SummaryResearch into the drug romosozumab began with the investigation of patients with excess bone formation. The understanding of the wingless-type mouse mammary tumor virus integration site (Wnt) signaling pathway in bone metabolism... more
SummaryResearch into the drug romosozumab began with the investigation of patients with excess bone formation. The understanding of the wingless-type mouse mammary tumor virus integration site (Wnt) signaling pathway in bone metabolism identified the negative regulator of bone mass sclerostin as a potential target for the treatment of osteoporosis. Preclinical studies confirmed this idea because they showed that sclerostin antibodies have the potential to increase bone formation. Biochemical analyses of clinical studies showed a significant increase in bone formation markers, which then slowly decreased within a year. This was accompanied by a particularly initially pronounced decrease in bone resorption. This dual mechanism of action led to an increase in bone mineral density and a significant reduction in fracture risk. Clinical vertebral fractures decreased by between 28 and 36%, nonvertebral fractures shown in a post hoc analysis by 42%. Romosozumab is administered once a month ...
The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. The proposed or... more
The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. The proposed or advertised ergogenic effect of many supplements is based on a presumptive metabolic pathway and may not necessarily translate to quantifiable changes in a variable as broadly defined as exercise performance. L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production. In some clinical circumstances (e.g., burn injury, sepsis) in which the demand for arginine cannot be fully met by de novo synthesis and normal dietary intake, exogenous arginine has been shown to facilitate the maintenance of lean body mass and functional capacity. However, the evidence that supplemental arginine may also confer an ergogenic effect in normal healthy individuals is...
Chronic reductions in tissue O2 tension (hypoxia) are associated with muscle atrophy and blunted hypertrophic responses to resistance exercise (RE) training. However, the effect of hypoxia on muscle protein synthesis (MPS) at rest and... more
Chronic reductions in tissue O2 tension (hypoxia) are associated with muscle atrophy and blunted hypertrophic responses to resistance exercise (RE) training. However, the effect of hypoxia on muscle protein synthesis (MPS) at rest and after RE is unknown. In a crossover study, seven healthy men (21.4 ± 0.7 yr) performed unilateral leg RE (6 × 8 repetitions at 70% 1-repetition maximum) under normoxic (20.9% inspired O2) and normobaric hypoxic (12% inspired O2 for 3.5 h) postabsorptive conditions. Immediately after RE the rested leg was biopsied, and a primed continuous infusion of [1,2-13C2]leucine was maintained for 2.5 h before final biopsies from both legs to measure tracer incorporation and signaling responses (i.e., ribosomal S6 kinase 1). After 3.5 h of hypoxia, MPS was not different from normoxia in the rested leg (normoxia 0.033 ± 0.016 vs. hypoxia 0.043 ± 0.016%/h). MPS increased significantly from baseline 2.5 h after RE in normoxia (0.033 ± 0.016 vs. 0.104 ± 0.038%/h) but ...
Objective: The aims of the present research were to determine the prevalence of the use of dietary supplements and anabolic-androgenic steroids (AAS) without professional guidance in the countryside of Northeastern Brazil, and to compare... more
Objective: The aims of the present research were to determine the prevalence of the use of dietary supplements and anabolic-androgenic steroids (AAS) without professional guidance in the countryside of Northeastern Brazil, and to compare blood pressure (BP) between nonusers of dietary supplements, thermogenic supplement users and AAS users. Methods: The sample consisted of 346 resistance training (RT) practitioners and bodybuilders. The participants answered a questionnaire on the use of dietary supplements and/or AAS. In addition, the participants underwent BP assessment. Results: 76.9% of the sample consumed dietary supplements and AAS at some point in their lives. 66.8% (95%CI: 61.5–71.7) of our sample used only food supplements without any guidance from a qualified professional. AAS and cosmetic doping was reported by 8.1% (95%CI: 5.6–11.2%) and 2.0% (95%CI: 1.0–4.2%) of the sample, respectively. Regarding BP, a significant difference was observed for systolic BP when nonusers of dietary supplements were compared to users of thermogenic supplements (126.5 ± 15.1 mmHg s. 134.7 ± 14.5 mmHg; p= .034) and when compared to AAS users (126.5 ± 15.1 mmHg vs. 136.6 ± 12.2 mmHg; p= .010). Conclusions: Our findings point to excessive consumption of dietary supplements and AAS (without professional guidance) by RT practitioners and bodybuilders. In addition, we observed high systolic blood pressure in users of thermogenic supplements and AAS users.
ABSTRACT Objective: The aims of the present research were to determine the prevalence of the use of dietary supplements and anabolic-androgenic steroids (AAS) without professional guidance in the countryside of Northeastern Brazil, and to... more
ABSTRACT Objective: The aims of the present research were to determine the prevalence of the use of dietary supplements and anabolic-androgenic steroids (AAS) without professional guidance in the countryside of Northeastern Brazil, and to compare blood pressure (BP) between nonusers of dietary supplements, thermogenic supplement users and AAS users. Methods: The sample consisted of 346 resistance training (RT) practitioners and bodybuilders. The participants answered a questionnaire on the use of dietary supplements and/or AAS. In addition, the participants underwent BP assessment. Results: 76.9% of the sample consumed dietary supplements and AAS at some point in their lives. 66.8% (95%CI: 61.5–71.7) of our sample used only food supplements without any guidance from a qualified professional. AAS and cosmetic doping was reported by 8.1% (95%CI: 5.6–11.2%) and 2.0% (95%CI: 1.0–4.2%) of the sample, respectively. Regarding BP, a significant difference was observed for systolic BP when nonusers of dietary supplements were compared to users of thermogenic supplements (126.5 ± 15.1 mmHg s. 134.7 ± 14.5 mmHg; p= .034) and when compared to AAS users (126.5 ± 15.1 mmHg vs. 136.6 ± 12.2 mmHg; p= .010). Conclusions: Our findings point to excessive consumption of dietary supplements and AAS (without professional guidance) by RT practitioners and bodybuilders. In addition, we observed high systolic blood pressure in users of thermogenic supplements and AAS users.
The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. The proposed or... more
The rationale for the use of nutritional supplements to enhance exercise capacity is based on the assumption that they will confer an ergogenic effect above and beyond that afforded by regular food ingestion alone. The proposed or advertised ergogenic effect of many supplements is based on a presumptive metabolic pathway and may not necessarily translate to quantifiable changes in a variable as broadly defined as exercise performance. L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production. In some clinical circumstances (e.g., burn injury, sepsis) in which the demand for arginine cannot be fully met by de novo synthesis and normal dietary intake, exogenous arginine has been shown to facilitate the maintenance of lean body mass and functional capacity. However, the evidence that supplemental arginine may also confer an ergogenic effect in normal healthy individuals is...
