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The production of erythroidines and other alkaloids was studied in cotyledons, callus and cell suspension cultures of Erythrina americana Miller. The cell suspension cultures, grown in Murashige & Skoog medium with naphthaleneacetic acid... more
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      EngineeringTechnologyBiotechnologyPlant Tissue Culture
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      ChemistryCrystallographyElectrochemistryMedicine
Tramadol is a synthetic opioid agonist used extensively in human and, to a lesser extent, veterinary medicine throughout the world. The clinical efficacy and pharmacokinetic profile of intravenous (i.v.) and extradural (e.d.) tramadol (2... more
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      Biological SciencesDogsHepatitis BHumans
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      GastroenterologyAdolescentHepatitis BHumans
In a double-blind, phase 3 trial, 663 HIV-infected, virologically suppressed adults were randomized to switch to tenofovir alafenamide (TAF; n=333) vs. remain on tenofovir disoproxil fumarate (TDF; n=330), each coformulated with... more
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      Treatment OutcomeHIVHumansClinical Sciences
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      ImmunologyConservationCryopreservationHumans
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      Molecular BiologyHepatitis CComorbidityHepatitis B
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      TechnologyBiological SciencesTemperatureUric Acid
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      Analytical ChemistryBiomedical EngineeringWaterBiosensors
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      DentistryDNAHumansFemale
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      Enzyme InhibitorsBiological ChemistryBiological SciencesHumans
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      Neural NetworkArabidopsis thalianaCompositional AnalysisPeroxidase
Astrocytes are involved in multiple brain functions in physiological conditions, participating in neuronal development, synaptic activity and homeostatic control of the extracellular environment. They also actively participate in the... more
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      Cognitive ScienceCystic FibrosisDevelopmental neuroscienceEnergy Metabolism
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      PhotochemistryBiologyPrebioticsMedicine
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      MicrobiologyMedical MicrobiologyTreatment OutcomeHIV
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      PhotochemistryOrganicCHEMICAL SCIENCESAdenine
Because accumulation of potentially toxic malfolded protein may be extensive in immunoglobulin-producing multiple myeloma (MM) cells, we investigated the phenomenon of autophagy in myeloma, a physiologic process that can protect against... more
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      BiologyMembrane ProteinsEnzyme InhibitorsAutophagy
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      EngineeringAgriculturalCHEMICAL SCIENCESBioreactors
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      GeneticsMicrobiologySaccharomyces cerevisiaeMutation
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      GeneticsCognitive ScienceMovement disordersHumans
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      TreatmentPharmacokineticsPreventionBiological Sciences
Chronic hepatitis B (CHB) virus infection is a global public health problem, affecting more than 400 million people worldwide. The clinical spectrum is wide, ranging from a subclinical inactive carrier state, to progressive chronic... more
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      HumansDrug Delivery SystemsGenotypeDisease Management
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      AminesTemperatureAmidesNucleosides
We have developed a reproducible system for efficient direct somatic embryogenesis from leaf and internodal explants of Paulownia elongata. The somatic embryos obtained were subsequently encapsulated as single embryos to produce synthetic... more
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      Plant BiologyPlant tissue Culture TechniquesPlant Growth RegulatorsPlant growth
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      Analytical ChemistryMiceAnimalsTandem Mass Spectrometry
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      RNABiologyBiological SciencesIn Vitro
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      ThermodynamicsOrganic ChemistryMagnetic Resonance SpectroscopyAdenine
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      Organic ChemistryMedicinal ChemistryHumansDrug Design
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      TranscriptomeHumansClinical SciencesCombination drug therapy
SAGM is currently the standard additive solution used in Europe, while AS-3 is the third additive solution that has been licensed in the USA, and is also the one used in part of Canada. Although AS-3 is based on a saline-adenine-glucose... more
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      HumansGlucoseTwo-Dimensional Gel ElectrophoresisCitric Acid
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      Treatment OutcomeMitochondriaInfectious DiseasesHIV
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      Medical MicrobiologyThailandAdolescentSouth Africa
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      MicrobiologyMedical MicrobiologyLinear modelsClinical Virology
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      Medication AdherenceHumansRisk factorsClinical Sciences