en œuvre des applications mobiles pour retracer les contacts étroits de la personne infectée par le SARS-CoV-2. Cependant, cette approche nécessite une large adhésion de la population pour être efficace. Cependant, depuis mars, de telles applications n’ont été installées que par 9,3 % des personnes dans le monde. Nos objectifs étaient d’estimer, en France, l’acceptabilité d’une application utilisant les téléphones mobiles pour retracer les contacts étroits entre les personnes lors d’épidémies, et les barrières potentielles à son utilisation. Méthodes Nos données ont été collectées parallèlement à l’enquête « Health Literacy Survey 2019 » réalisée en ligne auprès de 1003 français deux semaines après la fin du premier confinement en France (du 27 mai au 5 juin 2020). Les données utilisées étaient les caractéristiques sociodémographiques, la littératie en santé, la confiance dans les institutions et les connaissances sur la COVID-19 et les comportements préventifs. L’acceptabilité d’une application mobile de traçage a été mesurée par le biais d’une question ad hoc, dont les réponses ont été regroupées en trois modalités : App-partisan, App-favorable et App-réticent. Résultats Seulement 19,2 % étaient des partisans de l’application tandis que la moitié des participants (50,3 %) étaient réticents. Les facteurs associés à la non-réticence (App-adepte, App-favorable) étaient : l‘absence de difficultés financières et l’utilité perçue d’applications mobiles pour envoyer des questionnaires de santé aux médecins. L’âge de plus de 60 ans, la confiance dans les représentants politiques, les préoccupations envers la situation pandémique et des connaissances adéquates sur la transmission du SARS-CoV-2 augmentaient la probabilité d’adhérer complétement à l’application de traçage. Conclusion Les personnes les plus démunies, connues pour être plus à risque d’être atteintes par la COVID-19, sont également les plus réticentes à utiliser une application de traçage des contacts. Par conséquent, une adhésion optimale nécessite de mieux comprendre ces réticences et de larges campagnes de sensibilisation, proposant un discours rationalisé sur les avantages de santé publique d’adopter une telle application.
    To manoeuvre a complex and fragmented health care system, people need sufficient navigational health literacy (NAV-HL). The objective of this study was to validate the HLS19-NAV measurement scale applied in the European Health Literacy... more
    To manoeuvre a complex and fragmented health care system, people need sufficient navigational health literacy (NAV-HL). The objective of this study was to validate the HLS19-NAV measurement scale applied in the European Health Literacy Population Survey 2019–2021 (HLS19). From December 2019 to January 2021, data on NAV-HL was collected in eight European countries. The HLS19-NAV was translated into seven languages and successfully applied in and validated for eight countries, where language and survey method differed. The psychometric properties of the scale were assessed using confirmatory factor analysis (CFA) and Rasch modelling. The tested CFA models sufficiently well described the observed correlation structures. In most countries, the NAV-HL data displayed acceptable fit to the unidimensional Rasch partial credit model (PCM). For some countries, some items showed poor data–model fit when tested against the PCM, and some items displayed differential item functioning for selected...
    Cancer patients commonly experience psychological distress that may increase with the current COVID-19 pandemic. This prospective study aimed to measure post-traumatic stress disorder (PTSD) and anxiety in cancer patients following... more
    Cancer patients commonly experience psychological distress that may increase with the current COVID-19 pandemic. This prospective study aimed to measure post-traumatic stress disorder (PTSD) and anxiety in cancer patients following France’s first COVID-19-related lockdown, together with associated factors. Cancer patients receiving outpatient treatment or post-treatment follow-up completed a questionnaire which measured, among other things, PTSD (IES-R), anxiety (State-Trait Anxiety Inventory), and fear of cancer recurrence (FCR). Of the 1097 patients included in the study, 14.7% and 30.5% suffered from PTSD and anxiety, respectively. Patients afraid to come to hospital due to the risk of COVID-19 transmission (OR = 3.49, p < 0.001), those with a negative lockdown experience (OR = 0.98, p < 0.001), women (OR = 1.97; p = 0.009), and patients living alone (OR = 1.63, p = 0.045) were all more likely to have PTSD. Older patients (OR = 1.65, p = 0.020), women (OR = 1.62, p = 0.018)...
