BackgroundMelanoma guidelines recommend surgical excision with 10 mm margins for T1 melanomas (invasive melanomas with Breslow thickness ≤1 mm), including those in radial growth phase, which are without metastatic potential; however, such... more
BackgroundMelanoma guidelines recommend surgical excision with 10 mm margins for T1 melanomas (invasive melanomas with Breslow thickness ≤1 mm), including those in radial growth phase, which are without metastatic potential; however, such margins may be problematic on head‐and‐neck.ObjectiveWe compared outcomes of wide (10 mm margins) versus narrow (5 mm margins) excisions in patients with radial growth phase T1 melanoma on head‐and‐neck including face.MethodsWe retrospectively examined 610 consecutive patients excised with wide versus narrow margins, from 2001 to 2018, at six European centres. In all cases, radial growth phase, and clear margins with 5 or 10 mm of clearance, were ascertained histologically. Multivariable models investigated associations of margins and other factors with overall survival and local recurrence.ResultsThree hundred and sixteen (51.8%) patients received wide excision, 219 (69.3%) with primary wound closure, 97 (30.7%) with reconstruction; 294 (48.2%) pa...
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One of the most significant risk factors for melanoma is a positive family history of the disease. It is estimated that approximately 10 percent of melanoma cases report a first-or second-degree relative with melanoma. We reported the... more
One of the most significant risk factors for melanoma is a positive family history of the disease. It is estimated that approximately 10 percent of melanoma cases report a first-or second-degree relative with melanoma. We reported the experience of the Dermato-Oncologic Unit of Brescia, Italy.
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Background: Atypical melanocytic tumors (AMTs) include a wide spectrum of melanocytic neoplasms that represent a challenge for clinicians due to the lack of a definitive diagnosis and the related uncertainty about their management. This... more
Background: Atypical melanocytic tumors (AMTs) include a wide spectrum of melanocytic neoplasms that represent a challenge for clinicians due to the lack of a definitive diagnosis and the related uncertainty about their management. This study analyzed clinicopathologic features and sentinel node status as potential prognostic factors in patients with AMTs. Patients and Methods: Clinicopathologic and follow-up data of 238 children, adolescents, and adults with histologically proved AMTs consecutively treated at 12 European centers from 2000 through 2010 were retrieved from prospectively maintained databases. The binary association between all investigated covariates was studied by evaluating the Spearman correlation coefficients, and the association between progression-free survival and all investigated covariates was evaluated using univariable Cox models. The overall survival and progression-free survival curves were established using the Kaplan-Meier method. Results: Median follow...
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PURPOSE Thin melanomas (T1; ≤ 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma... more
PURPOSE Thin melanomas (T1; ≤ 1 mm) constitute 70% of newly diagnosed cutaneous melanomas. Regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor for T1 melanoma. However, current melanoma guidelines do not provide clear indications on when to perform SNB in T1 disease and stress an individualized approach to SNB that considers all clinicopathologic risk factors. We aimed to identify determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better select patients with T1 disease for SNB. PATIENTS AND METHODS The development cohort comprised 3,666 patients with T1 disease consecutively treated at the Istituto Nazionale Tumori (Milan, Italy) between 2001 and 2018; 4,227 patients with T1 disease treated at 13 other European centers over the same period formed the validation cohort. A random forest procedure was applied to the development data set to select characteristics associated with SN status f...
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ABSTRACT
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Research Interests: Dermatology, Medicine, Humans, Pubmed, Melanoma, and 6 moreMale, Scrotum, Adult, Dermoscopy, Skin Neoplasms, and angiokeratoma
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Among older patients, melanoma in general presents biological features related to a more aggressive biology, such as more locally advanced tumor. Management of melanoma in elderly may be difficult, mainly due to comorbidities. We report... more
Among older patients, melanoma in general presents biological features related to a more aggressive biology, such as more locally advanced tumor. Management of melanoma in elderly may be difficult, mainly due to comorbidities. We report the experience of the Melanoma Unit of ASST Spedali Civili in Brescia, Italy. Study subjects were drawn from 3444 patients with histological confirmed melanoma. Data were extracted from electronic database of the Melanoma Unit of ASST Spedali Civili in Brescia, Italy. Patients who received diagnosis of cutaneous melanoma at age of 65 years or older were retrospectively evaluated. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated. Of the 805 patients described in this study, 444 were males and 361 females. Statistically significant differences were found between patients aged 65-80 years and those aged >80 years considering melanoma prognostic factors, such as Breslow thickness, number of mitoses/mm2 ...
