Pde

It is well known that classical systems governed by ODE or PDE can have extremely complex emergent properties. Many researchers have asked: is it possible that the statistical correlations which emerge over time in classical systems would allow effects as complex as those generated by quantum field theory (QFT)? For example, could parallel computation based on classical statistical correlations in systems based on continuous variables, distributed over space, possibly be as powerful as quantum computing based on entanglement? This paper proves that the answer to this question is essentially "yes," with certain caveats. More precisely, the paper shows that the statistics of many classical ODE and PDE systems obey dynamics remarkably similar to the Heisenberg dynamics of the corresponding quantum field theory (QFT). It supports Einstein's conjecture that much of quantum mechanics may be derived as a statistical formalism describing the dynamics of classical systems. Pred...

Image Inpainting is technique in which mainly used to filling the region which are damaged and want to recover from unwanted object by collecting the information from the neighbouring pixels. Image inpainting technique has been widely used for reconstructing damaged old photographs and removing unwanted objects from images. In this paper, we present an improved Exemplar based Structure tensor inpainting method based on the exemplar-based image inpainting technique by modifying the distance function. The method proved to be effective in removing large objects from an image, ensuring accurate propagation of linear structures, and eliminating the drawback of “garbage growing ” which is a common problem in other methods. Experimental results show that our method improves the quality of image inpainting compared with the conventional exemplar-based image completion algorithms.

Materiales y métodos Corazones aislados de ratas Wistar macho de 6 meses de edad fueron perfundidos por el sistema de Langendorff y sometidos a 30 min de isquemia global (IG), seguidos de 60 min de reperfusión (R) [grupo CI]. Otros corazones fueron tratados 10 min antes de la IG y durante los primeros 10 min de la R con 30 μg/ml de G CP en ausencia ó en presencia de L -nitro-L-arginina metil éster [L-NAME, inhibidor de la enzima óxido nítrico sintasa (NOS)]. Al final de R se midió el tamaño del infarto (TI), mediante la tinción con sales de tetrazolio. Las funciones sistólica y diastólica fueron determinadas a través de la presión desarrollada del ventrículo izquierdo (PD) y la presión diastólica final (PDF), respectivamente. El estrés oxidativo fue evaluado a través del contenido de glutatión reducido (GSH) y de la concentración de sustancias reactivas al ácido tiobarbitúrico (TBARS). En mitocondrias aisladas se determinó la apertura del poro de 2+ permeabilidad transitoria inducid...

Introducción La insuficiencia cardíaca (IC) es un síndrome caracterizado por la imposibilidad del corazón de bombear sangre en los volúmenes adecuados para satisfacer las necesidades metabólicas de los tejidos. Numerosas observaciones relacionan el aumento de actividad de la CaMKII con el desarrollo de insuficiencia cardíaca (IC), pero no hay estudios longitudinales que describan el estado de fosforilación de esta proteína (PCaMKII) como indicador de su actividad durante la evolución de la hipertrofia a la IC.

In solving the wave equation for a given set of boundary and initial conditions, separation of variables can be used to find the solution provided that the boundary conditions are homogeneous. If they are not, it becomes very difficult to solve the wave equation but thanks to the integral transform technique which can be used to solve the wave equation no matter the circumstance of the boundary and initial conditions and regardless of the nature of the wave equation, whether it is linear or nonlinear. The only prerequisite in using the integral transform is that you first have to derive the wave profile that satisfies the boundary or initial conditions and then go ahead and solve.

Psoriasis is a common inflammatory skin condition, affecting 2–4% of the worldwide population. Psoriasis remains an important public health challenge because there are many clinical forms of psoriasis in particular sites, probably related to the dysregulation of different cytokines. Therefore, there is a continuous need to improve treatment options with mechanisms of action different from those of the currently known therapies. Advances in knowledge of the molecular bases of pathogenesis lead to a better understanding of the disease, thus influencing the development and management of effective treatments. Moreover, data from recent published work indicate that psoriasis coexists with cardiovascular diseases, metabolic syndrome, diabetes mellitus and psychiatric disorders. We present results from our 52‐week open‐label trial in a cohort of psoriatic and psoriatic arthritis patients treated with daily p.o. doses of apremilast 60 mg. We confirmed the efficacy and safety of the drug in ...