    Objective: We aimed to assess the long-term association of therapeutic strategies with urinary, sexual function and health-related quality of life (HR-QOL) for 5-year prostate cancer (PC) survivors. Materials & methods: The VICAN survey... more
    Objective: We aimed to assess the long-term association of therapeutic strategies with urinary, sexual function and health-related quality of life (HR-QOL) for 5-year prostate cancer (PC) survivors. Materials & methods: The VICAN survey consisted of self-reported data prospectively collected, including living conditions, treatment side effects and quality of life (QOL) of cancer survivors. Results: Among the 434 PC survivors, 52.8% reported urinary incontinence (UI) and 55.8% reported erectile dysfunction (ED). Patients treated with radical prostatectomy with salvage radiotherapy reported significantly more UI (p = 0.014) and more ED (p = 0.012) compared with other strategies. UI was significantly associated with physical and mental health-related QOL (p = 0.045 and p = 0.049, respectively). Conclusion: Self-assessed functional outcomes 5 years after PC diagnosis remain poor and could have an impact on health-related QOL.
    Additional file 1. Completed SPIRIT guidelines checklist for this DECODE trial protocol article.
    OBJECTIVES Our study aimed to provide an updated overview of the use of the French contact tracing application, TousAntiCovid, and identify evolutions since the beginning of the pandemic. STUDY DESIGN We conducted a survey study on a... more
    OBJECTIVES Our study aimed to provide an updated overview of the use of the French contact tracing application, TousAntiCovid, and identify evolutions since the beginning of the pandemic. STUDY DESIGN We conducted a survey study on a representative sample of the French adult population. METHODS Our data were collected by the Obervatoire Régional de la Santé (ORS) using a self-administered online questionnaire. This was completed by a sample of 2,022 people stratified to match French official census statistics for gender, age, occupation, and area of housing. We conducted statistical analysis using Python (Pandas - Scipy - Statsmodels) with chi-squared and Wilcoxon rank-sum tests to control for statistical significance. RESULTS A small majority of respondents used TousAntiCovid (55.5%), while 41.0% had never downloaded it. Only one-quarter of the respondents (23.3%) used it for contact tracing with Bluetooth, while a third (32.2%) used it only for storing their health pass. The app's use increased with education level, income, and younger age. A large majority (85%) of non-vaccinated respondents had never downloaded TousAntiCovid. CONCLUSION Our results suggest that the role and use of France's official COVID-19 app TousAntiCovid has evolved in line with the government's strategy; while initially focusing on contact tracing, its development has led to the possibility to store test and vaccination documentation. The survey also confirmed previous results pointing to the lasting differences in socio-economic status in terms of adoption of the app. This is problematic because the long-term nature of the pandemic could require the government to keep a range of strategies open, including contact tracing. Public discussion of the current and future roles of the French contact tracing app is therefore needed.
    INTRODUCTION The information provided at the time of diagnosis of Non Muscle-Invasive Bladder Cancer (NMIBC) is highly variable. Well-informed patient are more involved in shared decisions. The objective of our study was to assess the... more
    INTRODUCTION The information provided at the time of diagnosis of Non Muscle-Invasive Bladder Cancer (NMIBC) is highly variable. Well-informed patient are more involved in shared decisions. The objective of our study was to assess the information perceived by the patient at the time of NMIBC diagnosis and its impact on quality of life. METHODS The VICAN french cohort involved a representative sample of 4174 cancer patients and 5 years survivors. Patients reported outcomes (PROs) were collected by phone and self-questionnaire. Among the 118 NMIBC patients, the term used to define the pathology at diagnosis was prospectively evaluated. The impact on quality of life (using SF-12, EORTC-QLQ-C30 and HAD scale) and on adherence to the care protocol (endoscopic monitoring) has been assessed. RESULTS Only 26.8% of patients reported hearing the word « Cancer » at the time of NMIBC diagnosis. Conversely, 73.2% of them reported others terms, including « Tumor » (22%), « Polyp » (24%), and « Carcinoma » (17.1%). There was no difference in terms of physical, mental quality of life and anxiety, regardless of the term used. Adherence to the follow-up endoscopic protocol was better in the group of patients hearing the word "Cancer". CONCLUSION Three quarters of patients treated for NMIBC did not integrate the concept of « Cancer » at the time of diagnosis. Quality of life and anxiety did not differ significantly depending on the term used at diagnosis. However, adherence to care protocol appears to be higher when using the word "Cancer". LEVEL OF EVIDENCE 3.