Research Interests: Cancer, Natural History, Dermatology, Medicine, Humans, and 7 moreFemale, Melanoma, Male, Aged, Retrospective Studies, Age Factors, and Skin Neoplasms
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ABSTRACT No abstract available.
Research Interests: Chemotherapy and Medicine
Chronic urticaria is a common condition that can be very disabling when severe. A variety of causes has been reported to induce urticaria, including food, infections, drugs and other factors. In more than 50% of cases of chronic... more
Chronic urticaria is a common condition that can be very disabling when severe. A variety of causes has been reported to induce urticaria, including food, infections, drugs and other factors. In more than 50% of cases of chronic urticaria, however, the cause remains unknown and cannot be ascribed to allergic, physical, environmental or other factors. Although an association between chronic idiopathic urticaria and malignancy has been occasionally reported, such an association remains controversial because it is difficult to demonstrate it is not just coincidental. Here we report the cases of four female patients with occult papillary carcinoma of the thyroid who developed chronic urticaria. In all of these cases, removal of the tumor led to prompt resolution of the urticarial lesions, thus suggesting a pathogenetic relationship between the two. This is the first report of papillary thyroid carcinomas associated with chronic urticaria and highlights how chronic urticaria may be an im...
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Three patients with Crosti's lymphoma were treated with radiotherapy using electron accelerators. The energy radiations ranged from 5 to 9 Mev. with large fields. The total dose was 40 Gy, delivered in 2 Gy fractions daily. The... more
Three patients with Crosti's lymphoma were treated with radiotherapy using electron accelerators. The energy radiations ranged from 5 to 9 Mev. with large fields. The total dose was 40 Gy, delivered in 2 Gy fractions daily. The treatment lasted four weeks. No side effects were reported and no recurrence was remarked after 24 months.
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Background.The clinical presentation of desmoplastic melanoma is often challenging. We report the experience of the Melanoma Unit of Spedali Civili University Hospital of Brescia, Italy.Method.Study subjects were drawn from 1770 patients... more
Background.The clinical presentation of desmoplastic melanoma is often challenging. We report the experience of the Melanoma Unit of Spedali Civili University Hospital of Brescia, Italy.Method.Study subjects were drawn from 1770 patients with histologica confirmed melanoma. Within this group, desmoplastic melanoma developed in 5 patients. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated.Results.Of the 5 patients described in this study, 2 were males and 3 females. The average age was 62.4 years ranging from 56 to 68 years. Breslow thickness ranged from 2.1 to 12 mm with a mean thickness of 5.8 mm. Primary treatment of 5 patients included a wide local excision of their primary lesions.Conclusions.Desmoplastic melanoma is a rare neoplasm which clinically may mimic other tumours or cutaneous infiltrate of uncertain significance. The diagnosis is hiastopathological and radical resection is necessary.
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Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin. Though immunodeficiency is the most relevant risk factor, ultraviolet (UV) radiation is also involved, but as of yet we do not know the action spectrum,... more
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin. Though immunodeficiency is the most relevant risk factor, ultraviolet (UV) radiation is also involved, but as of yet we do not know the action spectrum, pattern or dose which would produce a dangerous exposure. A retrospective study of two immunosuppressed patients who developed MCC during, or soon after a treatment cycle with high dose UVA1 exposures was conducted, in order to understand wether repeated exposures to suberythemogenic UVA1 radiation may have a cancerogenic activity provoking MCC in immunosuppressed patients.
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Background. Recent studies have demonstrated that there exists a great variation in the lymphatic drainage in patients with malignant melanoma. Some patients have drainage to lymph nodes outside of conventional nodal basins. The lymph... more
Background. Recent studies have demonstrated that there exists a great variation in the lymphatic drainage in patients with malignant melanoma. Some patients have drainage to lymph nodes outside of conventional nodal basins. The lymph nodes that exist between a primary melanoma and its regional nodal basin are defined “interval nodes”. Interval node occurs in a small minority of patients with forearm melanoma. We report our experience of the Melanoma Unit of University Hospital Spedali Civili Brescia, Italy.Methods. Lymphatic mapping using cutaneous lymphoscintigraphy (LS) has become a standard preoperative diagnostic procedure to locate the sentinel lymph nodes (SLNs) in cutaneous melanoma. We used LS to identify sentinel lymph nodes biopsy (SLNB) in 480 patients.Results. From over 2100 patients affected by cutaneous melanoma, we identified 2 interval nodes in 480 patients with SLNB . The melanomas were both located in the left forearm. The interval nodes were also both located in ...