The aim of this paper is to review of six recent symmetric mapping functions. The mapping function can be largely used for GPS meteorological measurements, InSAR atmospheric corrections and precise measurements of very long baseline interferometry (VLBI). These spacebased techniques use radio signal that propagate through the Earth's atmosphere. The electrically-neutral region, predominantly the troposphere, affects the speed and direction of travel of radio waves leading to existence of excess path. The mapping function models the elevation angle dependence of the delay. Within the past decade, significant improvements have been achieved in order to use of Numerical Weather Models (NWM) for geodetic positioning. Ray-tracing algorithms have been performed through refractivity shells retrieved from NWMs in order to relate zenith delays to slant delays. Therefore, there seems to be a real need for deep review of recent developments in the mapping function domain. This paper propos...

Background— Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike the systemic circulation, pulmonary vascular resistance (R PA ) and compliance (C PA ) are consistently and inversely related regardless of age, pulmonary hypertension, or interstitial fibrosis and that this relation may be changed by elevated pulmonary capillary wedge pressure, augmenting right ventricular pulsatile load. Methods and Results— Several large clinical databases with right heart/pulmonary catheterization data were analyzed to determine the R PA -C PA relationship with pulmonary hypertension, pulmonary fibrosis, patient age, and varying pulmonary capillary wedge pressure. Patients with suspected or documented pulmonary hypertension (n=1009) and normal pulmonary capillary wedge pressure displayed a consistent R PA -C PA hyperbolic (inverse) dependence, C ...

The performance of hexa methylene tetra amine (HMTA) (C6H12N4) as a corrosion inhibitor for mild steel in
simulated CO2-saturated brine solution was investigated in the absence and presence of inhibitor at various HMTA
concentrations, temperatures, and velocities using weight loss technique. Doehlert Experimental Design (DED) was used
for designing of experiments. A second order polynomial equation with main, quadratic and interactive influences was
suggested and optimized. Nonlinear regression statistical analysis was used for estimation of polynomial coefficients
based on Quasi-Newton & Rosenbrock method. Inhibitor concentration showed a high positive impact in reducing the
corrosion rate, while temperature and mixing velocity showed the negative effect. The optimum (minimum) corrosion
rate was 18.714 gmd at 35.69 °C brine temperature, 74.47 ppm HMTA concentration, and 163.12 rpm mixing velocity.
At these optimum conditions a 92% inhibition efficiency was obtained.

Psoriasis Vulgaris is a complex multifactorial dermatological disease, with various genetic and environmental factors implicated in the onset and progression of the disease and comorbidities. Cardiovascular disease (CVD) and metabolic syndrome are essential psoriasis comorbidities that suggest a potential hypercoagulable background of the disease. To better understand the link between psoriasis, hypercoagulation and comorbidities, we investigated the prothrombotic polymorphism rs5918T > C in integrin B3 (ITGB3) in 102 patients diagnosed with psoriasis and 97 healthy controls, all Caucasian. The patients, carriers of rs5918T > C polymorphism, were compared with non-carriers for metabolic risk factors related to metabolic syndrome and CV disease. Our results revealed that the incidence of ITGB3rs5918(C) allele carriage was only slightly increased in psoriatic patients compared to healthy controls (20.6% vs 18.6%), and psoriatic patients with the polymorphism showed an increased incidence of metabolic risk factors. Dyslipidemia, high triglycerides (42.9% vs 27.5%), high cholesterol (66.7% vs 45.5%) and low High Density Lipoprotein (HDL) (47.6% vs 32.8%) were significantly more prevalent (p = .019) among psoriatic carriers of the rs5918(C) polymorphism compared to psoriatic non-carriers. The incidence of metabolic syndrome was significantly higher among polymorphism carriers (52.4%) compared to non-carriers (20.5%) within the psoriatic patient group (p = .014), whereas CVD incidence was higher but non-significantly. The carriage of ITGB3rs5918(C) polymorphism in patients with psoriasis was associated with a higher risk of metabolic syndrome and dyslipidaemias and a higher but non-significant prevalence of CVD compared to non-carriers. However, the frequency of this polymorphism was similar in psoriasis patients and healthy controls.