    220 Background: Active surveillance (AS) is an option for low-risk localized prostate cancer and its use is on the rise due to the good long-term oncologic results. However, its impact on the quality of live of patients, particularly in... more
    220 Background: Active surveillance (AS) is an option for low-risk localized prostate cancer and its use is on the rise due to the good long-term oncologic results. However, its impact on the quality of live of patients, particularly in terms of anxiety and emotional responses related to cancer is poorly evaluated. Methods: The french VICAN cohort is a representative sample of 4174 patients treated for cancer and survivors after 5 years. Patient-reported Outcomes (PROs) were collected prospectively by self-questionnaires on quality of live (SF-12) and treatments side effects. Among the 447 patients with prostate cancer, patients managed by active surveillance (AS), radiotherapy (RT), or radical prostatectomy (RP), for localized T1-T2 N0 M0 cancer with a Gleason score < 8 were selected. Data regarding depressive symptoms and percieved anxiety were analysed comparatively. Results: A total of 301 patients were included, among whom 68 (22.6%) managed by AS, 170 (56.5%) treated by RP ...
    Simple Summary Patient satisfaction is a key parameter of care quality. Among oncology patients undergoing chemotherapy (CT), the long waiting times associated with frequent and prolonged consultations have been shown to be a major source... more
    Simple Summary Patient satisfaction is a key parameter of care quality. Among oncology patients undergoing chemotherapy (CT), the long waiting times associated with frequent and prolonged consultations have been shown to be a major source of dissatisfaction. The aim of this study was to determine whether advance approval of outpatient CT via phone call the day before CT can optimize healthcare delivery without compromising patient satisfaction with care. Our results showed that the satisfaction level with physicians regarding technical skills, interpersonal skills, and availability were not decreased in patients who did not receive a face-to-face consultation with an oncologist the day of CT. We also found that waiting times were reduced for patients who were treated according to the advance approval procedure. These findings suggest that advanced approval of outpatient CT via phone call is a feasible alternative that does not compromise patient satisfaction with care. Abstract Pati...
    Introduction La vaccination des jeunes filles contre les infections a papillomavirus humains (HPV) est l’une des mesures de prevention du cancer du col de l’uterus chez la femme. Apres son introduction il y a 10 ans en France, le vaccin... more
    Introduction La vaccination des jeunes filles contre les infections a papillomavirus humains (HPV) est l’une des mesures de prevention du cancer du col de l’uterus chez la femme. Apres son introduction il y a 10 ans en France, le vaccin anti-HPV a une couverture vaccinale qui reste actuellement tres faible. D’autre part, certains departements d’Outre-Mer ont des taux d’incidence et de mortalite du cancer du col de l’uterus nettement plus eleves qu’en France metropolitaine. Le prealable a l’adoption d’un comportement de prevention est d’avoir connaissance de l’existence de ce moyen de prevention. Ainsi, l’objectif de cette etude etait d’identifier les facteurs socio-demo-economiques et culturels associes a la meconnaissance de la vaccination anti-HPV chez 1000 femmes d’un departement d’Outre-Mer multiculturel et aux inegalites sociales importantes. Materiels et methodes Il s’agissait d’une enquete transversale telephonique, menee aupres d’un echantillon de 1000 femmes, âgees de 25 a ...