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Classically, dermatofibrosarcoma protuberans (DFSP) is a disease of adults. The world literature revision shows that several pediatric cases have been reported so far; this might suggest that the number of infants with the condition might... more
Classically, dermatofibrosarcoma protuberans (DFSP) is a disease of adults. The world literature revision shows that several pediatric cases have been reported so far; this might suggest that the number of infants with the condition might be larger than that estimated previously. Here, we report the 183rd case of histologically confirmed DFSP in young age. A 14-year-old white male patient came under our care for a slowly growing, pale brownish lesion on the neck skin. A biopsy specimen showed a DFSP. Subsequently, a wide surgery excision with 3 cm of resection margins including the underlying fascia was performed. To date, the patient has been in follow-up for 6 years without evidence of recurrent disease. The clinical features and treatment of DFSP diagnosed in childhood and adolescence reported in the published literature are reviewed to provide new insights about this rare entity. The aim is to emphasize the importance of biopsy for histologic evaluation in the cases that show a persistent or a large cutaneous plaque or nodule without pathognomonic clinical features that permit a clinical diagnosis. An accurate knowledge of the disease is the prerequisite for a wider recognition and appropriate treatment.
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Research Interests: Kidney diseases, Crystallization, Dermatology, Medicine, Biopsy, and 8 moreHumans, Cholesterol, Female, Male, Skin, Clinical Sciences, Aged, and Skin Biopsy
ABSTRACT
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Use of biologic agents targeting epidermal growth factor receptor (EGFR) continues to increase in the treatment of various malignancies. A significant limiting issue in the use of these agents is dermatological toxicity, mainly the... more
Use of biologic agents targeting epidermal growth factor receptor (EGFR) continues to increase in the treatment of various malignancies. A significant limiting issue in the use of these agents is dermatological toxicity, mainly the papulopustular eruption in the seborrhoeic areas of the skin, reported in 60–80% of the patients. This dermatological toxicity often causes important physical discomfort and distress in patients interrupting the therapy. Many studies have shown significant correlation between the severity of skin toxicity and tumor response, so it is important for oncology practitioners to control the signs and symptoms of skin toxicity in order to prevent therapy interruption in these patients. The possible mechanism of EGFR inhibitor-related cutaneous toxicity is the inhibition of EGFR in the skin itself. EGFR plays a specific role in skin biophysiology and it is present mainly in keratinocytes, follicular epithelium, sebaceous sweat glands, and endothelium present in the dermis capillaries. At this time there is no consensus on management of EGFR inhibitorassociated rash, and a variety of treatment options have been used, such as steroids, antibiotics, and retinoic acid. We report the experience of the Dermato-Oncologic Unit of Brescia, Italy. Ten patients with severe follicular rash induced by cetuximab were evaluated for papular dermatitis that appeared on the face after 3 weeks of treatment with cetuximab. Dermatitis was diffuse. It was characterized by gradual appearance of erythematous, pruritic papules, and pustules on the trunk. Moist or weeping cutaneous lesions in the groin were common. Patients usually had itching and less often pain at the involved site. Often, as more lesions developed, various topical products composed of antibiotics, steroids, cosmetics, and antipruritic agents were applied to patients. It is possible that greasy and occlusive products might increase inflammation and itchy sensation. In order to protect against this natural tendency, physicians should provide more information to the patient on the currently available products, and cosmetics should be avoided. We treated these extensive cases with the administration of oral limecycline 300 mg/day. Locally, maintenance of cleanliness with sodium chloride (NaCl) solutions followed by local treatment with salicylic cream (salicylic acid 2% and sulfur colloid 2%) gradually improved dermatitis. Topical or oral steroid was not used because folliculitis may follow their application. It was recommended to all patients to avoid any traumatisms of papulopustular lesions and sun exposure. In these patients, treatment of pruritus with sedative antihistamine, such as hydroxyzine, seems reasonable. In all patients, skin reaction was well controlled and dose reduction or interruption of EGFR-target agent was not necessary. We think that a multidisciplinary program and collaboration between oncologist and dermatologist is very important for management of skin reactions, especially in cases of new therapeutic approach.
