Origin of COVID

Origin of COVID-19 By Iman , M. Bastawecy (21/06/2021) Dept. of Virology, Animal Health Research Institute, Dokki, Giza , Egypt In 5/2020, China knew that COVID-19 is a herpesvirus (ds DNA virus) and what it diagnosed is a messenger (m)RNA of this virus which is known as Epstein Barr Virus (EBV) in human medicine, and it also infects other species of domesticated, wild, avian and aquatics. However, it is known as ovine herpesvirus 2 (OvHV-2) in veterinary medicine. For years, about 30 kb mRNA of EBV was misdiagnosed as corona virus and when mutation occurs, the resulted variants called SARS, MERS, COVID-19, α, β, γ, δ, ε and so on forever. Fallacy happened in diagnosis of EBV mRNAs in the past explains why all the newly discovered viruses are RNA which in fact are mRNAs of EBV of different kb where EBV encodes more that 70 proteins which are translations of mRNAs transcribed on EBV genes. Infection with EBV is usually without symptoms, flu-like or with a variety of moderate to severe hematological, neurological, hepatic, respiratory and psychological complication in some individuals explaining what happens in the COVID-19 pandemic known by this name for most people where positive cases, sometimes have no signs, mild, moderate, sever or even death. EBV has a worldwide distribution and high prevalence. There is gradual increase with age beginning at childhood to reach more that 90% for adults. This 1 explains rapid detection of positive cases all over the world when PCR technique used for detection of this mRNA that became known as COVIS-19 pandemic which is in fact an EB viral infection. Infection with EBV occurs by first exposure to the virus or reactivation from latency. This explains repeated positivity for COVID-19 due to latency reactivation of EBV which is the real cause of COVID-19. Severity and types of symptoms depend on stress (quality, quantity or type of stress) and tissue, organ or systems infected (with EBV) respectively. This explains graduation and difference in symptoms of COVID-19 persons. The pathognomonic lesions of this lymphoproliferative disease (COVID-19) caused by EBV (OvHV-2) are necrotizing vasculitis (which may be fibrinoid), thrombosis and infiltration of tissues with lymphocytes and macrophages when detected histopathologically. Necrotizing vasculitis could be super infected with bacteria or fungi explaining what happened for some individuals misdiagnosed as COVID-19. OvHV-2 which is the other name of EBV infects all species and explain circling (i.e. moving in circles) of aquatic species in Japan due to stress caused by changing their medium or living place and explains thrombosis, circling and sudden death of 350 elephants in Botswana. Pathogenesis of EBV (OvHV-2) causing infection which is now known as COVID-19 (with fallacy) is related mainly to direct virus-cell interactions or immune mediated responses directed against infected cells. Unfortunately, EBV (OvHV-2) has proteins of sequence and functional homology with many proteins of the host and cytokines are examples of these proteins. 2 Cytokines mediate innate immune response and if their action sustained / or dysregulated, cytokine storm results explaining what happens in severe symptoms of EBV infection which now mentioned to be correlated with COVID-19! Cytokine storm results mainly due to prolonged treatment of EBV infected persons (misdiagnosed as COVID-19) with corticosteroids in addition to contaminated dialysis and condensed care equipment with EBV. EBV (OvHV-2) induces cytokines such as IL-15 (and consequently TNF) that maintains and induces proliferation of cytotoxic T cells, leading to the tissue damage seen in some cases. IL-6 is another example which induces excessive serum amyloid A (SAA), fibrinogen, haptoglobin, hepcidin and α1-antichymotrypsin. SAA explains cytomegalic cells and syncytia formation resulted from fusion of the infected cells with EBV on detection histopathologically in severely infected persons with EBV that misdiagnosed now as COVID-19! Fibrinogen explains thrombosis, sever blood clotting and viscosity in severely infected persons with EBV which misdiagnosed now as COVID-19! α1-antichymotrypsin explains failure of destroying the fibrinous formations resulted from the inflammatory processes due to EBV infection and misdiagnosed now as COVID-19! Haptoglobin increase explains tissue damage and / or dysfunction due to oxidative stress of free hemoglobin due to EBV infection which is misdiagnosed now as COVID-19! Hepcidin increase explains iron dysregulation with hypoferremia and anemia due to blocking of intestinal iron absorption resulted from EBV infection and now misdiagnosed as COVID-19! 3 OvHV-2 (EBV) sometimes causes mineralization in the infected host explaining their possessing of electric or magnetic charges. Vaccination results in antibody production which can only neutralize the virus in serum or body fluids but not viral particles in cells because once the virus enters the cells, no antibodies can enter the cells to neutralize it except nanobodies of camelids due to it is in nanometers. So, fallacy in diagnosis of COVID -19 without knowing the real cause which is EB Viral Infection and not COVID-19, increases exposures to EBV resulted from repeated reactivation of its viral particles latently found in infected cells to infect other cells or organs or systems. References: -Alagha, A. K., & Hirsch, A. R. (2015, September). 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