    Background Colorectal cancer (CRC) is a leading cause of cancer burden worldwide. In France, it is the second most common cause of cancer death after lung cancer. Systematic uptake of CRC screening can improve survival rates. However,... more
    Background Colorectal cancer (CRC) is a leading cause of cancer burden worldwide. In France, it is the second most common cause of cancer death after lung cancer. Systematic uptake of CRC screening can improve survival rates. However, people with limited health literacy (HL) and lower socioeconomic position rarely participate. Our aim is to assess the impact of an intervention combining HL and CRC screening training for general practitioners (GPs) with a pictorial brochure and video targeting eligible patients, to increase CRC screening and other secondary outcomes, after 1 year, in several underserved geographic areas in France. Methods We will use a two-arm multicentric randomized controlled cluster trial with 32 GPs primarily serving underserved populations across four regions in France with 1024 patients recruited. GPs practicing in underserved areas (identified using the European Deprivation Index) will be block-randomized to: 1) a combined intervention (HL and CRC training + b...
    Background Cancer recurrence and poor quality of life are major challenges of the growing population of breast cancer (BC) survivors. International guidelines encourage survivors to engage in regular physical activity (PA) and to maintain... more
    Background Cancer recurrence and poor quality of life are major challenges of the growing population of breast cancer (BC) survivors. International guidelines encourage survivors to engage in regular physical activity (PA) and to maintain a healthy body weight (BW), as both have a proven benefit on survival. Our aims were (1) to describe PA and BW 5 years after a BC diagnosis and (2) to define the predictors of long-term engagement in healthy lifestyle, in a representative sample of French survivors. Methods The French National VICAN surveys were implemented in 2012 and 2015 among cancer survivors. This analysis focused on 723 women with BC, without progression at 5 years, and who participated in both surveys. The questionnaires dealt with several topics including socioeconomic status, treatments and side effects, psychometric scales and lifestyle habits. Results Five years after diagnosis, 26% of women reported regular PA, 61% occasional PA and 14% no PA. Moreover, 27% reported a w...
    Contexte Le cancer engendre des changements de vie pouvant survenir pendant la phase de traitement et se prolonger de facon perenne a distance du diagnostic de la maladie. Ces changements peuvent etre contrains par la maladie, les... more
    Contexte Le cancer engendre des changements de vie pouvant survenir pendant la phase de traitement et se prolonger de facon perenne a distance du diagnostic de la maladie. Ces changements peuvent etre contrains par la maladie, les traitements et leurs sequelles, mais peuvent egalement resulter de choix personnels souhaites par la personne. Les mesures adoptees par les patients, a distance du diagnostic, interviennent dans le but de conserver une bonne qualite de vie et de prevenir le risque de recidive ou de second cancer. Precisons qu’en prevention tertiaire, de plus en plus d’etudes ont demontre les benefices de l’activite physique et du changement de l’alimentation chez les patients survivants du cancer. Methodes L’enquete nationale VICAN5, conduite cinq ans apres un diagnostic du cancer, fait suite a une premiere enquete qui avait ete menee a deux ans du diagnostic. Douze localisations cancereuses, parmi les plus frequentes, ont ete ciblees dans l’enquete : sein, prostate, melanome, thyroide, colon-rectum, voies aerodigestives superieures, vessie, rein, lymphome non hodgkinien, col et corps de l’uterus, poumon. Notre etude a ete restreinte aux femmes ayant repondu a l’enquete VICAN5, diagnostiquees d’un cancer du sein et qui n’ont connu aucune evolution pejorative au cours des cinq dernieres annees. La modification de l’activite physique et l’adoption d’une alimentation saine apres le diagnostic du cancer du sein ont ete mesurees par le biais de deux questions. Concernant le developpement post-traumatique (DPT), nous avons utilise l’echelle PTGI qui est composee de 21 items. Plus le score est eleve plus on considere que la personne a developpe des changements positifs a la suite de son cancer. Resultats Notre echantillon est compose de 1715 femmes dont l’âge moyen au diagnostic etait de 51 ans [23–80 ans]. Elles avaient un score moyen de DPT superieur a celui des autres localisations (57 versus 49 points ; p  Conclusion Les resultats presentes sont des analyses preliminaires transversales se focalisant sur le cancer du sein qui pourraient etre completees par des analyses longitudinales realisees sur les donnees des repondantes qui ont participe aux deux enquetes de VICAN. Les changements etudies peuvent concerner des personnes assez differentes. Le cancer du sein peut donc etre a l’origine de changements personnels differents mais qui necessitent pour certaines femmes un accompagnement medical et psychologique.
