Marja Lajunen
University of Oulu, Chemistry, Faculty Member
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Publikationsansicht. 31932989. Synthesis of some conjugated caradienes from 3-carene / (1991).Lajunen, Marja. Abstract. Tiivistelmä ja 5 erip. - Tiivistelmä myös erillisenä.. Diss. -- Oulun yliopisto. Details der Publikation.... more
Publikationsansicht. 31932989. Synthesis of some conjugated caradienes from 3-carene / (1991).Lajunen, Marja. Abstract. Tiivistelmä ja 5 erip. - Tiivistelmä myös erillisenä.. Diss. -- Oulun yliopisto. Details der Publikation. Download, http://worldcat.org/oclc/58497644. ...
... Oulun yliopisto, Finland Reprint requests to Prof. M. Lajunen. Fax: +358 8 553 1629. E-mail: marja.lajunen@oulu.fi Z. Naturforsch. 2007, 62b, 1317 1323; received March 3, 2007 An efficient, facile microwave-assisted synthesis ...
A set of isomeric para- and meta-trimethylsilylphenyl ortho-substituted N,N-phenyl -diimine ligands [(Ar-N C(Me)-(Me)C N-Ar) Ar=2,6-di(4-trimethylsilylphenyl)phenyl (16); Ar=2,6-di(3-trimethylsilylphenyl)phenyl (17)] have been synthesized... more
A set of isomeric para- and meta-trimethylsilylphenyl ortho-substituted N,N-phenyl -diimine ligands [(Ar-N C(Me)-(Me)C N-Ar) Ar=2,6-di(4-trimethylsilylphenyl)phenyl (16); Ar=2,6-di(3-trimethylsilylphenyl)phenyl (17)] have been synthesized through a two-step procedure. The palladium-catalyzed cross-coupling reaction between 2,6-dibromophenylamine (7) and 4-trimethylsilylphenylboronic acid (8), 3-trimethylsilylphenylboronic acid (9) was used to prepare 4,4-bis(trimethylsilyl)-[1,1;3,1]terphenyl-2-ylamine (10) and 3,3-bis(trimethylsilyl)-[1,1;3,1]terphenyl-2-ylamine (11). The di-1-adamantylphosphine oxide AdP(O)H (13) and di-tert-butyl-trimethylsilylanylmethylphosphine tert-BuP-CH-SiMe (14) were used for
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The microwave-assisted synthesis of terminal α-hydroxy ketones from acid chlorides and tris(trimethylsiloxy)ethylene in the presence of triethylamine is reported. The use of triethylamine had several advantages in the reaction: it... more
The microwave-assisted synthesis of terminal α-hydroxy ketones from acid chlorides and tris(trimethylsiloxy)ethylene in the presence of triethylamine is reported. The use of triethylamine had several advantages in the reaction: it increased the reactivity of the acid chloride, acted as a scavenger of the HCl that was produced in the reaction, protected the silylated enol from decomposition, and made the excess
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Abstract The use of environmentally benign reactions is currently an important topic in the field of synthetic chemistry. Here we report a high-yielding method to oxidize aliphatic or aromatic secondary alcohols into corresponding ketones... more
Abstract The use of environmentally benign reactions is currently an important topic in the field of synthetic chemistry. Here we report a high-yielding method to oxidize aliphatic or aromatic secondary alcohols into corresponding ketones using nonhazardous and ...
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Acid hydrolysis of starch is a commonly used modification that reduces the molecular size and produces soluble starch. The thermal treatment of starch in 1-butyl-3-methylimidazolium chloride,[BMIM] Cl, ionic liquid (IL) provides an... more
Acid hydrolysis of starch is a commonly used modification that reduces the molecular size and produces soluble starch. The thermal treatment of starch in 1-butyl-3-methylimidazolium chloride,[BMIM] Cl, ionic liquid (IL) provides an alternative method for that. Six native ...
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... alcohols by the bromate-bromide system using cyclic microwave heating in acidic water, Tetrahedron Letters (2010), doi: 10.1016/ j.tetlet.2010.10.009 This is a PDF file of an ... A mixture (2.5 mL) of NaBr (2 equiv.) and NaBrO 3 (1... more
... alcohols by the bromate-bromide system using cyclic microwave heating in acidic water, Tetrahedron Letters (2010), doi: 10.1016/ j.tetlet.2010.10.009 This is a PDF file of an ... A mixture (2.5 mL) of NaBr (2 equiv.) and NaBrO 3 (1 equiv.) in an acidic solution (H2SO4, 3 equiv. ...
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Crystallographic binding studies have been carried out to probe the active-site binding properties of a monomeric variant (A-TIM) of triosephosphate isomerase (TIM). These binding studies are part of a structure-based directed-evolution... more
Crystallographic binding studies have been carried out to probe the active-site binding properties of a monomeric variant (A-TIM) of triosephosphate isomerase (TIM). These binding studies are part of a structure-based directed-evolution project aimed towards changing the substrate specificity of monomeric TIM and are therefore aimed at finding binders which are substrate-like molecules. A-TIM has a modified more extended binding pocket between loop-7 and loop-8 compared with wild-type TIM. The A-TIM crystals were grown in the presence of citrate, which is bound in the active site of each of the two molecules in the asymmetric unit. In this complex, the active-site loops loop-6 and loop-7 adopt the closed conformation, similar to that observed in liganded wild-type TIM. Extensive crystal-soaking protocols have been developed to flush the bound citrate out of the active-site pocket of both molecules and the crystal structure shows that the unliganded open conformation of the A-TIM active site is the same as in unliganded wild-type TIM. It is also shown that sulfonate compounds corresponding to the transition-state analogue 2-phosphoglycolate bind in the active site, which has a closed conformation. It is also shown that the new binding pocket of A-TIM can bind 3-phosphoglycerate (3PGA; an analogue of a C4-sugar phosphate) and 4-phospho-D-erythronohydroxamic acid (4PEH; an analogue of a C5-sugar phosphate). Therefore, these studies have provided a rationale for starting directed-evolution experiments aimed at generating the catalytic properties of a C5-sugar phosphate isomerase on the A-TIM framework.