Nerve sprouting in regeneration occurs as a restorative process following nerve crush or section. During regeneration, the administration of ACTH or ACTH peptide fragments such as αMSH (ACTH 1–13), ACTH 4–10, or an analogue of ACTH 4–9... more
Nerve sprouting in regeneration occurs as a restorative process following nerve crush or section. During regeneration, the administration of ACTH or ACTH peptide fragments such as αMSH (ACTH 1–13), ACTH 4–10, or an analogue of ACTH 4–9 (Org. 2766), stimulates the formation of nerve sprouts. The accelerated return of motor and sensory function following treatment with ACTH peptides (Strand and Kung 1980; Bijlsma et al. 1983) is due to an earlier initiation of sprouting following crush denervation (Verhaagen et al. 1986 a). Reinnervated motor units formed under the influence of early peptide treatment are considerably smaller, thus permitting finer motor control, than in saline-treated animals (Saint-Come and Strand 1985, 1987). This suggests an organizational role for these peptides on the pattern by which regenerating axons reinnervate skeletal muscle.
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The current status of male and female sterilization is defined. Current techniques involved in the surgical occlusion of the vasa deferentia and the fallopian tubes are explored. These techniques are evaluated against criteria that... more
The current status of male and female sterilization is defined. Current techniques involved in the surgical occlusion of the vasa deferentia and the fallopian tubes are explored. These techniques are evaluated against criteria that include efficacy, reversibility and safety. Future developments in simpler surgical and non-surgical techniques as well as in safer chemical or physical occlusive agents are more fully elaborated.