Research Interests: Surgical Oncology, Medicine, Humans, Monoclonal Antibodies, Multidisciplinary Team, and 10 moreEpidermal Growth Factor Receptor, Patient Care Team, Neoplasms, Interdisciplinary Communication, Multidisciplinary Teams, Multidisciplinary Approach, Good Practice, Salicylic Acid, Antineoplastic Agents, and Drug Eruptions
Dear Editor, Here, we report a case of two melanomas arising in a patient receiving eculizumab for paroxysmal nocturnal hemoglobinuria (PNH) and affected by melanoma in situ. PNH is an acquired clonal disorder characterized by chronic... more
Dear Editor, Here, we report a case of two melanomas arising in a patient receiving eculizumab for paroxysmal nocturnal hemoglobinuria (PNH) and affected by melanoma in situ. PNH is an acquired clonal disorder characterized by chronic complement-mediated hemolysis. It ...
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No studies are available in the literature on the distribution of different melanoma features and risk factors in the Italian geographical areas. To identify the differences in clinical-pathological features of melanoma, the distribution... more
No studies are available in the literature on the distribution of different melanoma features and risk factors in the Italian geographical areas. To identify the differences in clinical-pathological features of melanoma, the distribution of risk factors and sun exposure in various Italian macro-areas. Multicentric-observational study involving 1,472 melanoma cases (713 north, 345 centre, 414 south) from 26 referral centres belonging to the Italian Multidisciplinary Group for Melanoma. Melanoma patients in northern regions are younger, with thinner melanoma, multiple primaries, lower-intermediate phototype and higher counts of naevi with respect to southern patients; detection of a primary was mostly connected with a physician examination, while relatives were more involved in the south. Northern patients reported a more frequent use of sunbeds and occurrence of sunburns before melanoma despite sunscreen use and a lower sun exposure during the central hours of the day. The understand...
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Herein we report a case of a melanoma arising in a patient receiving adalimumab and methotrexate for rheumatoid arthritis. A limited number of studies reported melanoma growth in patients undergoing treatment with biologics. This case... more
Herein we report a case of a melanoma arising in a patient receiving adalimumab and methotrexate for rheumatoid arthritis. A limited number of studies reported melanoma growth in patients undergoing treatment with biologics. This case report with a brief review of literature suggests that patients under treatment with biologics should be counseled to identify new pigmented lesions or changes in preexisting nevi. Clinicians' collaboration will facilitate recognition and timely diagnosis of early melanoma. If there is any doubt, excision for histological evaluation should be considered. Pending new studies, careful observation is encouraged.
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Background Although polychlorinated biphenyls (PCBs) have been classified as human carcinogens for their association with melanoma, few data are available for other skin lesions. Objectives To investigate the prevalence of skin disorders... more
Background Although polychlorinated biphenyls (PCBs) have been classified as human carcinogens for their association with melanoma, few data are available for other skin lesions. Objectives To investigate the prevalence of skin disorders in a highly PCB polluted area in northern Italy, with locally produced food as the main source of human contamination, and evaluate the association between skin lesions and PCB serum levels, taking account of possible confounders. Materials & Methods Thirty-three PCB congeners were quantitatively assessed and a total of 189 subjects were equally divided into three groups using the tertiles of total PCB serum concentrations. All subjects underwent a clinical examination and were interviewed on their risk factors and history of skin diseases. Results No statistically significant difference was found in the prevalence of skin cancer, nevi, pigmentary disorders as well as inflammatory and infectious skin diseases among the three PCB exposure groups. It should be noted that the use of questionnaires to assess subjects’ past sun exposure and photoprotection is intrinsically flawed due to random error. Conclusion Our study does not support the hypothesis that chronic PCB exposure, through the ingestion of contaminated food, determines an increased risk of developing skin diseases.
