This document summarizes information about the drug Coversyl (generic name: Perindopril), which is an ACE inhibitor used to treat essential hypertension and congestive heart failure, and to prevent stroke recurrence. It works by inhibiting the angiotensin-converting enzyme, which reduces vasoconstriction and sodium/water retention. Common side effects include dizziness, headache, cough, and abnormal ECG readings. It should be used cautiously in patients with impaired renal function or a history of angioedema. Nursing responsibilities include monitoring for hypotension, angioedema, and changes in renal function or potassium levels.
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This document summarizes information about the drug Coversyl (generic name: Perindopril), which is an ACE inhibitor used to treat essential hypertension and congestive heart failure, and to prevent stroke recurrence. It works by inhibiting the angiotensin-converting enzyme, which reduces vasoconstriction and sodium/water retention. Common side effects include dizziness, headache, cough, and abnormal ECG readings. It should be used cautiously in patients with impaired renal function or a history of angioedema. Nursing responsibilities include monitoring for hypotension, angioedema, and changes in renal function or potassium levels.
This document summarizes information about the drug Coversyl (generic name: Perindopril), which is an ACE inhibitor used to treat essential hypertension and congestive heart failure, and to prevent stroke recurrence. It works by inhibiting the angiotensin-converting enzyme, which reduces vasoconstriction and sodium/water retention. Common side effects include dizziness, headache, cough, and abnormal ECG readings. It should be used cautiously in patients with impaired renal function or a history of angioedema. Nursing responsibilities include monitoring for hypotension, angioedema, and changes in renal function or potassium levels.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
This document summarizes information about the drug Coversyl (generic name: Perindopril), which is an ACE inhibitor used to treat essential hypertension and congestive heart failure, and to prevent stroke recurrence. It works by inhibiting the angiotensin-converting enzyme, which reduces vasoconstriction and sodium/water retention. Common side effects include dizziness, headache, cough, and abnormal ECG readings. It should be used cautiously in patients with impaired renal function or a history of angioedema. Nursing responsibilities include monitoring for hypotension, angioedema, and changes in renal function or potassium levels.
Copyright:
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Brand Name: Coversyl
Generic Name: Perindopril
Indication: Essential Hypertension, CHF. Prevention of Stroke recurrence in combination with Indapamide in patients with a history of cerebrovascular disease. Drug Classification: Antihypertensive (ACE Inhibitor) Mechanism of Action: A prodrug that is converted by the liver to the active metabolite perindroprilat, which inhibits ACE activity, thereby preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Inhibition of ACE results in decreased vasoconstriction and decreased aldosterone activity,thus reducing sodium water 4, 4 mg P.O. once daily. Increase dosage until blood pressure is controlled or to maximum of 1mg/day; usually maintenance dose is 4 to 8 mg oce daily; may be given it two divided doses. Elderly patients:Initially, 4 mg P.O. daily as one dose or in two divided doses. Dosage may be increased by more than 8 mg/day only under close medical supervision. Special Precaution: Renal failure; renovascular hypertension; surgery/anesth; elderly. Hemodialysis: avoid combination with highly permeable membranes (polyacrylonitrile) Pregnancy Risk Category: C (D in second and third trimesters) Adverse Reaction: CNS: dizziness, asthenia, sleep disorder, paresthesia, depression, somnolence, nervousness, headache.CV: palpitations, edema, chest pain, abnormal ECG. EENT: rhinitis, sinusitis, ear infection, pharyngitis, tinnitus. GI: dyspepsia, diarrhea, abdominal pain, nausea, vomiting, flatulence. GU: proteinuria, urinarytract infection, male sexual dysfunction, menstrual disorder. Musculoskeletal: back pain, hyperonia, neck pain, joint pain, myalgia, arthritis, arm or leg pain Respiratory: cough, upper respiratory infection SKIN: Rash OTHER: viral infection, injury, seasonal allergy Contraindications: Contraindicated in patients hypersensitive to drug or other ACE inhibitors and in those with a history of angioedema secondary to ACE inhibitors. Also contraindicated in pregnant women. Form: Tablets 2mg, 4mg, 8 mg Nursing Responsibility: Use cautiously in patients with a history of angioedema unrelated to ACE inhibitor therapy. Also use cautiously in patients with impaired renal function, heart failure, ischemic heart disease or renal artery stenosis, and in patients with collagen vascular disease, such as systemic lupus erythematosus or scleroderma. Therapy with thiazide diuretic produces a more favorable response. ACE inhibitors appear to increase risk of angioedema in black patients. Angioedema involving the face extremities, lips, tongue, glottis, and larynx may occur. Stop drug and observe patient swelling disappear. If swelling is confined to lips and face, it will probably resolve without treatment, but antihistamines may be useful in relieving symptoms. (continuation of Coversyl) Excessive hypotension can occur when drug is given with diuretics. If possible, stop diuretic 2-3 days before starting perindropil to reduce the potential for excessive hypotension response. Monitor patient at risk for hypertension closely during initiation of therapy, for first 2 weeks of treatment, and whenever dosage of perindopril or concomitant diuretic is increased. In sever hypotension, place patient in a supine position. Volume and salt depletion should be corrected before starting drug. Monitor potassium level closely. Monitor renal function before and periodically throughout therapy.