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Herbs and spices are rich sources of potent antioxidants. For over 2000 years, herbs and spices are used in every kind of treatment in TIM (Traditional Indian Medicine) and TCM (Traditional Chinese Medicine), as flavoring, coloring, and... more
Herbs and spices are rich sources of potent antioxidants. For over 2000 years, herbs and spices are used in every kind of treatment in TIM (Traditional Indian Medicine) and TCM (Traditional Chinese Medicine), as flavoring, coloring, and fragrance agents. Herbs and spices have various kinds of bioactive constituents which are potential and promising sources of antioxidants. The herb’s and spice’s history is as old and long as the history of mankind. The antioxidants in herbs and spices are very much effective because they have excellent antioxidant activity. In recent times it is an increase in the interest for the recognition, identification of antioxidants compounds that are well-potentiate and have nominal or very much fewer side effects. This interest in growing and it is under various projects at a global level. This study provides some details on the most popular and most widely used herbs and spices and explains their antioxidant properties. Therefore, using herbs and spices is a safer option than using synthetic antioxidants, which have become prevalent and broadly acceptable by consumers.
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... Environ. Health Persp. , 110: 11471153. [CrossRef], [PubMed], [Web of Science ®], [CSA] View all references, 1414. Smith, L. 2003. Tracing Poison's Path. A. Witze: Dallas Morning News Feb 24;. (The story of Dr. Linda Smith ...... more
... Environ. Health Persp. , 110: 11471153. [CrossRef], [PubMed], [Web of Science ®], [CSA] View all references, 1414. Smith, L. 2003. Tracing Poison's Path. A. Witze: Dallas Morning News Feb 24;. (The story of Dr. Linda Smith ... Spallholz, JE, Boylan, LM and Rahman, MM. 2004. ...
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Research Interests: Medicine and Brucellosis
Ethosomes are elastic nanovesicles with phospholipid bases that are noninvasive delivery vehicles and have a high ethanol concentration (20–45%). As transdermal drug delivery confers poor penetration, the major obstacle is the low... more
Ethosomes are elastic nanovesicles with phospholipid bases that are noninvasive delivery vehicles and have a high ethanol concentration (20–45%). As transdermal drug delivery confers poor penetration, the major obstacle is the low diffusion rate of drugs across the stratum corneum. The sophisticated ethosomal delivery systems enable drugs to reach the deep skin layers and/or the systemic circulation. The development of these new carriers involves the employment of several preparatory processes. Ethosomal dispersions are added to gels, patches, and creams for ease of use and stability. Ethanol is known as an efficient permeation enhancer and has been added in the vesicular systems to prepare elastic nanovesicles. It has the potential to interact with the polar head group region of lipid molecules, lowering the melting point of the stratum corneum lipid and raising lipid fluidity and cell membrane permeability as a result. Ethosomes' special structure allows them to enclose and tr...
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Background: Huntington’s disease is an inherited autosomal dominant trait neuro-degenerative disorder caused by changes (mutations) of a gene called huntingtin (htt) that is located on the short arm (p) of chromosome 4, CAG expansion... more
Background: Huntington’s disease is an inherited autosomal dominant trait neuro-degenerative disorder caused by changes (mutations) of a gene called huntingtin (htt) that is located on the short arm (p) of chromosome 4, CAG expansion mutation. It is characterized by unusual movements, cognitive and psychiatric disorders. Objective: This review was undertaken to apprehend biological pathways of Huntington’s disease (HD) pathogenesis and its management by nature-derived products. Natural products can be lucrative for the management of HD as it shows protection against HD in pre-clinical trials. Advanced research is still required to assess the therapeutic effectiveness of the known organic products and their isolated compounds in HD experimental models. Summary: Degeneration of neurons in Huntington’s disease is distinguished by progressive loss of motor coordination and muscle function. This is due to the expansion of CAG trinucleotide in the first exon of the htt gene responsible fo...
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As per World Health Organization cancer remains as a leading killer disease causing nearly 10 million deaths in 2020. Since the burden of cancer increases worldwide, warranting an urgent search for anti-cancer compounds from natural... more
As per World Health Organization cancer remains as a leading killer disease causing nearly 10 million deaths in 2020. Since the burden of cancer increases worldwide, warranting an urgent search for anti-cancer compounds from natural sources. Secondary metabolites from plants, marine organisms exhibit a novel chemical and structural diversity holding a great promise as therapeutics in cancer treatment. These natural metabolites target only the cancer cells and the normal healthy cells are left unharmed. In the emerging trends of cancer treatment, the natural bioactive compounds have long become a part of cancer chemotherapy. In this review, we have tried to compile about eight bioactive compounds from plant origin viz. combretastatin, ginsenoside, lycopene, quercetin, resveratrol, silymarin, sulforaphane and withaferin A, four marine-derived compounds viz. bryostatins, dolastatins, eribulin, plitidepsin and three microorganisms viz. Clostridium , Mycobacterium bovis and Streptococcus pyogenes with their well-established anticancer potential, mechanism of action and clinical establishments are presented.