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Aims and backgroundSunburn during childhood is associated with an increased risk for developing melanoma in an adult age. The aim of the present study was to define the validity of our educational program in order to teach the positive... more
Aims and backgroundSunburn during childhood is associated with an increased risk for developing melanoma in an adult age. The aim of the present study was to define the validity of our educational program in order to teach the positive effects and risks of sun exposure during childhood.Patients and methodsWe conducted a population-based, case-control study in primary schools of three towns in Northern Italy (Brescia, Bergamo and Trento) between 2001 and 2002. The study was carried out on 1945 pupils (aged 8-9 years) and included 1309 case children who received an educational program before the summer to increase awareness towards sun exposure and 636 control children who did not. Parents of case and control children were interviewed using a questionnaire about their children's skin characteristics, sun protective behavior and sunburns. The questionnaire was completed twice, before and after the summer, to verify the changes of sun exposure habits.ResultsA significant decrease in...
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Sir, A limited number of studies have reported cutaneous metastases in colorectal adenocarcinoma patients. Here, we report a case of a solitary cutaneous metastasis of colorectal adenocarcinoma in a 51‐year‐old man. We emphasize the... more
Sir, A limited number of studies have reported cutaneous metastases in colorectal adenocarcinoma patients. Here, we report a case of a solitary cutaneous metastasis of colorectal adenocarcinoma in a 51‐year‐old man. We emphasize the importance of dermatologic evaluation in oncologic patients that show a persistent cutaneous plaque or nodule. and stress that combining dermoscopy and reflectance confocal microscopy improves diagnostic accuracy for equivocal lesions.
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A giant congenital nevus is a melanocytic nevus present at birth with wide extent on the skin surface. The management of this nevus remains controversial and needs to be personalized for each patient. A retrospective multicenter study was... more
A giant congenital nevus is a melanocytic nevus present at birth with wide extent on the skin surface. The management of this nevus remains controversial and needs to be personalized for each patient. A retrospective multicenter study was carried out in the Dermatological Departments of Brescia, Padua, and Pavia, Italy. The inclusion criterion was the diagnosis of a giant congenital melanocytic nevus on the basis of clinical observation. Nine patients with giant congenital nevus are reported. None developed melanoma, whereas giant congenital nevi have been slowly fading in pigmentation. Having regard to the doubts on treatment that persist in the literature, we should consider that decisional management of giant congenital melanocytic nevi can be really complex, because of the size and depth of lesions. Indeed, the ablative surgery or other treatments might cause significant troubles and complete excision of deeper layers of the lesion is almost impossible to achieve. Moreover, the ...
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A case of generalized melanosis associated with malignant melanoma, characterized by up-to-date, previously undescribed histologic findings, is reported. Markedly dilated dermal lymphatics with features resembling secondary lymphangioma... more
A case of generalized melanosis associated with malignant melanoma, characterized by up-to-date, previously undescribed histologic findings, is reported. Markedly dilated dermal lymphatics with features resembling secondary lymphangioma were found. We speculate that a further mechanism, as well as those previously reported in the literature, could be operative in the pathogenesis of this disorder of altered pigmentation.
Research Interests: Pathology, Pathogenesis, Dermatology, Macrophages, Medicine, and 8 moreHumans, Melanoma, Male, Epidermis, Aged, Lymphangioma, Melanosis, and Skin Neoplasms
The relationship between the occurrence of skin diseases and skin tattoos remains unclear. Dermatologic disorders have been reported to occur in about 2% of cases. In addition, tattoo pigment can migrate to the regional lymph nodes... more
The relationship between the occurrence of skin diseases and skin tattoos remains unclear. Dermatologic disorders have been reported to occur in about 2% of cases. In addition, tattoo pigment can migrate to the regional lymph nodes through the lymphatic vessels and subsequently mimic metastatic disease from melanoma. A 23-year-old Caucasian man presented with a pigmented lesion on the left scapular region, which had slowly enlarged over time. The patient exhibited an extensive tattoo on the left upper arm, left shoulder, and part of the upper back. His medical history was unremarkable. The pigmented lesion was excised. Histology confirmed malignant melanoma. Ultrasound examination of the abdomen, neck, and inguinal and axillary lymph nodes and a total body computed tomography scan showed no sign of disease. A re-excision with 2-cm margins and sentinel lymph node biopsy (SLNB) were performed. Two grossly enlarged, black sentinel lymph nodes (SLNs) highly suggestive of melanoma metastases were removed. No evidence of melanoma metastasis was found in any of the sampled tissues. Large amounts of pigment were present within the subcapsular space and sinusoid areas of the two clinically suspicious lymph nodes. Immunohistochemical analysis was negative. Sentinel lymph node biopsy is widely performed in cutaneous melanoma. Histologic confirmation of any enlarged, pigmented SLN is essential prior to radical surgery, especially when pigmented SLNs are found near a tattoo. Tattoo pigments may deposit in the regional lymph nodes and may clinically mimic metastatic disease. A history of tattooing should be considered in all melanoma patients eligible for SLNB. In a finding of darkly pigmented nodes during SLNB, radical lymphadenectomy should be withheld until immunohistologic confirmation of metastasis in the SLN is obtained.