    Les 40es Journées de la SFSPM se sont tenues à Avignon du 7 au 9 novembre 2018. Le thème abordé—Cancer du sein : optimisation du parcours de soins — a réuni plus de 1 200 participants sous les voûtes du Palais des Papes. La fluidité de... more
    Les 40es Journées de la SFSPM se sont tenues à Avignon du 7 au 9 novembre 2018. Le thème abordé—Cancer du sein : optimisation du parcours de soins — a réuni plus de 1 200 participants sous les voûtes du Palais des Papes. La fluidité de chaque segment du parcours a été analysée en termes de risques de rupture de continuité des soins tant au sein du segment lui-même qu’en amont et en aval. Dans un parcours par essence pluridisciplinaire et plurimétiers, la nécessité d’une réflexion globale et d’une coordination active réalisées par des professionnels formés a été rappelée à chaque session. Chacun des intervenants a esquissé de potentiels indicateurs de qualité tenant compte à la fois de son implication dans son segment d’intervention, mais tenant compte aussi d’une vision plus globale de ce que devrait être le parcours au travers de la maladie et des soins. La parole a été très largement partagée entre soignants et associations de malades, entre paramédicaux et acteurs en sciences hum...
    Background Information request for cancer patients is high with frequent reported unmet needs. This aims of this study is: – To measure the level of satisfaction with information received on minor/severe symptoms patients may suffer from,... more
    Background Information request for cancer patients is high with frequent reported unmet needs. This aims of this study is: – To measure the level of satisfaction with information received on minor/severe symptoms patients may suffer from, among cancer survivors 5 years after diagnosis. – To identify the factors associated with the non-satisfaction with this level of information in both cases (minor symptoms and severe symptoms). Methods The VICAN survey consisted in a French representative sample of 4174 5-years cancer survivors. Self-reported data were collected by telephone interviews and self-administrated questionnaires. Only non-gendered cancers were selected. Weighted univariate and multivariate analyses were performed using statistical software STATA version 12.0, to identify factors associated non-satisfaction of the level of information received. The significativity threshold used for the univariate analysis was 20% and 5% for the multivariate. Results A total of 2243 out of 4174 patients were selected, 54.2% were male, median age was 58 years and men were significantly older (63 vs 55, P  Conclusion Cancer survivors have been found to benefit from health care information. In this large prospective analysis including non-gendered cancers, women reported lower levels of information than men and searched online information more frequently. Gender difference and preference for information is an important issue in order to give appropriate information to cancer patients.
    Context The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) was developed in its English version to assess anxiety in people with prostate cancer. Since there was no French version, the aim of our study was to translate and evaluate... more
    Context The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) was developed in its English version to assess anxiety in people with prostate cancer. Since there was no French version, the aim of our study was to translate and evaluate the psychometric properties of the 3-factors initial English scale on a sample of French men. Methods The MAX-PC was translated from English to French and distributed online by two associations (Seintinelles and ANAMACaP). The questionnaire, consisting of Hospital Anxiety and Depression Scale (HADS), Short Form-12 (SF12) and Zimbardo Time Perspective Inventory (ZTPI) scales, was intended for patients over 18 years of age who have been diagnosed with prostate cancer for less than 12 months. Factor structure was analyzed by exploratory factor analysis (EFA) on 56.2% of respondents (n = 104) and confirmed by confirmatory factor analysis (CFA) on the rest of the sample (n = 81). To measure the reliability of the scale, we used the Cronbach's alpha and construct validity was evaluated by the correlation between MAX-PC, HADS and SF12 scales and their subscales. Results 185 patients responded to our questionnaire, of which 168 responded to all items of the MAX-PC scale. The average age of participants was 65.1 years SD (7.70). The EFA and CFA confirms the same structure as the original version. The French version demonstrated a good reliability since Cronbach alpha coefficient for the total score and the three subscales were 0.92, 0.90, 0.68 and 0.87, respectively. It was also shown a strong validity. In addition, the MAX-PC total score was correlated highly with HADS-Anxiety (r = 0.68, p  Conclusion The MAX-PC scale has shown good reliability and validity among French men. We believe that its use in future studies and routine clinical care will better identify patients for whom a psychological support would be needed to decrease prostate cancer related anxiety.
