Anne Walls
University of Copenhagen, ILF, Post-Doc
•
The Glutamine–Glutamate/GABA Cycle: Function, Regional Differences in Glutamate and GABA Production and Effects of Interference with GABA Metabolismmore
by Anne Walls and Helle Waagepetersen
Publication Date: 2014
Publication Name: Neurochemical Research
Research Interests:
•
Functional Importance of the Astrocytic Glycogen-Shunt and Glycolysis for Maintenance of an Intact Intra/Extracellular Glutamate Gradientmore
by Helle Waagepetersen and Anne Walls
It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in... more
It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.
Publication Date: 2010
Publication Name: Neurotoxicity Research
Research Interests:
•
Publication Date: 2008
Publication Name: Journal of Neurochemistry
Research Interests:
•
GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activitymore
by Anne Walls and Helle Waagepetersen
Publication Date: 2010
Publication Name: Journal of Neurochemistry
Research Interests:
•
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca 2+ levelsmore
by Helle Waagepetersen and Anne Walls
Publication Date: 2009
Publication Name: Journal of Neurochemistry
Research Interests:
•
Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutaminemore
by Anne Walls and Helle Waagepetersen
Publication Date: 2011
Publication Name: Journal of Cerebral Blood Flow & Metabolism
Research Interests: Neuroscience, Neurology, Nuclear Magnetic Resonance, Magnetic Resonance Spectroscopy, Western blotting, and 21 moreHippocampus, Glutamate, Neurovascular, Glucose, Cerebral Cortex, Brain Circulation, Mice, Animals, Astrocyte, Astrocytes, Clinical Sciences, Cerebral, Glutamine, SYNAPSES, Gas Chromatography/mass Spectrometry, Vigabatrin, Knockout Mice, Neurosciences, Glutamic Acid, Glutamate decarboxylase, and Gamma-Aminobutyric Acid
•
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivomore
by Helle Waagepetersen and Anne Walls
Despite the well-established use of kainate as a model for seizure activity and temporal lobe epilepsy, most studies have been performed at doses giving rise to general limbic seizures and have mainly focused on neuronal function. Little... more
Despite the well-established use of kainate as a model for seizure activity and temporal lobe epilepsy, most studies have been performed at doses giving rise to general limbic seizures and have mainly focused on neuronal function. Little is known about the effect of lower doses of kainate on cerebral metabolism and particularly that associated with astrocytes. We investigated astrocytic and neuronal metabolism in the cerebral cortex of adult mice after treatment with saline (controls), a subconvulsive or a mildly convulsive dose of kainate. A combination of [1,2-(13)C]acetate and [1-(13)C]glucose was injected and subsequent nuclear magnetic resonance spectroscopy of cortical extracts was employed to distinctively map astrocytic and neuronal metabolism. The subconvulsive dose of kainate led to an instantaneous increase in the cortical lactate content, a subsequent reduction in the amount of [4,5-(13)C]glutamine and an increase in the calculated astrocytic TCA cycle activity. In contr...