Apoptosis is a biological process of death or cellular suicide present in all the cells of the metazoans. It maintains the balance between the regeneration of pluripotential cells -or stem cells- and the elimination of cells that have already served their function, of cells that have reproduced in excess, or have been genetically damaged beyond repair. Apoptosis activation in cardiomyocytes is a common problem in a large variety of cardiomyopathies; it has been suggested that it is an important contributor ventricular hypertrophy and to the increase of the infarct size in patients with cardiac failure and cardiovascular disease. Clinical diagnosis of apoptosis is a reality in the medical science, its application in different aspects of cardiology includes from coronary cardiopathy to rhythm alterations. In this sense, the use of the non-invasive imaging, can be very useful for the in vivo detection of this type of cellular death in patients with myocardial necrosis, acute myocardial infarct, acute rejection of cardiac transplantation, myocarditis, intracardial malignant tumours, as well as in cardiotoxicity cases and other cardiomyopathies. Particularly, binding of Tc99m-labeled Annexin V, produces gammagraphic images that allow the identification of apoptotic cells in vivo in SPECT and SestaMiBi systems. In summary, the use of these techniques will be invaluable in the near future for anti-apoptosis therapy and intervention in the routine of the daily Cardiology practice.

Compartmentalisation of cAMP and PKA activity in cardiac muscle cells plays a key role in maintaining basal and enhanced contractility stimulated by sympathetic nerve activity. In cardiomyocytes, activation of adrenergic receptor increases cAMP production, which is countered by the hydrolytic activity of selective phosphodiesterases (PDEs). The intracellular regional dynamics of cAMP production and hydrolysis modulate downstream signals resulting in different biological responses. The interplay between beta receptors (βARs) signalling and phosphodiesterase 5 (PDE5) activity remains to be addressed. Using combined strategies with pharmacological inhibitors and genetic deletion of PDEs and βAR isoforms, we revealed a specific pool of cAMP that is under dual regulation by PDE2 and, indirectly, PDE5 activity. Inhibition of PDE5 with sildenafil produces a cGMP-dependent activation of PDE2 that attenuates cAMP generation induced by βAR agonists, with concomitant modulation of stimulated c...

In this paper, we employ the logistic map and the cubic map to locate the relaxation and the convergence to the periodic xed point of a system, speci cally, the period-1 xed point. e study has shown that the period-1 xed point of a logistic map as a recurrence has its convergence at a transcritical bifurcation having its power-law t with exponent β − 1 when α 1 and μ 0. e cubic map shows its convergence to the xed point at a pitchfork bifurcation decaying at a power law with exponent β − (1/2) α 1 and μ 0. However, the system shows their relaxation time at the same power law with exponents and z − 1.

Image Inpainting refers to restoring a damaged image in such a manner that manipulation and modification in an image is not recognizable by the observer. In this paper we have simulated and compared results of two different existing algorithms that are based on convolution as given by Oliveira and Hadhoud. The algorithm given by Hadhoud gives faster results but produces strokes in the resultant image while algorithm given by Oliveira is slow but fills the region from all the sides.

Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladder (UAB). The present article addresses Proposal 1: “Are oxidative stress and ischemia significant causes of bladder damage leading to LUTD?” from the 2019 International Consultation on Incontinence – Research Society (ICI-RS) meeting. Bladder ischemia in animals and humans is briefly described, along with the proposed progression from ischemia to LUTD. Bladder ischemia is compared to ischemia other organs, and the ongoing development of pelvic ischemia animal models is discussed. In addition, the distribution of blood within the bladder during filling and voiding and the challenges of quantification of blood flow in vivo are described. Furthermore, oxidative stress, including potential biomarkers and treatments, and challenges regarding antioxidant therapy for the treatment of LUTD are discussed. Finally, seven critical research questions and proposed studies to answer those questions were identified as priorities that would lead to major advances in the understanding and treatment of LUTS/LUTD associated with pelvic ischemia and oxidative stress.