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Herbs and spices are rich sources of potent antioxidants. For over 2000 years, herbs and spices are used in every kind of treatment in TIM (Traditional Indian Medicine) and TCM (Traditional Chinese Medicine), as flavoring, coloring, and... more
Herbs and spices are rich sources of potent antioxidants. For over 2000 years, herbs and spices are used in every kind of treatment in TIM (Traditional Indian Medicine) and TCM (Traditional Chinese Medicine), as flavoring, coloring, and fragrance agents. Herbs and spices have various kinds of bioactive constituents which are potential and promising sources of antioxidants. The herb’s and spice’s history is as old and long as the history of mankind. The antioxidants in herbs and spices are very much effective because they have excellent antioxidant activity. In recent times it is an increase in the interest for the recognition, identification of antioxidants compounds that are well-potentiate and have nominal or very much fewer side effects. This interest in growing and it is under various projects at a global level. This study provides some details on the most popular and most widely used herbs and spices and explains their antioxidant properties. Therefore, using herbs and spices i...
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Vitamin D is one of the essential nutrients to sustain the human health. Vitamin D functions in the body through both an endocrine mechanism (regulation of calcium absorption) and an autocrine mechanism (facilitation of gene expression).... more
Vitamin D is one of the essential nutrients to sustain the human health. Vitamin D functions in the body through both an endocrine mechanism (regulation of calcium absorption) and an autocrine mechanism (facilitation of gene expression). The role of Vitamin D deficiency in increasing the risk factor of many common and serious chronic diseases, including cancers, type 1 diabetes, cardiovascular disease and osteoporosis. Numerous epidemiologic studies suggest that exposure to sunlight, which enhances the production of Vitamin D₃ in the skin, is important in preventing many chronic diseases. 25(OH)D (25-hydrovitamin D) is the metabolite that should be measured in the blood to determine Vitamin D status. 25(OH)D deficiency is prevalent in infants who are solely breastfed and who do not receive Vitamin D₃ supplementation and in adults of all ages who have increased skin pigmentation or who always wear sun protection or limit their outdoor activities. It is therefore necessary to know the...
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Mental disease, often known as mental health problems, encompasses a broad variety of disorders that impact your emotions, thought, and behavior. Depression, anxiety disorders, schizophrenia, eating disorders, and addictive behaviors are... more
Mental disease, often known as mental health problems, encompasses a broad variety of disorders that impact your emotions, thought, and behavior. Depression, anxiety disorders, schizophrenia, eating disorders, and addictive behaviors are all examples of mental illness. Many people suffer from mental health issues from time totime. When persistent indications and symptoms create regular stress and impair your capacity to operate, a mental health problem becomes a mental disease.Mental illness can make you unhappy and cause issues in your everyday life, such as in school, work, or in your relationships. Symptoms may usually be controlled with a combination of medicines and talk therapy (psychotherapy). Mental illness has no age, gender, geography, money, social position, race/ethnicity, religion/spirituality, sexual orientation, background, or other element of cultural identification; it can afflict anybody. While mental illness can strike at any age, 3/4 of all cases begin before the...
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Due to the lack of conventional therapies and the severe side effects of chemotherapy, cancer is a major public health concern across the world. After cardiac disorder, it is the second leading cause of death globally. Since ancient... more
Due to the lack of conventional therapies and the severe side effects of chemotherapy, cancer is a major public health concern across the world. After cardiac disorder, it is the second leading cause of death globally. Since ancient times, medicinal plants have been utilized to cure a variety of diseases. Natural products play an essential role in the battle against cancer and serve as a useful access source for the development and testing of novel therapeutic agents. The discovery and development of anticancer drugs can be aided by medicinal plants which contain various bioactive secondary phytochemicals viz. Alkaloids, phenolics, flavonoids, carotenoids, and other secondary metabolites. The therapeutic plants and their bioactive constituents exerted anticancer effects by induction of apoptosis, removing free radicals and antioxidant effects, inhibition of angiogenesis, and cell cycle arrest. This review explains an overview of potential therapeutic plants, including a brief descri...
