Transcriptional regulation
18 Followers
Recent papers in Transcriptional regulation
Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights into these processes in hepatocytes and multiple... more
Sulfate is required for detoxification of xenobiotics such as acetaminophen (APAP), a leading cause of liver failure in humans. The NaS1 sulfate transporter maintains blood sulfate levels sufficiently high for sulfonation reactions to... more
We previously identified a gene, slr0374, in the unicellular cyanobacterium, Synechocystis sp. strain PCC 6803, that was highly expressed under iron-deficient conditions [J. Bacteriol. 182 (2000) 3536]. The gene product contains an AAA... more
Bacteria sense and respond to a wide range of physical and chemical signals. Central to sensing and responding to these signals are two-component systems, which have a sensor histidine kinase (SK) and a response regulator (RR) as basic... more
The Pax3FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t (2; 13)(q35; q14) chromosomal translocation. Its oncogenic activity is dependent on a combination of proteinDNA and proteinprotein interactions... more
Genes in prokaryotic and eukaryotic cells are typically regulated by complex promoters containing multiple binding sites for a variety of transcription factors leading to a specific functional dependence between regulatory inputs and... more
The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link... more
Heart development results from a complex but highly integrated series of interactions involving various cell types of diverse origin. These interactions are carried out in a strictly regulated environment at both genetic and epigenetic... more
Regulation of gene expression in Corynebacterium glutamicum represents an important issue since this Gram-positive bacterium is a notable industrial amino acid producer. Transcription initiation, beginning by binding of RNA polymerase to... more
Mitogen-activated protein kinases (MAPKs) are important components of the tripartite mitogen-activated protein kinase signaling cascade and play an important role in plant growth and development. Although members of the MAPK gene family... more
Background DNA methylation in promoters is closely linked to downstream gene repression. However, whether DNA methylation is a cause or a consequence of gene repression remains an open question. If it is a cause, then DNA methylation may... more
RADICAL-INDUCED CELL DEATH1 (RCD1) is an important regulator of stress and hormonal and developmental responses in Arabidopsis thaliana. Together with its closest homolog, SIMILAR TO RCD-ONE1 (SRO1), it is the only Arabidopsis protein... more
Aging is one of the chief biomedical problems of the 21st century. After decades of basic research on biogerontology (the science of aging), the aging process still remains an enigma. Although hundreds of "theories" on aging have been... more