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Recent findings suggest that the inhibition of Aurora A (AURKA) kinase may offer a novel treatment strategy against metastatic cancers. In the current study, we determined the effects of AURKA inhibition by the small molecule inhibitor... more
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      Cell AdhesionAutophagyMedicineSignal Transduction
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      RadiationOxidative StressBiological SciencesReactive Oxygen Species
A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the μ opioid... more
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      Organic ChemistryKineticsBrainMice
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      EngineeringAgriculturalCHEMICAL SCIENCESFat oxidation
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      Near InfraredOrganicCHEMICAL SCIENCESOxidation-Reduction
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Alkaline wet oxidation pre-treatment (water, sodium carbonate, oxygen, high temperature and pressure) of wheat straw was performed as a 24−1 fractional factorial design with the process parameters: temperature, reaction time, sodium... more
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      Principal Component AnalysisPolysaccharidesMultidisciplinaryMultivariate Analysis
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      BiomassMultidisciplinaryNeurospora crassaSaccharomyces cerevisiae
Xylitol was produced by Candida guilliermondii by fermentation of sugarcane bagasse hemicellulosic hydrolysate. Undesirable impurities were extracted from the broth using either ethyl acetate, chloroform or dichloromethane. The best... more
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      Organic ChemistryCarbonAsymmetric SynthesisAlkenes
R 1 = alkyl; R 2 = H, alkyl; R 3 = H, alkyl R 1 = Allyl 8 examples 37–96% Abstract An efficient approach to bridged pentacyclic nitrogen het-erocycles via the tandem acylation/intramolecular Diels–Alder furan (IMDAF) reaction of... more
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      Heterocyclic chemistryCycloaddition reactionsDiels-Alder reactionFurans
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      Chemical EngineeringFood SciencePigmentationQuality Control
Easy construction of furo[2,3-f]isoindole core by the IMDAV reaction between 3-(furyl)allylamines and a,b-unsaturated acid anhydrides a b s t r a c t The vinylogues of furfurylamines, easily available in two steps from furylacroleins... more
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      Heterocyclic chemistryCycloaddition reactionsDiels-Alder reactionFurans
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      Natural ProductsArgentinaMagnetic Resonance SpectroscopyBiological Sciences