    Background Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence... more
    Background Several countries have implemented mobile apps in an attempt to trace close contacts of patients with COVID-19 and, in turn, reduce the spread of SARS-CoV-2. However, the effectiveness of this approach depends on the adherence of a large segment of the population. Objective The aims of this study were to evaluate the acceptability of a COVID-19 contact tracing mobile app among the French population and to investigate the barriers to its use. Methods The Health Literacy Survey 2019 questioned 1003 people in France during the COVID-19 pandemic on the basis of quota sampling. The survey collected sociodemographic characteristics and health literacy data, as well as information on participants’ communication with caregivers, trust in institutions, and COVID-19 knowledge and preventive behaviors. The acceptability of a mobile app for contact tracing was measured by a single question, the responses to which were grouped into three modalities: app-supporting, app-willing, and ap...
    Background Colorectal cancer (CRC) is a leading cause of cancer burden worldwide. In France, it is the second most common cause of cancer death after lung cancer. Systematic uptake of CRC screening can improve survival rates. However,... more
    Background Colorectal cancer (CRC) is a leading cause of cancer burden worldwide. In France, it is the second most common cause of cancer death after lung cancer. Systematic uptake of CRC screening can improve survival rates. However, people with limited health literacy (HL) and lower socioeconomic position rarely participate. Our aim is to assess the impact of an intervention combining HL and CRC screening training for general practitioners (GPs) with a pictorial brochure and video targeting eligible patients, to increase CRC screening and other secondary outcomes, after 1 year, in several underserved geographic areas in France. Methods We will use a two-arm multicentric randomized controlled cluster trial with 32 GPs primarily serving underserved populations across four regions in France with 1024 patients recruited. GPs practicing in underserved areas (identified using the European Deprivation Index) will be block-randomized to: 1) a combined intervention (HL and CRC training + b...
    Little is known about cancer survivors’ sexual health (SH)—particularly, from well after diagnosis and in cancers unrelated to sexuality. This study aimed to assess SH deterioration five years after diagnosis. We analyzed data from the... more
    Little is known about cancer survivors’ sexual health (SH)—particularly, from well after diagnosis and in cancers unrelated to sexuality. This study aimed to assess SH deterioration five years after diagnosis. We analyzed data from the French national VIe après le CANcer (VICAN) survey. Six items from the Relationship and Sexuality Scale were used to assess SH. Respondents were grouped according to an ascending hierarchical classification in four clusters: strong, moderate, and weak deterioration or stable (WD, SD, MD, or St). Out of 2195 eligible participants, 57.3% reported substantial SH deterioration as either SD (30.8%) or MD (26.5%), while WD and St accounted for 31.2% and 11.5% of respondents, respectively. Substantial deterioration was reported in all cancer sites (from 27.7% in melanoma to 83.1% in prostate). Treatment type, cancer sequelae, and pain, as well as psychological consequences (depression and anxiety, especially for younger patients) were associated with substan...
    6588 Background: Patients’ satisfaction is known to be closely linked to the time spent with the physician. However, longer waiting times may be a source of dissatisfaction as well as organizational dysfunctions of the outpatient unit. Is... more
    6588 Background: Patients’ satisfaction is known to be closely linked to the time spent with the physician. However, longer waiting times may be a source of dissatisfaction as well as organizational dysfunctions of the outpatient unit. Is a validation of chemotherapy by phone call instead of a medical consultation with a senior physician before chemotherapy (CT) is feasible without compromising patients’ satisfaction and quality of life? Methods: Pts with OMS < 1, able to respond to phone call, < 76 years, receiving day 8 and or d15 of CT were included. We enrolled 343 pts in a before/after study between 2013 and 2016. In the “before” step (control arm), 168 pts had a systematic physician consultation the same day before CT administration. In the intervention arm 175 pts received a phone call by a junior physician the day preceding CT administration. A specific questionnaire for CT -related toxicity of the previous cycle was recorded and CT was validated or not by physician. T...
    It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in... more
    It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels' tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top-down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The ...

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