Ali Saffet Gonul
Ege, Psychiatry, Faculty Member
Although it is generally accepted that negative symptoms of schizophrenia are associated with larger lateral ventricles, this general assumption could not be validated in patients with primary negative symptoms. To elucidate this issue,... more
Although it is generally accepted that negative symptoms of schizophrenia are associated with larger lateral ventricles, this general assumption could not be validated in patients with primary negative symptoms. To elucidate this issue, we conducted a five-year longitudinal study, including deficit (n = 13) and non-deficit (n = 26) schizophrenia patients with healthy controls (n = 18). Analysis with linear mixed effects modeling showed that both the left and the right lateral ventricles of the deficit patients enlarged more than the non-deficit patients. Our results suggest that structural alterations in deficit patients might follow a different trajectory than those in non-deficit patients.
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Over the last three decades, the brain's functional and structural imaging has become more prevalent in psychiatric research and clinical application. A substantial amount of psychiatric research is based on neuroimaging studies that... more
Over the last three decades, the brain's functional and structural imaging has become more prevalent in psychiatric research and clinical application. A substantial amount of psychiatric research is based on neuroimaging studies that aim to illuminate neural mechanisms underlying psychiatric disorders. Single-photon emission computed tomography (SPECT) is one of those developing brain imaging techniques among various neuroimaging technologies. Compared to PET, SPECT imaging is easy, less expensive, and practical for radioligand use. Current technologies increased the spatial accuracy of SPECT findings by combining the functional SPECT images with CT images. The radioligands bind to receptors such as 5-hydroxytryptamine 2A, and dopamine transporters can help us comprehend neural mechanisms of psychiatric disorders based on neurochemicals. This mini-review focuses on the SPECT-based neuroimaging approach to psychiatric disorders such as schizophrenia and major depressive disorder ...
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In the present study, subclinical lesion involvement was investigated using the P50 component in Behcet`s patients without neurological manifestation. We performed this clinical research in Erciyes University, Faculty of Medicine between... more
In the present study, subclinical lesion involvement was investigated using the P50 component in Behcet`s patients without neurological manifestation. We performed this clinical research in Erciyes University, Faculty of Medicine between December 2000 and November 2001. The studies were carried out on 18 Behcet`s patients without neurologic findings and 18 volunteers for control. Standard Ag/AgCl electrodes in plastic cups were used for monopolar EEG derivations. They were attached with electrode paste and tape at the Cz (vertex) according to the 10-20 system. The auditory stimuli were delivered in pairs. The P50 waves, which may be taken from approximately 50 msec from the stimuli, were collected by computer system. Amplitudes and latencies of the P50 components were measured in the same system. This study showed that the suppression of P50 responses performed by the test stimuli, was significantly more decreased in Behcet`s patients than the control subjects. The decrease of the s...
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in schizophrenia patients
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Research Interests: Psychiatry, Schizophrenia, Bipolar Disorder, Imaging, Neurodevelopment, and 15 moreMedicine, Biological Sciences, Biological Psychiatry, Brain, Humans, Female, Journal Article, Male, Young Adult, Meta Analysis, Middle Aged, Adult, Cohort Studies, Psychology and Cognitive Sciences, and Medical and Health Sciences
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Research Interests: Psychology, Clinical Psychology, Psychiatry, Facial Recognition, Fear, and 15 moreMedicine, Emotions, Humans, Child, Aggression, Child Abuse, Female, Male, Middle Aged, Adult, Facial emotion recognition, Irritability, Psychology and Cognitive Sciences, Medical and Health Sciences, and Positive and Negative Syndrome Scale
Research Interests: Psychology, Cognitive Science, Psychiatry, Neuroimaging, Medicine, and 15 morePrefrontal Cortex, Family history, Humans, Major Depressive Disorder, Female, Mothers, Clinical Sciences, Middle Aged, Adult, Nuclear Family, Cortical Thickness, Neurosciences, Gray Matter, Case Control Studies, and Medical and Health Sciences
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In schizophrenia, the disruption of the communication between two brain hemispheres has not been shown clearly in the anatomical aspect despite other studies with different modalities suggested so. In this study, the structural integrity... more
In schizophrenia, the disruption of the communication between two brain hemispheres has not been shown clearly in the anatomical aspect despite other studies with different modalities suggested so. In this study, the structural integrity and the variables affecting the structural integrity of the corpus callosum, which is the main connection between two hemispheres, was investigated via diffusion tensor imaging (DTI). The participants were evaluated by SCID-I and symptoms of the patients were assessed with PANSS. DT images of 25 schizophrenia patients and 17 healthy volunteers were acquired via 1.5 T MR. Fractioned Anisotropy (FA) values of two groups, measured on the DT images, were compared. It was found that fractioned anisotropy (FA) values were lower in the genu of the patients than the healthy controls; however, there was no difference between the FA values of the patients and the controls in the splenium. Moreover, a significant negative correlation between the splenium FA va...
