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Open AccessMulti-omic characterization of allele-specific regulatory variation in hybrid pigs
Hybrid mapping is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai...
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Open AccessPeriodic heat waves-induced neuronal etiology in the elderly is mediated by gut-liver-brain axis: a transcriptome profiling approach
Heat stress exposure in intermittent heat waves and subsequent exposure during war theaters pose a clinical challenge that can lead to multi-organ dysfunction and long-term complications in the elderly. Using ...
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Open AccessIncidence, risk and prognosis of second primary malignancy of patients with gastric adenocarcinoma
Due to the long-term low survival rates of gastric adenocarcinoma (GAC) patients, the occurrence and prognosis of second primary malignancies (SPMs) are often underreported and overlooked as a significant conc...
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Open AccessField experiments show no consistent reductions in soil microbial carbon in response to warming
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Open AccessPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a Mammalian cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applica...
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Open AccessIncreasing tropical cyclone intensity in the western North Pacific partly driven by warming Tibetan Plateau
The increase in intense tropical cyclone (TC) activity across the western North Pacific (WNP) has often been attributed to a warming ocean. However, it is essential to recognize that the tropical WNP region al...
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Open AccessIntranasal mask for protecting the respiratory tract against viral aerosols
The spread of many infectious diseases relies on aerosol transmission to the respiratory tract. Here we design an intranasal mask comprising a positively-charged thermosensitive hydrogel and cell-derived micro...
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Open AccessBuilding a eukaryotic chromosome arm by de novo design and synthesis
The genome of an organism is inherited from its ancestor and continues to evolve over time, however, the extent to which the current version could be altered remains unknown. To probe the genome plasticity of Sac...
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Geminal-atom catalysis for cross-coupling
Single-atom catalysts (SACs) have well-defined active sites, making them of potential interest for organic synthesis1–4. However, the architecture of these mononuclear metal species stabilized on solid supports m...
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Open AccessSCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity
CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC (hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we perform a metabolic gene CRISPR/Cas9...
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Open AccessStable and oxidative charged Ru enhance the acidic oxygen evolution reaction activity in two-dimensional ruthenium-iridium oxide
The oxygen evolution reactions in acid play an important role in multiple energy storage devices. The practical promising Ru-Ir based catalysts need both the stable high oxidation state of the Ru centers and t...
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Open AccessMolecular cloning, prokaryotic expression and its application potential evaluation of interferon (IFN)-ω of forest musk deer
Forest musk deer (Moschus berezovskii) are currently a threatened species under conservation, and the development of captive populations is restricted by health problems. To evaluate the application potential of ...
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Open AccessRecovery of homogeneous photocatalysts by covalent organic framework membranes
Transition metal-based homogeneous photocatalysts offer a wealth of opportunities for organic synthesis. The most versatile ruthenium(II) and iridium(III) polypyridyl complexes, however, are among the rarest m...
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Open AccessPhotocatalyzed regioselective hydrosilylation for the divergent synthesis of geminal and vicinal borosilanes
Geminal and vicinal borosilanes are useful building blocks in synthetic chemistry and material science. Hydrosilylation/hydroborylation of unsaturated systems offer expedient access to these motifs. In contras...
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Open AccessUrinary miR-16-5p can be used as a potential marker of endocapillary hypercellularity in IgA nephropathy
The most prevalent primary glomerulonephritis and leading cause of end-stage renal disease worldwide is IgA nephropathy (IgAN). More and more studies are describing urinary microRNA (miRNA) as a non-invasive m...
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Open AccessGiant piezoresistivity in a van der Waals material induced by intralayer atomic motions
The presence of the van der Waals gap in layered materials creates a wealth of intriguing phenomena different to their counterparts in conventional materials. For example, pressurization can generate a large a...
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Open AccessHypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids
Diabetic retinopathy (DR) is the most common diabetic microvascular complication and cause of blindness in adults under the age of 65. Our results suggest that, when comparing transcriptomes of cultures grown ...
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Open AccessHuntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
The complexity of affected brain regions and cell types is a challenge for Huntington’s disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate molecular pathology in the cortex and st...
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Open AccessAccessing chiral sulfones bearing quaternary carbon stereocenters via photoinduced radical sulfur dioxide insertion and Truce–Smiles rearrangement
From the viewpoint of synthetic accessibility and functional group compatibility, photoredox-catalyzed sulfur dioxide insertion strategy enables in situ generation of functionalized sulfonyl radicals from easi...
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Open AccessGraph-generative neural network for EEG-based epileptic seizure detection via discovery of dynamic brain functional connectivity
Dynamic complexity in brain functional connectivity has hindered the effective use of signal processing or machine learning methods to diagnose neurological disorders such as epilepsy. This paper proposed a ne...