creatinine clearance
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Recent papers in creatinine clearance
Bretylium kinetics were examined in patients with varying degrees of renal impairment after a single intravenous dose of bretylium tosylate. Maximum plasma concentrations achieved at the end of the infusion, when normalized to the dose,... more
MATERIAL: Estimation of glomerular filtration rate (eGFR) is the most widely accepted marker of renal function. Precise calculation is not routinely performed in clinical practice. Several methods have been developed for eGFR: creatinine... more
Quality of care in diabetic patients receiving pharmacologic treatment. Diabetes mellitus is a chronic disease with an increasing prevalence. Appropriate treatment of the disease and preven- tion of chronic complications reduce morbidity... more
The pharmacokinetics of imipenem were studied in 11 adult patients with severe burns who were receiving a therapeutic regimen of imipenem-cilastatin 500 mg intravenously every 6 hours. Serial blood samples for measuring imipenem and... more
This article reviews the pharmacokinetics of heroin after intravenous, oral, intranasal, intramuscular and rectal application and after inhalation in humans, with a special focus on heroin maintenance therapy in heroin dependent patients.... more
Abstract BACKGROUND: Severe hypoglycemia is a frequent cause of hospi- talization in Mexico. OBJECTIVE: To identify the clinical and laboratory characteristics as- sociated to severe hypoglycemia in consecutive patients with severe... more
Background: Relaxin (Rlx), a 6-kD protein hormone, belongs to the insulin growth factor family. We have previously shown that Rlx reduces interstitial fibrosis in a model of chronic papillary necrosis. Hypothesis: The purpose of this... more
A subtype of antenatal Bartter syndrome and sensorineural deafness (BSND) was originally described among families from southern Israel, and its gene (Barttin, OMIM #606412) has recently been identified. A report has suggested that these... more
Methods. Adult Wistar female rats (210–250 g) were randomly allocated to four groups: (i) an ARF group that received PD [15 mg/kg body weight (bw), single dose subcutaneously]; (ii) a group that received PD plus RA (1 mg/kg bw) beginning... more
Cisplatin (c-DDP) is a widely used antineoplastic drug whose main side effect is nephrotoxicity. Selenium, administered intravenously or intraperitoneally, has been shown to provided protection against c-DDP-induced nephrotoxicity in... more
Key findings There was a good correlation between 24-h Ccr and 1/Scys-C (r 2 = 0.616), whereas less marked correlation was observed between 24-h Ccr and 1/Scr (r 2 = 0.221). On the other hand, vancomycin concentration was predicted from... more
In β-thalassemia, profound anemia and severe hemosiderosis cause functional and physiological abnormalities in various organ systems. In recent years, there have been few published studies demonstrating proteinuria, aminoaciduria, low... more
Acute kidney injury (AKI) is a devastating complication following cardiac surgery and the ideal management is controversial. This prospective, randomized, open-label and double-blinded study analyzed the renoprotective effects of... more
Potassium dichromate (K 2 Cr 2 O 7 )-induced nephrotoxicity is associated with oxidative and nitrosative stress. In this study we investigated the relation between the time course of the oxidative and nitrosative stress with kidney damage... more