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Previous structural brain-imaging studies in first-degree relatives of depressed patients showed alterations that are generally accepted as vulnerability markers for depression. However, only half of the relatives had depression at... more
Previous structural brain-imaging studies in first-degree relatives of depressed patients showed alterations that are generally accepted as vulnerability markers for depression. However, only half of the relatives had depression at follow-up, while the other half did not. The aim of this study was to identify the brain areas associated with resilience to depression in high-risk subjects with familial depression. We recruited 59 young women with a history of depressed mothers. Twenty-nine of them (high-risk group [HRG]) had no depression history, while 30 (depressive group) had at least 1 depressive episode in adolescence. The brain structures of the groups were compared through voxel-based morphometry and analysis of cortical thickness. Individual amygdala nuclei and hippocampal subfield volumes were measured. The analysis showed larger amygdala volume, thicker subcallosal cortex and bilateral insula in the women in the HRG compared with those in the depressive group. In addition, we detected more gray matter in the left temporal pole in the HRG. The larger gray matter volume and increased cortical thickness in the key hub regions of the salience network (amygdala and insula) and structurally connected regions in the limbic network (subcallosal area and temporal pole) might prevent women in the HRG from converting to depression.
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Rs-fmri provides to establish the default mode network that comprises the connections of the neural networks of the brain and the relations of these connections with each other in the state of rest. However, unexpected signal alterations... more
Rs-fmri provides to establish the default mode network that comprises the connections of the neural networks of the brain and the relations of these connections with each other in the state of rest. However, unexpected signal alterations and changes may also occur in fmri signals in areas outside the default network. In this study, the magnitude and probability of random fluctuations in these signals were estimated by Bayesian-based change point analysis in Nucleus Accumbens signals that are not expected to be activated in resting state. The data set was acquired from 23 healthy and voluntary university students using 3T MRI scanners. With the proposed method, signals containing unexpected activation from rs-fmri signals can be estimated in linear time.
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This study presents and discusses the outcomes of different de-noising approaches, which are applied to low SNR real fMRI BOLD signals. These signals are acquired during a psychiatric fMRI experiment that is specifically designed for... more
This study presents and discusses the outcomes of different de-noising approaches, which are applied to low SNR real fMRI BOLD signals. These signals are acquired during a psychiatric fMRI experiment that is specifically designed for observing emotional mood changes (EMC). Despite a priori knowledge about activations and change points for motor tasks, EMC signals in this study do not have a ground truth. Up to our knowledge, the challenges of such a task has never been visited. Accordingly, this study aims to compare the performance of three de-noising methods, which have inherently different characteristics, on preserving the waveform characteristics of change points and activation durations while removing noise from EMC-BOLD signals through expert guided qualitative analysis.
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Change point analysis is an efficient method for understanding the unexpected behavior of the data used in many different disciplines including medical imaging. It is important to find the instances the activations occur as much as... more
Change point analysis is an efficient method for understanding the unexpected behavior of the data used in many different disciplines including medical imaging. It is important to find the instances the activations occur as much as finding the activation areas in the analysis of functional magnetic resonance imaging (fMRI). Change point detection algorithms can be used to find the activation instances. In this study, a regression based point detection method is proposed to find the activation instances in fMRI experiments. The proposed method is applied to a fMRI experiment which includes a motor task. A linear based evaluation method is also proposed. The analyses show that the activations are in accordance with the established methods in the literature.
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Amac: Epidemiyolojik calismalarda sigara icme ile anksiyete bozukluklari arasinda iliski bulundugu bildirilmesine ragmen, genellesmis anksiyete bozuklugu ile sigaranin iliskisini arastiran calisma sayisi oldukca azdir. Bu calismada... more
Amac: Epidemiyolojik calismalarda sigara icme ile anksiyete bozukluklari arasinda iliski bulundugu bildirilmesine ragmen, genellesmis anksiyete bozuklugu ile sigaranin iliskisini arastiran calisma sayisi oldukca azdir. Bu calismada amacimiz sigara icmenin anksiyete bozukluklarinda rolu oldugu kabul edilen gama-amino butirik asit (GABA) 'in plazma duzeyleri uzerinde bir etkisi olup olmadigini ve bu suretle genellesmis anksiyete bozuklugunun gelismesine katkida bulunup bulunmadigini arastirmakti. Yontem: Otuz dort duzenli sigara icen (20 kadin, 14 erkek, yas ortalamasi 31.6±+6.2yil), 32 sigara icmeyen (26 kadin, 6 erkek, yas ortalamasi 32.2±7.3 yil) genellesmis anksiyete bozuklugu olan hasta ve 33 duzenli sigara icen (13 kadin, 20 erkek, yas ortalamasi 30.2±6.8yil) ve 33 sigara icmeyen (20 kadin, 13 erkek, yas ortalamasi 29.9±5.8yil) saglikli kontrol deneginin plazma GABA konsantrasyonlari spektrofotometrik olarak olculdu ve degerlerin istatistiksel karsilastirmalari yapildi. Bulg...