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We have learned over the last several decades that the brain is an important target for insulin action. In central nervous system (CNS) it mainly affects feeding behaviour and various aspects of memory and cognition. Insulin signalling in... more
We have learned over the last several decades that the brain is an important target for insulin action. In central nervous system (CNS) it mainly affects feeding behaviour and various aspects of memory and cognition. Insulin signalling in CNS has emerged as a novel field of research since decreases brain insulin levels and signalling were associated to impaired learning, memory and age-related neurodegenerative diseases. Alterations of these functional activities may contribute to the manifestation of several clinical entities, such as central insulin resistance, type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). A close alliance between T2DM and AD has been reported, to the extent that AD is twice more frequent in diabetic patients. There are links between T2DM and AD through mitochondrial alterations and oxidative stress, altered energy and glucose metabolism, cholesterol modifications, dysfunctional protein O-GlcNAcylation, formation of amyloid plaques, altered Aβ meta...
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ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 762 Agrobacterium-Mediated Transformation in Oryza Sativa (Rice) to Improve Crop Yield: A Review Sneha Sabu, Sofia Khanam, A. Jothilin Subitsha MSc, Department of Microbiology Centre... more
ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 762 Agrobacterium-Mediated Transformation in Oryza Sativa (Rice) to Improve Crop Yield: A Review Sneha Sabu, Sofia Khanam, A. Jothilin Subitsha MSc, Department of Microbiology Centre for Marine Science & Technology, Manonmaniam Sundaranar University Rajakkamangalam, Kanyakumari, Tamil Nadu, India MPharm, Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah-711316, West Bengal, India
Insomnia Disorder is one of the most prevalent sleep disorders, and it involves both sleep complications and daytime complaints. Adequate quality sleep is crucial for good health and high quality of life. Despite this, the high prevalence... more
Insomnia Disorder is one of the most prevalent sleep disorders, and it involves both sleep complications and daytime complaints. Adequate quality sleep is crucial for good health and high quality of life. Despite this, the high prevalence and burden of insomnia disorder, which may be acute (short-term) or chronic, is growing globally. This systemic review focuses on insomnia and its management. The main causes and risk factors for insomnia are discussed, as well as the diagnostic criteria for a correct diagnosis. The treatment of insomnia, which is typically a mixture of cognitive-behavioral therapy and pharmacological treatment, is addressed, as well as the vital role pharmacists may play in not just treating insomnia but also determining the root cause/s of sleep disruptions. Keywords: Insomnia, Sleep disorder, Management, Pharmacological Treatment, Diagnosis.
In the back few decades, there has been a great increase in costal eutrophication across the globe resulting in hypoxia and anoxia, degradation of habitat, food-web modifications, and biodiversity loss due to the unregulated inputs of... more
In the back few decades, there has been a great increase in costal eutrophication across the globe resulting in hypoxia and anoxia, degradation of habitat, food-web modifications, and biodiversity loss due to the unregulated inputs of nitrogen to mariculture bodies. Before the 1850 and 1950 decades, before the industrial and green revolution, the rate of nitrogen supply on the Earth was limited to the bacterial nitrogen fixation rate but human deeds have adversely doubled the rate of the making of reactive, biologically available nitrogen on the Earth's landmass and which is being supplied in an uncontrolled way to the mariculture bodies causing the threat to mariculture by eutrophication. The artistic eutrophication of the coastal marine ecosystem has the potential to cause toxicological and ecological effects to the proliferation of primary producers either directly or indirectly. The depletion of the level of dissolved oxygen has the potential to the manufacturing of the reduced compounds, like hydrogen sulfide, further resulting in higher adverse toxic effects on aquatic animals. Various inorganic nitrogenous compounds like NH 4 + , NH 3 , NO 2 − , HNO 2 , NO 3 − can be produced which can be taken up by the aquatic animals directly from the ambient water out of which ammonia (unionized) is highly toxic, while nitrate and ammonium (ions) are the least toxic but have the potential cause adverse effects on other flora and fauna also on humans.
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Recently there is an increase in the interest in the secondary or non-primary metabolites produced by the marine flora and fauna. It has become the center of attraction of chemists and pharmacologists in the previous decades. Stakeholders... more
Recently there is an increase in the interest in the secondary or non-primary metabolites produced by the marine flora and fauna. It has become the center of attraction of chemists and pharmacologists in the previous decades. Stakeholders of the natural viewpoint emphasize that the examination of new and unusual organic molecules from marine organisms while the synthetic stakeholders' faiths in targeting these novel structures for the development of new analogs and new synthetic strategies and methodologies. The chemistry of marine organisms has changed dramatically in concern of investigating rationale. Analogous to the examination of terrestrial plants, many of the recent research and studies have concentrated on the potential application of marine extracted products in the treatment, curing of human diseases, and various other works. Marine products are the major components having biomedical-oriented natural products which can be used for various purposes. Marine natural prod...