Research Interests: Dermatology, Risk assessment, Metastasis, Medicine, Biopsy, and 15 moreHumans, Melanoma, Male, Differential Diagnosis, Clinical Sciences, Tattooing, Public health systems and services research, Hyperpigmentation, Risk Assessment, Axilla, Lymph nodes, Skin Neoplasms, Sentinel lymph node biopsy, Sentinel Lymph Node, and coloring agents
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Research Interests: Dermatology, Adolescent, Medicine, Italy, Humans, and 11 moreFemale, Melanoma, Male, Young Adult, Incidence, Clinical Sciences, Aged, Middle Aged, Adult, Skin Neoplasms, and Nevus
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1. McDonald CJ. Cytotoxic agents for use in dermatology. J AM ACAD DERMATOL 1985;12:753-75. 2. Kennedy BJ, Smith LR, Goltz RW. Skin changessecondary to hydroxyurea therapy. Arch DermatoI1975;3:183-7. 3. Sigal M, Crickx B, Blanchet P, et... more
1. McDonald CJ. Cytotoxic agents for use in dermatology. J AM ACAD DERMATOL 1985;12:753-75. 2. Kennedy BJ, Smith LR, Goltz RW. Skin changessecondary to hydroxyurea therapy. Arch DermatoI1975;3:183-7. 3. Sigal M, Crickx B, Blanchet P, et al. Lesions cutanees induites par l'utilisation au longcours de l'hydroxyuree. Ann Dermatol Venereol 1984;3:895-900. 4. Burns DA, Sarkany I, Craylarde P. Effectsofhydroxyurea therapy on normal skin: a case report. Clin Exp Derrnatol 1980;5:447-9. 5. Barety M, Audoly P, Migozzi B, et al. Pigmentation ungueale et cutanee au cours d'un traitement par hydroxyuree, Bull Soc Fr Dermatol Syph 1975;82:208-9, 6. Hood AF, Haynes HA. Mucocutaneous complications of cancer therapy. In: Fitzpatrick TB, Eisen AZ, Wolff K, ct al, eds. Update dermatology in general medicine. New York: McGraw-Hill 1983:80-97. 7. Bronner AK, Hood AF. Cutaneous complications of chemotherapcuticagents. J AMACAD DERMATOL 1983;9:64563. 8. Dahl MH, LomaishJS. Long-term effectsofhydroxyurea in psoriasis. Br Med J 1972;4:585-7. 9. Jeanmougin M, Civatte J, Bonvalet D, et al. Chrornonychies et chimiotherapie anti-cancereuse, Ann Dermatol VenereoI1982;109:l69-72, 10. Moschella SL, Greenwald MA. Psoriasis with hydroxyurea. Arch Dermatol 1973;107:363-8. 11. Sharon R, Tatarsky I, Ben-Arieh Y. Treatment of polycythemia vera with hydroxyurea. Cancer 1986;57:718-20. 12. Roe LD, WilsonJW. Hydroxyurea therapy, Arch Dermatol 1973;108:426-7. 13. Levine LE, Medenica MM, LorinezAt, et al. Distinctive acral erythema occurring during therapy for severe myelogenous leukemia. Arch DermatoI1985;121:102-4. 14. Burgdorf WEC, Gilmore WA, Ganick RG. Peculiaracral erythema secondary to high-dose chemotherapy for acute myelogenous leukemia. Ann Intern Med 1982;97:61-2. 15. Crider MK, Jansen J, Norins AL, et a1. Chemotherapy-induced acral erythema in patients receiving bone marrow transplantation. Areh Dermatol 1986;122:1023-7. 16. Doyle LA, Berg C, Bottino G, et a1. Erythema and desquamation after high-dose metrotrexate, Ann Intern Med 1983;98:61 J-2. 17. Feldman LD,Ajani lA. Derrnite desmains et des piedsliee aux traitemcnts par le fluoro-uracile, JAMA 1986;11:47-8. 18. Herzig RH, Wolff SN, Lazarus HM, et al. High-dose cytosine arabinoside therapy for retractory leukemia. Blood 1983;62:361-9. 19. Silver FS, Espinoza LR, Hartmann RC. Acral erythema and hydroxyurea [Letter]. Ann Intern Med 1983;98:675. 20. Nielsen M. Painful palmar-plantar erythema in myeloproliferative disease. Arch Dermatol 1985;121:]240-1. 21. Dangoumau J, Evreux JC, Jouglard J. Methode d'imputabilite des effets indesirables des medicaments. Therapie 1978;33:373-81.