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To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder... more
To examine theeffects on the brain of 2-month treatment withamethylphenidate extended-release formulation (OROS-MPH) using [Tc-] TRODAT-1SPECT in a sample of treatment-naïve adolescents with Attention Deficit/Hyperactivity Disorder (ADHD). In addition, to assess whether risk alleles (homozygosity for 10-repeat allele at the DAT1 gene were associated with alterations in striatal DAT availability. Twenty adolescents with ADHD underwent brain single-photon emission computed tomography (SPECT) scans with [Tc-] TRODAT-1 at baseline and two months after starting OROS-MPH treatment with dosages up to 1 mg/kg/day. Severity of illness was estimated using the Clinical Global Impression Scale (CGI-S) and DuPaul ADHD Rating Scale-Clinician version (ARS) before treatment,1 month and 2 months after initiating OROS-MPH treatment. Decreased DAT availability was found in both the right caudate (pretreatment DAT binding: 224.76 ± 33.77, post-treatment DAT binding: 208.86 ± 28.75, p = 0.02) and right ...
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IntroductionThe thought of greater loss of brain tissue in Deficit Syndrome (DS) i.e. subgroup of schizophrenia with enduring primary negative symptoms defined by Carpenter et al.; this has not been verified by recent... more
IntroductionThe thought of greater loss of brain tissue in Deficit Syndrome (DS) i.e. subgroup of schizophrenia with enduring primary negative symptoms defined by Carpenter et al.; this has not been verified by recent studies.ObjectiveAccumulated researches suggest that enlargement in Lateral Ventricles (LV) is related with current negative symptoms and poor prognosis. However, this has not been validated in DS.AimsOur aim is to study the association between the enduring negative symptoms and LV changes schizophrenia. We included both deficit and non-deficit patients for comparison with controls.MethodsForty-five patients (18 DS, 27 non-DS) and 37 healthy controls were recruited, evaluated for positive and negative symptoms, depression and extrapyramidal symptoms. Structural magnetic resonance imaging was performed. LV was assessed by MANCOVA (gender, age total brain volume as confounding factors) in 3-dimensional (3D) shape analyses. Correlations between clinical and imaging data w...
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Research Interests: Medicine, Prevention, Brain Mapping, Brain, Humans, and 15 moreMagnesium, Placebo, Female, Migraine, Male, Anesthesia, Aura, Middle Aged, Single Photon Emission Computed Tomography, Adult, Prophylaxis, Trace element, Migraine With Aura, Migraine without Aura, and Pharmacology and pharmaceutical sciences
... Yazışma adresi: Dr. Ersin Hatice Karslıoğlu, Sağlık Bakanlığı Dr. A. Yurtarslan Onkoloji Eğitim ve Araştırma Hastanesi Psikiyatri Kliniği, Ankara, ehkarslioglu@gmail.com ... Ceylan ME, Yazan B (2000) Anksiyete Bozuklukları, Araştırma... more
... Yazışma adresi: Dr. Ersin Hatice Karslıoğlu, Sağlık Bakanlığı Dr. A. Yurtarslan Onkoloji Eğitim ve Araştırma Hastanesi Psikiyatri Kliniği, Ankara, ehkarslioglu@gmail.com ... Ceylan ME, Yazan B (2000) Anksiyete Bozuklukları, Araştırma ve Klinik Uygulamada Biyolojik Psikiyatri. ...
Şu Anki Durum : Ege Üniversitesi Tip Fakültesi Psikiyatri Anabilim dalinda doçent ayni zamanda Beyin araştirmalari ve Uygulama Merkezinde çalişmaktayim. Mayis 2007'den itibaren ABD'nin Georgia Eyaletindeki Mercer Üniversitesi Psikiyatri ve Davraniş Bilimleri Bölümünde 10 yil süre ile (adjuct) kli...more
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ABSTRACT Functional magnetic resonance imaging (fMRI) is a neuroimaging technique that provides brain activation maps with a spatial resolution of a few millimeters. The BOLD (blood oxygenation level dependent) fMRI method is the most... more
ABSTRACT Functional magnetic resonance imaging (fMRI) is a neuroimaging technique that provides brain activation maps with a spatial resolution of a few millimeters. The BOLD (blood oxygenation level dependent) fMRI method is the most commonly used technique. ...
[No abstract available