Phisiology
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Most cited papers in Phisiology
The making and sealing of a tight junction (TJ) requires cell-cell contacts and Ca2−, and can be gauged through the development of transepithelial electrical resistance (TER) and the accumulation of ZO-1 peptide at the cell borders. We... more
Upon transferring confluent monolayers of Madin-Darby canine kidney (MDCK) cells from a low-Ca2+ médium (1-5 M) to one with 1.8 mM Ca2+ (Ca switch), tight junctions (TJs) assemble and seal, and transepithelial electrical resistance (TER)... more
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal survival rate. Persistent activation of pancreatic stellate cells (PSCs) can perturb the biomechanical homoeostasis of the tumour microenvironment to... more
Recent reports have indicated the participation of tight junction (TJ) proteins in the regulation of gene expression and cell proliferation. Here, we have studied the role of zona occludens (ZO)-2, a TJ peripheral protein, in the... more
The propose of this study was to compare human endotelial cells from Schlemm´s canal (SCEs) and the trabecular meshwork (TMEs) in terms of ZO-1 isoform expression, hydraulic conductivity (HC) properties, and "giant" vacuole (GV) formation.
Growth arrest specific 1 (GAS1) is a GPI-anchored protein that inhibits proliferation when over expressed in tumors but during development is promotes proliferation and survival of different organs and tissues.
The aim of this study was to identify cellular proteins that bind protein kinase C (PKC) and may influence its activity and its localization. A 32-kDa PKC-binding protein was purified to homogeneity from the Triton X-100-insoluble... more
One of the main roles of epitelial membranes is to act as diffusion barriers between two compartments, one of them being the interstitium in free connection with bloodand the other representing the environment, even if this environment is... more
Affective and cognitive factors play an important role in the activation and regulation of men’s sexual arousal. Barlow (1986) argued that initial affective reactions determine the allocation of attention to sexual stimuli. We applied... more
Madin Darby canine kidney (MDCK) cells plated at confluence and incubated for 20 h in low (5 M) Ca2+ have no tight junctions (TJs), and their Na+ -K+-ATPase is randomly distributed over the surface.
Tight junctions seal the luminal border of epitelial cells and restrict the passage of substances across the paracellular route. The resistance offered by this path way is variable and depends on the number of strands, the length of the... more
Giardia lamblia: Electrophysiology and ultrastructure of cytopathology in cultured epithe-lial cells. Experimental Parasitology 61, 379-389. The pathogenicity of Giardia lamblia is a subject of debate. Some studies of human biopsy... more
Severe dengue (SD) is a life-threatening complication of dengue that includes vascular permeability syndrome (VPS) and respiratory distress. Secondary infections are considered a risk factor for developing SD, presumably through a... more
SUMMARY MDCK cells (epithelioid, derived from the kidney of a normal dog) cultured in monolayers on a permeable support, exhibit properties of natural transporting epithelia. Comparisons of the electrical resistance across the plasma... more
In order to infect pathogens must breach the epitelial barriers that separate the organism from the external environment or that cover the internal cavities and ducts of the body.
Objective: There is much interest in the role of dietary protein for weight control. However, there remains a need to characterize individual determinants of the thermogenic effects of protein. This study aimed to investigate the... more
Cells from transporting epithelia have two basic properties: 1) a plasma membrane divided into an apical and a basolateral domain that confers vectoriality, and 2) tight junctions that transform epithelia into diffusion barriers. The... more
Claudins are integral proteins of the TJ. Each epithelia in the organism expresses a unique set of claudins that determines the degree of sealing of the paracellular pathway and the ionic selectivity of the tissue. TJs are dynamic... more
[Abstract] Dengue virus infection usually courses as a benign self-limited fever, called dengue fever. However, on occasions it can progress to a life-threatening complication known as severe dengue (SD). A hallmark of SD is a sharp... more
Testosterone is a steroid hormone involved in the expression of many morphological, physiological, and behavioral traits that arguably affect reproductive success. The evidence for that link is, however, incomplete or absent in the... more
Background Acute and chronic effects of nitric oxide on oxidative stress and neuronal demyelination have been reported in human and animal models. Objective Oxidative stress is involved in the pathogenesis of demyelinated animals; thus,... more
Emperipolesis is considered a physiological phenomena often present in various pathophysiological conditions, but its etiology is still unknown. In this study, we analyzed the number of megakaryocytes and the percentage of emperipoletic... more
Se analiza la relación de la teleología platónica y la fisiología médica de Alcmeón de Crotona y del papel hígado en el Timeo de Platón, su función en el cuerpo y su relación con el alma apetitiva. A continuación, se explora la... more
In the context of the great philosophical synthesis of Francis Suárez, between XVI and XVII centuries, his commentary to De Anima manifest the originality of his thought, between continuity and innovation in front of the big issues that... more
Continuous inability of Mozambique's National Assembly to timely respond to issues of common national interest presented by the opposition parties has prompted me to equate the FRELIMO party's Members of Parliament (MPs) in Mozambique to... more
Anticarsia gemmatalis and Spodoptera frugiperda (Lepidoptera: Noctuidae) are serious defoliators of a number of crops. In order to better understand the digestion process of these pests and considering that the midgut is one of the most... more