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1. Int J Epidemiol. 1989 Dec;18(4):999-1000. Frequency of HIV infection in patients attending sexually transmitted disease clinics in Italy. Naldi L, Parazzini F, Sena P, Manganoni A, Pansera B, Cainelli T. PMID: 2621042 [PubMed - indexed... more
1. Int J Epidemiol. 1989 Dec;18(4):999-1000. Frequency of HIV infection in patients attending sexually transmitted disease clinics in Italy. Naldi L, Parazzini F, Sena P, Manganoni A, Pansera B, Cainelli T. PMID: 2621042 [PubMed - indexed for MEDLINE]. Publication Types: ...
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Previous studies have reported that repeated solar and artificial UVB (280-320 nm) and UVA (320-400 nm) exposures can modify acquired melanocytic nevi (AMN). We therefore investigated the clinical, dermoscopic, histological and... more
Previous studies have reported that repeated solar and artificial UVB (280-320 nm) and UVA (320-400 nm) exposures can modify acquired melanocytic nevi (AMN). We therefore investigated the clinical, dermoscopic, histological and immunohistochemical changes in AMN exposed to UVB and UVA radiation. Twenty healthy volunteers with at least three AMN on the trunk were enrolled in the present study and randomized into two groups to receive equally effective doses of narrow-band (NB)-UVB or UVA1. Three exposures per week were delivered for a total of 4 weeks. During exposures, one AMN was left unprotected, a second one was shielded with an opaque adhesive tape and the third nevus was covered with a commercial sunscreen. After the irradiation cycle, the AMN were surgically removed and underwent histological and immunohistochemical assessment of melanocyte/melanogenesis-related proteins (MART-1, tyrosinase, HMB-45), cell cycle activation markers (Ki-67, topoisomerase IIalpha, p53, Cdk2) and transcription factors (microphthalmia-associated transcription factor, STAT3). Nevi that were exposed to NB-UVB or UVA1 also showed statistically significant increase in size and changes in their dermoscopic features, including overall darkening, increased pigment network expression, formation of branched streaks, and increased number and size of brown globules and dots. AMN that had been covered with opaque tape or sunscreen did not show changes in size or dermoscopic features following UVA1 or NB-UVB exposure. Histological and immunohistochemical analysis did not show any significant change in exposed AMN in comparison with AMN shielded with an opaque adhesive tape or covered with the sunscreen.
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Background: Fas ligand (Fas-L), which is expressed by melanoma cells, can be cleaved from cell membranes and become soluble (soluble Fas-L, sFas-L). No previous study examined sFas-L levels in patients affected with all clinical stages of... more
Background: Fas ligand (Fas-L), which is expressed by melanoma cells, can be cleaved from cell membranes and become soluble (soluble Fas-L, sFas-L). No previous study examined sFas-L levels in patients affected with all clinical stages of melanoma. Objective: To investigate if sFas-L can be considered a serological marker for melanoma. Methods: Serological sFas-L values in 114 patients with melanoma and 25 controls were measured by using ELISA. Results: sFas-L values in patients were not significantly higher than in controls. They were not significantly different, moreover, when patient groups belonging to different clinical stages were compared with the control group. Two patients affected with distant metastases had the highest sFas-L values. Conclusion: sFas-L cannot be considered, within the limits of this study, as a serological marker for the detection of melanoma. Further studies are needed to evaluate whether sFas-L can be used as a marker for disease progression and/or pred...